Amino acid dipepetide frequency for halophilic archaeon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.37AlaAla: 12.37 ± 0.131
0.693AlaCys: 0.693 ± 0.022
9.256AlaAsp: 9.256 ± 0.107
7.755AlaGlu: 7.755 ± 0.084
4.18AlaPhe: 4.18 ± 0.053
9.113AlaGly: 9.113 ± 0.094
1.771AlaHis: 1.771 ± 0.035
4.374AlaIle: 4.374 ± 0.069
2.055AlaLys: 2.055 ± 0.045
10.19AlaLeu: 10.19 ± 0.1
2.036AlaMet: 2.036 ± 0.041
2.612AlaAsn: 2.612 ± 0.045
3.889AlaPro: 3.889 ± 0.048
2.163AlaGln: 2.163 ± 0.043
6.067AlaArg: 6.067 ± 0.08
5.593AlaSer: 5.593 ± 0.062
6.95AlaThr: 6.95 ± 0.074
10.647AlaVal: 10.647 ± 0.101
1.15AlaTrp: 1.15 ± 0.029
2.685AlaTyr: 2.685 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.606CysAla: 0.606 ± 0.024
0.096CysCys: 0.096 ± 0.009
0.564CysAsp: 0.564 ± 0.02
0.583CysGlu: 0.583 ± 0.02
0.192CysPhe: 0.192 ± 0.011
0.791CysGly: 0.791 ± 0.025
0.225CysHis: 0.225 ± 0.013
0.263CysIle: 0.263 ± 0.013
0.133CysLys: 0.133 ± 0.01
0.544CysLeu: 0.544 ± 0.019
0.106CysMet: 0.106 ± 0.008
0.195CysAsn: 0.195 ± 0.013
0.512CysPro: 0.512 ± 0.022
0.188CysGln: 0.188 ± 0.011
0.476CysArg: 0.476 ± 0.019
0.449CysSer: 0.449 ± 0.016
0.4CysThr: 0.4 ± 0.018
0.523CysVal: 0.523 ± 0.019
0.091CysTrp: 0.091 ± 0.007
0.206CysTyr: 0.206 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
10.13AspAla: 10.13 ± 0.126
0.723AspCys: 0.723 ± 0.023
7.887AspAsp: 7.887 ± 0.101
7.769AspGlu: 7.769 ± 0.095
1.967AspPhe: 1.967 ± 0.039
7.552AspGly: 7.552 ± 0.085
1.907AspHis: 1.907 ± 0.042
2.698AspIle: 2.698 ± 0.046
1.107AspLys: 1.107 ± 0.036
6.891AspLeu: 6.891 ± 0.084
1.188AspMet: 1.188 ± 0.028
1.304AspAsn: 1.304 ± 0.03
4.442AspPro: 4.442 ± 0.062
1.766AspGln: 1.766 ± 0.04
6.275AspArg: 6.275 ± 0.075
3.415AspSer: 3.415 ± 0.052
3.625AspThr: 3.625 ± 0.051
8.275AspVal: 8.275 ± 0.084
1.079AspTrp: 1.079 ± 0.028
1.979AspTyr: 1.979 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.371GluAla: 7.371 ± 0.092
0.523GluCys: 0.523 ± 0.022
5.347GluAsp: 5.347 ± 0.072
6.765GluGlu: 6.765 ± 0.105
3.08GluPhe: 3.08 ± 0.045
4.875GluGly: 4.875 ± 0.068
1.915GluHis: 1.915 ± 0.035
3.345GluIle: 3.345 ± 0.055
2.124GluLys: 2.124 ± 0.045
7.137GluLeu: 7.137 ± 0.088
1.964GluMet: 1.964 ± 0.034
2.482GluAsn: 2.482 ± 0.042
3.347GluPro: 3.347 ± 0.05
2.759GluGln: 2.759 ± 0.049
7.761GluArg: 7.761 ± 0.109
4.854GluSer: 4.854 ± 0.061
6.336GluThr: 6.336 ± 0.082
5.39GluVal: 5.39 ± 0.072
1.104GluTrp: 1.104 ± 0.032
