Amino acid dipepetide frequency for Collinsella intestinalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.729AlaAla: 14.729 ± 0.293
2.117AlaCys: 2.117 ± 0.071
6.859AlaAsp: 6.859 ± 0.143
8.256AlaGlu: 8.256 ± 0.165
4.08AlaPhe: 4.08 ± 0.101
9.567AlaGly: 9.567 ± 0.153
2.314AlaHis: 2.314 ± 0.069
6.131AlaIle: 6.131 ± 0.126
4.005AlaLys: 4.005 ± 0.125
11.759AlaLeu: 11.759 ± 0.178
3.298AlaMet: 3.298 ± 0.083
2.897AlaAsn: 2.897 ± 0.088
4.85AlaPro: 4.85 ± 0.152
3.461AlaGln: 3.461 ± 0.1
7.556AlaArg: 7.556 ± 0.169
6.627AlaSer: 6.627 ± 0.128
5.417AlaThr: 5.417 ± 0.12
8.381AlaVal: 8.381 ± 0.157
1.152AlaTrp: 1.152 ± 0.049
2.914AlaTyr: 2.914 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
1.828CysAla: 1.828 ± 0.069
0.235CysCys: 0.235 ± 0.023
1.084CysAsp: 1.084 ± 0.047
1.023CysGlu: 1.023 ± 0.046
0.523CysPhe: 0.523 ± 0.034
1.725CysGly: 1.725 ± 0.066
0.312CysHis: 0.312 ± 0.027
0.73CysIle: 0.73 ± 0.037
0.398CysLys: 0.398 ± 0.028
1.166CysLeu: 1.166 ± 0.044
0.402CysMet: 0.402 ± 0.032
0.338CysAsn: 0.338 ± 0.029
0.782CysPro: 0.782 ± 0.051
0.338CysGln: 0.338 ± 0.028
0.903CysArg: 0.903 ± 0.048
0.834CysSer: 0.834 ± 0.046
0.851CysThr: 0.851 ± 0.047
1.253CysVal: 1.253 ± 0.046
0.141CysTrp: 0.141 ± 0.017
0.346CysTyr: 0.346 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
8.212AspAla: 8.212 ± 0.144
0.853AspCys: 0.853 ± 0.046
3.623AspAsp: 3.623 ± 0.088
5.461AspGlu: 5.461 ± 0.109
2.397AspPhe: 2.397 ± 0.069
5.59AspGly: 5.59 ± 0.139
1.132AspHis: 1.132 ± 0.05
3.334AspIle: 3.334 ± 0.083
1.977AspLys: 1.977 ± 0.062
5.877AspLeu: 5.877 ± 0.11
1.709AspMet: 1.709 ± 0.059
1.321AspAsn: 1.321 ± 0.067
3.211AspPro: 3.211 ± 0.072
1.259AspGln: 1.259 ± 0.05
3.897AspArg: 3.897 ± 0.097
2.694AspSer: 2.694 ± 0.071
2.719AspThr: 2.719 ± 0.075
5.065AspVal: 5.065 ± 0.105
0.664AspTrp: 0.664 ± 0.038
1.824AspTyr: 1.824 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
7.691GluAla: 7.691 ± 0.158
0.78GluCys: 0.78 ± 0.045
4.032GluAsp: 4.032 ± 0.108
4.474GluGlu: 4.474 ± 0.114
2.238GluPhe: 2.238 ± 0.068
5.341GluGly: 5.341 ± 0.114
1.778GluHis: 1.778 ± 0.067
3.358GluIle: 3.358 ± 0.093
2.568GluLys: 2.568 ± 0.094
7.478GluLeu: 7.478 ± 0.146
2.003GluMet: 2.003 ± 0.068
2.16GluAsn: 2.16 ± 0.061
2.775GluPro: 2.775 ± 0.079
2.513GluGln: 2.513 ± 0.082
5.711GluArg: 5.711 ± 0.14
3.064GluSer: 3.064 ± 0.072
3.074GluThr: 3.074 ± 0.079
5.174GluVal: 5.174 ± 0.107
0.579GluTrp: 0.579 ± 0.038
1.657GluTyr: 1.657 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
4.098PheAla: 4.098 ± 0.104
0.664PheCys: 0.664 ± 0.038
2.996PheAsp: 2.996 ± 0.082
2.433PheGlu: 2.433 ± 0.084
1.432PhePhe: 1.432 ± 0.064
3.499PheGly: 3.499 ± 0.089
0.682PheHis: 0.682 ± 0.04
1.82PheIle: 1.82 ± 0.066
1.223PheLys: 1.223 ± 0.054
2.996PheLeu: 2.996 ± 0.088
1.044PheMet: 1.044 ± 0.048
1.086PheAsn: 1.086 ± 0.059
1.351PhePro: 1.351 ± 0.051
0.796PheGln: 0.796 ± 0.04
1.635PheArg: 1.635 ± 0.064
2.353PheSer: 2.353 ± 0.068
2.284PheThr: 2.284 ± 0.09
2.881PheVal: 2.881 ± 0.088
0.4PheTrp: 0.4 ± 0.033
0.999PheTyr: 0.999 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
8.867GlyAla: 8.867 ± 0.166
1.544GlyCys: 1.544 ± 0.064
4.842GlyAsp: 4.842 ± 0.119
5.491GlyGlu: 5.491 ± 0.115
3.255GlyPhe: 3.255 ± 0.079
6.66GlyGly: 6.66 ± 0.165
1.667GlyHis: 1.667 ± 0.072
5.158GlyIle: 5.158 ± 0.115
3.617GlyLys: 3.617 ± 0.109
7.319GlyLeu: 7.319 ± 0.116
2.684GlyMet: 2.684 ± 0.073
2.371GlyAsn: 2.371 ± 0.086
2.419GlyPro: 2.419 ± 0.075
2.073GlyGln: 2.073 ± 0.068
4.977GlyArg: 4.977 ± 0.113
5.083GlySer: 5.083 ± 0.111
4.695GlyThr: 4.695 ± 0.121
6.833GlyVal: 6.833 ± 0.121
0.895GlyTrp: 0.895 ± 0.047
2.463GlyTyr: 2.463 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
2.276HisAla: 2.276 ± 0.076
0.286HisCys: 0.286 ± 0.027
1.271HisAsp: 1.271 ± 0.051
1.42HisGlu: 1.42 ± 0.061
0.708HisPhe: 0.708 ± 0.036
1.86HisGly: 1.86 ± 0.063
0.464HisHis: 0.464 ± 0.031
1.14HisIle: 1.14 ± 0.049
0.525HisLys: 0.525 ± 0.035
1.597HisLeu: 1.597 ± 0.068
0.541HisMet: 0.541 ± 0.032
0.509HisAsn: 0.509 ± 0.031
1.132HisPro: 1.132 ± 0.048
0.458HisGln: 0.458 ± 0.025
1.214HisArg: 1.214 ± 0.056
0.847HisSer: 0.847 ± 0.045
0.909HisThr: 0.909 ± 0.044
1.868HisVal: 1.868 ± 0.062
0.157HisTrp: 0.157 ± 0.018
0.513HisTyr: 0.513 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
7.007IleAla: 7.007 ± 0.133
0.838IleCys: 0.838 ± 0.045
4.269IleAsp: 4.269 ± 0.095
4.251IleGlu: 4.251 ± 0.095
1.685IlePhe: 1.685 ± 0.062
4.096IleGly: 4.096 ± 0.118
0.899IleHis: 0.899 ± 0.044
2.594IleIle: 2.594 ± 0.091
1.854IleLys: 1.854 ± 0.069
4.106IleLeu: 4.106 ± 0.107
1.393IleMet: 1.393 ± 0.055
1.424IleAsn: 1.424 ± 0.056
2.6IlePro: 2.6 ± 0.065
1.253IleGln: 1.253 ± 0.053
2.719IleArg: 2.719 ± 0.078
3.241IleSer: 3.241 ± 0.083
2.789IleThr: 2.789 ± 0.086
4.669IleVal: 4.669 ± 0.094
0.428IleTrp: 0.428 ± 0.029
1.136IleTyr: 1.136 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
3.563LysAla: 3.563 ± 0.104
0.346LysCys: 0.346 ± 0.028
1.95LysAsp: 1.95 ± 0.088
1.854LysGlu: 1.854 ± 0.073
1.042LysPhe: 1.042 ± 0.055
2.698LysGly: 2.698 ± 0.087
0.674LysHis: 0.674 ± 0.041
1.981LysIle: 1.981 ± 0.066
1.848LysLys: 1.848 ± 0.079
3.352LysLeu: 3.352 ± 0.1
1.138LysMet: 1.138 ± 0.051
1.241LysAsn: 1.241 ± 0.06
1.786LysPro: 1.786 ± 0.074
1.038LysGln: 1.038 ± 0.051
2.753LysArg: 2.753 ± 0.07
1.971LysSer: 1.971 ± 0.076
2.318LysThr: 2.318 ± 0.095
2.723LysVal: 2.723 ± 0.095
0.269LysTrp: 0.269 ± 0.023
0.949LysTyr: 0.949 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
11.385LeuAla: 11.385 ± 0.185
1.297LeuCys: 1.297 ± 0.054
6.392LeuAsp: 6.392 ± 0.142
5.978LeuGlu: 5.978 ± 0.132
3.396LeuPhe: 3.396 ± 0.091
7.77LeuGly: 7.77 ± 0.135
1.595LeuHis: 1.595 ± 0.056
4.721LeuIle: 4.721 ± 0.114
3.187LeuLys: 3.187 ± 0.083
7.953LeuLeu: 7.953 ± 0.17
2.789LeuMet: 2.789 ± 0.085
2.519LeuAsn: 2.519 ± 0.081
4.126LeuPro: 4.126 ± 0.085
2.166LeuGln: 2.166 ± 0.075
5.405LeuArg: 5.405 ± 0.125
6.076LeuSer: 6.076 ± 0.129
5.3LeuThr: 5.3 ± 0.106
7.613LeuVal: 7.613 ± 0.123
0.714LeuTrp: 0.714 ± 0.038
2.22LeuTyr: 2.22 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
3.261MetAla: 3.261 ± 0.095
0.388MetCys: 0.388 ± 0.028
1.661MetAsp: 1.661 ± 0.067
1.514MetGlu: 1.514 ± 0.058
0.893MetPhe: 0.893 ± 0.041
2.646MetGly: 2.646 ± 0.067
0.541MetHis: 0.541 ± 0.033
1.359MetIle: 1.359 ± 0.059
0.981MetLys: 0.981 ± 0.045
2.731MetLeu: 2.731 ± 0.079
0.744MetMet: 0.744 ± 0.04
0.953MetAsn: 0.953 ± 0.045
1.54MetPro: 1.54 ± 0.052
0.921MetGln: 0.921 ± 0.042
1.975MetArg: 1.975 ± 0.068
1.798MetSer: 1.798 ± 0.066
1.584MetThr: 1.584 ± 0.061
2.105MetVal: 2.105 ± 0.065
0.245MetTrp: 0.245 ± 0.021
0.571MetTyr: 0.571 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.109AsnAla: 3.109 ± 0.085
0.352AsnCys: 0.352 ± 0.027
1.637AsnAsp: 1.637 ± 0.064
1.727AsnGlu: 1.727 ± 0.066
0.917AsnPhe: 0.917 ± 0.039
2.517AsnGly: 2.517 ± 0.09
0.547AsnHis: 0.547 ± 0.033
1.609AsnIle: 1.609 ± 0.064
0.991AsnLys: 0.991 ± 0.054
2.678AsnLeu: 2.678 ± 0.068
0.78AsnMet: 0.78 ± 0.039
0.843AsnAsn: 0.843 ± 0.047
1.725AsnPro: 1.725 ± 0.062
0.732AsnGln: 0.732 ± 0.04
1.647AsnArg: 1.647 ± 0.062
1.371AsnSer: 1.371 ± 0.056
1.383AsnThr: 1.383 ± 0.069
2.258AsnVal: 2.258 ± 0.065
0.257AsnTrp: 0.257 ± 0.018
0.734AsnTyr: 0.734 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
5.353ProAla: 5.353 ± 0.147
0.569ProCys: 0.569 ± 0.037
2.761ProAsp: 2.761 ± 0.083
3.664ProGlu: 3.664 ± 0.086
1.709ProPhe: 1.709 ± 0.056
3.529ProGly: 3.529 ± 0.094
0.871ProHis: 0.871 ± 0.043
2.073ProIle: 2.073 ± 0.071
1.444ProLys: 1.444 ± 0.058
3.798ProLeu: 3.798 ± 0.083
1.038ProMet: 1.038 ± 0.038
1.267ProAsn: 1.267 ± 0.048
1.058ProPro: 1.058 ± 0.05
1.371ProGln: 1.371 ± 0.051
2.445ProArg: 2.445 ± 0.079
2.684ProSer: 2.684 ± 0.073
2.236ProThr: 2.236 ± 0.068
4.001ProVal: 4.001 ± 0.085
0.515ProTrp: 0.515 ± 0.031
1.253ProTyr: 1.253 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.068GlnAla: 3.068 ± 0.085
0.257GlnCys: 0.257 ± 0.023
1.319GlnAsp: 1.319 ± 0.047
1.452GlnGlu: 1.452 ± 0.062
0.957GlnPhe: 0.957 ± 0.049
2.194GlnGly: 2.194 ± 0.066
0.495GlnHis: 0.495 ± 0.032
1.574GlnIle: 1.574 ± 0.054
1.044GlnLys: 1.044 ± 0.051
2.831GlnLeu: 2.831 ± 0.073
0.877GlnMet: 0.877 ± 0.044
0.79GlnAsn: 0.79 ± 0.043
1.16GlnPro: 1.16 ± 0.048
1.038GlnGln: 1.038 ± 0.048
1.91GlnArg: 1.91 ± 0.067
1.373GlnSer: 1.373 ± 0.049
1.375GlnThr: 1.375 ± 0.06
2.264GlnVal: 2.264 ± 0.062
0.255GlnTrp: 0.255 ± 0.022
0.623GlnTyr: 0.623 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
7.454ArgAla: 7.454 ± 0.142
0.847ArgCys: 0.847 ± 0.051
3.933ArgAsp: 3.933 ± 0.092
4.934ArgGlu: 4.934 ± 0.095
2.316ArgPhe: 2.316 ± 0.079
4.57ArgGly: 4.57 ± 0.106
1.229ArgHis: 1.229 ± 0.056
3.549ArgIle: 3.549 ± 0.086
2.152ArgLys: 2.152 ± 0.075
5.538ArgLeu: 5.538 ± 0.13
2.037ArgMet: 2.037 ± 0.068
1.458ArgAsn: 1.458 ± 0.055
2.562ArgPro: 2.562 ± 0.082
1.683ArgGln: 1.683 ± 0.07
4.745ArgArg: 4.745 ± 0.135
3.621ArgSer: 3.621 ± 0.094
3.103ArgThr: 3.103 ± 0.088
5.202ArgVal: 5.202 ± 0.118
0.587ArgTrp: 0.587 ± 0.036
1.866ArgTyr: 1.866 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
6.414SerAla: 6.414 ± 0.119
0.881SerCys: 0.881 ± 0.045
3.4SerAsp: 3.4 ± 0.089
3.372SerGlu: 3.372 ± 0.086
2.544SerPhe: 2.544 ± 0.078
5.081SerGly: 5.081 ± 0.11
1.17SerHis: 1.17 ± 0.06
3.245SerIle: 3.245 ± 0.089
1.93SerLys: 1.93 ± 0.071
5.188SerLeu: 5.188 ± 0.116
1.57SerMet: 1.57 ± 0.066
1.637SerAsn: 1.637 ± 0.054
2.326SerPro: 2.326 ± 0.082
1.514SerGln: 1.514 ± 0.055
3.412SerArg: 3.412 ± 0.101
3.511SerSer: 3.511 ± 0.095
3.066SerThr: 3.066 ± 0.074
4.454SerVal: 4.454 ± 0.096
0.66SerTrp: 0.66 ± 0.039
1.697SerTyr: 1.697 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
5.445ThrAla: 5.445 ± 0.119
0.945ThrCys: 0.945 ± 0.047
2.914ThrAsp: 2.914 ± 0.077
2.779ThrGlu: 2.779 ± 0.073
2.135ThrPhe: 2.135 ± 0.098
4.77ThrGly: 4.77 ± 0.113
1.138ThrHis: 1.138 ± 0.049
2.853ThrIle: 2.853 ± 0.096
1.691ThrLys: 1.691 ± 0.074
5.087ThrLeu: 5.087 ± 0.113
1.303ThrMet: 1.303 ± 0.057
1.363ThrAsn: 1.363 ± 0.069
2.902ThrPro: 2.902 ± 0.072
1.341ThrGln: 1.341 ± 0.054
2.807ThrArg: 2.807 ± 0.087
3.048ThrSer: 3.048 ± 0.081
2.783ThrThr: 2.783 ± 0.09
4.723ThrVal: 4.723 ± 0.111
0.607ThrTrp: 0.607 ± 0.041
1.703ThrTyr: 1.703 ± 0.119
0.0ThrXaa: 0.0 ± 0.0
Val
9.016ValAla: 9.016 ± 0.175
1.444ValCys: 1.444 ± 0.05
5.489ValAsp: 5.489 ± 0.108
5.835ValGlu: 5.835 ± 0.122
3.082ValPhe: 3.082 ± 0.085
5.739ValGly: 5.739 ± 0.121
1.422ValHis: 1.422 ± 0.06
4.355ValIle: 4.355 ± 0.085
2.839ValLys: 2.839 ± 0.095
7.536ValLeu: 7.536 ± 0.139
2.133ValMet: 2.133 ± 0.07
2.487ValAsn: 2.487 ± 0.073
3.73ValPro: 3.73 ± 0.088
1.848ValGln: 1.848 ± 0.051
5.093ValArg: 5.093 ± 0.125
4.94ValSer: 4.94 ± 0.112
4.498ValThr: 4.498 ± 0.132
6.716ValVal: 6.716 ± 0.137
0.672ValTrp: 0.672 ± 0.039
2.041ValTyr: 2.041 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.042
0.153TrpCys: 0.153 ± 0.019
0.591TrpAsp: 0.591 ± 0.039
0.643TrpGlu: 0.643 ± 0.033
0.386TrpPhe: 0.386 ± 0.029
0.843TrpGly: 0.843 ± 0.05
0.217TrpHis: 0.217 ± 0.025
0.477TrpIle: 0.477 ± 0.03
0.354TrpLys: 0.354 ± 0.025
0.983TrpLeu: 0.983 ± 0.047
0.308TrpMet: 0.308 ± 0.026
0.362TrpAsn: 0.362 ± 0.029
0.37TrpPro: 0.37 ± 0.027
0.312TrpGln: 0.312 ± 0.026
0.643TrpArg: 0.643 ± 0.036
0.535TrpSer: 0.535 ± 0.032
0.481TrpThr: 0.481 ± 0.03
0.649TrpVal: 0.649 ± 0.039
0.141TrpTrp: 0.141 ± 0.017
0.259TrpTyr: 0.259 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.717TyrAla: 2.717 ± 0.08
0.416TyrCys: 0.416 ± 0.028
1.796TyrAsp: 1.796 ± 0.065
1.884TyrGlu: 1.884 ± 0.053
0.975TyrPhe: 0.975 ± 0.04
2.22TyrGly: 2.22 ± 0.067
0.549TyrHis: 0.549 ± 0.031
1.19TyrIle: 1.19 ± 0.049
0.865TyrLys: 0.865 ± 0.065
2.628TyrLeu: 2.628 ± 0.085
0.619TyrMet: 0.619 ± 0.035
0.79TyrAsn: 0.79 ± 0.041
1.233TyrPro: 1.233 ± 0.05
0.744TyrGln: 0.744 ± 0.044
1.938TyrArg: 1.938 ± 0.061
1.399TyrSer: 1.399 ± 0.05
1.472TyrThr: 1.472 ± 0.081
2.085TyrVal: 2.085 ± 0.067
0.247TyrTrp: 0.247 ± 0.023
0.746TyrTyr: 0.746 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1430 proteins (497327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski