Amino acid dipepetide frequency for BK polyomavirus (BKPyV) (Human polyomavirus 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.998AlaAla: 10.998 ± 5.671
0.0AlaCys: 0.0 ± 0.0
4.23AlaAsp: 4.23 ± 0.638
3.384AlaGlu: 3.384 ± 0.912
0.846AlaPhe: 0.846 ± 0.645
3.384AlaGly: 3.384 ± 1.764
0.846AlaHis: 0.846 ± 0.919
5.922AlaIle: 5.922 ± 2.611
3.384AlaLys: 3.384 ± 1.755
8.46AlaLeu: 8.46 ± 3.628
0.0AlaMet: 0.0 ± 0.0
1.692AlaAsn: 1.692 ± 0.877
7.614AlaPro: 7.614 ± 2.155
2.538AlaGln: 2.538 ± 1.186
2.538AlaArg: 2.538 ± 0.626
4.23AlaSer: 4.23 ± 1.901
4.23AlaThr: 4.23 ± 1.432
3.384AlaVal: 3.384 ± 1.444
0.846AlaTrp: 0.846 ± 0.919
4.23AlaTyr: 4.23 ± 0.638
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.919
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.692CysPhe: 1.692 ± 0.938
1.692CysGly: 1.692 ± 1.29
0.0CysHis: 0.0 ± 0.0
0.846CysIle: 0.846 ± 0.919
2.538CysLys: 2.538 ± 1.742
0.0CysLeu: 0.0 ± 0.0
0.846CysMet: 0.846 ± 0.919
0.0CysAsn: 0.0 ± 0.0
2.538CysPro: 2.538 ± 1.742
0.846CysGln: 0.846 ± 0.919
0.846CysArg: 0.846 ± 1.194
0.846CysSer: 0.846 ± 0.919
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.846CysTrp: 0.846 ± 0.645
1.692CysTyr: 1.692 ± 0.938
0.0CysXaa: 0.0 ± 0.0
Asp
2.538AspAla: 2.538 ± 0.626
1.692AspCys: 1.692 ± 1.838
3.384AspAsp: 3.384 ± 1.755
3.384AspGlu: 3.384 ± 0.577
1.692AspPhe: 1.692 ± 1.838
4.23AspGly: 4.23 ± 1.183
1.692AspHis: 1.692 ± 0.733
4.23AspIle: 4.23 ± 1.381
3.384AspLys: 3.384 ± 2.622
5.922AspLeu: 5.922 ± 2.566
0.846AspMet: 0.846 ± 0.645
0.846AspAsn: 0.846 ± 0.645
5.076AspPro: 5.076 ± 2.061
0.0AspGln: 0.0 ± 0.0
1.692AspArg: 1.692 ± 1.29
8.46AspSer: 8.46 ± 3.25
0.846AspThr: 0.846 ± 0.919
0.846AspVal: 0.846 ± 0.919
0.846AspTrp: 0.846 ± 0.623
1.692AspTyr: 1.692 ± 0.877
0.0AspXaa: 0.0 ± 0.0
Glu
5.076GluAla: 5.076 ± 2.011
2.538GluCys: 2.538 ± 1.935
4.23GluAsp: 4.23 ± 1.127
4.23GluGlu: 4.23 ± 1.401
3.384GluPhe: 3.384 ± 1.527
3.384GluGly: 3.384 ± 0.912
0.0GluHis: 0.0 ± 0.0
0.846GluIle: 0.846 ± 0.623
1.692GluLys: 1.692 ± 0.877
6.768GluLeu: 6.768 ± 2.628
1.692GluMet: 1.692 ± 1.29
4.23GluAsn: 4.23 ± 1.46
1.692GluPro: 1.692 ± 0.938
2.538GluGln: 2.538 ± 1.322
4.23GluArg: 4.23 ± 1.696
1.692GluSer: 1.692 ± 0.938
4.23GluThr: 4.23 ± 1.401
7.614GluVal: 7.614 ± 2.164
0.846GluTrp: 0.846 ± 0.919
1.692GluTyr: 1.692 ± 0.877
0.0GluXaa: 0.0 ± 0.0
Phe
3.384PheAla: 3.384 ± 0.912
0.846PheCys: 0.846 ± 1.194
1.692PheAsp: 1.692 ± 1.29
0.0PheGlu: 0.0 ± 0.0
3.384PhePhe: 3.384 ± 0.912
4.23PheGly: 4.23 ± 1.401
1.692PheHis: 1.692 ± 0.938
2.538PheIle: 2.538 ± 1.388
0.846PheLys: 0.846 ± 0.645
4.23PheLeu: 4.23 ± 0.638
0.0PheMet: 0.0 ± 0.0
1.692PheAsn: 1.692 ± 0.877
2.538PhePro: 2.538 ± 1.044
0.0PheGln: 0.0 ± 0.0
2.538PheArg: 2.538 ± 1.044
1.692PheSer: 1.692 ± 1.247
1.692PheThr: 1.692 ± 0.938
1.692PheVal: 1.692 ± 0.877
0.0PheTrp: 0.0 ± 0.0
1.692PheTyr: 1.692 ± 0.877
0.0PheXaa: 0.0 ± 0.0
Gly
5.076GlyAla: 5.076 ± 2.011
0.0GlyCys: 0.0 ± 0.0
4.23GlyAsp: 4.23 ± 1.651
5.922GlyGlu: 5.922 ± 0.808
1.692GlyPhe: 1.692 ± 1.247
6.768GlyGly: 6.768 ± 2.371
1.692GlyHis: 1.692 ± 0.877
2.538GlyIle: 2.538 ± 1.198
1.692GlyLys: 1.692 ± 1.241
6.768GlyLeu: 6.768 ± 1.243
1.692GlyMet: 1.692 ± 0.733
1.692GlyAsn: 1.692 ± 0.938
4.23GlyPro: 4.23 ± 1.381
1.692GlyGln: 1.692 ± 1.29
0.0GlyArg: 0.0 ± 0.0
3.384GlySer: 3.384 ± 0.92
10.152GlyThr: 10.152 ± 1.142
5.076GlyVal: 5.076 ± 2.061
0.0GlyTrp: 0.0 ± 0.0
1.692GlyTyr: 1.692 ± 0.733
0.0GlyXaa: 0.0 ± 0.0
His
0.846HisAla: 0.846 ± 0.645
0.846HisCys: 0.846 ± 0.919
0.0HisAsp: 0.0 ± 0.0
0.846HisGlu: 0.846 ± 0.645
0.846HisPhe: 0.846 ± 0.645
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.692HisLys: 1.692 ± 0.733
0.846HisLeu: 0.846 ± 0.919
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.846HisPro: 0.846 ± 0.919
0.846HisGln: 0.846 ± 0.919
0.0HisArg: 0.0 ± 0.0
1.692HisSer: 1.692 ± 0.877
1.692HisThr: 1.692 ± 0.877
2.538HisVal: 2.538 ± 0.626
1.692HisTrp: 1.692 ± 0.877
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.922IleAla: 5.922 ± 3.475
1.692IleCys: 1.692 ± 0.938
4.23IleAsp: 4.23 ± 1.401
2.538IleGlu: 2.538 ± 1.216
0.846IlePhe: 0.846 ± 1.194
2.538IleGly: 2.538 ± 0.832
0.0IleHis: 0.0 ± 0.0
0.846IleIle: 0.846 ± 0.919
0.846IleLys: 0.846 ± 0.645
3.384IleLeu: 3.384 ± 2.437
0.0IleMet: 0.0 ± 0.0
0.846IleAsn: 0.846 ± 0.645
3.384IlePro: 3.384 ± 0.92
6.768IleGln: 6.768 ± 2.458
5.076IleArg: 5.076 ± 1.252
3.384IleSer: 3.384 ± 0.912
4.23IleThr: 4.23 ± 1.01
1.692IleVal: 1.692 ± 0.877
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.23LysAla: 4.23 ± 0.638
0.846LysCys: 0.846 ± 0.919
1.692LysAsp: 1.692 ± 2.389
5.076LysGlu: 5.076 ± 2.298
0.846LysPhe: 0.846 ± 0.919
4.23LysGly: 4.23 ± 0.638
0.0LysHis: 0.0 ± 0.0
0.846LysIle: 0.846 ± 0.645
5.076LysLys: 5.076 ± 1.727
1.692LysLeu: 1.692 ± 0.938
3.384LysMet: 3.384 ± 1.877
3.384LysAsn: 3.384 ± 2.065
2.538LysPro: 2.538 ± 1.322
0.0LysGln: 0.0 ± 0.0
6.768LysArg: 6.768 ± 0.986
0.846LysSer: 0.846 ± 1.194
5.922LysThr: 5.922 ± 1.361
4.23LysVal: 4.23 ± 1.891
0.0LysTrp: 0.0 ± 0.0
0.846LysTyr: 0.846 ± 0.645
0.0LysXaa: 0.0 ± 0.0
Leu
4.23LeuAla: 4.23 ± 2.286
2.538LeuCys: 2.538 ± 1.742
4.23LeuAsp: 4.23 ± 0.638
9.306LeuGlu: 9.306 ± 2.322
5.922LeuPhe: 5.922 ± 2.228
3.384LeuGly: 3.384 ± 1.22
1.692LeuHis: 1.692 ± 1.29
3.384LeuIle: 3.384 ± 1.444
0.846LeuLys: 0.846 ± 0.919
10.152LeuLeu: 10.152 ± 1.783
3.384LeuMet: 3.384 ± 2.438
4.23LeuAsn: 4.23 ± 2.201
6.768LeuPro: 6.768 ± 1.755
3.384LeuGln: 3.384 ± 0.577
8.46LeuArg: 8.46 ± 3.094
3.384LeuSer: 3.384 ± 1.117
3.384LeuThr: 3.384 ± 1.137
1.692LeuVal: 1.692 ± 0.961
1.692LeuTrp: 1.692 ± 0.877
5.076LeuTyr: 5.076 ± 1.336
0.0LeuXaa: 0.0 ± 0.0
Met
2.538MetAla: 2.538 ± 0.626
0.0MetCys: 0.0 ± 0.0
1.692MetAsp: 1.692 ± 1.838
4.23MetGlu: 4.23 ± 1.401
0.0MetPhe: 0.0 ± 0.0
1.692MetGly: 1.692 ± 0.733
0.0MetHis: 0.0 ± 0.0
0.846MetIle: 0.846 ± 0.645
0.846MetLys: 0.846 ± 0.919
4.23MetLeu: 4.23 ± 0.638
0.0MetMet: 0.0 ± 0.0
2.538MetAsn: 2.538 ± 1.322
0.0MetPro: 0.0 ± 0.0
0.846MetGln: 0.846 ± 0.645
0.846MetArg: 0.846 ± 0.919
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
3.384MetVal: 3.384 ± 1.117
0.846MetTrp: 0.846 ± 0.645
0.846MetTyr: 0.846 ± 0.645
0.0MetXaa: 0.0 ± 0.0
Asn
2.538AsnAla: 2.538 ± 0.626
0.0AsnCys: 0.0 ± 0.0
0.846AsnAsp: 0.846 ± 0.645
1.692AsnGlu: 1.692 ± 1.29
4.23AsnPhe: 4.23 ± 1.381
0.846AsnGly: 0.846 ± 0.645
0.0AsnHis: 0.0 ± 0.0
1.692AsnIle: 1.692 ± 0.877
4.23AsnLys: 4.23 ± 1.992
5.076AsnLeu: 5.076 ± 1.146
0.0AsnMet: 0.0 ± 0.0
2.538AsnAsn: 2.538 ± 0.626
4.23AsnPro: 4.23 ± 1.46
3.384AsnGln: 3.384 ± 1.755
2.538AsnArg: 2.538 ± 1.742
0.846AsnSer: 0.846 ± 0.645
5.076AsnThr: 5.076 ± 1.146
2.538AsnVal: 2.538 ± 0.626
0.0AsnTrp: 0.0 ± 0.0
2.538AsnTyr: 2.538 ± 0.626
0.0AsnXaa: 0.0 ± 0.0
Pro
4.23ProAla: 4.23 ± 1.992
1.692ProCys: 1.692 ± 0.938
7.614ProAsp: 7.614 ± 2.392
1.692ProGlu: 1.692 ± 1.29
0.846ProPhe: 0.846 ± 0.919
5.922ProGly: 5.922 ± 1.436
0.0ProHis: 0.0 ± 0.0
4.23ProIle: 4.23 ± 0.638
3.384ProLys: 3.384 ± 2.58
6.768ProLeu: 6.768 ± 2.178
0.846ProMet: 0.846 ± 0.645
2.538ProAsn: 2.538 ± 0.626
0.846ProPro: 0.846 ± 0.645
2.538ProGln: 2.538 ± 1.216
2.538ProArg: 2.538 ± 0.626
5.076ProSer: 5.076 ± 1.151
1.692ProThr: 1.692 ± 1.29
4.23ProVal: 4.23 ± 1.46
0.0ProTrp: 0.0 ± 0.0
0.846ProTyr: 0.846 ± 0.645
0.0ProXaa: 0.0 ± 0.0
Gln
2.538GlnAla: 2.538 ± 1.388
0.0GlnCys: 0.0 ± 0.0
2.538GlnAsp: 2.538 ± 1.044
3.384GlnGlu: 3.384 ± 1.755
0.0GlnPhe: 0.0 ± 0.0
3.384GlnGly: 3.384 ± 2.58
0.0GlnHis: 0.0 ± 0.0
1.692GlnIle: 1.692 ± 0.961
4.23GlnLys: 4.23 ± 1.381
3.384GlnLeu: 3.384 ± 1.629
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
1.692GlnPro: 1.692 ± 0.938
1.692GlnGln: 1.692 ± 0.733
6.768GlnArg: 6.768 ± 2.298
1.692GlnSer: 1.692 ± 0.733
2.538GlnThr: 2.538 ± 1.198
6.768GlnVal: 6.768 ± 1.512
4.23GlnTrp: 4.23 ± 1.401
1.692GlnTyr: 1.692 ± 0.877
0.0GlnXaa: 0.0 ± 0.0
Arg
3.384ArgAla: 3.384 ± 1.527
0.0ArgCys: 0.0 ± 0.0
4.23ArgAsp: 4.23 ± 1.696
2.538ArgGlu: 2.538 ± 1.044
4.23ArgPhe: 4.23 ± 2.027
4.23ArgGly: 4.23 ± 1.183
2.538ArgHis: 2.538 ± 1.044
3.384ArgIle: 3.384 ± 1.117
5.922ArgLys: 5.922 ± 3.563
2.538ArgLeu: 2.538 ± 1.322
2.538ArgMet: 2.538 ± 1.044
2.538ArgAsn: 2.538 ± 0.626
1.692ArgPro: 1.692 ± 0.877
4.23ArgGln: 4.23 ± 2.226
5.922ArgArg: 5.922 ± 2.228
5.922ArgSer: 5.922 ± 2.228
5.076ArgThr: 5.076 ± 1.252
3.384ArgVal: 3.384 ± 0.92
0.0ArgTrp: 0.0 ± 0.0
2.538ArgTyr: 2.538 ± 1.935
0.0ArgXaa: 0.0 ± 0.0
Ser
2.538SerAla: 2.538 ± 0.626
0.0SerCys: 0.0 ± 0.0
2.538SerAsp: 2.538 ± 1.232
2.538SerGlu: 2.538 ± 1.334
0.846SerPhe: 0.846 ± 0.645
3.384SerGly: 3.384 ± 0.912
0.0SerHis: 0.0 ± 0.0
1.692SerIle: 1.692 ± 0.877
1.692SerLys: 1.692 ± 1.534
6.768SerLeu: 6.768 ± 1.825
5.922SerMet: 5.922 ± 1.241
2.538SerAsn: 2.538 ± 0.626
2.538SerPro: 2.538 ± 0.626
7.614SerGln: 7.614 ± 1.878
6.768SerArg: 6.768 ± 2.298
6.768SerSer: 6.768 ± 1.604
3.384SerThr: 3.384 ± 1.433
5.922SerVal: 5.922 ± 3.456
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
6.768ThrAla: 6.768 ± 2.616
0.846ThrCys: 0.846 ± 0.645
0.846ThrAsp: 0.846 ± 0.645
5.076ThrGlu: 5.076 ± 1.146
1.692ThrPhe: 1.692 ± 0.877
4.23ThrGly: 4.23 ± 1.569
0.0ThrHis: 0.0 ± 0.0
5.076ThrIle: 5.076 ± 2.632
3.384ThrLys: 3.384 ± 2.065
2.538ThrLeu: 2.538 ± 2.757
0.0ThrMet: 0.0 ± 0.0
3.384ThrAsn: 3.384 ± 0.92
4.23ThrPro: 4.23 ± 0.681
5.922ThrGln: 5.922 ± 0.778
2.538ThrArg: 2.538 ± 0.626
4.23ThrSer: 4.23 ± 1.432
5.076ThrThr: 5.076 ± 1.579
6.768ThrVal: 6.768 ± 2.045
3.384ThrTrp: 3.384 ± 1.527
3.384ThrTyr: 3.384 ± 0.912
0.0ThrXaa: 0.0 ± 0.0
Val
4.23ValAla: 4.23 ± 1.632
0.846ValCys: 0.846 ± 0.919
2.538ValAsp: 2.538 ± 1.576
4.23ValGlu: 4.23 ± 2.444
0.846ValPhe: 0.846 ± 0.645
3.384ValGly: 3.384 ± 1.466
3.384ValHis: 3.384 ± 0.577
3.384ValIle: 3.384 ± 0.912
5.922ValLys: 5.922 ± 3.717
5.076ValLeu: 5.076 ± 2.506
1.692ValMet: 1.692 ± 1.206
8.46ValAsn: 8.46 ± 4.387
1.692ValPro: 1.692 ± 1.29
2.538ValGln: 2.538 ± 0.832
2.538ValArg: 2.538 ± 0.626
5.076ValSer: 5.076 ± 1.548
6.768ValThr: 6.768 ± 1.512
0.0ValVal: 0.0 ± 0.0
0.846ValTrp: 0.846 ± 0.919
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.846TrpAsp: 0.846 ± 0.623
0.846TrpGlu: 0.846 ± 0.645
0.846TrpPhe: 0.846 ± 0.919
2.538TrpGly: 2.538 ± 1.044
1.692TrpHis: 1.692 ± 0.877
1.692TrpIle: 1.692 ± 0.938
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
1.692TrpMet: 1.692 ± 0.877
0.0TrpAsn: 0.0 ± 0.0
0.846TrpPro: 0.846 ± 0.919
0.0TrpGln: 0.0 ± 0.0
0.846TrpArg: 0.846 ± 0.645
0.846TrpSer: 0.846 ± 0.919
2.538TrpThr: 2.538 ± 1.388
0.846TrpVal: 0.846 ± 0.919
0.846TrpTrp: 0.846 ± 0.919
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.846TyrAla: 0.846 ± 0.623
1.692TyrCys: 1.692 ± 1.838
1.692TyrAsp: 1.692 ± 0.877
1.692TyrGlu: 1.692 ± 0.877
1.692TyrPhe: 1.692 ± 1.29
2.538TyrGly: 2.538 ± 0.626
0.0TyrHis: 0.0 ± 0.0
2.538TyrIle: 2.538 ± 0.626
0.846TyrLys: 0.846 ± 0.919
3.384TyrLeu: 3.384 ± 0.577
0.0TyrMet: 0.0 ± 0.0
1.692TyrAsn: 1.692 ± 0.877
2.538TyrPro: 2.538 ± 1.935
0.846TyrGln: 0.846 ± 0.623
3.384TyrArg: 3.384 ± 0.912
3.384TyrSer: 3.384 ± 0.92
0.846TyrThr: 0.846 ± 0.645
0.846TyrVal: 0.846 ± 0.645
0.0TyrTrp: 0.0 ± 0.0
3.384TyrTyr: 3.384 ± 1.755
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski