Amino acid dipepetide frequency for Streptomyces chattanoogensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.773AlaAla: 22.773 ± 0.162	1.155AlaCys: 1.155 ± 0.023	8.479AlaAsp: 8.479 ± 0.076	8.752AlaGlu: 8.752 ± 0.076	3.669AlaPhe: 3.669 ± 0.047	13.481AlaGly: 13.481 ± 0.096	3.139AlaHis: 3.139 ± 0.042	3.543AlaIle: 3.543 ± 0.042	3.003AlaLys: 3.003 ± 0.048	14.968AlaLeu: 14.968 ± 0.111	2.594AlaMet: 2.594 ± 0.036	1.876AlaAsn: 1.876 ± 0.032	7.627AlaPro: 7.627 ± 0.076	3.908AlaGln: 3.908 ± 0.048	10.512AlaArg: 10.512 ± 0.078	5.581AlaSer: 5.581 ± 0.041	6.927AlaThr: 6.927 ± 0.057	12.153AlaVal: 12.153 ± 0.093	1.843AlaTrp: 1.843 ± 0.028	2.754AlaTyr: 2.754 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.205CysAla: 1.205 ± 0.024	0.108CysCys: 0.108 ± 0.007	0.511CysAsp: 0.511 ± 0.016	0.418CysGlu: 0.418 ± 0.013	0.24CysPhe: 0.24 ± 0.011	0.992CysGly: 0.992 ± 0.023	0.21CysHis: 0.21 ± 0.009	0.224CysIle: 0.224 ± 0.01	0.117CysLys: 0.117 ± 0.007	0.802CysLeu: 0.802 ± 0.017	0.138CysMet: 0.138 ± 0.007	0.141CysAsn: 0.141 ± 0.008	0.529CysPro: 0.529 ± 0.017	0.176CysGln: 0.176 ± 0.008	0.661CysArg: 0.661 ± 0.017	0.454CysSer: 0.454 ± 0.014	0.558CysThr: 0.558 ± 0.016	0.644CysVal: 0.644 ± 0.018	0.124CysTrp: 0.124 ± 0.007	0.172CysTyr: 0.172 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.871AspAla: 7.871 ± 0.067	0.455AspCys: 0.455 ± 0.015	3.562AspAsp: 3.562 ± 0.038	3.799AspGlu: 3.799 ± 0.046	1.616AspPhe: 1.616 ± 0.026	6.465AspGly: 6.465 ± 0.061	1.471AspHis: 1.471 ± 0.026	1.965AspIle: 1.965 ± 0.029	1.19AspLys: 1.19 ± 0.026	6.088AspLeu: 6.088 ± 0.051	0.783AspMet: 0.783 ± 0.016	0.952AspAsn: 0.952 ± 0.02	4.46AspPro: 4.46 ± 0.045	1.463AspGln: 1.463 ± 0.022	4.991AspArg: 4.991 ± 0.048	2.329AspSer: 2.329 ± 0.032	3.119AspThr: 3.119 ± 0.042	4.247AspVal: 4.247 ± 0.043	1.025AspTrp: 1.025 ± 0.022	1.1AspTyr: 1.1 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.379GluAla: 7.379 ± 0.086	0.379GluCys: 0.379 ± 0.013	2.743GluAsp: 2.743 ± 0.035	3.522GluGlu: 3.522 ± 0.048	1.456GluPhe: 1.456 ± 0.027	4.231GluGly: 4.231 ± 0.047	1.48GluHis: 1.48 ± 0.024	2.263GluIle: 2.263 ± 0.028	1.418GluLys: 1.418 ± 0.03	6.824GluLeu: 6.824 ± 0.066	0.919GluMet: 0.919 ± 0.021	0.974GluAsn: 0.974 ± 0.022	3.308GluPro: 3.308 ± 0.051	2.182GluGln: 2.182 ± 0.033	5.567GluArg: 5.567 ± 0.066	2.435GluSer: 2.435 ± 0.034	2.78GluThr: 2.78 ± 0.032	4.353GluVal: 4.353 ± 0.048	0.757GluTrp: 0.757 ± 0.02	1.044GluTyr: 1.044 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.809PheAla: 3.809 ± 0.041	0.284PheCys: 0.284 ± 0.011	1.917PheAsp: 1.917 ± 0.033	1.343PheGlu: 1.343 ± 0.026	0.918PhePhe: 0.918 ± 0.021	3.013PheGly: 3.013 ± 0.034	0.674PheHis: 0.674 ± 0.017	0.766PheIle: 0.766 ± 0.02	0.495PheLys: 0.495 ± 0.017	2.677PheLeu: 2.677 ± 0.039	0.386PheMet: 0.386 ± 0.013	0.533PheAsn: 0.533 ± 0.018	1.464PhePro: 1.464 ± 0.027	0.663PheGln: 0.663 ± 0.018	1.91PheArg: 1.91 ± 0.032	1.479PheSer: 1.479 ± 0.025	2.003PheThr: 2.003 ± 0.031	2.133PheVal: 2.133 ± 0.029	0.417PheTrp: 0.417 ± 0.013	0.561PheTyr: 0.561 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.309GlyAla: 11.309 ± 0.091	0.901GlyCys: 0.901 ± 0.02	5.022GlyAsp: 5.022 ± 0.051	5.123GlyGlu: 5.123 ± 0.061	2.836GlyPhe: 2.836 ± 0.041	8.878GlyGly: 8.878 ± 0.095	2.459GlyHis: 2.459 ± 0.04	3.681GlyIle: 3.681 ± 0.045	2.585GlyLys: 2.585 ± 0.046	9.577GlyLeu: 9.577 ± 0.072	2.07GlyMet: 2.07 ± 0.027	1.739GlyAsn: 1.739 ± 0.031	5.484GlyPro: 5.484 ± 0.057	2.767GlyGln: 2.767 ± 0.033	7.992GlyArg: 7.992 ± 0.07	5.239GlySer: 5.239 ± 0.058	6.28GlyThr: 6.28 ± 0.056	7.101GlyVal: 7.101 ± 0.062	1.685GlyTrp: 1.685 ± 0.028	2.218GlyTyr: 2.218 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.871HisAla: 2.871 ± 0.038	0.24HisCys: 0.24 ± 0.011	1.398HisAsp: 1.398 ± 0.025	1.205HisGlu: 1.205 ± 0.023	0.696HisPhe: 0.696 ± 0.018	2.567HisGly: 2.567 ± 0.034	0.788HisHis: 0.788 ± 0.021	0.744HisIle: 0.744 ± 0.017	0.415HisLys: 0.415 ± 0.013	2.615HisLeu: 2.615 ± 0.036	0.353HisMet: 0.353 ± 0.012	0.387HisAsn: 0.387 ± 0.013	2.016HisPro: 2.016 ± 0.033	0.723HisGln: 0.723 ± 0.018	2.263HisArg: 2.263 ± 0.035	1.099HisSer: 1.099 ± 0.022	1.464HisThr: 1.464 ± 0.029	1.573HisVal: 1.573 ± 0.027	0.401HisTrp: 0.401 ± 0.012	0.499HisTyr: 0.499 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.08IleAla: 5.08 ± 0.048	0.299IleCys: 0.299 ± 0.011	2.297IleAsp: 2.297 ± 0.031	2.068IleGlu: 2.068 ± 0.035	0.728IlePhe: 0.728 ± 0.019	3.777IleGly: 3.777 ± 0.05	0.639IleHis: 0.639 ± 0.017	0.9IleIle: 0.9 ± 0.023	0.78IleLys: 0.78 ± 0.019	2.369IleLeu: 2.369 ± 0.033	0.452IleMet: 0.452 ± 0.015	0.713IleAsn: 0.713 ± 0.017	1.881IlePro: 1.881 ± 0.035	0.711IleGln: 0.711 ± 0.016	2.391IleArg: 2.391 ± 0.036	1.725IleSer: 1.725 ± 0.026	2.21IleThr: 2.21 ± 0.031	2.702IleVal: 2.702 ± 0.038	0.384IleTrp: 0.384 ± 0.012	0.54IleTyr: 0.54 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.973LysAla: 2.973 ± 0.042	0.115LysCys: 0.115 ± 0.007	1.414LysAsp: 1.414 ± 0.031	1.239LysGlu: 1.239 ± 0.023	0.49LysPhe: 0.49 ± 0.015	1.913LysGly: 1.913 ± 0.038	0.459LysHis: 0.459 ± 0.014	0.895LysIle: 0.895 ± 0.023	0.972LysLys: 0.972 ± 0.032	2.03LysLeu: 2.03 ± 0.034	0.403LysMet: 0.403 ± 0.014	0.549LysAsn: 0.549 ± 0.02	1.395LysPro: 1.395 ± 0.031	0.696LysGln: 0.696 ± 0.017	1.496LysArg: 1.496 ± 0.03	1.166LysSer: 1.166 ± 0.023	1.3LysThr: 1.3 ± 0.028	1.852LysVal: 1.852 ± 0.037	0.271LysTrp: 0.271 ± 0.012	0.43LysTyr: 0.43 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.713LeuAla: 15.713 ± 0.115	0.914LeuCys: 0.914 ± 0.019	6.61LeuAsp: 6.61 ± 0.063	4.767LeuGlu: 4.767 ± 0.05	2.629LeuPhe: 2.629 ± 0.04	9.374LeuGly: 9.374 ± 0.076	2.492LeuHis: 2.492 ± 0.032	3.476LeuIle: 3.476 ± 0.044	1.974LeuLys: 1.974 ± 0.034	11.482LeuLeu: 11.482 ± 0.091	1.642LeuMet: 1.642 ± 0.028	1.649LeuAsn: 1.649 ± 0.024	6.776LeuPro: 6.776 ± 0.065	2.367LeuGln: 2.367 ± 0.035	8.845LeuArg: 8.845 ± 0.063	5.336LeuSer: 5.336 ± 0.048	6.944LeuThr: 6.944 ± 0.058	8.436LeuVal: 8.436 ± 0.056	1.324LeuTrp: 1.324 ± 0.026	1.81LeuTyr: 1.81 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.439MetAla: 2.439 ± 0.036	0.142MetCys: 0.142 ± 0.008	0.917MetAsp: 0.917 ± 0.022	0.756MetGlu: 0.756 ± 0.018	0.444MetPhe: 0.444 ± 0.014	1.364MetGly: 1.364 ± 0.029	0.385MetHis: 0.385 ± 0.014	0.661MetIle: 0.661 ± 0.017	0.415MetLys: 0.415 ± 0.014	1.706MetLeu: 1.706 ± 0.027	0.301MetMet: 0.301 ± 0.012	0.435MetAsn: 0.435 ± 0.013	1.208MetPro: 1.208 ± 0.023	0.457MetGln: 0.457 ± 0.015	1.412MetArg: 1.412 ± 0.024	1.258MetSer: 1.258 ± 0.024	1.52MetThr: 1.52 ± 0.027	1.274MetVal: 1.274 ± 0.025	0.221MetTrp: 0.221 ± 0.01	0.311MetTyr: 0.311 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.179AsnAla: 2.179 ± 0.033	0.179AsnCys: 0.179 ± 0.009	0.936AsnAsp: 0.936 ± 0.024	0.799AsnGlu: 0.799 ± 0.019	0.47AsnPhe: 0.47 ± 0.014	1.884AsnGly: 1.884 ± 0.027	0.411AsnHis: 0.411 ± 0.014	0.668AsnIle: 0.668 ± 0.017	0.452AsnLys: 0.452 ± 0.015	1.599AsnLeu: 1.599 ± 0.028	0.292AsnMet: 0.292 ± 0.012	0.404AsnAsn: 0.404 ± 0.015	1.305AsnPro: 1.305 ± 0.025	0.482AsnGln: 0.482 ± 0.016	1.223AsnArg: 1.223 ± 0.024	0.872AsnSer: 0.872 ± 0.022	1.056AsnThr: 1.056 ± 0.026	1.275AsnVal: 1.275 ± 0.022	0.293AsnTrp: 0.293 ± 0.012	0.393AsnTyr: 0.393 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.053ProAla: 9.053 ± 0.078	0.387ProCys: 0.387 ± 0.013	4.61ProAsp: 4.61 ± 0.05	4.427ProGlu: 4.427 ± 0.053	1.598ProPhe: 1.598 ± 0.026	6.895ProGly: 6.895 ± 0.059	1.568ProHis: 1.568 ± 0.024	1.244ProIle: 1.244 ± 0.025	1.262ProLys: 1.262 ± 0.027	5.577ProLeu: 5.577 ± 0.05	1.04ProMet: 1.04 ± 0.02	0.866ProAsn: 0.866 ± 0.02	3.728ProPro: 3.728 ± 0.064	2.055ProGln: 2.055 ± 0.036	4.098ProArg: 4.098 ± 0.041	3.143ProSer: 3.143 ± 0.042	3.089ProThr: 3.089 ± 0.034	5.536ProVal: 5.536 ± 0.054	0.937ProTrp: 0.937 ± 0.022	1.478ProTyr: 1.478 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.829GlnAla: 3.829 ± 0.051	0.194GlnCys: 0.194 ± 0.009	1.478GlnAsp: 1.478 ± 0.027	1.588GlnGlu: 1.588 ± 0.034	0.691GlnPhe: 0.691 ± 0.015	2.343GlnGly: 2.343 ± 0.039	0.726GlnHis: 0.726 ± 0.017	1.079GlnIle: 1.079 ± 0.023	0.63GlnLys: 0.63 ± 0.019	3.26GlnLeu: 3.26 ± 0.038	0.532GlnMet: 0.532 ± 0.013	0.481GlnAsn: 0.481 ± 0.016	1.79GlnPro: 1.79 ± 0.037	1.335GlnGln: 1.335 ± 0.041	2.537GlnArg: 2.537 ± 0.036	1.239GlnSer: 1.239 ± 0.022	1.289GlnThr: 1.289 ± 0.024	2.298GlnVal: 2.298 ± 0.032	0.517GlnTrp: 0.517 ± 0.016	0.568GlnTyr: 0.568 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.856ArgAla: 9.856 ± 0.076	0.644ArgCys: 0.644 ± 0.017	4.254ArgAsp: 4.254 ± 0.049	4.611ArgGlu: 4.611 ± 0.048	2.39ArgPhe: 2.39 ± 0.034	5.817ArgGly: 5.817 ± 0.053	2.247ArgHis: 2.247 ± 0.033	3.555ArgIle: 3.555 ± 0.039	1.776ArgLys: 1.776 ± 0.032	9.036ArgLeu: 9.036 ± 0.072	1.803ArgMet: 1.803 ± 0.028	1.446ArgAsn: 1.446 ± 0.028	5.255ArgPro: 5.255 ± 0.05	2.47ArgGln: 2.47 ± 0.033	7.986ArgArg: 7.986 ± 0.079	4.063ArgSer: 4.063 ± 0.044	5.615ArgThr: 5.615 ± 0.054	5.379ArgVal: 5.379 ± 0.051	1.367ArgTrp: 1.367 ± 0.025	1.833ArgTyr: 1.833 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.626SerAla: 6.626 ± 0.054	0.426SerCys: 0.426 ± 0.014	2.504SerAsp: 2.504 ± 0.03	2.285SerGlu: 2.285 ± 0.035	1.508SerPhe: 1.508 ± 0.026	5.793SerGly: 5.793 ± 0.06	1.069SerHis: 1.069 ± 0.02	1.346SerIle: 1.346 ± 0.022	1.01SerLys: 1.01 ± 0.021	4.792SerLeu: 4.792 ± 0.045	1.067SerMet: 1.067 ± 0.023	0.772SerAsn: 0.772 ± 0.019	3.224SerPro: 3.224 ± 0.041	1.226SerGln: 1.226 ± 0.021	3.612SerArg: 3.612 ± 0.041	2.675SerSer: 2.675 ± 0.039	2.768SerThr: 2.768 ± 0.034	4.014SerVal: 4.014 ± 0.041	0.895SerTrp: 0.895 ± 0.021	1.152SerTyr: 1.152 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.115ThrAla: 9.115 ± 0.073	0.426ThrCys: 0.426 ± 0.013	3.541ThrAsp: 3.541 ± 0.041	3.11ThrGlu: 3.11 ± 0.037	1.591ThrPhe: 1.591 ± 0.025	6.63ThrGly: 6.63 ± 0.055	1.263ThrHis: 1.263 ± 0.025	1.595ThrIle: 1.595 ± 0.032	1.156ThrLys: 1.156 ± 0.025	5.731ThrLeu: 5.731 ± 0.058	0.911ThrMet: 0.911 ± 0.021	0.95ThrAsn: 0.95 ± 0.022	4.06ThrPro: 4.06 ± 0.039	1.372ThrGln: 1.372 ± 0.025	3.797ThrArg: 3.797 ± 0.042	2.927ThrSer: 2.927 ± 0.037	3.605ThrThr: 3.605 ± 0.045	5.947ThrVal: 5.947 ± 0.056	0.865ThrTrp: 0.865 ± 0.019	1.256ThrTyr: 1.256 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.212ValAla: 10.212 ± 0.071	0.809ValCys: 0.809 ± 0.017	4.509ValAsp: 4.509 ± 0.042	4.25ValGlu: 4.25 ± 0.053	2.324ValPhe: 2.324 ± 0.03	6.156ValGly: 6.156 ± 0.055	2.018ValHis: 2.018 ± 0.027	2.996ValIle: 2.996 ± 0.042	1.649ValLys: 1.649 ± 0.029	9.45ValLeu: 9.45 ± 0.075	1.393ValMet: 1.393 ± 0.021	1.579ValAsn: 1.579 ± 0.028	5.198ValPro: 5.198 ± 0.051	2.092ValGln: 2.092 ± 0.03	6.95ValArg: 6.95 ± 0.059	3.983ValSer: 3.983 ± 0.045	5.255ValThr: 5.255 ± 0.048	7.221ValVal: 7.221 ± 0.071	1.114ValTrp: 1.114 ± 0.024	1.459ValTyr: 1.459 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.026	0.181TrpCys: 0.181 ± 0.009	0.796TrpAsp: 0.796 ± 0.02	0.73TrpGlu: 0.73 ± 0.019	0.509TrpPhe: 0.509 ± 0.015	1.067TrpGly: 1.067 ± 0.024	0.43TrpHis: 0.43 ± 0.013	0.563TrpIle: 0.563 ± 0.017	0.373TrpLys: 0.373 ± 0.014	1.835TrpLeu: 1.835 ± 0.032	0.309TrpMet: 0.309 ± 0.012	0.36TrpAsn: 0.36 ± 0.013	0.82TrpPro: 0.82 ± 0.018	0.663TrpGln: 0.663 ± 0.018	1.317TrpArg: 1.317 ± 0.025	0.892TrpSer: 0.892 ± 0.018	0.981TrpThr: 0.981 ± 0.02	0.945TrpVal: 0.945 ± 0.021	0.339TrpTrp: 0.339 ± 0.012	0.347TrpTyr: 0.347 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.768TyrAla: 2.768 ± 0.036	0.186TyrCys: 0.186 ± 0.009	1.452TyrAsp: 1.452 ± 0.024	1.222TyrGlu: 1.222 ± 0.025	0.642TyrPhe: 0.642 ± 0.016	2.307TyrGly: 2.307 ± 0.032	0.389TyrHis: 0.389 ± 0.013	0.483TyrIle: 0.483 ± 0.015	0.385TyrLys: 0.385 ± 0.015	2.144TyrLeu: 2.144 ± 0.03	0.237TyrMet: 0.237 ± 0.01	0.364TyrAsn: 0.364 ± 0.013	1.064TyrPro: 1.064 ± 0.021	0.597TyrGln: 0.597 ± 0.016	1.841TyrArg: 1.841 ± 0.03	0.867TyrSer: 0.867 ± 0.021	1.087TyrThr: 1.087 ± 0.022	1.535TyrVal: 1.535 ± 0.026	0.352TyrTrp: 0.352 ± 0.013	0.431TyrTyr: 0.431 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7423 proteins (2369380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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