Amino acid dipepetide frequency for Terribacillus goriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.285AlaAla: 8.285 ± 0.123	0.607AlaCys: 0.607 ± 0.023	4.519AlaAsp: 4.519 ± 0.087	5.634AlaGlu: 5.634 ± 0.084	3.649AlaPhe: 3.649 ± 0.07	6.306AlaGly: 6.306 ± 0.102	1.398AlaHis: 1.398 ± 0.04	6.383AlaIle: 6.383 ± 0.092	4.648AlaLys: 4.648 ± 0.08	7.934AlaLeu: 7.934 ± 0.113	2.236AlaMet: 2.236 ± 0.053	2.825AlaAsn: 2.825 ± 0.051	2.459AlaPro: 2.459 ± 0.095	2.517AlaGln: 2.517 ± 0.06	2.933AlaArg: 2.933 ± 0.066	4.878AlaSer: 4.878 ± 0.077	3.79AlaThr: 3.79 ± 0.061	6.429AlaVal: 6.429 ± 0.085	0.71AlaTrp: 0.71 ± 0.03	2.891AlaTyr: 2.891 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.403CysAla: 0.403 ± 0.021	0.055CysCys: 0.055 ± 0.007	0.307CysAsp: 0.307 ± 0.019	0.359CysGlu: 0.359 ± 0.021	0.33CysPhe: 0.33 ± 0.02	0.554CysGly: 0.554 ± 0.024	0.155CysHis: 0.155 ± 0.012	0.43CysIle: 0.43 ± 0.023	0.267CysLys: 0.267 ± 0.019	0.613CysLeu: 0.613 ± 0.026	0.193CysMet: 0.193 ± 0.016	0.202CysAsn: 0.202 ± 0.014	0.276CysPro: 0.276 ± 0.018	0.189CysGln: 0.189 ± 0.013	0.231CysArg: 0.231 ± 0.016	0.406CysSer: 0.406 ± 0.02	0.371CysThr: 0.371 ± 0.02	0.378CysVal: 0.378 ± 0.018	0.068CysTrp: 0.068 ± 0.008	0.235CysTyr: 0.235 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.276AspAla: 4.276 ± 0.074	0.29AspCys: 0.29 ± 0.018	2.793AspAsp: 2.793 ± 0.061	4.422AspGlu: 4.422 ± 0.086	2.494AspPhe: 2.494 ± 0.059	3.726AspGly: 3.726 ± 0.094	1.159AspHis: 1.159 ± 0.036	4.125AspIle: 4.125 ± 0.073	3.584AspLys: 3.584 ± 0.067	5.113AspLeu: 5.113 ± 0.079	1.527AspMet: 1.527 ± 0.039	2.058AspAsn: 2.058 ± 0.059	2.19AspPro: 2.19 ± 0.054	2.173AspGln: 2.173 ± 0.052	2.376AspArg: 2.376 ± 0.054	2.81AspSer: 2.81 ± 0.063	3.044AspThr: 3.044 ± 0.077	3.924AspVal: 3.924 ± 0.069	0.693AspTrp: 0.693 ± 0.033	2.31AspTyr: 2.31 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.459GluAla: 6.459 ± 0.126	0.235GluCys: 0.235 ± 0.016	4.218GluAsp: 4.218 ± 0.077	7.232GluGlu: 7.232 ± 0.112	2.129GluPhe: 2.129 ± 0.056	4.258GluGly: 4.258 ± 0.069	1.51GluHis: 1.51 ± 0.044	4.88GluIle: 4.88 ± 0.079	5.696GluLys: 5.696 ± 0.093	7.178GluLeu: 7.178 ± 0.085	2.099GluMet: 2.099 ± 0.052	3.266GluAsn: 3.266 ± 0.066	2.071GluPro: 2.071 ± 0.047	4.019GluGln: 4.019 ± 0.07	3.551GluArg: 3.551 ± 0.067	3.539GluSer: 3.539 ± 0.066	4.149GluThr: 4.149 ± 0.073	4.887GluVal: 4.887 ± 0.076	0.764GluTrp: 0.764 ± 0.031	1.95GluTyr: 1.95 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.202PheAla: 3.202 ± 0.065	0.322PheCys: 0.322 ± 0.018	2.334PheAsp: 2.334 ± 0.048	2.647PheGlu: 2.647 ± 0.057	2.173PhePhe: 2.173 ± 0.056	3.387PheGly: 3.387 ± 0.066	0.962PheHis: 0.962 ± 0.032	3.393PheIle: 3.393 ± 0.069	1.888PheLys: 1.888 ± 0.047	4.614PheLeu: 4.614 ± 0.085	1.11PheMet: 1.11 ± 0.038	1.47PheAsn: 1.47 ± 0.04	1.624PhePro: 1.624 ± 0.043	1.737PheGln: 1.737 ± 0.043	1.789PheArg: 1.789 ± 0.044	2.985PheSer: 2.985 ± 0.06	2.584PheThr: 2.584 ± 0.055	3.05PheVal: 3.05 ± 0.063	0.491PheTrp: 0.491 ± 0.024	1.617PheTyr: 1.617 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.33GlyAla: 5.33 ± 0.087	0.513GlyCys: 0.513 ± 0.026	3.341GlyAsp: 3.341 ± 0.064	4.552GlyGlu: 4.552 ± 0.079	3.475GlyPhe: 3.475 ± 0.072	4.922GlyGly: 4.922 ± 0.081	1.294GlyHis: 1.294 ± 0.04	6.018GlyIle: 6.018 ± 0.074	4.678GlyLys: 4.678 ± 0.073	6.708GlyLeu: 6.708 ± 0.097	2.167GlyMet: 2.167 ± 0.054	2.717GlyAsn: 2.717 ± 0.071	1.82GlyPro: 1.82 ± 0.076	2.285GlyGln: 2.285 ± 0.061	2.622GlyArg: 2.622 ± 0.054	4.221GlySer: 4.221 ± 0.074	4.184GlyThr: 4.184 ± 0.072	5.116GlyVal: 5.116 ± 0.08	0.799GlyTrp: 0.799 ± 0.033	2.701GlyTyr: 2.701 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.61HisAla: 1.61 ± 0.039	0.163HisCys: 0.163 ± 0.013	1.199HisAsp: 1.199 ± 0.041	1.236HisGlu: 1.236 ± 0.036	0.965HisPhe: 0.965 ± 0.032	1.427HisGly: 1.427 ± 0.046	0.643HisHis: 0.643 ± 0.024	1.553HisIle: 1.553 ± 0.04	0.975HisLys: 0.975 ± 0.034	2.072HisLeu: 2.072 ± 0.052	0.585HisMet: 0.585 ± 0.026	0.769HisAsn: 0.769 ± 0.027	1.107HisPro: 1.107 ± 0.037	0.834HisGln: 0.834 ± 0.027	0.921HisArg: 0.921 ± 0.029	1.089HisSer: 1.089 ± 0.032	1.133HisThr: 1.133 ± 0.034	1.497HisVal: 1.497 ± 0.041	0.223HisTrp: 0.223 ± 0.015	0.955HisTyr: 0.955 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.451IleAla: 6.451 ± 0.084	0.609IleCys: 0.609 ± 0.027	4.166IleAsp: 4.166 ± 0.073	4.868IleGlu: 4.868 ± 0.084	3.081IlePhe: 3.081 ± 0.07	6.157IleGly: 6.157 ± 0.085	1.553IleHis: 1.553 ± 0.042	5.626IleIle: 5.626 ± 0.104	3.741IleLys: 3.741 ± 0.057	7.102IleLeu: 7.102 ± 0.098	1.744IleMet: 1.744 ± 0.048	2.572IleAsn: 2.572 ± 0.056	3.119IlePro: 3.119 ± 0.067	2.91IleGln: 2.91 ± 0.056	3.178IleArg: 3.178 ± 0.052	4.711IleSer: 4.711 ± 0.073	4.318IleThr: 4.318 ± 0.064	5.502IleVal: 5.502 ± 0.079	0.638IleTrp: 0.638 ± 0.025	2.23IleTyr: 2.23 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.65LysAla: 4.65 ± 0.077	0.221LysCys: 0.221 ± 0.016	3.625LysAsp: 3.625 ± 0.066	6.021LysGlu: 6.021 ± 0.079	1.636LysPhe: 1.636 ± 0.045	3.798LysGly: 3.798 ± 0.064	1.36LysHis: 1.36 ± 0.041	3.544LysIle: 3.544 ± 0.063	4.614LysLys: 4.614 ± 0.077	5.64LysLeu: 5.64 ± 0.073	1.816LysMet: 1.816 ± 0.037	2.38LysAsn: 2.38 ± 0.05	2.045LysPro: 2.045 ± 0.048	3.756LysGln: 3.756 ± 0.079	3.209LysArg: 3.209 ± 0.063	2.948LysSer: 2.948 ± 0.059	3.228LysThr: 3.228 ± 0.063	3.905LysVal: 3.905 ± 0.065	0.681LysTrp: 0.681 ± 0.031	1.689LysTyr: 1.689 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	8.31LeuAla: 8.31 ± 0.097	0.596LeuCys: 0.596 ± 0.027	5.341LeuAsp: 5.341 ± 0.081	6.735LeuGlu: 6.735 ± 0.096	4.658LeuPhe: 4.658 ± 0.098	6.562LeuGly: 6.562 ± 0.109	2.265LeuHis: 2.265 ± 0.051	7.101LeuIle: 7.101 ± 0.107	5.383LeuLys: 5.383 ± 0.077	11.04LeuLeu: 11.04 ± 0.152	2.419LeuMet: 2.419 ± 0.052	3.408LeuAsn: 3.408 ± 0.07	4.244LeuPro: 4.244 ± 0.077	4.284LeuGln: 4.284 ± 0.072	3.97LeuArg: 3.97 ± 0.065	6.581LeuSer: 6.581 ± 0.086	5.78LeuThr: 5.78 ± 0.078	6.529LeuVal: 6.529 ± 0.089	0.812LeuTrp: 0.812 ± 0.031	3.168LeuTyr: 3.168 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.045MetAla: 2.045 ± 0.047	0.128MetCys: 0.128 ± 0.012	1.574MetAsp: 1.574 ± 0.036	2.163MetGlu: 2.163 ± 0.043	0.986MetPhe: 0.986 ± 0.032	1.689MetGly: 1.689 ± 0.039	0.562MetHis: 0.562 ± 0.027	1.878MetIle: 1.878 ± 0.044	2.242MetLys: 2.242 ± 0.046	2.872MetLeu: 2.872 ± 0.062	0.781MetMet: 0.781 ± 0.035	1.286MetAsn: 1.286 ± 0.035	1.061MetPro: 1.061 ± 0.041	1.341MetGln: 1.341 ± 0.04	1.176MetArg: 1.176 ± 0.036	1.528MetSer: 1.528 ± 0.04	1.7MetThr: 1.7 ± 0.042	1.675MetVal: 1.675 ± 0.043	0.182MetTrp: 0.182 ± 0.013	0.739MetTyr: 0.739 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.698AsnAla: 2.698 ± 0.053	0.212AsnCys: 0.212 ± 0.015	2.023AsnAsp: 2.023 ± 0.051	2.818AsnGlu: 2.818 ± 0.06	1.452AsnPhe: 1.452 ± 0.039	3.026AsnGly: 3.026 ± 0.064	0.777AsnHis: 0.777 ± 0.026	2.884AsnIle: 2.884 ± 0.054	2.405AsnLys: 2.405 ± 0.055	3.449AsnLeu: 3.449 ± 0.059	1.181AsnMet: 1.181 ± 0.042	1.642AsnAsn: 1.642 ± 0.05	1.933AsnPro: 1.933 ± 0.048	1.656AsnGln: 1.656 ± 0.043	1.826AsnArg: 1.826 ± 0.04	2.088AsnSer: 2.088 ± 0.053	2.057AsnThr: 2.057 ± 0.053	2.686AsnVal: 2.686 ± 0.052	0.529AsnTrp: 0.529 ± 0.039	1.373AsnTyr: 1.373 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.1ProAla: 3.1 ± 0.109	0.179ProCys: 0.179 ± 0.014	2.44ProAsp: 2.44 ± 0.061	3.225ProGlu: 3.225 ± 0.063	1.797ProPhe: 1.797 ± 0.047	2.498ProGly: 2.498 ± 0.063	0.731ProHis: 0.731 ± 0.03	2.727ProIle: 2.727 ± 0.054	1.902ProLys: 1.902 ± 0.047	3.366ProLeu: 3.366 ± 0.062	0.813ProMet: 0.813 ± 0.029	1.471ProAsn: 1.471 ± 0.035	0.898ProPro: 0.898 ± 0.032	1.103ProGln: 1.103 ± 0.036	1.107ProArg: 1.107 ± 0.036	2.206ProSer: 2.206 ± 0.051	1.913ProThr: 1.913 ± 0.041	3.074ProVal: 3.074 ± 0.119	0.389ProTrp: 0.389 ± 0.021	1.328ProTyr: 1.328 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.721GlnAla: 3.721 ± 0.072	0.155GlnCys: 0.155 ± 0.013	2.203GlnAsp: 2.203 ± 0.053	3.339GlnGlu: 3.339 ± 0.072	1.561GlnPhe: 1.561 ± 0.042	2.289GlnGly: 2.289 ± 0.056	1.063GlnHis: 1.063 ± 0.035	2.678GlnIle: 2.678 ± 0.06	2.563GlnLys: 2.563 ± 0.05	4.524GlnLeu: 4.524 ± 0.076	1.177GlnMet: 1.177 ± 0.038	1.513GlnAsn: 1.513 ± 0.04	1.416GlnPro: 1.416 ± 0.044	2.576GlnGln: 2.576 ± 0.074	1.684GlnArg: 1.684 ± 0.045	2.148GlnSer: 2.148 ± 0.047	2.36GlnThr: 2.36 ± 0.048	2.726GlnVal: 2.726 ± 0.049	0.334GlnTrp: 0.334 ± 0.019	1.318GlnTyr: 1.318 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.679ArgAla: 2.679 ± 0.056	0.234ArgCys: 0.234 ± 0.016	2.145ArgAsp: 2.145 ± 0.051	3.232ArgGlu: 3.232 ± 0.063	1.974ArgPhe: 1.974 ± 0.054	2.285ArgGly: 2.285 ± 0.05	0.897ArgHis: 0.897 ± 0.031	3.25ArgIle: 3.25 ± 0.056	3.054ArgLys: 3.054 ± 0.059	4.021ArgLeu: 4.021 ± 0.07	1.389ArgMet: 1.389 ± 0.037	1.952ArgAsn: 1.952 ± 0.044	1.295ArgPro: 1.295 ± 0.034	1.8ArgGln: 1.8 ± 0.051	1.946ArgArg: 1.946 ± 0.054	2.384ArgSer: 2.384 ± 0.047	2.25ArgThr: 2.25 ± 0.048	2.685ArgVal: 2.685 ± 0.064	0.422ArgTrp: 0.422 ± 0.022	1.704ArgTyr: 1.704 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.303SerAla: 4.303 ± 0.062	0.334SerCys: 0.334 ± 0.019	3.137SerAsp: 3.137 ± 0.077	3.735SerGlu: 3.735 ± 0.073	3.161SerPhe: 3.161 ± 0.057	4.571SerGly: 4.571 ± 0.065	1.108SerHis: 1.108 ± 0.029	4.894SerIle: 4.894 ± 0.087	3.371SerLys: 3.371 ± 0.068	5.794SerLeu: 5.794 ± 0.086	1.745SerMet: 1.745 ± 0.045	2.286SerAsn: 2.286 ± 0.056	1.992SerPro: 1.992 ± 0.047	1.9SerGln: 1.9 ± 0.043	2.351SerArg: 2.351 ± 0.058	3.853SerSer: 3.853 ± 0.088	3.102SerThr: 3.102 ± 0.068	4.227SerVal: 4.227 ± 0.069	0.653SerTrp: 0.653 ± 0.025	2.371SerTyr: 2.371 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.981ThrAla: 4.981 ± 0.08	0.361ThrCys: 0.361 ± 0.019	3.28ThrAsp: 3.28 ± 0.077	3.992ThrGlu: 3.992 ± 0.08	2.554ThrPhe: 2.554 ± 0.053	4.249ThrGly: 4.249 ± 0.065	1.089ThrHis: 1.089 ± 0.036	4.441ThrIle: 4.441 ± 0.057	3.076ThrLys: 3.076 ± 0.058	5.239ThrLeu: 5.239 ± 0.084	1.434ThrMet: 1.434 ± 0.044	2.204ThrAsn: 2.204 ± 0.053	2.297ThrPro: 2.297 ± 0.055	1.553ThrGln: 1.553 ± 0.042	1.827ThrArg: 1.827 ± 0.046	3.343ThrSer: 3.343 ± 0.057	3.062ThrThr: 3.062 ± 0.069	4.363ThrVal: 4.363 ± 0.079	0.507ThrTrp: 0.507 ± 0.024	2.136ThrTyr: 2.136 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	5.492ValAla: 5.492 ± 0.092	0.537ValCys: 0.537 ± 0.025	3.851ValAsp: 3.851 ± 0.072	4.723ValGlu: 4.723 ± 0.062	3.106ValPhe: 3.106 ± 0.063	4.679ValGly: 4.679 ± 0.091	1.38ValHis: 1.38 ± 0.042	5.428ValIle: 5.428 ± 0.072	4.062ValLys: 4.062 ± 0.066	7.309ValLeu: 7.309 ± 0.086	1.962ValMet: 1.962 ± 0.045	2.832ValAsn: 2.832 ± 0.06	2.711ValPro: 2.711 ± 0.052	2.676ValGln: 2.676 ± 0.054	2.753ValArg: 2.753 ± 0.05	4.655ValSer: 4.655 ± 0.077	4.388ValThr: 4.388 ± 0.079	5.076ValVal: 5.076 ± 0.089	0.638ValTrp: 0.638 ± 0.029	2.265ValTyr: 2.265 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.602TrpAla: 0.602 ± 0.025	0.066TrpCys: 0.066 ± 0.008	0.519TrpAsp: 0.519 ± 0.024	0.706TrpGlu: 0.706 ± 0.027	0.503TrpPhe: 0.503 ± 0.025	0.603TrpGly: 0.603 ± 0.029	0.225TrpHis: 0.225 ± 0.016	0.787TrpIle: 0.787 ± 0.031	0.715TrpLys: 0.715 ± 0.03	1.122TrpLeu: 1.122 ± 0.038	0.334TrpMet: 0.334 ± 0.018	0.511TrpAsn: 0.511 ± 0.024	0.244TrpPro: 0.244 ± 0.015	0.463TrpGln: 0.463 ± 0.02	0.459TrpArg: 0.459 ± 0.025	0.589TrpSer: 0.589 ± 0.025	0.531TrpThr: 0.531 ± 0.026	0.618TrpVal: 0.618 ± 0.026	0.125TrpTrp: 0.125 ± 0.011	0.353TrpTyr: 0.353 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.434TyrAla: 2.434 ± 0.047	0.206TyrCys: 0.206 ± 0.014	2.071TyrAsp: 2.071 ± 0.052	2.454TyrGlu: 2.454 ± 0.053	1.696TyrPhe: 1.696 ± 0.051	2.476TyrGly: 2.476 ± 0.056	0.823TyrHis: 0.823 ± 0.029	2.256TyrIle: 2.256 ± 0.046	1.902TyrLys: 1.902 ± 0.052	3.474TyrLeu: 3.474 ± 0.062	0.896TyrMet: 0.896 ± 0.029	1.352TyrAsn: 1.352 ± 0.043	1.462TyrPro: 1.462 ± 0.048	1.577TyrGln: 1.577 ± 0.041	1.687TyrArg: 1.687 ± 0.044	1.927TyrSer: 1.927 ± 0.043	2.043TyrThr: 2.043 ± 0.052	2.178TyrVal: 2.178 ± 0.046	0.419TyrTrp: 0.419 ± 0.02	1.402TyrTyr: 1.402 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3230 proteins (951185 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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