Amino acid dipepetide frequency for Electrophorus electricus (Electric eel) (Gymnotus electricus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.607AlaAla: 5.607 ± 0.024	1.528AlaCys: 1.528 ± 0.007	3.209AlaAsp: 3.209 ± 0.011	4.61AlaGlu: 4.61 ± 0.018	2.648AlaPhe: 2.648 ± 0.009	4.354AlaGly: 4.354 ± 0.014	1.691AlaHis: 1.691 ± 0.009	3.011AlaIle: 3.011 ± 0.011	3.402AlaLys: 3.402 ± 0.016	7.034AlaLeu: 7.034 ± 0.022	1.681AlaMet: 1.681 ± 0.009	2.194AlaAsn: 2.194 ± 0.01	3.261AlaPro: 3.261 ± 0.013	2.915AlaGln: 2.915 ± 0.013	3.366AlaArg: 3.366 ± 0.012	5.15AlaSer: 5.15 ± 0.018	3.411AlaThr: 3.411 ± 0.012	5.233AlaVal: 5.233 ± 0.015	0.741AlaTrp: 0.741 ± 0.006	1.718AlaTyr: 1.718 ± 0.008	0.01AlaXaa: 0.01 ± 0.001
Cys	1.397CysAla: 1.397 ± 0.008	0.707CysCys: 0.707 ± 0.005	1.121CysAsp: 1.121 ± 0.009	1.284CysGlu: 1.284 ± 0.01	1.019CysPhe: 1.019 ± 0.006	1.579CysGly: 1.579 ± 0.011	0.702CysHis: 0.702 ± 0.006	1.125CysIle: 1.125 ± 0.007	1.204CysLys: 1.204 ± 0.007	2.467CysLeu: 2.467 ± 0.012	0.574CysMet: 0.574 ± 0.004	0.855CysAsn: 0.855 ± 0.007	1.32CysPro: 1.32 ± 0.011	1.001CysGln: 1.001 ± 0.008	1.364CysArg: 1.364 ± 0.009	2.164CysSer: 2.164 ± 0.012	1.329CysThr: 1.329 ± 0.008	2.099CysVal: 2.099 ± 0.015	0.344CysTrp: 0.344 ± 0.004	0.693CysTyr: 0.693 ± 0.005	0.005CysXaa: 0.005 ± 0.0
Asp	2.981AspAla: 2.981 ± 0.011	1.151AspCys: 1.151 ± 0.008	2.902AspAsp: 2.902 ± 0.015	3.562AspGlu: 3.562 ± 0.015	2.194AspPhe: 2.194 ± 0.009	3.525AspGly: 3.525 ± 0.016	1.221AspHis: 1.221 ± 0.007	2.834AspIle: 2.834 ± 0.011	2.611AspLys: 2.611 ± 0.012	5.127AspLeu: 5.127 ± 0.014	1.364AspMet: 1.364 ± 0.006	1.829AspAsn: 1.829 ± 0.009	2.824AspPro: 2.824 ± 0.012	1.853AspGln: 1.853 ± 0.009	2.566AspArg: 2.566 ± 0.01	4.015AspSer: 4.015 ± 0.014	2.678AspThr: 2.678 ± 0.011	3.456AspVal: 3.456 ± 0.011	0.706AspTrp: 0.706 ± 0.005	1.648AspTyr: 1.648 ± 0.009	0.003AspXaa: 0.003 ± 0.0
Glu	4.658GluAla: 4.658 ± 0.019	1.328GluCys: 1.328 ± 0.011	4.118GluAsp: 4.118 ± 0.015	6.819GluGlu: 6.819 ± 0.034	2.138GluPhe: 2.138 ± 0.009	4.041GluGly: 4.041 ± 0.014	1.573GluHis: 1.573 ± 0.007	2.905GluIle: 2.905 ± 0.011	4.507GluLys: 4.507 ± 0.023	6.333GluLeu: 6.333 ± 0.021	1.746GluMet: 1.746 ± 0.009	2.669GluAsn: 2.669 ± 0.012	2.607GluPro: 2.607 ± 0.011	3.021GluGln: 3.021 ± 0.014	4.139GluArg: 4.139 ± 0.019	4.009GluSer: 4.009 ± 0.013	3.141GluThr: 3.141 ± 0.011	4.385GluVal: 4.385 ± 0.013	0.735GluTrp: 0.735 ± 0.006	1.725GluTyr: 1.725 ± 0.009	0.005GluXaa: 0.005 ± 0.0
Phe	2.151PheAla: 2.151 ± 0.009	1.086PheCys: 1.086 ± 0.007	1.867PheAsp: 1.867 ± 0.009	2.028PheGlu: 2.028 ± 0.009	1.808PhePhe: 1.808 ± 0.01	2.413PheGly: 2.413 ± 0.011	1.096PheHis: 1.096 ± 0.007	2.149PheIle: 2.149 ± 0.011	1.928PheLys: 1.928 ± 0.009	4.275PheLeu: 4.275 ± 0.017	0.9PheMet: 0.9 ± 0.007	1.546PheAsn: 1.546 ± 0.008	1.89PhePro: 1.89 ± 0.009	1.712PheGln: 1.712 ± 0.007	2.01PheArg: 2.01 ± 0.009	3.508PheSer: 3.508 ± 0.013	2.402PheThr: 2.402 ± 0.01	2.473PheVal: 2.473 ± 0.011	0.524PheTrp: 0.524 ± 0.005	1.33PheTyr: 1.33 ± 0.009	0.004PheXaa: 0.004 ± 0.0
Gly	4.061GlyAla: 4.061 ± 0.014	1.294GlyCys: 1.294 ± 0.008	3.147GlyAsp: 3.147 ± 0.013	3.94GlyGlu: 3.94 ± 0.014	2.51GlyPhe: 2.51 ± 0.012	4.677GlyGly: 4.677 ± 0.021	1.739GlyHis: 1.739 ± 0.01	2.779GlyIle: 2.779 ± 0.012	3.623GlyLys: 3.623 ± 0.013	5.606GlyLeu: 5.606 ± 0.017	1.576GlyMet: 1.576 ± 0.009	2.356GlyAsn: 2.356 ± 0.01	3.076GlyPro: 3.076 ± 0.021	2.689GlyGln: 2.689 ± 0.011	3.555GlyArg: 3.555 ± 0.013	5.162GlySer: 5.162 ± 0.017	3.574GlyThr: 3.574 ± 0.015	4.134GlyVal: 4.134 ± 0.016	0.835GlyTrp: 0.835 ± 0.007	1.96GlyTyr: 1.96 ± 0.011	0.011GlyXaa: 0.011 ± 0.001
His	1.595HisAla: 1.595 ± 0.009	0.84HisCys: 0.84 ± 0.007	1.05HisAsp: 1.05 ± 0.006	1.313HisGlu: 1.313 ± 0.007	1.175HisPhe: 1.175 ± 0.007	1.676HisGly: 1.676 ± 0.009	0.9HisHis: 0.9 ± 0.009	1.407HisIle: 1.407 ± 0.008	1.313HisLys: 1.313 ± 0.007	2.843HisLeu: 2.843 ± 0.012	0.716HisMet: 0.716 ± 0.005	1.005HisAsn: 1.005 ± 0.005	1.541HisPro: 1.541 ± 0.009	1.152HisGln: 1.152 ± 0.007	1.618HisArg: 1.618 ± 0.008	2.33HisSer: 2.33 ± 0.012	1.905HisThr: 1.905 ± 0.013	1.667HisVal: 1.667 ± 0.008	0.374HisTrp: 0.374 ± 0.004	0.919HisTyr: 0.919 ± 0.006	0.003HisXaa: 0.003 ± 0.0
Ile	2.804IleAla: 2.804 ± 0.011	1.176IleCys: 1.176 ± 0.007	2.216IleAsp: 2.216 ± 0.01	2.493IleGlu: 2.493 ± 0.011	2.05IlePhe: 2.05 ± 0.01	2.476IleGly: 2.476 ± 0.011	1.34IleHis: 1.34 ± 0.008	2.63IleIle: 2.63 ± 0.012	2.641IleLys: 2.641 ± 0.012	4.593IleLeu: 4.593 ± 0.015	1.183IleMet: 1.183 ± 0.006	2.023IleAsn: 2.023 ± 0.008	2.458IlePro: 2.458 ± 0.01	2.196IleGln: 2.196 ± 0.009	2.535IleArg: 2.535 ± 0.009	3.847IleSer: 3.847 ± 0.013	2.937IleThr: 2.937 ± 0.011	2.849IleVal: 2.849 ± 0.01	0.527IleTrp: 0.527 ± 0.004	1.579IleTyr: 1.579 ± 0.008	0.003IleXaa: 0.003 ± 0.0
Lys	3.806LysAla: 3.806 ± 0.014	1.103LysCys: 1.103 ± 0.007	3.157LysAsp: 3.157 ± 0.013	4.43LysGlu: 4.43 ± 0.021	1.752LysPhe: 1.752 ± 0.008	3.162LysGly: 3.162 ± 0.015	1.502LysHis: 1.502 ± 0.008	2.636LysIle: 2.636 ± 0.01	4.161LysLys: 4.161 ± 0.024	5.121LysLeu: 5.121 ± 0.018	1.478LysMet: 1.478 ± 0.007	2.287LysAsn: 2.287 ± 0.011	2.625LysPro: 2.625 ± 0.011	2.528LysGln: 2.528 ± 0.012	3.267LysArg: 3.267 ± 0.013	3.558LysSer: 3.558 ± 0.014	3.032LysThr: 3.032 ± 0.013	3.678LysVal: 3.678 ± 0.014	0.622LysTrp: 0.622 ± 0.005	1.636LysTyr: 1.636 ± 0.009	0.004LysXaa: 0.004 ± 0.0
Leu	6.624LeuAla: 6.624 ± 0.017	2.531LeuCys: 2.531 ± 0.012	4.963LeuAsp: 4.963 ± 0.014	6.506LeuGlu: 6.506 ± 0.023	3.851LeuPhe: 3.851 ± 0.015	5.496LeuGly: 5.496 ± 0.017	2.959LeuHis: 2.959 ± 0.011	4.143LeuIle: 4.143 ± 0.014	5.753LeuLys: 5.753 ± 0.015	10.612LeuLeu: 10.612 ± 0.033	2.252LeuMet: 2.252 ± 0.01	3.693LeuAsn: 3.693 ± 0.011	5.253LeuPro: 5.253 ± 0.017	5.475LeuGln: 5.475 ± 0.019	5.8LeuArg: 5.8 ± 0.018	8.284LeuSer: 8.284 ± 0.023	5.32LeuThr: 5.32 ± 0.015	5.924LeuVal: 5.924 ± 0.016	1.176LeuTrp: 1.176 ± 0.007	2.912LeuTyr: 2.912 ± 0.011	0.01LeuXaa: 0.01 ± 0.001
Met	2.015MetAla: 2.015 ± 0.008	0.581MetCys: 0.581 ± 0.005	1.466MetAsp: 1.466 ± 0.007	1.991MetGlu: 1.991 ± 0.009	0.94MetPhe: 0.94 ± 0.005	1.47MetGly: 1.47 ± 0.009	0.569MetHis: 0.569 ± 0.004	0.955MetIle: 0.955 ± 0.006	1.504MetLys: 1.504 ± 0.009	2.27MetLeu: 2.27 ± 0.01	0.672MetMet: 0.672 ± 0.007	0.959MetAsn: 0.959 ± 0.006	1.137MetPro: 1.137 ± 0.006	1.046MetGln: 1.046 ± 0.007	1.238MetArg: 1.238 ± 0.006	1.803MetSer: 1.803 ± 0.007	1.28MetThr: 1.28 ± 0.007	1.667MetVal: 1.667 ± 0.009	0.291MetTrp: 0.291 ± 0.003	0.71MetTyr: 0.71 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	2.205AsnAla: 2.205 ± 0.009	0.89AsnCys: 0.89 ± 0.007	1.68AsnAsp: 1.68 ± 0.009	2.077AsnGlu: 2.077 ± 0.01	1.516AsnPhe: 1.516 ± 0.008	2.603AsnGly: 2.603 ± 0.014	0.943AsnHis: 0.943 ± 0.007	2.284AsnIle: 2.284 ± 0.009	2.152AsnLys: 2.152 ± 0.011	3.634AsnLeu: 3.634 ± 0.013	1.061AsnMet: 1.061 ± 0.006	1.616AsnAsn: 1.616 ± 0.011	2.212AsnPro: 2.212 ± 0.011	1.572AsnGln: 1.572 ± 0.008	1.914AsnArg: 1.914 ± 0.009	2.942AsnSer: 2.942 ± 0.011	2.177AsnThr: 2.177 ± 0.009	2.435AsnVal: 2.435 ± 0.009	0.487AsnTrp: 0.487 ± 0.004	1.225AsnTyr: 1.225 ± 0.007	0.002AsnXaa: 0.002 ± 0.0
Pro	3.851ProAla: 3.851 ± 0.017	1.128ProCys: 1.128 ± 0.008	2.755ProAsp: 2.755 ± 0.01	3.607ProGlu: 3.607 ± 0.013	1.883ProPhe: 1.883 ± 0.01	3.725ProGly: 3.725 ± 0.022	1.467ProHis: 1.467 ± 0.008	1.904ProIle: 1.904 ± 0.009	2.41ProLys: 2.41 ± 0.011	4.825ProLeu: 4.825 ± 0.017	1.017ProMet: 1.017 ± 0.007	1.812ProAsn: 1.812 ± 0.009	4.465ProPro: 4.465 ± 0.028	2.306ProGln: 2.306 ± 0.011	2.617ProArg: 2.617 ± 0.012	4.781ProSer: 4.781 ± 0.019	2.818ProThr: 2.818 ± 0.01	3.66ProVal: 3.66 ± 0.013	0.603ProTrp: 0.603 ± 0.006	1.465ProTyr: 1.465 ± 0.008	0.014ProXaa: 0.014 ± 0.001
Gln	3.304GlnAla: 3.304 ± 0.015	1.05GlnCys: 1.05 ± 0.008	2.241GlnAsp: 2.241 ± 0.009	3.31GlnGlu: 3.31 ± 0.015	1.451GlnPhe: 1.451 ± 0.007	2.61GlnGly: 2.61 ± 0.012	1.314GlnHis: 1.314 ± 0.008	1.959GlnIle: 1.959 ± 0.009	2.562GlnLys: 2.562 ± 0.012	4.46GlnLeu: 4.46 ± 0.016	1.143GlnMet: 1.143 ± 0.007	1.711GlnAsn: 1.711 ± 0.009	2.217GlnPro: 2.217 ± 0.011	2.722GlnGln: 2.722 ± 0.021	2.86GlnArg: 2.86 ± 0.013	3.029GlnSer: 3.029 ± 0.011	2.335GlnThr: 2.335 ± 0.01	2.922GlnVal: 2.922 ± 0.011	0.572GlnTrp: 0.572 ± 0.005	1.344GlnTyr: 1.344 ± 0.007	0.004GlnXaa: 0.004 ± 0.0
Arg	3.687ArgAla: 3.687 ± 0.013	1.296ArgCys: 1.296 ± 0.009	2.917ArgAsp: 2.917 ± 0.01	3.841ArgGlu: 3.841 ± 0.015	2.08ArgPhe: 2.08 ± 0.009	3.303ArgGly: 3.303 ± 0.014	1.581ArgHis: 1.581 ± 0.009	2.468ArgIle: 2.468 ± 0.01	3.436ArgLys: 3.436 ± 0.013	5.388ArgLeu: 5.388 ± 0.016	1.365ArgMet: 1.365 ± 0.007	2.099ArgAsn: 2.099 ± 0.009	2.754ArgPro: 2.754 ± 0.012	2.553ArgGln: 2.553 ± 0.011	3.929ArgArg: 3.929 ± 0.017	4.037ArgSer: 4.037 ± 0.015	2.855ArgThr: 2.855 ± 0.011	3.593ArgVal: 3.593 ± 0.012	0.697ArgTrp: 0.697 ± 0.005	1.642ArgTyr: 1.642 ± 0.009	0.009ArgXaa: 0.009 ± 0.001
Ser	5.232SerAla: 5.232 ± 0.016	1.908SerCys: 1.908 ± 0.011	3.937SerAsp: 3.937 ± 0.013	4.586SerGlu: 4.586 ± 0.016	3.095SerPhe: 3.095 ± 0.011	5.199SerGly: 5.199 ± 0.016	2.106SerHis: 2.106 ± 0.01	3.384SerIle: 3.384 ± 0.012	3.792SerLys: 3.792 ± 0.013	8.16SerLeu: 8.16 ± 0.023	1.793SerMet: 1.793 ± 0.007	2.725SerAsn: 2.725 ± 0.011	4.942SerPro: 4.942 ± 0.022	3.403SerGln: 3.403 ± 0.012	4.186SerArg: 4.186 ± 0.014	8.151SerSer: 8.151 ± 0.032	4.458SerThr: 4.458 ± 0.015	5.409SerVal: 5.409 ± 0.015	0.994SerTrp: 0.994 ± 0.006	2.159SerTyr: 2.159 ± 0.012	0.01SerXaa: 0.01 ± 0.001
Thr	3.958ThrAla: 3.958 ± 0.012	1.419ThrCys: 1.419 ± 0.01	2.826ThrAsp: 2.826 ± 0.012	3.506ThrGlu: 3.506 ± 0.013	2.253ThrPhe: 2.253 ± 0.011	3.694ThrGly: 3.694 ± 0.014	1.719ThrHis: 1.719 ± 0.014	2.538ThrIle: 2.538 ± 0.01	2.585ThrLys: 2.585 ± 0.011	5.657ThrLeu: 5.657 ± 0.014	1.234ThrMet: 1.234 ± 0.007	1.88ThrAsn: 1.88 ± 0.009	3.309ThrPro: 3.309 ± 0.016	2.305ThrGln: 2.305 ± 0.01	2.52ThrArg: 2.52 ± 0.01	4.24ThrSer: 4.24 ± 0.014	2.956ThrThr: 2.956 ± 0.014	4.215ThrVal: 4.215 ± 0.014	0.697ThrTrp: 0.697 ± 0.006	1.573ThrTyr: 1.573 ± 0.008	0.008ThrXaa: 0.008 ± 0.001
Val	4.445ValAla: 4.445 ± 0.015	2.259ValCys: 2.259 ± 0.016	3.287ValAsp: 3.287 ± 0.012	4.155ValGlu: 4.155 ± 0.013	2.885ValPhe: 2.885 ± 0.013	3.746ValGly: 3.746 ± 0.012	1.757ValHis: 1.757 ± 0.008	3.203ValIle: 3.203 ± 0.011	3.644ValLys: 3.644 ± 0.014	6.909ValLeu: 6.909 ± 0.019	1.66ValMet: 1.66 ± 0.008	2.526ValAsn: 2.526 ± 0.011	3.376ValPro: 3.376 ± 0.013	2.882ValGln: 2.882 ± 0.01	3.545ValArg: 3.545 ± 0.012	5.293ValSer: 5.293 ± 0.015	3.958ValThr: 3.958 ± 0.013	4.606ValVal: 4.606 ± 0.014	0.867ValTrp: 0.867 ± 0.006	2.047ValTyr: 2.047 ± 0.009	0.009ValXaa: 0.009 ± 0.001
Trp	0.763TrpAla: 0.763 ± 0.005	0.299TrpCys: 0.299 ± 0.003	0.683TrpAsp: 0.683 ± 0.005	0.804TrpGlu: 0.804 ± 0.005	0.493TrpPhe: 0.493 ± 0.004	0.691TrpGly: 0.691 ± 0.005	0.308TrpHis: 0.308 ± 0.004	0.606TrpIle: 0.606 ± 0.005	0.76TrpLys: 0.76 ± 0.005	1.25TrpLeu: 1.25 ± 0.007	0.371TrpMet: 0.371 ± 0.004	0.58TrpAsn: 0.58 ± 0.005	0.467TrpPro: 0.467 ± 0.004	0.52TrpGln: 0.52 ± 0.004	0.75TrpArg: 0.75 ± 0.006	0.959TrpSer: 0.959 ± 0.007	0.731TrpThr: 0.731 ± 0.006	0.801TrpVal: 0.801 ± 0.006	0.217TrpTrp: 0.217 ± 0.003	0.384TrpTyr: 0.384 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.619TyrAla: 1.619 ± 0.007	0.771TyrCys: 0.771 ± 0.006	1.503TyrAsp: 1.503 ± 0.009	1.735TyrGlu: 1.735 ± 0.008	1.356TyrPhe: 1.356 ± 0.008	1.852TyrGly: 1.852 ± 0.01	0.852TyrHis: 0.852 ± 0.006	1.635TyrIle: 1.635 ± 0.009	1.553TyrLys: 1.553 ± 0.009	2.964TyrLeu: 2.964 ± 0.011	0.778TyrMet: 0.778 ± 0.006	1.257TyrAsn: 1.257 ± 0.008	1.369TyrPro: 1.369 ± 0.007	1.261TyrGln: 1.261 ± 0.007	1.741TyrArg: 1.741 ± 0.01	2.356TyrSer: 2.356 ± 0.01	1.791TyrThr: 1.791 ± 0.01	1.848TyrVal: 1.848 ± 0.009	0.427TyrTrp: 0.427 ± 0.005	1.102TyrTyr: 1.102 ± 0.007	0.003TyrXaa: 0.003 ± 0.0
Xaa	0.01XaaAla: 0.01 ± 0.001	0.007XaaCys: 0.007 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.005XaaGlu: 0.005 ± 0.0	0.004XaaPhe: 0.004 ± 0.0	0.012XaaGly: 0.012 ± 0.001	0.004XaaHis: 0.004 ± 0.0	0.004XaaIle: 0.004 ± 0.0	0.004XaaLys: 0.004 ± 0.0	0.01XaaLeu: 0.01 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.014XaaPro: 0.014 ± 0.001	0.005XaaGln: 0.005 ± 0.0	0.007XaaArg: 0.007 ± 0.001	0.01XaaSer: 0.01 ± 0.001	0.005XaaThr: 0.005 ± 0.0	0.009XaaVal: 0.009 ± 0.0	0.002XaaTrp: 0.002 ± 0.0	0.003XaaTyr: 0.003 ± 0.0	0.762XaaXaa: 0.762 ± 0.086

Statistics based on 50899 proteins (29296342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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