Amino acid dipepetide frequency for Algibacter alginicilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.744AlaAla: 3.744 ± 0.07	0.544AlaCys: 0.544 ± 0.025	3.069AlaAsp: 3.069 ± 0.061	3.663AlaGlu: 3.663 ± 0.056	3.287AlaPhe: 3.287 ± 0.058	3.669AlaGly: 3.669 ± 0.079	1.067AlaHis: 1.067 ± 0.028	5.31AlaIle: 5.31 ± 0.079	4.403AlaLys: 4.403 ± 0.072	5.8AlaLeu: 5.8 ± 0.087	1.385AlaMet: 1.385 ± 0.032	3.605AlaAsn: 3.605 ± 0.063	1.737AlaPro: 1.737 ± 0.045	2.127AlaGln: 2.127 ± 0.051	1.765AlaArg: 1.765 ± 0.042	4.087AlaSer: 4.087 ± 0.055	3.591AlaThr: 3.591 ± 0.067	3.659AlaVal: 3.659 ± 0.052	0.637AlaTrp: 0.637 ± 0.027	2.575AlaTyr: 2.575 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.419CysAla: 0.419 ± 0.022	0.092CysCys: 0.092 ± 0.01	0.402CysAsp: 0.402 ± 0.023	0.449CysGlu: 0.449 ± 0.022	0.435CysPhe: 0.435 ± 0.02	0.573CysGly: 0.573 ± 0.026	0.181CysHis: 0.181 ± 0.015	0.61CysIle: 0.61 ± 0.024	0.545CysLys: 0.545 ± 0.025	0.623CysLeu: 0.623 ± 0.023	0.143CysMet: 0.143 ± 0.012	0.432CysAsn: 0.432 ± 0.02	0.297CysPro: 0.297 ± 0.021	0.197CysGln: 0.197 ± 0.013	0.174CysArg: 0.174 ± 0.013	0.573CysSer: 0.573 ± 0.024	0.406CysThr: 0.406 ± 0.024	0.432CysVal: 0.432 ± 0.018	0.065CysTrp: 0.065 ± 0.006	0.302CysTyr: 0.302 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.697AspAla: 3.697 ± 0.052	0.411AspCys: 0.411 ± 0.023	3.244AspAsp: 3.244 ± 0.064	3.532AspGlu: 3.532 ± 0.055	3.612AspPhe: 3.612 ± 0.06	3.596AspGly: 3.596 ± 0.074	0.803AspHis: 0.803 ± 0.025	4.97AspIle: 4.97 ± 0.069	4.034AspLys: 4.034 ± 0.064	5.279AspLeu: 5.279 ± 0.062	1.11AspMet: 1.11 ± 0.032	3.481AspAsn: 3.481 ± 0.063	1.504AspPro: 1.504 ± 0.043	1.288AspGln: 1.288 ± 0.037	1.652AspArg: 1.652 ± 0.038	3.174AspSer: 3.174 ± 0.054	2.901AspThr: 2.901 ± 0.054	3.793AspVal: 3.793 ± 0.061	0.779AspTrp: 0.779 ± 0.023	3.074AspTyr: 3.074 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.314GluAla: 4.314 ± 0.062	0.332GluCys: 0.332 ± 0.019	3.52GluAsp: 3.52 ± 0.063	4.087GluGlu: 4.087 ± 0.066	2.976GluPhe: 2.976 ± 0.053	3.601GluGly: 3.601 ± 0.061	1.15GluHis: 1.15 ± 0.03	5.437GluIle: 5.437 ± 0.078	5.384GluLys: 5.384 ± 0.081	5.862GluLeu: 5.862 ± 0.073	1.363GluMet: 1.363 ± 0.031	5.053GluAsn: 5.053 ± 0.076	1.535GluPro: 1.535 ± 0.034	2.086GluGln: 2.086 ± 0.051	2.236GluArg: 2.236 ± 0.043	3.595GluSer: 3.595 ± 0.064	4.012GluThr: 4.012 ± 0.052	3.968GluVal: 3.968 ± 0.061	0.617GluTrp: 0.617 ± 0.022	2.336GluTyr: 2.336 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.637PheAla: 2.637 ± 0.051	0.446PheCys: 0.446 ± 0.024	3.229PheAsp: 3.229 ± 0.059	3.351PheGlu: 3.351 ± 0.05	2.652PhePhe: 2.652 ± 0.059	3.489PheGly: 3.489 ± 0.062	0.839PheHis: 0.839 ± 0.025	4.22PheIle: 4.22 ± 0.067	4.155PheLys: 4.155 ± 0.074	4.624PheLeu: 4.624 ± 0.072	1.091PheMet: 1.091 ± 0.03	3.833PheAsn: 3.833 ± 0.07	1.667PhePro: 1.667 ± 0.039	1.524PheGln: 1.524 ± 0.037	1.493PheArg: 1.493 ± 0.038	4.186PheSer: 4.186 ± 0.067	3.042PheThr: 3.042 ± 0.058	2.999PheVal: 2.999 ± 0.054	0.554PheTrp: 0.554 ± 0.021	2.199PheTyr: 2.199 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	3.955GlyAla: 3.955 ± 0.077	0.592GlyCys: 0.592 ± 0.04	3.344GlyAsp: 3.344 ± 0.061	3.455GlyGlu: 3.455 ± 0.056	3.567GlyPhe: 3.567 ± 0.057	4.39GlyGly: 4.39 ± 0.088	1.182GlyHis: 1.182 ± 0.032	5.372GlyIle: 5.372 ± 0.082	4.698GlyLys: 4.698 ± 0.077	5.592GlyLeu: 5.592 ± 0.073	1.445GlyMet: 1.445 ± 0.037	3.872GlyAsn: 3.872 ± 0.072	1.325GlyPro: 1.325 ± 0.039	1.8GlyGln: 1.8 ± 0.043	1.965GlyArg: 1.965 ± 0.048	3.853GlySer: 3.853 ± 0.066	3.915GlyThr: 3.915 ± 0.088	4.382GlyVal: 4.382 ± 0.066	0.801GlyTrp: 0.801 ± 0.03	2.927GlyTyr: 2.927 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.929HisAla: 0.929 ± 0.03	0.178HisCys: 0.178 ± 0.014	0.903HisAsp: 0.903 ± 0.03	0.933HisGlu: 0.933 ± 0.029	1.176HisPhe: 1.176 ± 0.035	1.092HisGly: 1.092 ± 0.032	0.484HisHis: 0.484 ± 0.021	1.579HisIle: 1.579 ± 0.039	1.274HisLys: 1.274 ± 0.037	1.837HisLeu: 1.837 ± 0.036	0.321HisMet: 0.321 ± 0.015	1.101HisAsn: 1.101 ± 0.033	0.857HisPro: 0.857 ± 0.03	0.662HisGln: 0.662 ± 0.024	0.616HisArg: 0.616 ± 0.024	1.11HisSer: 1.11 ± 0.032	0.98HisThr: 0.98 ± 0.027	0.979HisVal: 0.979 ± 0.03	0.248HisTrp: 0.248 ± 0.015	0.842HisTyr: 0.842 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.28IleAla: 5.28 ± 0.076	0.623IleCys: 0.623 ± 0.024	5.142IleAsp: 5.142 ± 0.059	5.906IleGlu: 5.906 ± 0.08	3.698IlePhe: 3.698 ± 0.065	5.288IleGly: 5.288 ± 0.091	1.407IleHis: 1.407 ± 0.038	6.879IleIle: 6.879 ± 0.089	6.662IleLys: 6.662 ± 0.083	7.284IleLeu: 7.284 ± 0.098	1.457IleMet: 1.457 ± 0.039	5.641IleAsn: 5.641 ± 0.083	3.287IlePro: 3.287 ± 0.056	2.614IleGln: 2.614 ± 0.051	2.402IleArg: 2.402 ± 0.048	6.214IleSer: 6.214 ± 0.08	5.257IleThr: 5.257 ± 0.079	4.793IleVal: 4.793 ± 0.073	0.719IleTrp: 0.719 ± 0.026	3.073IleTyr: 3.073 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.907LysAla: 4.907 ± 0.082	0.352LysCys: 0.352 ± 0.019	4.534LysAsp: 4.534 ± 0.067	5.732LysGlu: 5.732 ± 0.084	3.054LysPhe: 3.054 ± 0.055	4.463LysGly: 4.463 ± 0.069	1.575LysHis: 1.575 ± 0.04	6.351LysIle: 6.351 ± 0.092	6.919LysLys: 6.919 ± 0.092	6.754LysLeu: 6.754 ± 0.074	1.907LysMet: 1.907 ± 0.043	6.066LysAsn: 6.066 ± 0.09	2.638LysPro: 2.638 ± 0.052	2.968LysGln: 2.968 ± 0.052	2.739LysArg: 2.739 ± 0.054	4.876LysSer: 4.876 ± 0.08	5.251LysThr: 5.251 ± 0.075	4.45LysVal: 4.45 ± 0.072	0.817LysTrp: 0.817 ± 0.029	3.18LysTyr: 3.18 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.214LeuAla: 5.214 ± 0.075	0.661LeuCys: 0.661 ± 0.028	4.901LeuAsp: 4.901 ± 0.072	5.963LeuGlu: 5.963 ± 0.084	4.823LeuPhe: 4.823 ± 0.085	5.648LeuGly: 5.648 ± 0.084	1.536LeuHis: 1.536 ± 0.04	7.391LeuIle: 7.391 ± 0.097	8.313LeuLys: 8.313 ± 0.103	8.359LeuLeu: 8.359 ± 0.115	1.909LeuMet: 1.909 ± 0.044	6.474LeuAsn: 6.474 ± 0.095	3.433LeuPro: 3.433 ± 0.063	2.988LeuGln: 2.988 ± 0.056	2.84LeuArg: 2.84 ± 0.049	6.654LeuSer: 6.654 ± 0.083	5.107LeuThr: 5.107 ± 0.062	5.147LeuVal: 5.147 ± 0.075	0.85LeuTrp: 0.85 ± 0.037	3.315LeuTyr: 3.315 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.521MetAla: 1.521 ± 0.04	0.143MetCys: 0.143 ± 0.011	1.032MetAsp: 1.032 ± 0.03	1.22MetGlu: 1.22 ± 0.037	0.919MetPhe: 0.919 ± 0.03	1.254MetGly: 1.254 ± 0.037	0.391MetHis: 0.391 ± 0.019	1.448MetIle: 1.448 ± 0.036	2.035MetLys: 2.035 ± 0.05	1.852MetLeu: 1.852 ± 0.05	0.523MetMet: 0.523 ± 0.022	1.251MetAsn: 1.251 ± 0.031	0.813MetPro: 0.813 ± 0.026	0.779MetGln: 0.779 ± 0.029	0.752MetArg: 0.752 ± 0.026	1.441MetSer: 1.441 ± 0.041	1.114MetThr: 1.114 ± 0.033	1.31MetVal: 1.31 ± 0.036	0.167MetTrp: 0.167 ± 0.012	0.683MetTyr: 0.683 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.847AsnAla: 3.847 ± 0.06	0.508AsnCys: 0.508 ± 0.023	3.68AsnAsp: 3.68 ± 0.07	4.048AsnGlu: 4.048 ± 0.059	3.342AsnPhe: 3.342 ± 0.055	4.268AsnGly: 4.268 ± 0.08	1.295AsnHis: 1.295 ± 0.034	6.052AsnIle: 6.052 ± 0.093	5.224AsnLys: 5.224 ± 0.079	6.017AsnLeu: 6.017 ± 0.081	1.387AsnMet: 1.387 ± 0.034	4.955AsnAsn: 4.955 ± 0.094	2.866AsnPro: 2.866 ± 0.06	2.46AsnGln: 2.46 ± 0.047	2.221AsnArg: 2.221 ± 0.045	4.398AsnSer: 4.398 ± 0.071	4.394AsnThr: 4.394 ± 0.074	3.761AsnVal: 3.761 ± 0.06	0.823AsnTrp: 0.823 ± 0.029	3.317AsnTyr: 3.317 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.688ProAla: 1.688 ± 0.043	0.206ProCys: 0.206 ± 0.015	1.976ProAsp: 1.976 ± 0.047	2.785ProGlu: 2.785 ± 0.052	1.947ProPhe: 1.947 ± 0.041	1.751ProGly: 1.751 ± 0.048	0.633ProHis: 0.633 ± 0.025	2.858ProIle: 2.858 ± 0.055	2.572ProLys: 2.572 ± 0.051	2.903ProLeu: 2.903 ± 0.048	0.633ProMet: 0.633 ± 0.021	2.64ProAsn: 2.64 ± 0.056	0.807ProPro: 0.807 ± 0.034	1.064ProGln: 1.064 ± 0.033	0.868ProArg: 0.868 ± 0.028	2.105ProSer: 2.105 ± 0.046	1.98ProThr: 1.98 ± 0.046	2.104ProVal: 2.104 ± 0.043	0.335ProTrp: 0.335 ± 0.019	1.425ProTyr: 1.425 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.907GlnAla: 1.907 ± 0.039	0.18GlnCys: 0.18 ± 0.014	1.695GlnAsp: 1.695 ± 0.04	1.996GlnGlu: 1.996 ± 0.049	1.681GlnPhe: 1.681 ± 0.042	1.823GlnGly: 1.823 ± 0.041	0.605GlnHis: 0.605 ± 0.022	2.694GlnIle: 2.694 ± 0.049	2.616GlnLys: 2.616 ± 0.056	3.32GlnLeu: 3.32 ± 0.056	0.74GlnMet: 0.74 ± 0.026	2.224GlnAsn: 2.224 ± 0.043	1.04GlnPro: 1.04 ± 0.033	1.29GlnGln: 1.29 ± 0.039	1.124GlnArg: 1.124 ± 0.032	1.922GlnSer: 1.922 ± 0.044	1.931GlnThr: 1.931 ± 0.043	1.926GlnVal: 1.926 ± 0.049	0.358GlnTrp: 0.358 ± 0.017	1.358GlnTyr: 1.358 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.945ArgAla: 1.945 ± 0.045	0.177ArgCys: 0.177 ± 0.014	1.703ArgAsp: 1.703 ± 0.041	1.827ArgGlu: 1.827 ± 0.05	1.732ArgPhe: 1.732 ± 0.036	1.914ArgGly: 1.914 ± 0.045	0.581ArgHis: 0.581 ± 0.023	2.666ArgIle: 2.666 ± 0.05	2.392ArgLys: 2.392 ± 0.049	3.031ArgLeu: 3.031 ± 0.053	0.744ArgMet: 0.744 ± 0.025	2.018ArgAsn: 2.018 ± 0.038	1.014ArgPro: 1.014 ± 0.033	1.01ArgGln: 1.01 ± 0.032	1.164ArgArg: 1.164 ± 0.035	1.726ArgSer: 1.726 ± 0.039	1.782ArgThr: 1.782 ± 0.041	2.001ArgVal: 2.001 ± 0.036	0.428ArgTrp: 0.428 ± 0.019	1.519ArgTyr: 1.519 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.52SerAla: 3.52 ± 0.055	0.616SerCys: 0.616 ± 0.025	3.555SerAsp: 3.555 ± 0.06	4.28SerGlu: 4.28 ± 0.056	3.74SerPhe: 3.74 ± 0.053	4.626SerGly: 4.626 ± 0.076	1.27SerHis: 1.27 ± 0.031	5.759SerIle: 5.759 ± 0.077	5.458SerLys: 5.458 ± 0.073	5.986SerLeu: 5.986 ± 0.084	1.261SerMet: 1.261 ± 0.033	4.59SerAsn: 4.59 ± 0.072	2.027SerPro: 2.027 ± 0.043	2.129SerGln: 2.129 ± 0.04	2.034SerArg: 2.034 ± 0.04	4.329SerSer: 4.329 ± 0.086	3.651SerThr: 3.651 ± 0.062	4.04SerVal: 4.04 ± 0.057	0.703SerTrp: 0.703 ± 0.024	2.842SerTyr: 2.842 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.453ThrAla: 3.453 ± 0.053	0.364ThrCys: 0.364 ± 0.026	3.4ThrAsp: 3.4 ± 0.059	3.454ThrGlu: 3.454 ± 0.052	3.066ThrPhe: 3.066 ± 0.048	3.965ThrGly: 3.965 ± 0.077	1.073ThrHis: 1.073 ± 0.025	5.397ThrIle: 5.397 ± 0.078	4.241ThrLys: 4.241 ± 0.071	5.569ThrLeu: 5.569 ± 0.064	0.978ThrMet: 0.978 ± 0.028	3.966ThrAsn: 3.966 ± 0.076	2.528ThrPro: 2.528 ± 0.058	1.812ThrGln: 1.812 ± 0.034	1.565ThrArg: 1.565 ± 0.04	4.108ThrSer: 4.108 ± 0.07	3.731ThrThr: 3.731 ± 0.08	3.662ThrVal: 3.662 ± 0.068	0.613ThrTrp: 0.613 ± 0.026	2.603ThrTyr: 2.603 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.693ValAla: 3.693 ± 0.068	0.514ValCys: 0.514 ± 0.025	3.575ValAsp: 3.575 ± 0.064	3.821ValGlu: 3.821 ± 0.059	3.439ValPhe: 3.439 ± 0.058	3.591ValGly: 3.591 ± 0.063	0.933ValHis: 0.933 ± 0.031	4.84ValIle: 4.84 ± 0.067	4.4ValLys: 4.4 ± 0.063	5.951ValLeu: 5.951 ± 0.076	1.199ValMet: 1.199 ± 0.031	3.776ValAsn: 3.776 ± 0.053	2.044ValPro: 2.044 ± 0.042	1.648ValGln: 1.648 ± 0.037	1.812ValArg: 1.812 ± 0.043	4.582ValSer: 4.582 ± 0.068	3.473ValThr: 3.473 ± 0.077	3.922ValVal: 3.922 ± 0.069	0.608ValTrp: 0.608 ± 0.025	2.425ValTyr: 2.425 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.581TrpAla: 0.581 ± 0.025	0.092TrpCys: 0.092 ± 0.008	0.659TrpAsp: 0.659 ± 0.027	0.698TrpGlu: 0.698 ± 0.027	0.576TrpPhe: 0.576 ± 0.023	0.701TrpGly: 0.701 ± 0.028	0.266TrpHis: 0.266 ± 0.015	0.761TrpIle: 0.761 ± 0.031	0.806TrpLys: 0.806 ± 0.029	0.989TrpLeu: 0.989 ± 0.032	0.306TrpMet: 0.306 ± 0.016	0.752TrpAsn: 0.752 ± 0.026	0.284TrpPro: 0.284 ± 0.016	0.426TrpGln: 0.426 ± 0.02	0.413TrpArg: 0.413 ± 0.019	0.647TrpSer: 0.647 ± 0.024	0.559TrpThr: 0.559 ± 0.027	0.663TrpVal: 0.663 ± 0.023	0.157TrpTrp: 0.157 ± 0.013	0.462TrpTyr: 0.462 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.474TyrAla: 2.474 ± 0.048	0.32TyrCys: 0.32 ± 0.018	2.366TyrAsp: 2.366 ± 0.048	2.263TyrGlu: 2.263 ± 0.047	2.508TyrPhe: 2.508 ± 0.05	2.732TyrGly: 2.732 ± 0.054	0.833TyrHis: 0.833 ± 0.027	3.033TyrIle: 3.033 ± 0.053	3.404TyrLys: 3.404 ± 0.056	3.894TyrLeu: 3.894 ± 0.06	0.747TyrMet: 0.747 ± 0.024	3.133TyrAsn: 3.133 ± 0.057	1.573TyrPro: 1.573 ± 0.039	1.56TyrGln: 1.56 ± 0.039	1.538TyrArg: 1.538 ± 0.038	2.836TyrSer: 2.836 ± 0.052	2.47TyrThr: 2.47 ± 0.058	2.255TyrVal: 2.255 ± 0.05	0.519TyrTrp: 0.519 ± 0.023	2.03TyrTyr: 2.03 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3236 proteins (1177855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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