Amino acid dipepetide frequency for Butyricicoccus pullicaecorum 1.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.05AlaAla: 11.05 ± 0.142	1.66AlaCys: 1.66 ± 0.042	5.802AlaAsp: 5.802 ± 0.084	6.306AlaGlu: 6.306 ± 0.103	3.508AlaPhe: 3.508 ± 0.063	7.189AlaGly: 7.189 ± 0.109	1.864AlaHis: 1.864 ± 0.046	5.727AlaIle: 5.727 ± 0.091	4.331AlaLys: 4.331 ± 0.078	9.651AlaLeu: 9.651 ± 0.115	2.778AlaMet: 2.778 ± 0.063	2.649AlaAsn: 2.649 ± 0.061	3.302AlaPro: 3.302 ± 0.068	4.302AlaGln: 4.302 ± 0.078	4.815AlaArg: 4.815 ± 0.09	4.546AlaSer: 4.546 ± 0.07	4.072AlaThr: 4.072 ± 0.072	7.592AlaVal: 7.592 ± 0.096	0.844AlaTrp: 0.844 ± 0.031	2.917AlaTyr: 2.917 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.791CysAla: 1.791 ± 0.043	0.305CysCys: 0.305 ± 0.018	0.986CysAsp: 0.986 ± 0.031	1.122CysGlu: 1.122 ± 0.042	0.604CysPhe: 0.604 ± 0.026	1.794CysGly: 1.794 ± 0.053	0.328CysHis: 0.328 ± 0.02	1.02CysIle: 1.02 ± 0.03	0.768CysLys: 0.768 ± 0.03	1.322CysLeu: 1.322 ± 0.04	0.423CysMet: 0.423 ± 0.022	0.494CysAsn: 0.494 ± 0.023	0.886CysPro: 0.886 ± 0.039	0.538CysGln: 0.538 ± 0.029	0.956CysArg: 0.956 ± 0.035	0.874CysSer: 0.874 ± 0.032	1.082CysThr: 1.082 ± 0.04	1.18CysVal: 1.18 ± 0.041	0.153CysTrp: 0.153 ± 0.011	0.509CysTyr: 0.509 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	5.806AspAla: 5.806 ± 0.093	0.991AspCys: 0.991 ± 0.037	3.392AspAsp: 3.392 ± 0.08	4.151AspGlu: 4.151 ± 0.069	2.509AspPhe: 2.509 ± 0.054	5.155AspGly: 5.155 ± 0.083	1.16AspHis: 1.16 ± 0.039	3.597AspIle: 3.597 ± 0.055	2.79AspLys: 2.79 ± 0.055	5.41AspLeu: 5.41 ± 0.084	1.554AspMet: 1.554 ± 0.042	1.836AspAsn: 1.836 ± 0.045	2.573AspPro: 2.573 ± 0.058	1.814AspGln: 1.814 ± 0.047	3.218AspArg: 3.218 ± 0.066	2.906AspSer: 2.906 ± 0.064	3.452AspThr: 3.452 ± 0.064	3.935AspVal: 3.935 ± 0.065	0.77AspTrp: 0.77 ± 0.029	2.284AspTyr: 2.284 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.882GluAla: 5.882 ± 0.09	0.749GluCys: 0.749 ± 0.031	3.702GluAsp: 3.702 ± 0.069	4.586GluGlu: 4.586 ± 0.085	1.938GluPhe: 1.938 ± 0.044	3.914GluGly: 3.914 ± 0.074	1.488GluHis: 1.488 ± 0.046	4.403GluIle: 4.403 ± 0.069	3.894GluLys: 3.894 ± 0.08	6.203GluLeu: 6.203 ± 0.096	2.059GluMet: 2.059 ± 0.049	2.959GluAsn: 2.959 ± 0.065	2.105GluPro: 2.105 ± 0.054	3.596GluGln: 3.596 ± 0.075	4.063GluArg: 4.063 ± 0.077	2.994GluSer: 2.994 ± 0.053	3.671GluThr: 3.671 ± 0.071	4.11GluVal: 4.11 ± 0.062	0.618GluTrp: 0.618 ± 0.028	2.138GluTyr: 2.138 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.654PheAla: 3.654 ± 0.067	0.87PheCys: 0.87 ± 0.031	2.677PheAsp: 2.677 ± 0.059	2.332PheGlu: 2.332 ± 0.047	1.528PhePhe: 1.528 ± 0.048	3.174PheGly: 3.174 ± 0.068	0.744PheHis: 0.744 ± 0.028	2.072PheIle: 2.072 ± 0.051	1.216PheLys: 1.216 ± 0.035	3.632PheLeu: 3.632 ± 0.068	0.843PheMet: 0.843 ± 0.028	1.166PheAsn: 1.166 ± 0.037	1.384PhePro: 1.384 ± 0.038	1.26PheGln: 1.26 ± 0.041	1.851PheArg: 1.851 ± 0.045	2.546PheSer: 2.546 ± 0.057	2.355PheThr: 2.355 ± 0.051	2.705PheVal: 2.705 ± 0.065	0.449PheTrp: 0.449 ± 0.02	1.345PheTyr: 1.345 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.619GlyAla: 6.619 ± 0.098	1.46GlyCys: 1.46 ± 0.044	3.96GlyAsp: 3.96 ± 0.067	4.522GlyGlu: 4.522 ± 0.075	2.994GlyPhe: 2.994 ± 0.061	5.807GlyGly: 5.807 ± 0.115	1.407GlyHis: 1.407 ± 0.04	5.078GlyIle: 5.078 ± 0.104	4.584GlyLys: 4.584 ± 0.076	6.849GlyLeu: 6.849 ± 0.101	2.514GlyMet: 2.514 ± 0.052	2.618GlyAsn: 2.618 ± 0.061	1.487GlyPro: 1.487 ± 0.042	2.821GlyGln: 2.821 ± 0.053	3.701GlyArg: 3.701 ± 0.061	4.032GlySer: 4.032 ± 0.073	4.8GlyThr: 4.8 ± 0.09	5.751GlyVal: 5.751 ± 0.091	0.85GlyTrp: 0.85 ± 0.03	2.965GlyTyr: 2.965 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.775HisAla: 1.775 ± 0.044	0.372HisCys: 0.372 ± 0.021	1.203HisAsp: 1.203 ± 0.037	1.231HisGlu: 1.231 ± 0.044	0.852HisPhe: 0.852 ± 0.03	1.521HisGly: 1.521 ± 0.042	0.537HisHis: 0.537 ± 0.04	1.347HisIle: 1.347 ± 0.04	0.933HisLys: 0.933 ± 0.033	1.774HisLeu: 1.774 ± 0.038	0.503HisMet: 0.503 ± 0.022	0.719HisAsn: 0.719 ± 0.028	1.215HisPro: 1.215 ± 0.043	0.599HisGln: 0.599 ± 0.027	1.062HisArg: 1.062 ± 0.033	1.006HisSer: 1.006 ± 0.032	1.209HisThr: 1.209 ± 0.034	1.25HisVal: 1.25 ± 0.036	0.254HisTrp: 0.254 ± 0.018	0.753HisTyr: 0.753 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.274IleAla: 6.274 ± 0.098	1.148IleCys: 1.148 ± 0.037	3.883IleAsp: 3.883 ± 0.068	3.945IleGlu: 3.945 ± 0.064	2.29IlePhe: 2.29 ± 0.056	4.802IleGly: 4.802 ± 0.079	1.17IleHis: 1.17 ± 0.04	3.481IleIle: 3.481 ± 0.076	2.377IleLys: 2.377 ± 0.053	5.971IleLeu: 5.971 ± 0.1	1.434IleMet: 1.434 ± 0.041	1.941IleAsn: 1.941 ± 0.046	3.096IlePro: 3.096 ± 0.057	2.102IleGln: 2.102 ± 0.048	3.35IleArg: 3.35 ± 0.061	3.809IleSer: 3.809 ± 0.071	3.707IleThr: 3.707 ± 0.068	4.639IleVal: 4.639 ± 0.083	0.55IleTrp: 0.55 ± 0.024	2.026IleTyr: 2.026 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.228LysAla: 4.228 ± 0.076	0.597LysCys: 0.597 ± 0.028	2.462LysAsp: 2.462 ± 0.055	3.162LysGlu: 3.162 ± 0.069	1.449LysPhe: 1.449 ± 0.043	2.935LysGly: 2.935 ± 0.064	0.913LysHis: 0.913 ± 0.034	3.111LysIle: 3.111 ± 0.064	3.518LysLys: 3.518 ± 0.08	4.48LysLeu: 4.48 ± 0.077	1.549LysMet: 1.549 ± 0.042	2.132LysAsn: 2.132 ± 0.045	1.981LysPro: 1.981 ± 0.053	2.034LysGln: 2.034 ± 0.053	2.729LysArg: 2.729 ± 0.062	2.57LysSer: 2.57 ± 0.049	3.189LysThr: 3.189 ± 0.056	3.114LysVal: 3.114 ± 0.064	0.461LysTrp: 0.461 ± 0.023	1.695LysTyr: 1.695 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	8.475LeuAla: 8.475 ± 0.092	2.103LeuCys: 2.103 ± 0.049	5.647LeuAsp: 5.647 ± 0.092	5.601LeuGlu: 5.601 ± 0.095	3.78LeuPhe: 3.78 ± 0.077	6.838LeuGly: 6.838 ± 0.103	2.091LeuHis: 2.091 ± 0.048	5.538LeuIle: 5.538 ± 0.085	4.108LeuLys: 4.108 ± 0.075	9.029LeuLeu: 9.029 ± 0.116	2.606LeuMet: 2.606 ± 0.069	2.996LeuAsn: 2.996 ± 0.059	4.372LeuPro: 4.372 ± 0.074	3.004LeuGln: 3.004 ± 0.062	5.393LeuArg: 5.393 ± 0.094	6.865LeuSer: 6.865 ± 0.101	6.547LeuThr: 6.547 ± 0.082	5.694LeuVal: 5.694 ± 0.089	0.853LeuTrp: 0.853 ± 0.031	3.201LeuTyr: 3.201 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.64MetAla: 2.64 ± 0.061	0.373MetCys: 0.373 ± 0.019	1.636MetAsp: 1.636 ± 0.042	1.854MetGlu: 1.854 ± 0.05	0.889MetPhe: 0.889 ± 0.032	2.076MetGly: 2.076 ± 0.047	0.562MetHis: 0.562 ± 0.024	1.656MetIle: 1.656 ± 0.053	1.736MetLys: 1.736 ± 0.041	2.929MetLeu: 2.929 ± 0.064	0.788MetMet: 0.788 ± 0.031	1.205MetAsn: 1.205 ± 0.036	1.264MetPro: 1.264 ± 0.038	1.347MetGln: 1.347 ± 0.044	1.508MetArg: 1.508 ± 0.041	1.657MetSer: 1.657 ± 0.041	1.885MetThr: 1.885 ± 0.047	1.83MetVal: 1.83 ± 0.046	0.162MetTrp: 0.162 ± 0.013	0.743MetTyr: 0.743 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.257AsnAla: 3.257 ± 0.055	0.495AsnCys: 0.495 ± 0.026	1.881AsnAsp: 1.881 ± 0.054	1.949AsnGlu: 1.949 ± 0.047	1.205AsnPhe: 1.205 ± 0.04	3.039AsnGly: 3.039 ± 0.08	0.761AsnHis: 0.761 ± 0.029	2.299AsnIle: 2.299 ± 0.048	1.44AsnLys: 1.44 ± 0.043	3.289AsnLeu: 3.289 ± 0.062	0.928AsnMet: 0.928 ± 0.031	1.259AsnAsn: 1.259 ± 0.043	1.893AsnPro: 1.893 ± 0.049	1.278AsnGln: 1.278 ± 0.042	1.918AsnArg: 1.918 ± 0.044	1.594AsnSer: 1.594 ± 0.039	2.021AsnThr: 2.021 ± 0.056	2.2AsnVal: 2.2 ± 0.051	0.34AsnTrp: 0.34 ± 0.019	1.241AsnTyr: 1.241 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.86ProAla: 3.86 ± 0.067	0.588ProCys: 0.588 ± 0.028	3.181ProAsp: 3.181 ± 0.063	3.651ProGlu: 3.651 ± 0.069	1.61ProPhe: 1.61 ± 0.045	2.72ProGly: 2.72 ± 0.054	0.845ProHis: 0.845 ± 0.032	2.355ProIle: 2.355 ± 0.057	1.764ProLys: 1.764 ± 0.049	3.351ProLeu: 3.351 ± 0.063	1.117ProMet: 1.117 ± 0.033	1.389ProAsn: 1.389 ± 0.038	1.221ProPro: 1.221 ± 0.04	1.463ProGln: 1.463 ± 0.038	1.606ProArg: 1.606 ± 0.041	2.162ProSer: 2.162 ± 0.05	2.197ProThr: 2.197 ± 0.053	3.436ProVal: 3.436 ± 0.064	0.367ProTrp: 0.367 ± 0.019	1.461ProTyr: 1.461 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	4.009GlnAla: 4.009 ± 0.071	0.493GlnCys: 0.493 ± 0.024	1.976GlnAsp: 1.976 ± 0.048	2.38GlnGlu: 2.38 ± 0.051	1.221GlnPhe: 1.221 ± 0.034	2.436GlnGly: 2.436 ± 0.055	0.681GlnHis: 0.681 ± 0.028	2.528GlnIle: 2.528 ± 0.051	2.209GlnLys: 2.209 ± 0.048	3.286GlnLeu: 3.286 ± 0.075	1.353GlnMet: 1.353 ± 0.034	1.684GlnAsn: 1.684 ± 0.045	1.708GlnPro: 1.708 ± 0.053	1.848GlnGln: 1.848 ± 0.069	1.867GlnArg: 1.867 ± 0.054	2.229GlnSer: 2.229 ± 0.052	2.692GlnThr: 2.692 ± 0.067	2.358GlnVal: 2.358 ± 0.053	0.397GlnTrp: 0.397 ± 0.023	1.409GlnTyr: 1.409 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	4.996ArgAla: 4.996 ± 0.094	0.814ArgCys: 0.814 ± 0.033	3.051ArgAsp: 3.051 ± 0.063	4.08ArgGlu: 4.08 ± 0.086	2.118ArgPhe: 2.118 ± 0.047	3.269ArgGly: 3.269 ± 0.07	0.969ArgHis: 0.969 ± 0.035	3.35ArgIle: 3.35 ± 0.057	3.019ArgLys: 3.019 ± 0.063	5.108ArgLeu: 5.108 ± 0.091	1.936ArgMet: 1.936 ± 0.049	1.693ArgAsn: 1.693 ± 0.045	1.993ArgPro: 1.993 ± 0.054	2.241ArgGln: 2.241 ± 0.059	3.468ArgArg: 3.468 ± 0.072	2.432ArgSer: 2.432 ± 0.057	3.09ArgThr: 3.09 ± 0.058	3.593ArgVal: 3.593 ± 0.064	0.546ArgTrp: 0.546 ± 0.024	2.083ArgTyr: 2.083 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.159SerAla: 5.159 ± 0.083	0.839SerCys: 0.839 ± 0.026	3.454SerAsp: 3.454 ± 0.069	3.481SerGlu: 3.481 ± 0.065	2.364SerPhe: 2.364 ± 0.059	5.015SerGly: 5.015 ± 0.08	1.078SerHis: 1.078 ± 0.039	3.426SerIle: 3.426 ± 0.063	2.333SerLys: 2.333 ± 0.051	4.845SerLeu: 4.845 ± 0.08	1.67SerMet: 1.67 ± 0.043	1.728SerAsn: 1.728 ± 0.043	2.181SerPro: 2.181 ± 0.043	1.902SerGln: 1.902 ± 0.051	2.938SerArg: 2.938 ± 0.06	3.222SerSer: 3.222 ± 0.095	2.882SerThr: 2.882 ± 0.062	4.062SerVal: 4.062 ± 0.073	0.591SerTrp: 0.591 ± 0.025	2.023SerTyr: 2.023 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	6.086ThrAla: 6.086 ± 0.097	0.915ThrCys: 0.915 ± 0.032	3.435ThrAsp: 3.435 ± 0.066	3.759ThrGlu: 3.759 ± 0.069	2.248ThrPhe: 2.248 ± 0.054	5.092ThrGly: 5.092 ± 0.081	1.085ThrHis: 1.085 ± 0.034	3.789ThrIle: 3.789 ± 0.065	2.167ThrLys: 2.167 ± 0.051	5.88ThrLeu: 5.88 ± 0.093	1.587ThrMet: 1.587 ± 0.037	1.715ThrAsn: 1.715 ± 0.044	2.95ThrPro: 2.95 ± 0.057	1.955ThrGln: 1.955 ± 0.048	2.872ThrArg: 2.872 ± 0.06	2.904ThrSer: 2.904 ± 0.06	3.226ThrThr: 3.226 ± 0.068	5.243ThrVal: 5.243 ± 0.09	0.518ThrTrp: 0.518 ± 0.024	1.955ThrTyr: 1.955 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.536ValAla: 5.536 ± 0.087	1.549ValCys: 1.549 ± 0.043	3.972ValAsp: 3.972 ± 0.058	4.012ValGlu: 4.012 ± 0.068	2.841ValPhe: 2.841 ± 0.062	4.788ValGly: 4.788 ± 0.074	1.386ValHis: 1.386 ± 0.038	4.63ValIle: 4.63 ± 0.068	3.238ValLys: 3.238 ± 0.064	7.309ValLeu: 7.309 ± 0.109	1.94ValMet: 1.94 ± 0.048	2.324ValAsn: 2.324 ± 0.054	3.023ValPro: 3.023 ± 0.053	2.66ValGln: 2.66 ± 0.049	3.974ValArg: 3.974 ± 0.076	4.575ValSer: 4.575 ± 0.075	4.481ValThr: 4.481 ± 0.085	4.967ValVal: 4.967 ± 0.079	0.757ValTrp: 0.757 ± 0.033	2.374ValTyr: 2.374 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.729TrpAla: 0.729 ± 0.031	0.177TrpCys: 0.177 ± 0.014	0.598TrpAsp: 0.598 ± 0.028	0.619TrpGlu: 0.619 ± 0.027	0.419TrpPhe: 0.419 ± 0.018	0.678TrpGly: 0.678 ± 0.028	0.24TrpHis: 0.24 ± 0.018	0.581TrpIle: 0.581 ± 0.027	0.557TrpLys: 0.557 ± 0.026	1.056TrpLeu: 1.056 ± 0.032	0.333TrpMet: 0.333 ± 0.02	0.482TrpAsn: 0.482 ± 0.025	0.268TrpPro: 0.268 ± 0.016	0.506TrpGln: 0.506 ± 0.026	0.534TrpArg: 0.534 ± 0.025	0.545TrpSer: 0.545 ± 0.025	0.548TrpThr: 0.548 ± 0.03	0.557TrpVal: 0.557 ± 0.026	0.159TrpTrp: 0.159 ± 0.017	0.416TrpTyr: 0.416 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.078TyrAla: 3.078 ± 0.049	0.634TyrCys: 0.634 ± 0.031	2.403TyrAsp: 2.403 ± 0.058	2.327TyrGlu: 2.327 ± 0.049	1.438TyrPhe: 1.438 ± 0.042	2.576TyrGly: 2.576 ± 0.056	0.805TyrHis: 0.805 ± 0.031	2.011TyrIle: 2.011 ± 0.047	1.327TyrLys: 1.327 ± 0.038	3.371TyrLeu: 3.371 ± 0.059	0.822TyrMet: 0.822 ± 0.028	1.3TyrAsn: 1.3 ± 0.035	1.441TyrPro: 1.441 ± 0.038	1.495TyrGln: 1.495 ± 0.042	2.026TyrArg: 2.026 ± 0.046	1.731TyrSer: 1.731 ± 0.048	2.274TyrThr: 2.274 ± 0.059	2.12TyrVal: 2.12 ± 0.052	0.36TyrTrp: 0.36 ± 0.02	1.363TyrTyr: 1.363 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3107 proteins (955345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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