2.597GluTyr: 2.597 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.856PheAla: 3.856 ± 0.06
0.268PheCys: 0.268 ± 0.015
3.434PheAsp: 3.434 ± 0.052
3.043PheGlu: 3.043 ± 0.048
1.135PhePhe: 1.135 ± 0.034
3.359PheGly: 3.359 ± 0.053
0.716PheHis: 0.716 ± 0.023
1.144PheIle: 1.144 ± 0.036
0.576PheLys: 0.576 ± 0.02
3.075PheLeu: 3.075 ± 0.051
0.558PheMet: 0.558 ± 0.02
0.76PheAsn: 0.76 ± 0.024
1.462PhePro: 1.462 ± 0.03
0.883PheGln: 0.883 ± 0.029
1.951PheArg: 1.951 ± 0.038
1.86PheSer: 1.86 ± 0.041
1.989PheThr: 1.989 ± 0.035
3.61PheVal: 3.61 ± 0.061
0.482PheTrp: 0.482 ± 0.02
0.882PheTyr: 0.882 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
7.618GlyAla: 7.618 ± 0.092
0.684GlyCys: 0.684 ± 0.021
6.443GlyAsp: 6.443 ± 0.085
6.848GlyGlu: 6.848 ± 0.07
3.239GlyPhe: 3.239 ± 0.053
7.297GlyGly: 7.297 ± 0.108
1.655GlyHis: 1.655 ± 0.035
3.922GlyIle: 3.922 ± 0.066
2.097GlyLys: 2.097 ± 0.045
7.18GlyLeu: 7.18 ± 0.09
1.822GlyMet: 1.822 ± 0.033
2.13GlyAsn: 2.13 ± 0.042
3.246GlyPro: 3.246 ± 0.05
2.061GlyGln: 2.061 ± 0.039
4.916GlyArg: 4.916 ± 0.065
4.773GlySer: 4.773 ± 0.063
5.635GlyThr: 5.635 ± 0.072
7.904GlyVal: 7.904 ± 0.082
1.148GlyTrp: 1.148 ± 0.028
2.717GlyTyr: 2.717 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.029HisAla: 2.029 ± 0.041
0.2HisCys: 0.2 ± 0.011
1.796HisAsp: 1.796 ± 0.039
1.67HisGlu: 1.67 ± 0.032
0.633HisPhe: 0.633 ± 0.021
1.979HisGly: 1.979 ± 0.037
0.558HisHis: 0.558 ± 0.022
0.623HisIle: 0.623 ± 0.016
0.322HisLys: 0.322 ± 0.015
1.816HisLeu: 1.816 ± 0.038
0.304HisMet: 0.304 ± 0.014
0.495HisAsn: 0.495 ± 0.019
1.269HisPro: 1.269 ± 0.032
0.518HisGln: 0.518 ± 0.021
1.338HisArg: 1.338 ± 0.032
0.907HisSer: 0.907 ± 0.022
0.966HisThr: 0.966 ± 0.027
2.061HisVal: 2.061 ± 0.036
0.245HisTrp: 0.245 ± 0.013
0.612HisTyr: 0.612 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
4.333IleAla: 4.333 ± 0.066
0.265IleCys: 0.265 ± 0.013
3.209IleAsp: 3.209 ± 0.053
3.386IleGlu: 3.386 ± 0.055
1.063IlePhe: 1.063 ± 0.032
3.45IleGly: 3.45 ± 0.061
0.755IleHis: 0.755 ± 0.022
1.422IleIle: 1.422 ± 0.033
0.704IleLys: 0.704 ± 0.027
3.088IleLeu: 3.088 ± 0.065
0.522IleMet: 0.522 ± 0.021
1.027IleAsn: 1.027 ± 0.026
2.056IlePro: 2.056 ± 0.041
1.087IleGln: 1.087 ± 0.032
2.253IleArg: 2.253 ± 0.042
2.135IleSer: 2.135 ± 0.046
2.29IleThr: 2.29 ± 0.046
3.556IleVal: 3.556 ± 0.056
0.344IleTrp: 0.344 ± 0.016
0.866IleTyr: 0.866 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
1.961LysAla: 1.961 ± 0.042
0.139LysCys: 0.139 ± 0.009
1.231LysAsp: 1.231 ± 0.039
1.535LysGlu: 1.535 ± 0.04
0.651LysPhe: 0.651 ± 0.019
1.465LysGly: 1.465 ± 0.036
0.503LysHis: 0.503 ± 0.018
0.918LysIle: 0.918 ± 0.029
0.782LysLys: 0.782 ± 0.037
1.894LysLeu: 1.894 ± 0.037
0.506LysMet: 0.506 ± 0.02
0.78LysAsn: 0.78 ± 0.028
1.023LysPro: 1.023 ± 0.03
0.933LysGln: 0.933 ± 0.032
1.729LysArg: 1.729 ± 0.037
1.301LysSer: 1.301 ± 0.032
1.526LysThr: 1.526 ± 0.036
1.39LysVal: 1.39 ± 0.039
0.315LysTrp: 0.315 ± 0.016
0.716LysTyr: 0.716 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
11.051LeuAla: 11.051 ± 0.105
0.541LeuCys: 0.541 ± 0.02
7.613LeuAsp: 7.613 ± 0.094
5.859LeuGlu: 5.859 ± 0.074
3.383LeuPhe: 3.383 ± 0.06
7.457LeuGly: 7.457 ± 0.082
1.61LeuHis: 1.61 ± 0.032
2.721LeuIle: 2.721 ± 0.052
1.755LeuLys: 1.755 ± 0.041
8.838LeuLeu: 8.838 ± 0.121
1.373LeuMet: 1.373 ± 0.029
1.975LeuAsn: 1.975 ± 0.033
4.301LeuPro: 4.301 ± 0.058
2.244LeuGln: 2.244 ± 0.041
5.66LeuArg: 5.66 ± 0.066
5.732LeuSer: 5.732 ± 0.067
5.272LeuThr: 5.272 ± 0.058
8.781LeuVal: 8.781 ± 0.096
0.957LeuTrp: 0.957 ± 0.029
2.399LeuTyr: 2.399 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.958MetAla: 1.958 ± 0.04
0.089MetCys: 0.089 ± 0.008
1.284MetAsp: 1.284 ± 0.031
1.12MetGlu: 1.12 ± 0.03
0.565MetPhe: 0.565 ± 0.018
1.45MetGly: 1.45 ± 0.036
0.351MetHis: 0.351 ± 0.016
0.674MetIle: 0.674 ± 0.026
0.533MetLys: 0.533 ± 0.02
1.58MetLeu: 1.58 ± 0.037
0.371MetMet: 0.371 ± 0.017
0.666MetAsn: 0.666 ± 0.02
0.834MetPro: 0.834 ± 0.024
0.564MetGln: 0.564 ± 0.019
1.12MetArg: 1.12 ± 0.026
1.49MetSer: 1.49 ± 0.034
1.61MetThr: 1.61 ± 0.033
1.404MetVal: 1.404 ± 0.035
0.188MetTrp: 0.188 ± 0.013
0.463MetTyr: 0.463 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.723AsnAla: 2.723 ± 0.051
0.247AsnCys: 0.247 ± 0.014
1.853AsnAsp: 1.853 ± 0.041
1.911AsnGlu: 1.911 ± 0.039
0.779AsnPhe: 0.779 ± 0.024
2.212AsnGly: 2.212 ± 0.043
0.578AsnHis: 0.578 ± 0.02
0.961AsnIle: 0.961 ± 0.027
0.54AsnLys: 0.54 ± 0.023
2.247AsnLeu: 2.247 ± 0.037
0.443AsnMet: 0.443 ± 0.02
0.719AsnAsn: 0.719 ± 0.026
1.697AsnPro: 1.697 ± 0.034
0.796AsnGln: 0.796 ± 0.027
1.725AsnArg: 1.725 ± 0.037
1.215AsnSer: 1.215 ± 0.033
1.383AsnThr: 1.383 ± 0.034
2.578AsnVal: 2.578 ± 0.041
0.366AsnTrp: 0.366 ± 0.017
0.757AsnTyr: 0.757 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
4.474ProAla: 4.474 ± 0.062
0.248ProCys: 0.248 ± 0.016
4.705ProAsp: 4.705 ± 0.074
4.324ProGlu: 4.324 ± 0.068
1.688ProPhe: 1.688 ± 0.036
3.759ProGly: 3.759 ± 0.045
0.939ProHis: 0.939 ± 0.024
1.687ProIle: 1.687 ± 0.037
1.069ProLys: 1.069 ± 0.035
3.785ProLeu: 3.785 ± 0.057
0.871ProMet: 0.871 ± 0.025
1.272ProAsn: 1.272 ± 0.031
2.277ProPro: 2.277 ± 0.042
1.077ProGln: 1.077 ± 0.029
2.407ProArg: 2.407 ± 0.041
2.715ProSer: 2.715 ± 0.043
3.158ProThr: 3.158 ± 0.04
4.125ProVal: 4.125 ± 0.051
0.556ProTrp: 0.556 ± 0.019
1.206ProTyr: 1.206 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.469GlnAla: 2.469 ± 0.044
0.177GlnCys: 0.177 ± 0.011
1.487GlnAsp: 1.487 ± 0.036
1.758GlnGlu: 1.758 ± 0.042
1.21GlnPhe: 1.21 ± 0.03
1.747GlnGly: 1.747 ± 0.042
0.615GlnHis: 0.615 ± 0.02
1.163GlnIle: 1.163 ± 0.026
0.763GlnLys: 0.763 ± 0.025
2.266GlnLeu: 2.266 ± 0.039
0.58GlnMet: 0.58 ± 0.02
0.906GlnAsn: 0.906 ± 0.027
1.145GlnPro: 1.145 ± 0.031
1.257GlnGln: 1.257 ± 0.037
2.093GlnArg: 2.093 ± 0.043
1.795GlnSer: 1.795 ± 0.04
1.881GlnThr: 1.881 ± 0.034
1.945GlnVal: 1.945 ± 0.037
0.388GlnTrp: 0.388 ± 0.016
0.907GlnTyr: 0.907 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.088ArgAla: 6.088 ± 0.088
0.516ArgCys: 0.516 ± 0.022
5.306ArgAsp: 5.306 ± 0.054
6.659ArgGlu: 6.659 ± 0.09
2.441ArgPhe: 2.441 ± 0.042
4.561ArgGly: 4.561 ± 0.065
1.264ArgHis: 1.264 ± 0.035
2.723ArgIle: 2.723 ± 0.042
1.618ArgLys: 1.618 ± 0.034
5.819ArgLeu: 5.819 ± 0.07
1.315ArgMet: 1.315 ± 0.032
1.825ArgAsn: 1.825 ± 0.038
2.687ArgPro: 2.687 ± 0.046
1.858ArgGln: 1.858 ± 0.039
5.259ArgArg: 5.259 ± 0.088
3.775ArgSer: 3.775 ± 0.05
4.258ArgThr: 4.258 ± 0.06
5.547ArgVal: 5.547 ± 0.079
0.824ArgTrp: 0.824 ± 0.026
1.977ArgTyr: 1.977 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.178SerAla: 5.178 ± 0.062
0.359SerCys: 0.359 ± 0.019
4.379SerAsp: 4.379 ± 0.061
4.165SerGlu: 4.165 ± 0.061
2.067SerPhe: 2.067 ± 0.045
5.262SerGly: 5.262 ± 0.07
1.009SerHis: 1.009 ± 0.026
2.362SerIle: 2.362 ± 0.048
1.432SerLys: 1.432 ± 0.036
5.055SerLeu: 5.055 ± 0.065
1.155SerMet: 1.155 ± 0.031
1.582SerAsn: 1.582 ± 0.033
2.634SerPro: 2.634 ± 0.042
1.563SerGln: 1.563 ± 0.035
3.281SerArg: 3.281 ± 0.049
3.34SerSer: 3.34 ± 0.068
3.676SerThr: 3.676 ± 0.055
5.081SerVal: 5.081 ± 0.066
0.692SerTrp: 0.692 ± 0.025
1.435SerTyr: 1.435 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.793ThrAla: 6.793 ± 0.071
0.356ThrCys: 0.356 ± 0.017
5.245ThrAsp: 5.245 ± 0.07
4.507ThrGlu: 4.507 ± 0.065
2.204ThrPhe: 2.204 ± 0.045
5.612ThrGly: 5.612 ± 0.059
1.205ThrHis: 1.205 ± 0.029
2.748ThrIle: 2.748 ± 0.049
1.253ThrLys: 1.253 ± 0.031
5.77ThrLeu: 5.77 ± 0.056
1.171ThrMet: 1.171 ± 0.027
1.691ThrAsn: 1.691 ± 0.043
3.325ThrPro: 3.325 ± 0.064
1.445ThrGln: 1.445 ± 0.037
3.275ThrArg: 3.275 ± 0.055
3.246ThrSer: 3.246 ± 0.055
5.009ThrThr: 5.009 ± 0.106
7.265ThrVal: 7.265 ± 0.083
0.74ThrTrp: 0.74 ± 0.024
1.785ThrTyr: 1.785 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.804ValAla: 10.804 ± 0.12
0.666ValCys: 0.666 ± 0.023
7.537ValAsp: 7.537 ± 0.08
8.15ValGlu: 8.15 ± 0.098
3.078ValPhe: 3.078 ± 0.045
8.137ValGly: 8.137 ± 0.101
1.832ValHis: 1.832 ± 0.036
2.789ValIle: 2.789 ± 0.051
1.6ValLys: 1.6 ± 0.035
8.419ValLeu: 8.419 ± 0.093
1.413ValMet: 1.413 ± 0.033
2.146ValAsn: 2.146 ± 0.035
4.417ValPro: 4.417 ± 0.06
2.147ValGln: 2.147 ± 0.04
5.734ValArg: 5.734 ± 0.08
5.069ValSer: 5.069 ± 0.061
6.321ValThr: 6.321 ± 0.078
9.867ValVal: 9.867 ± 0.101
0.922ValTrp: 0.922 ± 0.029
2.261ValTyr: 2.261 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.942TrpAla: 0.942 ± 0.024
0.097TrpCys: 0.097 ± 0.01
0.8TrpAsp: 0.8 ± 0.024
0.887TrpGlu: 0.887 ± 0.023
0.531TrpPhe: 0.531 ± 0.021
0.898TrpGly: 0.898 ± 0.024
0.26TrpHis: 0.26 ± 0.014
0.525TrpIle: 0.525 ± 0.02
0.356TrpLys: 0.356 ± 0.015
1.289TrpLeu: 1.289 ± 0.037
0.234TrpMet: 0.234 ± 0.013
0.442TrpAsn: 0.442 ± 0.017
0.504TrpPro: 0.504 ± 0.019
0.443TrpGln: 0.443 ± 0.018
0.917TrpArg: 0.917 ± 0.026
0.695TrpSer: 0.695 ± 0.023
0.882TrpThr: 0.882 ± 0.025
0.894TrpVal: 0.894 ± 0.027
0.215TrpTrp: 0.215 ± 0.013
0.381TrpTyr: 0.381 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.045
0.253TyrCys: 0.253 ± 0.014
2.603TyrAsp: 2.603 ± 0.046
2.381TyrGlu: 2.381 ± 0.039
0.961TyrPhe: 0.961 ± 0.028
2.358TyrGly: 2.358 ± 0.042
0.672TyrHis: 0.672 ± 0.022
0.749TyrIle: 0.749 ± 0.024
0.48TyrLys: 0.48 ± 0.018
2.642TyrLeu: 2.642 ± 0.046
0.379TyrMet: 0.379 ± 0.016
0.721TyrAsn: 0.721 ± 0.025
1.273TyrPro: 1.273 ± 0.026
0.8TyrGln: 0.8 ± 0.02
2.084TyrArg: 2.084 ± 0.042
1.345TyrSer: 1.345 ± 0.035
1.48TyrThr: 1.48 ± 0.035
2.467TyrVal: 2.467 ± 0.046
0.385TyrTrp: 0.385 ± 0.018
0.969TyrTyr: 0.969 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5207 proteins (1468061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski