Amino acid dipepetide frequency for Sulfuracidifex tepidarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.78AlaAla: 2.78 ± 0.098
0.349AlaCys: 0.349 ± 0.022
2.544AlaAsp: 2.544 ± 0.061
3.616AlaGlu: 3.616 ± 0.077
2.928AlaPhe: 2.928 ± 0.08
4.177AlaGly: 4.177 ± 0.087
0.748AlaHis: 0.748 ± 0.033
4.751AlaIle: 4.751 ± 0.095
3.757AlaLys: 3.757 ± 0.091
6.299AlaLeu: 6.299 ± 0.111
1.809AlaMet: 1.809 ± 0.055
1.853AlaAsn: 1.853 ± 0.056
1.702AlaPro: 1.702 ± 0.057
1.225AlaGln: 1.225 ± 0.041
2.622AlaArg: 2.622 ± 0.067
4.99AlaSer: 4.99 ± 0.089
2.791AlaThr: 2.791 ± 0.07
4.892AlaVal: 4.892 ± 0.087
0.537AlaTrp: 0.537 ± 0.029
2.33AlaTyr: 2.33 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.285CysAla: 0.285 ± 0.017
0.085CysCys: 0.085 ± 0.011
0.379CysAsp: 0.379 ± 0.024
0.481CysGlu: 0.481 ± 0.028
0.256CysPhe: 0.256 ± 0.02
0.731CysGly: 0.731 ± 0.04
0.121CysHis: 0.121 ± 0.014
0.407CysIle: 0.407 ± 0.03
0.446CysLys: 0.446 ± 0.025
0.496CysLeu: 0.496 ± 0.025
0.182CysMet: 0.182 ± 0.016
0.313CysAsn: 0.313 ± 0.02
0.511CysPro: 0.511 ± 0.036
0.13CysGln: 0.13 ± 0.014
0.303CysArg: 0.303 ± 0.021
0.535CysSer: 0.535 ± 0.033
0.301CysThr: 0.301 ± 0.02
0.469CysVal: 0.469 ± 0.028
0.06CysTrp: 0.06 ± 0.01
0.302CysTyr: 0.302 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.611AspAla: 2.611 ± 0.062
0.332AspCys: 0.332 ± 0.025
2.289AspAsp: 2.289 ± 0.065
3.907AspGlu: 3.907 ± 0.084
2.475AspPhe: 2.475 ± 0.061
3.129AspGly: 3.129 ± 0.078
0.625AspHis: 0.625 ± 0.031
3.62AspIle: 3.62 ± 0.079
3.382AspLys: 3.382 ± 0.08
5.123AspLeu: 5.123 ± 0.086
1.349AspMet: 1.349 ± 0.051
1.817AspAsn: 1.817 ± 0.048
2.404AspPro: 2.404 ± 0.06
1.077AspGln: 1.077 ± 0.039
2.099AspArg: 2.099 ± 0.062
3.274AspSer: 3.274 ± 0.082
1.881AspThr: 1.881 ± 0.055
4.97AspVal: 4.97 ± 0.105
0.493AspTrp: 0.493 ± 0.026
2.148AspTyr: 2.148 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.119GluAla: 4.119 ± 0.076
0.477GluCys: 0.477 ± 0.026
3.66GluAsp: 3.66 ± 0.081
6.209GluGlu: 6.209 ± 0.119
2.515GluPhe: 2.515 ± 0.06
4.896GluGly: 4.896 ± 0.087
0.775GluHis: 0.775 ± 0.033
6.185GluIle: 6.185 ± 0.094
5.9GluLys: 5.9 ± 0.103
5.728GluLeu: 5.728 ± 0.109
1.953GluMet: 1.953 ± 0.062
3.142GluAsn: 3.142 ± 0.071
1.824GluPro: 1.824 ± 0.051
1.216GluGln: 1.216 ± 0.043
3.739GluArg: 3.739 ± 0.083
3.684GluSer: 3.684 ± 0.084
2.945GluThr: 2.945 ± 0.07
6.335GluVal: 6.335 ± 0.11
0.662GluTrp: 0.662 ± 0.034
2.31GluTyr: 2.31 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.467PheAla: 2.467 ± 0.078
0.322PheCys: 0.322 ± 0.022
2.135PheAsp: 2.135 ± 0.056
2.025PheGlu: 2.025 ± 0.056
2.458PhePhe: 2.458 ± 0.081
2.753PheGly: 2.753 ± 0.076
0.855PheHis: 0.855 ± 0.03
3.32PheIle: 3.32 ± 0.095
2.512PheLys: 2.512 ± 0.062
5.791PheLeu: 5.791 ± 0.131
1.463PheMet: 1.463 ± 0.046
2.267PheAsn: 2.267 ± 0.059
2.176PhePro: 2.176 ± 0.049
1.071PheGln: 1.071 ± 0.045
1.958PheArg: 1.958 ± 0.057
4.63PheSer: 4.63 ± 0.091
2.646PheThr: 2.646 ± 0.066
3.317PheVal: 3.317 ± 0.077
0.476PheTrp: 0.476 ± 0.027
2.196PheTyr: 2.196 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.805GlyAla: 3.805 ± 0.097
0.426GlyCys: 0.426 ± 0.025
3.427GlyAsp: 3.427 ± 0.066
4.909GlyGlu: 4.909 ± 0.085
3.397GlyPhe: 3.397 ± 0.073
4.985GlyGly: 4.985 ± 0.099
0.983GlyHis: 0.983 ± 0.041
6.692GlyIle: 6.692 ± 0.108
5.875GlyLys: 5.875 ± 0.106
6.19GlyLeu: 6.19 ± 0.106
1.975GlyMet: 1.975 ± 0.05
3.12GlyAsn: 3.12 ± 0.076
1.753GlyPro: 1.753 ± 0.052
1.333GlyGln: 1.333 ± 0.056
3.236GlyArg: 3.236 ± 0.075
4.654GlySer: 4.654 ± 0.081
3.627GlyThr: 3.627 ± 0.094
5.915GlyVal: 5.915 ± 0.093
0.815GlyTrp: 0.815 ± 0.033
3.415GlyTyr: 3.415 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
0.893HisAla: 0.893 ± 0.031
0.1HisCys: 0.1 ± 0.011
0.755HisAsp: 0.755 ± 0.037
1.048HisGlu: 1.048 ± 0.039
0.704HisPhe: 0.704 ± 0.029
1.232HisGly: 1.232 ± 0.043
0.319HisHis: 0.319 ± 0.023
0.832HisIle: 0.832 ± 0.035
0.629HisLys: 0.629 ± 0.032
1.33HisLeu: 1.33 ± 0.043
0.386HisMet: 0.386 ± 0.022
0.501HisAsn: 0.501 ± 0.027
0.743HisPro: 0.743 ± 0.031
0.278HisGln: 0.278 ± 0.023
0.585HisArg: 0.585 ± 0.031
0.964HisSer: 0.964 ± 0.035
0.59HisThr: 0.59 ± 0.029
1.451HisVal: 1.451 ± 0.049
0.125HisTrp: 0.125 ± 0.013
0.595HisTyr: 0.595 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.428IleAla: 5.428 ± 0.09
0.456IleCys: 0.456 ± 0.027
4.134IleAsp: 4.134 ± 0.091
4.922IleGlu: 4.922 ± 0.083
3.33IlePhe: 3.33 ± 0.08
5.442IleGly: 5.442 ± 0.11
1.07IleHis: 1.07 ± 0.04
5.542IleIle: 5.542 ± 0.116
4.898IleLys: 4.898 ± 0.093
7.075IleLeu: 7.075 ± 0.12
1.928IleMet: 1.928 ± 0.048
3.283IleAsn: 3.283 ± 0.073
3.862IlePro: 3.862 ± 0.085
1.564IleGln: 1.564 ± 0.054
3.464IleArg: 3.464 ± 0.081
6.944IleSer: 6.944 ± 0.107
3.995IleThr: 3.995 ± 0.08
5.735IleVal: 5.735 ± 0.087
0.533IleTrp: 0.533 ± 0.025
3.143IleTyr: 3.143 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
4.117LysAla: 4.117 ± 0.083
0.528LysCys: 0.528 ± 0.03
4.019LysAsp: 4.019 ± 0.084
6.869LysGlu: 6.869 ± 0.131
2.581LysPhe: 2.581 ± 0.058
5.664LysGly: 5.664 ± 0.084
0.704LysHis: 0.704 ± 0.035
5.281LysIle: 5.281 ± 0.095
4.807LysLys: 4.807 ± 0.096
6.242LysLeu: 6.242 ± 0.116
1.916LysMet: 1.916 ± 0.058
2.527LysAsn: 2.527 ± 0.067
2.324LysPro: 2.324 ± 0.062
1.364LysGln: 1.364 ± 0.048
3.646LysArg: 3.646 ± 0.072
3.888LysSer: 3.888 ± 0.074
2.941LysThr: 2.941 ± 0.067
7.097LysVal: 7.097 ± 0.108
0.732LysTrp: 0.732 ± 0.029
2.762LysTyr: 2.762 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
5.994LeuAla: 5.994 ± 0.117
0.618LeuCys: 0.618 ± 0.032
4.802LeuAsp: 4.802 ± 0.092
5.825LeuGlu: 5.825 ± 0.098
4.482LeuPhe: 4.482 ± 0.101
7.224LeuGly: 7.224 ± 0.121
1.416LeuHis: 1.416 ± 0.046
7.419LeuIle: 7.419 ± 0.126
7.008LeuLys: 7.008 ± 0.118
9.595LeuLeu: 9.595 ± 0.158
2.759LeuMet: 2.759 ± 0.06
4.307LeuAsn: 4.307 ± 0.079
4.14LeuPro: 4.14 ± 0.091
2.158LeuGln: 2.158 ± 0.062
4.667LeuArg: 4.667 ± 0.105
9.123LeuSer: 9.123 ± 0.139
5.079LeuThr: 5.079 ± 0.105
7.534LeuVal: 7.534 ± 0.122
0.879LeuTrp: 0.879 ± 0.04
3.694LeuTyr: 3.694 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.621MetAla: 1.621 ± 0.051
0.148MetCys: 0.148 ± 0.014
1.491MetAsp: 1.491 ± 0.051
2.176MetGlu: 2.176 ± 0.059
1.048MetPhe: 1.048 ± 0.04
2.039MetGly: 2.039 ± 0.058
0.279MetHis: 0.279 ± 0.018
2.264MetIle: 2.264 ± 0.057
2.752MetLys: 2.752 ± 0.069
2.25MetLeu: 2.25 ± 0.07
0.856MetMet: 0.856 ± 0.04
1.333MetAsn: 1.333 ± 0.044
0.926MetPro: 0.926 ± 0.036
0.541MetGln: 0.541 ± 0.029
1.631MetArg: 1.631 ± 0.051
2.246MetSer: 2.246 ± 0.054
1.438MetThr: 1.438 ± 0.047
1.99MetVal: 1.99 ± 0.052
0.281MetTrp: 0.281 ± 0.019
0.833MetTyr: 0.833 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.564AsnAla: 2.564 ± 0.062
0.342AsnCys: 0.342 ± 0.021
1.923AsnAsp: 1.923 ± 0.056
2.783AsnGlu: 2.783 ± 0.063
2.108AsnPhe: 2.108 ± 0.051
3.368AsnGly: 3.368 ± 0.094
0.471AsnHis: 0.471 ± 0.027
2.68AsnIle: 2.68 ± 0.069
2.472AsnLys: 2.472 ± 0.066
4.152AsnLeu: 4.152 ± 0.072
1.152AsnMet: 1.152 ± 0.041
1.696AsnAsn: 1.696 ± 0.06
2.279AsnPro: 2.279 ± 0.055
1.01AsnGln: 1.01 ± 0.043
1.564AsnArg: 1.564 ± 0.046
3.345AsnSer: 3.345 ± 0.088
1.907AsnThr: 1.907 ± 0.053
4.264AsnVal: 4.264 ± 0.085
0.387AsnTrp: 0.387 ± 0.022
2.058AsnTyr: 2.058 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
1.918ProAla: 1.918 ± 0.056
0.268ProCys: 0.268 ± 0.02
1.923ProAsp: 1.923 ± 0.052
2.699ProGlu: 2.699 ± 0.067
2.414ProPhe: 2.414 ± 0.07
2.41ProGly: 2.41 ± 0.066
0.743ProHis: 0.743 ± 0.032
2.621ProIle: 2.621 ± 0.066
2.235ProLys: 2.235 ± 0.061
4.295ProLeu: 4.295 ± 0.075
0.95ProMet: 0.95 ± 0.039
1.681ProAsn: 1.681 ± 0.053
1.904ProPro: 1.904 ± 0.05
1.075ProGln: 1.075 ± 0.044
1.631ProArg: 1.631 ± 0.04
3.79ProSer: 3.79 ± 0.079
2.139ProThr: 2.139 ± 0.055
3.199ProVal: 3.199 ± 0.076
0.444ProTrp: 0.444 ± 0.023
1.951ProTyr: 1.951 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.268GlnAla: 1.268 ± 0.042
0.134GlnCys: 0.134 ± 0.016
1.105GlnAsp: 1.105 ± 0.04
1.679GlnGlu: 1.679 ± 0.055
0.882GlnPhe: 0.882 ± 0.036
1.867GlnGly: 1.867 ± 0.057
0.266GlnHis: 0.266 ± 0.022
1.54GlnIle: 1.54 ± 0.047
1.337GlnLys: 1.337 ± 0.052
2.049GlnLeu: 2.049 ± 0.052
0.685GlnMet: 0.685 ± 0.03
0.984GlnAsn: 0.984 ± 0.04
0.812GlnPro: 0.812 ± 0.049
0.624GlnGln: 0.624 ± 0.039
0.997GlnArg: 0.997 ± 0.038
1.396GlnSer: 1.396 ± 0.041
0.977GlnThr: 0.977 ± 0.041
1.864GlnVal: 1.864 ± 0.051
0.211GlnTrp: 0.211 ± 0.016
0.873GlnTyr: 0.873 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.47ArgAla: 2.47 ± 0.06
0.375ArgCys: 0.375 ± 0.024
2.541ArgAsp: 2.541 ± 0.068
4.27ArgGlu: 4.27 ± 0.095
1.883ArgPhe: 1.883 ± 0.061
3.344ArgGly: 3.344 ± 0.08
0.607ArgHis: 0.607 ± 0.032
3.595ArgIle: 3.595 ± 0.08
4.304ArgLys: 4.304 ± 0.077
4.009ArgLeu: 4.009 ± 0.085
1.283ArgMet: 1.283 ± 0.043
2.085ArgAsn: 2.085 ± 0.062
1.411ArgPro: 1.411 ± 0.041
0.886ArgGln: 0.886 ± 0.031
2.995ArgArg: 2.995 ± 0.075
2.742ArgSer: 2.742 ± 0.064
1.908ArgThr: 1.908 ± 0.058
3.543ArgVal: 3.543 ± 0.083
0.486ArgTrp: 0.486 ± 0.026
1.611ArgTyr: 1.611 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.952SerAla: 3.952 ± 0.087
0.61SerCys: 0.61 ± 0.032
3.011SerAsp: 3.011 ± 0.065
4.058SerGlu: 4.058 ± 0.073
4.408SerPhe: 4.408 ± 0.1
4.717SerGly: 4.717 ± 0.08
1.192SerHis: 1.192 ± 0.045
5.99SerIle: 5.99 ± 0.106
4.963SerLys: 4.963 ± 0.086
9.685SerLeu: 9.685 ± 0.151
2.478SerMet: 2.478 ± 0.052
3.058SerAsn: 3.058 ± 0.08
3.689SerPro: 3.689 ± 0.084
1.963SerGln: 1.963 ± 0.06
3.411SerArg: 3.411 ± 0.076
7.721SerSer: 7.721 ± 0.154
4.136SerThr: 4.136 ± 0.093
5.72SerVal: 5.72 ± 0.09
0.874SerTrp: 0.874 ± 0.034
3.314SerTyr: 3.314 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
2.73ThrAla: 2.73 ± 0.067
0.385ThrCys: 0.385 ± 0.021
1.958ThrAsp: 1.958 ± 0.052
2.494ThrGlu: 2.494 ± 0.065
2.696ThrPhe: 2.696 ± 0.063
3.63ThrGly: 3.63 ± 0.084
0.766ThrHis: 0.766 ± 0.033
3.419ThrIle: 3.419 ± 0.079
2.742ThrLys: 2.742 ± 0.058
5.455ThrLeu: 5.455 ± 0.1
1.322ThrMet: 1.322 ± 0.05
1.762ThrAsn: 1.762 ± 0.045
2.42ThrPro: 2.42 ± 0.064
1.156ThrGln: 1.156 ± 0.045
1.971ThrArg: 1.971 ± 0.059
4.293ThrSer: 4.293 ± 0.095
2.591ThrThr: 2.591 ± 0.075
4.441ThrVal: 4.441 ± 0.087
0.58ThrTrp: 0.58 ± 0.031
2.156ThrTyr: 2.156 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.764ValAla: 4.764 ± 0.102
0.48ValCys: 0.48 ± 0.024
4.21ValAsp: 4.21 ± 0.075
5.321ValGlu: 5.321 ± 0.096
3.729ValPhe: 3.729 ± 0.079
5.398ValGly: 5.398 ± 0.102
1.199ValHis: 1.199 ± 0.033
7.239ValIle: 7.239 ± 0.101
6.929ValLys: 6.929 ± 0.115
7.409ValLeu: 7.409 ± 0.123
2.366ValMet: 2.366 ± 0.058
4.176ValAsn: 4.176 ± 0.087
3.27ValPro: 3.27 ± 0.065
1.692ValGln: 1.692 ± 0.047
3.798ValArg: 3.798 ± 0.078
6.692ValSer: 6.692 ± 0.1
4.553ValThr: 4.553 ± 0.088
7.004ValVal: 7.004 ± 0.124
0.648ValTrp: 0.648 ± 0.033
3.294ValTyr: 3.294 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.518TrpAla: 0.518 ± 0.031
0.064TrpCys: 0.064 ± 0.01
0.501TrpAsp: 0.501 ± 0.027
0.654TrpGlu: 0.654 ± 0.033
0.504TrpPhe: 0.504 ± 0.028
0.728TrpGly: 0.728 ± 0.033
0.13TrpHis: 0.13 ± 0.014
0.766TrpIle: 0.766 ± 0.03
0.795TrpLys: 0.795 ± 0.033
0.947TrpLeu: 0.947 ± 0.04
0.306TrpMet: 0.306 ± 0.02
0.527TrpAsn: 0.527 ± 0.029
0.234TrpPro: 0.234 ± 0.018
0.158TrpGln: 0.158 ± 0.016
0.534TrpArg: 0.534 ± 0.028
0.608TrpSer: 0.608 ± 0.029
0.434TrpThr: 0.434 ± 0.024
0.769TrpVal: 0.769 ± 0.037
0.157TrpTrp: 0.157 ± 0.016
0.483TrpTyr: 0.483 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.397TyrAla: 2.397 ± 0.062
0.296TyrCys: 0.296 ± 0.02
2.199TyrAsp: 2.199 ± 0.058
2.331TyrGlu: 2.331 ± 0.063
2.041TyrPhe: 2.041 ± 0.057
2.799TyrGly: 2.799 ± 0.071
0.793TyrHis: 0.793 ± 0.032
2.583TyrIle: 2.583 ± 0.066
2.264TyrLys: 2.264 ± 0.06
4.603TyrLeu: 4.603 ± 0.089
1.025TyrMet: 1.025 ± 0.037
2.094TyrAsn: 2.094 ± 0.068
1.904TyrPro: 1.904 ± 0.062
1.03TyrGln: 1.03 ± 0.039
1.495TyrArg: 1.495 ± 0.05
3.427TyrSer: 3.427 ± 0.076
2.085TyrThr: 2.085 ± 0.062
3.662TyrVal: 3.662 ± 0.079
0.439TyrTrp: 0.439 ± 0.025
2.098TyrTyr: 2.098 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2770 proteins (702152 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski