Amino acid dipepetide frequency for Paenibacillus sp. oral taxon 786 str. D14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.357AlaAla: 9.357 ± 0.115	0.75AlaCys: 0.75 ± 0.025	4.27AlaAsp: 4.27 ± 0.059	6.519AlaGlu: 6.519 ± 0.093	3.289AlaPhe: 3.289 ± 0.059	7.183AlaGly: 7.183 ± 0.079	1.398AlaHis: 1.398 ± 0.034	5.202AlaIle: 5.202 ± 0.063	4.633AlaLys: 4.633 ± 0.062	8.697AlaLeu: 8.697 ± 0.085	2.474AlaMet: 2.474 ± 0.05	2.638AlaAsn: 2.638 ± 0.049	2.867AlaPro: 2.867 ± 0.05	2.788AlaGln: 2.788 ± 0.047	3.887AlaArg: 3.887 ± 0.058	4.905AlaSer: 4.905 ± 0.064	3.616AlaThr: 3.616 ± 0.055	6.499AlaVal: 6.499 ± 0.097	1.108AlaTrp: 1.108 ± 0.032	2.711AlaTyr: 2.711 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.553CysAla: 0.553 ± 0.019	0.121CysCys: 0.121 ± 0.01	0.382CysAsp: 0.382 ± 0.018	0.425CysGlu: 0.425 ± 0.021	0.302CysPhe: 0.302 ± 0.014	0.797CysGly: 0.797 ± 0.024	0.189CysHis: 0.189 ± 0.011	0.46CysIle: 0.46 ± 0.018	0.292CysLys: 0.292 ± 0.015	0.736CysLeu: 0.736 ± 0.024	0.175CysMet: 0.175 ± 0.013	0.253CysAsn: 0.253 ± 0.014	0.362CysPro: 0.362 ± 0.016	0.219CysGln: 0.219 ± 0.012	0.502CysArg: 0.502 ± 0.022	0.502CysSer: 0.502 ± 0.02	0.38CysThr: 0.38 ± 0.017	0.444CysVal: 0.444 ± 0.018	0.084CysTrp: 0.084 ± 0.008	0.263CysTyr: 0.263 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.962AspAla: 3.962 ± 0.061	0.352AspCys: 0.352 ± 0.016	2.3AspAsp: 2.3 ± 0.046	3.86AspGlu: 3.86 ± 0.053	2.089AspPhe: 2.089 ± 0.038	4.036AspGly: 4.036 ± 0.057	1.085AspHis: 1.085 ± 0.026	3.234AspIle: 3.234 ± 0.058	2.46AspLys: 2.46 ± 0.047	5.108AspLeu: 5.108 ± 0.059	1.348AspMet: 1.348 ± 0.034	1.68AspAsn: 1.68 ± 0.036	2.641AspPro: 2.641 ± 0.044	1.924AspGln: 1.924 ± 0.04	2.906AspArg: 2.906 ± 0.047	2.433AspSer: 2.433 ± 0.041	2.474AspThr: 2.474 ± 0.046	3.492AspVal: 3.492 ± 0.058	0.851AspTrp: 0.851 ± 0.03	2.052AspTyr: 2.052 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.676GluAla: 6.676 ± 0.076	0.383GluCys: 0.383 ± 0.017	3.229GluAsp: 3.229 ± 0.051	5.858GluGlu: 5.858 ± 0.091	2.187GluPhe: 2.187 ± 0.039	4.754GluGly: 4.754 ± 0.067	1.545GluHis: 1.545 ± 0.034	4.496GluIle: 4.496 ± 0.058	3.899GluLys: 3.899 ± 0.057	7.679GluLeu: 7.679 ± 0.08	2.073GluMet: 2.073 ± 0.042	2.387GluAsn: 2.387 ± 0.045	2.573GluPro: 2.573 ± 0.048	3.67GluGln: 3.67 ± 0.062	4.554GluArg: 4.554 ± 0.063	3.356GluSer: 3.356 ± 0.056	3.504GluThr: 3.504 ± 0.045	4.984GluVal: 4.984 ± 0.07	0.961GluTrp: 0.961 ± 0.026	2.051GluTyr: 2.051 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.346PheAla: 3.346 ± 0.049	0.347PheCys: 0.347 ± 0.016	2.138PheAsp: 2.138 ± 0.042	2.343PheGlu: 2.343 ± 0.047	1.834PhePhe: 1.834 ± 0.042	3.299PheGly: 3.299 ± 0.055	0.884PheHis: 0.884 ± 0.026	2.563PheIle: 2.563 ± 0.05	1.864PheLys: 1.864 ± 0.038	3.867PheLeu: 3.867 ± 0.069	1.139PheMet: 1.139 ± 0.026	1.478PheAsn: 1.478 ± 0.035	1.62PhePro: 1.62 ± 0.033	1.433PheGln: 1.433 ± 0.034	2.173PheArg: 2.173 ± 0.039	2.593PheSer: 2.593 ± 0.044	2.482PheThr: 2.482 ± 0.042	2.927PheVal: 2.927 ± 0.046	0.584PheTrp: 0.584 ± 0.022	1.454PheTyr: 1.454 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.803GlyAla: 5.803 ± 0.078	0.729GlyCys: 0.729 ± 0.026	3.628GlyAsp: 3.628 ± 0.056	5.127GlyGlu: 5.127 ± 0.064	3.311GlyPhe: 3.311 ± 0.053	5.993GlyGly: 5.993 ± 0.086	1.515GlyHis: 1.515 ± 0.038	5.565GlyIle: 5.565 ± 0.068	4.579GlyLys: 4.579 ± 0.064	7.613GlyLeu: 7.613 ± 0.091	2.338GlyMet: 2.338 ± 0.049	2.73GlyAsn: 2.73 ± 0.057	2.202GlyPro: 2.202 ± 0.044	2.775GlyGln: 2.775 ± 0.046	3.874GlyArg: 3.874 ± 0.056	4.644GlySer: 4.644 ± 0.076	4.478GlyThr: 4.478 ± 0.07	5.494GlyVal: 5.494 ± 0.067	1.11GlyTrp: 1.11 ± 0.03	3.001GlyTyr: 3.001 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.549HisAla: 1.549 ± 0.034	0.189HisCys: 0.189 ± 0.011	0.938HisAsp: 0.938 ± 0.029	1.301HisGlu: 1.301 ± 0.035	0.989HisPhe: 0.989 ± 0.026	1.55HisGly: 1.55 ± 0.035	0.578HisHis: 0.578 ± 0.025	1.253HisIle: 1.253 ± 0.032	0.783HisLys: 0.783 ± 0.027	2.239HisLeu: 2.239 ± 0.066	0.52HisMet: 0.52 ± 0.019	0.61HisAsn: 0.61 ± 0.021	1.37HisPro: 1.37 ± 0.03	0.776HisGln: 0.776 ± 0.022	1.213HisArg: 1.213 ± 0.028	1.06HisSer: 1.06 ± 0.031	0.966HisThr: 0.966 ± 0.023	1.405HisVal: 1.405 ± 0.033	0.32HisTrp: 0.32 ± 0.018	0.843HisTyr: 0.843 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.821IleAla: 5.821 ± 0.067	0.562IleCys: 0.562 ± 0.02	3.442IleAsp: 3.442 ± 0.056	4.136IleGlu: 4.136 ± 0.061	2.367IlePhe: 2.367 ± 0.037	5.335IleGly: 5.335 ± 0.077	1.363IleHis: 1.363 ± 0.03	3.699IleIle: 3.699 ± 0.062	2.806IleLys: 2.806 ± 0.049	5.673IleLeu: 5.673 ± 0.067	1.477IleMet: 1.477 ± 0.032	2.213IleAsn: 2.213 ± 0.045	3.116IlePro: 3.116 ± 0.045	2.431IleGln: 2.431 ± 0.043	3.917IleArg: 3.917 ± 0.055	4.139IleSer: 4.139 ± 0.065	3.705IleThr: 3.705 ± 0.055	5.012IleVal: 5.012 ± 0.074	0.733IleTrp: 0.733 ± 0.023	2.079IleTyr: 2.079 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.483LysAla: 4.483 ± 0.062	0.239LysCys: 0.239 ± 0.014	2.699LysAsp: 2.699 ± 0.052	4.217LysGlu: 4.217 ± 0.061	1.541LysPhe: 1.541 ± 0.034	3.449LysGly: 3.449 ± 0.053	1.032LysHis: 1.032 ± 0.027	3.096LysIle: 3.096 ± 0.055	2.989LysLys: 2.989 ± 0.055	5.5LysLeu: 5.5 ± 0.062	1.531LysMet: 1.531 ± 0.032	1.887LysAsn: 1.887 ± 0.04	2.316LysPro: 2.316 ± 0.041	2.387LysGln: 2.387 ± 0.045	3.012LysArg: 3.012 ± 0.045	2.725LysSer: 2.725 ± 0.049	2.767LysThr: 2.767 ± 0.048	3.604LysVal: 3.604 ± 0.057	0.698LysTrp: 0.698 ± 0.025	1.837LysTyr: 1.837 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	8.983LeuAla: 8.983 ± 0.103	0.763LeuCys: 0.763 ± 0.024	5.237LeuAsp: 5.237 ± 0.06	6.799LeuGlu: 6.799 ± 0.079	4.391LeuPhe: 4.391 ± 0.065	7.223LeuGly: 7.223 ± 0.096	2.102LeuHis: 2.102 ± 0.044	6.552LeuIle: 6.552 ± 0.084	5.319LeuLys: 5.319 ± 0.064	11.244LeuLeu: 11.244 ± 0.136	2.574LeuMet: 2.574 ± 0.046	3.692LeuAsn: 3.692 ± 0.056	4.815LeuPro: 4.815 ± 0.064	4.147LeuGln: 4.147 ± 0.056	5.644LeuArg: 5.644 ± 0.073	6.799LeuSer: 6.799 ± 0.069	5.772LeuThr: 5.772 ± 0.062	6.617LeuVal: 6.617 ± 0.072	1.095LeuTrp: 1.095 ± 0.034	3.179LeuTyr: 3.179 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.3MetAla: 2.3 ± 0.039	0.163MetCys: 0.163 ± 0.011	1.442MetAsp: 1.442 ± 0.029	1.868MetGlu: 1.868 ± 0.038	1.01MetPhe: 1.01 ± 0.027	1.8MetGly: 1.8 ± 0.039	0.435MetHis: 0.435 ± 0.017	1.909MetIle: 1.909 ± 0.037	1.969MetLys: 1.969 ± 0.039	2.879MetLeu: 2.879 ± 0.055	0.883MetMet: 0.883 ± 0.027	1.398MetAsn: 1.398 ± 0.031	1.11MetPro: 1.11 ± 0.028	0.97MetGln: 0.97 ± 0.026	1.336MetArg: 1.336 ± 0.033	1.671MetSer: 1.671 ± 0.037	1.608MetThr: 1.608 ± 0.03	1.747MetVal: 1.747 ± 0.037	0.238MetTrp: 0.238 ± 0.013	0.761MetTyr: 0.761 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.782AsnAla: 2.782 ± 0.05	0.242AsnCys: 0.242 ± 0.014	1.729AsnAsp: 1.729 ± 0.039	2.431AsnGlu: 2.431 ± 0.048	1.315AsnPhe: 1.315 ± 0.033	3.171AsnGly: 3.171 ± 0.053	0.791AsnHis: 0.791 ± 0.023	2.118AsnIle: 2.118 ± 0.042	1.756AsnLys: 1.756 ± 0.038	3.395AsnLeu: 3.395 ± 0.053	0.92AsnMet: 0.92 ± 0.028	1.474AsnAsn: 1.474 ± 0.038	2.062AsnPro: 2.062 ± 0.04	1.403AsnGln: 1.403 ± 0.033	2.094AsnArg: 2.094 ± 0.041	1.917AsnSer: 1.917 ± 0.041	1.916AsnThr: 1.916 ± 0.046	2.561AsnVal: 2.561 ± 0.045	0.515AsnTrp: 0.515 ± 0.018	1.378AsnTyr: 1.378 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.594ProAla: 3.594 ± 0.058	0.274ProCys: 0.274 ± 0.014	2.69ProAsp: 2.69 ± 0.05	3.915ProGlu: 3.915 ± 0.062	1.867ProPhe: 1.867 ± 0.037	3.381ProGly: 3.381 ± 0.054	0.93ProHis: 0.93 ± 0.024	2.484ProIle: 2.484 ± 0.046	1.945ProLys: 1.945 ± 0.035	4.171ProLeu: 4.171 ± 0.062	0.996ProMet: 0.996 ± 0.027	1.594ProAsn: 1.594 ± 0.034	1.377ProPro: 1.377 ± 0.03	1.549ProGln: 1.549 ± 0.037	1.665ProArg: 1.665 ± 0.039	2.509ProSer: 2.509 ± 0.04	1.98ProThr: 1.98 ± 0.037	3.374ProVal: 3.374 ± 0.054	0.582ProTrp: 0.582 ± 0.02	1.637ProTyr: 1.637 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.637GlnAla: 3.637 ± 0.057	0.183GlnCys: 0.183 ± 0.011	1.693GlnAsp: 1.693 ± 0.034	2.817GlnGlu: 2.817 ± 0.047	1.463GlnPhe: 1.463 ± 0.031	2.863GlnGly: 2.863 ± 0.051	0.752GlnHis: 0.752 ± 0.026	2.485GlnIle: 2.485 ± 0.041	1.899GlnLys: 1.899 ± 0.04	4.125GlnLeu: 4.125 ± 0.054	1.154GlnMet: 1.154 ± 0.031	1.329GlnAsn: 1.329 ± 0.034	1.635GlnPro: 1.635 ± 0.037	1.869GlnGln: 1.869 ± 0.039	2.114GlnArg: 2.114 ± 0.045	2.058GlnSer: 2.058 ± 0.048	2.012GlnThr: 2.012 ± 0.041	2.725GlnVal: 2.725 ± 0.043	0.483GlnTrp: 0.483 ± 0.021	1.24GlnTyr: 1.24 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.601ArgAla: 3.601 ± 0.057	0.397ArgCys: 0.397 ± 0.016	2.699ArgAsp: 2.699 ± 0.042	4.367ArgGlu: 4.367 ± 0.072	2.401ArgPhe: 2.401 ± 0.037	3.437ArgGly: 3.437 ± 0.052	1.216ArgHis: 1.216 ± 0.034	3.76ArgIle: 3.76 ± 0.056	3.314ArgLys: 3.314 ± 0.049	5.835ArgLeu: 5.835 ± 0.073	1.729ArgMet: 1.729 ± 0.031	2.046ArgAsn: 2.046 ± 0.039	2.025ArgPro: 2.025 ± 0.041	2.318ArgGln: 2.318 ± 0.042	3.462ArgArg: 3.462 ± 0.068	3.159ArgSer: 3.159 ± 0.046	2.777ArgThr: 2.777 ± 0.042	3.429ArgVal: 3.429 ± 0.049	0.784ArgTrp: 0.784 ± 0.023	1.995ArgTyr: 1.995 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.701SerAla: 4.701 ± 0.056	0.425SerCys: 0.425 ± 0.02	2.823SerAsp: 2.823 ± 0.049	3.704SerGlu: 3.704 ± 0.058	2.721SerPhe: 2.721 ± 0.054	5.286SerGly: 5.286 ± 0.072	1.148SerHis: 1.148 ± 0.031	3.801SerIle: 3.801 ± 0.055	2.904SerLys: 2.904 ± 0.052	6.118SerLeu: 6.118 ± 0.07	1.637SerMet: 1.637 ± 0.039	1.99SerAsn: 1.99 ± 0.044	2.521SerPro: 2.521 ± 0.042	1.896SerGln: 1.896 ± 0.038	3.155SerArg: 3.155 ± 0.047	3.864SerSer: 3.864 ± 0.068	2.943SerThr: 2.943 ± 0.056	4.226SerVal: 4.226 ± 0.06	0.818SerTrp: 0.818 ± 0.028	2.013SerTyr: 2.013 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.69ThrAla: 4.69 ± 0.062	0.341ThrCys: 0.341 ± 0.017	2.69ThrAsp: 2.69 ± 0.045	3.356ThrGlu: 3.356 ± 0.051	2.263ThrPhe: 2.263 ± 0.048	4.683ThrGly: 4.683 ± 0.068	1.005ThrHis: 1.005 ± 0.03	3.504ThrIle: 3.504 ± 0.053	2.457ThrLys: 2.457 ± 0.045	5.551ThrLeu: 5.551 ± 0.06	1.328ThrMet: 1.328 ± 0.029	1.824ThrAsn: 1.824 ± 0.041	2.631ThrPro: 2.631 ± 0.049	1.549ThrGln: 1.549 ± 0.031	2.4ThrArg: 2.4 ± 0.042	3.147ThrSer: 3.147 ± 0.058	2.888ThrThr: 2.888 ± 0.06	4.48ThrVal: 4.48 ± 0.067	0.695ThrTrp: 0.695 ± 0.026	1.854ThrTyr: 1.854 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.419ValAla: 5.419 ± 0.058	0.61ValCys: 0.61 ± 0.023	3.672ValAsp: 3.672 ± 0.058	4.545ValGlu: 4.545 ± 0.065	2.858ValPhe: 2.858 ± 0.049	4.626ValGly: 4.626 ± 0.059	1.438ValHis: 1.438 ± 0.032	4.821ValIle: 4.821 ± 0.07	3.917ValLys: 3.917 ± 0.056	7.534ValLeu: 7.534 ± 0.078	1.979ValMet: 1.979 ± 0.04	2.768ValAsn: 2.768 ± 0.048	3.289ValPro: 3.289 ± 0.047	2.631ValGln: 2.631 ± 0.042	3.803ValArg: 3.803 ± 0.056	4.521ValSer: 4.521 ± 0.065	4.508ValThr: 4.508 ± 0.076	5.062ValVal: 5.062 ± 0.07	0.87ValTrp: 0.87 ± 0.027	2.43ValTyr: 2.43 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.86TrpAla: 0.86 ± 0.026	0.094TrpCys: 0.094 ± 0.009	0.72TrpAsp: 0.72 ± 0.022	0.891TrpGlu: 0.891 ± 0.028	0.64TrpPhe: 0.64 ± 0.021	0.88TrpGly: 0.88 ± 0.03	0.252TrpHis: 0.252 ± 0.012	0.95TrpIle: 0.95 ± 0.029	0.735TrpLys: 0.735 ± 0.023	1.472TrpLeu: 1.472 ± 0.038	0.434TrpMet: 0.434 ± 0.017	0.668TrpAsn: 0.668 ± 0.022	0.391TrpPro: 0.391 ± 0.018	0.54TrpGln: 0.54 ± 0.024	0.717TrpArg: 0.717 ± 0.022	0.791TrpSer: 0.791 ± 0.029	0.716TrpThr: 0.716 ± 0.023	0.828TrpVal: 0.828 ± 0.027	0.2TrpTrp: 0.2 ± 0.013	0.404TrpTyr: 0.404 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.674TyrAla: 2.674 ± 0.042	0.278TyrCys: 0.278 ± 0.016	1.865TyrAsp: 1.865 ± 0.04	2.341TyrGlu: 2.341 ± 0.043	1.531TyrPhe: 1.531 ± 0.033	2.761TyrGly: 2.761 ± 0.051	0.789TyrHis: 0.789 ± 0.026	2.075TyrIle: 2.075 ± 0.037	1.491TyrLys: 1.491 ± 0.037	3.512TyrLeu: 3.512 ± 0.052	0.785TyrMet: 0.785 ± 0.023	1.311TyrAsn: 1.311 ± 0.03	1.591TyrPro: 1.591 ± 0.037	1.262TyrGln: 1.262 ± 0.027	2.325TyrArg: 2.325 ± 0.044	1.902TyrSer: 1.902 ± 0.037	1.843TyrThr: 1.843 ± 0.039	2.391TyrVal: 2.391 ± 0.045	0.454TyrTrp: 0.454 ± 0.019	1.379TyrTyr: 1.379 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4460 proteins (1399382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---