Amino acid dipepetide frequency for Hypocrea jecorina (strain QM6a) (Trichoderma reesei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.982AlaAla: 10.982 ± 0.086	1.087AlaCys: 1.087 ± 0.017	4.626AlaAsp: 4.626 ± 0.039	5.568AlaGlu: 5.568 ± 0.041	3.236AlaPhe: 3.236 ± 0.031	6.036AlaGly: 6.036 ± 0.052	1.875AlaHis: 1.875 ± 0.022	4.372AlaIle: 4.372 ± 0.038	4.424AlaLys: 4.424 ± 0.037	8.097AlaLeu: 8.097 ± 0.05	2.112AlaMet: 2.112 ± 0.021	3.07AlaAsn: 3.07 ± 0.03	5.079AlaPro: 5.079 ± 0.052	3.676AlaGln: 3.676 ± 0.036	5.277AlaArg: 5.277 ± 0.043	7.92AlaSer: 7.92 ± 0.054	5.314AlaThr: 5.314 ± 0.037	5.761AlaVal: 5.761 ± 0.041	1.236AlaTrp: 1.236 ± 0.021	2.239AlaTyr: 2.239 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.016	0.255CysCys: 0.255 ± 0.009	0.675CysAsp: 0.675 ± 0.014	0.599CysGlu: 0.599 ± 0.016	0.557CysPhe: 0.557 ± 0.014	0.923CysGly: 0.923 ± 0.02	0.327CysHis: 0.327 ± 0.008	0.682CysIle: 0.682 ± 0.013	0.493CysLys: 0.493 ± 0.012	1.254CysLeu: 1.254 ± 0.022	0.256CysMet: 0.256 ± 0.007	0.424CysAsn: 0.424 ± 0.01	0.64CysPro: 0.64 ± 0.015	0.442CysGln: 0.442 ± 0.009	0.757CysArg: 0.757 ± 0.014	0.919CysSer: 0.919 ± 0.017	0.634CysThr: 0.634 ± 0.013	0.794CysVal: 0.794 ± 0.017	0.197CysTrp: 0.197 ± 0.007	0.354CysTyr: 0.354 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.389AspAla: 5.389 ± 0.04	0.623AspCys: 0.623 ± 0.013	4.808AspAsp: 4.808 ± 0.051	4.8AspGlu: 4.8 ± 0.046	2.228AspPhe: 2.228 ± 0.025	4.422AspGly: 4.422 ± 0.035	1.208AspHis: 1.208 ± 0.018	2.979AspIle: 2.979 ± 0.028	2.617AspLys: 2.617 ± 0.031	4.998AspLeu: 4.998 ± 0.035	1.321AspMet: 1.321 ± 0.019	1.834AspAsn: 1.834 ± 0.023	3.19AspPro: 3.19 ± 0.03	1.794AspGln: 1.794 ± 0.019	3.047AspArg: 3.047 ± 0.036	3.981AspSer: 3.981 ± 0.036	2.692AspThr: 2.692 ± 0.024	3.921AspVal: 3.921 ± 0.033	0.876AspTrp: 0.876 ± 0.012	1.569AspTyr: 1.569 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.193GluAla: 6.193 ± 0.048	0.607GluCys: 0.607 ± 0.013	4.245GluAsp: 4.245 ± 0.038	5.649GluGlu: 5.649 ± 0.066	1.915GluPhe: 1.915 ± 0.022	3.687GluGly: 3.687 ± 0.03	1.395GluHis: 1.395 ± 0.018	2.82GluIle: 2.82 ± 0.025	3.493GluLys: 3.493 ± 0.04	5.304GluLeu: 5.304 ± 0.042	1.539GluMet: 1.539 ± 0.02	1.986GluAsn: 1.986 ± 0.021	2.867GluPro: 2.867 ± 0.033	2.534GluGln: 2.534 ± 0.025	3.97GluArg: 3.97 ± 0.041	4.061GluSer: 4.061 ± 0.034	3.39GluThr: 3.39 ± 0.029	3.482GluVal: 3.482 ± 0.031	0.902GluTrp: 0.902 ± 0.016	1.661GluTyr: 1.661 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.165PheAla: 3.165 ± 0.027	0.559PheCys: 0.559 ± 0.013	2.304PheAsp: 2.304 ± 0.026	2.099PheGlu: 2.099 ± 0.021	1.639PhePhe: 1.639 ± 0.027	2.839PheGly: 2.839 ± 0.031	0.888PheHis: 0.888 ± 0.013	1.796PheIle: 1.796 ± 0.022	1.52PheLys: 1.52 ± 0.022	3.371PheLeu: 3.371 ± 0.03	0.806PheMet: 0.806 ± 0.014	1.397PheAsn: 1.397 ± 0.016	1.891PhePro: 1.891 ± 0.022	1.373PheGln: 1.373 ± 0.019	1.955PheArg: 1.955 ± 0.023	2.894PheSer: 2.894 ± 0.029	2.098PheThr: 2.098 ± 0.022	2.444PheVal: 2.444 ± 0.024	0.641PheTrp: 0.641 ± 0.013	1.114PheTyr: 1.114 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.498GlyAla: 5.498 ± 0.04	0.851GlyCys: 0.851 ± 0.016	3.838GlyAsp: 3.838 ± 0.033	3.728GlyGlu: 3.728 ± 0.032	2.764GlyPhe: 2.764 ± 0.028	6.008GlyGly: 6.008 ± 0.069	1.732GlyHis: 1.732 ± 0.022	3.542GlyIle: 3.542 ± 0.032	3.437GlyLys: 3.437 ± 0.034	6.136GlyLeu: 6.136 ± 0.052	1.571GlyMet: 1.571 ± 0.02	2.465GlyAsn: 2.465 ± 0.034	3.29GlyPro: 3.29 ± 0.035	2.582GlyGln: 2.582 ± 0.028	4.222GlyArg: 4.222 ± 0.037	5.789GlySer: 5.789 ± 0.05	3.876GlyThr: 3.876 ± 0.036	4.334GlyVal: 4.334 ± 0.033	1.189GlyTrp: 1.189 ± 0.018	2.049GlyTyr: 2.049 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.875HisAla: 1.875 ± 0.024	0.328HisCys: 0.328 ± 0.009	1.399HisAsp: 1.399 ± 0.019	1.311HisGlu: 1.311 ± 0.017	0.889HisPhe: 0.889 ± 0.015	1.76HisGly: 1.76 ± 0.019	0.969HisHis: 0.969 ± 0.019	1.207HisIle: 1.207 ± 0.016	0.956HisLys: 0.956 ± 0.018	2.281HisLeu: 2.281 ± 0.025	0.514HisMet: 0.514 ± 0.011	0.809HisAsn: 0.809 ± 0.012	1.586HisPro: 1.586 ± 0.023	1.037HisGln: 1.037 ± 0.017	1.541HisArg: 1.541 ± 0.019	1.704HisSer: 1.704 ± 0.023	1.179HisThr: 1.179 ± 0.017	1.49HisVal: 1.49 ± 0.021	0.35HisTrp: 0.35 ± 0.009	0.68HisTyr: 0.68 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.188IleAla: 4.188 ± 0.034	0.724IleCys: 0.724 ± 0.015	2.794IleAsp: 2.794 ± 0.03	2.755IleGlu: 2.755 ± 0.03	1.925IlePhe: 1.925 ± 0.023	3.078IleGly: 3.078 ± 0.028	1.172IleHis: 1.172 ± 0.017	2.428IleIle: 2.428 ± 0.025	2.232IleLys: 2.232 ± 0.024	4.412IleLeu: 4.412 ± 0.039	1.011IleMet: 1.011 ± 0.014	1.752IleAsn: 1.752 ± 0.021	2.893IlePro: 2.893 ± 0.023	1.888IleGln: 1.888 ± 0.026	2.859IleArg: 2.859 ± 0.026	3.593IleSer: 3.593 ± 0.033	2.681IleThr: 2.681 ± 0.025	3.156IleVal: 3.156 ± 0.032	0.724IleTrp: 0.724 ± 0.014	1.34IleTyr: 1.34 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.693LysAla: 4.693 ± 0.036	0.473LysCys: 0.473 ± 0.012	2.802LysAsp: 2.802 ± 0.029	3.294LysGlu: 3.294 ± 0.034	1.464LysPhe: 1.464 ± 0.023	2.99LysGly: 2.99 ± 0.03	1.129LysHis: 1.129 ± 0.016	2.12LysIle: 2.12 ± 0.025	3.441LysLys: 3.441 ± 0.048	4.236LysLeu: 4.236 ± 0.038	1.045LysMet: 1.045 ± 0.017	1.611LysAsn: 1.611 ± 0.02	2.791LysPro: 2.791 ± 0.031	1.907LysGln: 1.907 ± 0.023	3.419LysArg: 3.419 ± 0.035	3.352LysSer: 3.352 ± 0.032	2.732LysThr: 2.732 ± 0.025	2.794LysVal: 2.794 ± 0.027	0.655LysTrp: 0.655 ± 0.013	1.33LysTyr: 1.33 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	8.223LeuAla: 8.223 ± 0.049	1.2LeuCys: 1.2 ± 0.019	5.334LeuAsp: 5.334 ± 0.038	5.519LeuGlu: 5.519 ± 0.046	3.348LeuPhe: 3.348 ± 0.034	5.982LeuGly: 5.982 ± 0.045	2.171LeuHis: 2.171 ± 0.023	3.901LeuIle: 3.901 ± 0.032	4.234LeuLys: 4.234 ± 0.036	8.577LeuLeu: 8.577 ± 0.065	1.828LeuMet: 1.828 ± 0.024	3.059LeuAsn: 3.059 ± 0.032	5.47LeuPro: 5.47 ± 0.041	3.835LeuGln: 3.835 ± 0.04	5.915LeuArg: 5.915 ± 0.046	7.286LeuSer: 7.286 ± 0.052	4.731LeuThr: 4.731 ± 0.037	5.629LeuVal: 5.629 ± 0.048	1.24LeuTrp: 1.24 ± 0.017	2.329LeuTyr: 2.329 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.442MetAla: 2.442 ± 0.026	0.243MetCys: 0.243 ± 0.008	1.294MetAsp: 1.294 ± 0.02	1.3MetGlu: 1.3 ± 0.017	0.726MetPhe: 0.726 ± 0.015	1.488MetGly: 1.488 ± 0.021	0.47MetHis: 0.47 ± 0.012	0.951MetIle: 0.951 ± 0.014	0.978MetLys: 0.978 ± 0.017	1.958MetLeu: 1.958 ± 0.02	0.628MetMet: 0.628 ± 0.013	0.768MetAsn: 0.768 ± 0.012	1.388MetPro: 1.388 ± 0.02	0.873MetGln: 0.873 ± 0.015	1.31MetArg: 1.31 ± 0.018	1.815MetSer: 1.815 ± 0.023	1.289MetThr: 1.289 ± 0.017	1.289MetVal: 1.289 ± 0.018	0.264MetTrp: 0.264 ± 0.008	0.534MetTyr: 0.534 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.096AsnAla: 3.096 ± 0.028	0.415AsnCys: 0.415 ± 0.01	1.879AsnAsp: 1.879 ± 0.021	1.826AsnGlu: 1.826 ± 0.019	1.286AsnPhe: 1.286 ± 0.017	2.922AsnGly: 2.922 ± 0.033	0.803AsnHis: 0.803 ± 0.013	1.92AsnIle: 1.92 ± 0.018	1.567AsnLys: 1.567 ± 0.021	3.122AsnLeu: 3.122 ± 0.03	0.833AsnMet: 0.833 ± 0.015	1.525AsnAsn: 1.525 ± 0.03	2.313AsnPro: 2.313 ± 0.025	1.233AsnGln: 1.233 ± 0.019	1.871AsnArg: 1.871 ± 0.02	2.501AsnSer: 2.501 ± 0.024	1.923AsnThr: 1.923 ± 0.02	2.245AsnVal: 2.245 ± 0.022	0.542AsnTrp: 0.542 ± 0.012	1.021AsnTyr: 1.021 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.46ProAla: 5.46 ± 0.055	0.549ProCys: 0.549 ± 0.013	3.309ProAsp: 3.309 ± 0.027	3.817ProGlu: 3.817 ± 0.033	2.046ProPhe: 2.046 ± 0.022	3.926ProGly: 3.926 ± 0.036	1.315ProHis: 1.315 ± 0.019	2.378ProIle: 2.378 ± 0.022	2.673ProLys: 2.673 ± 0.026	4.821ProLeu: 4.821 ± 0.035	1.118ProMet: 1.118 ± 0.018	2.073ProAsn: 2.073 ± 0.025	5.463ProPro: 5.463 ± 0.084	2.483ProGln: 2.483 ± 0.035	3.471ProArg: 3.471 ± 0.037	5.901ProSer: 5.901 ± 0.052	3.703ProThr: 3.703 ± 0.037	3.568ProVal: 3.568 ± 0.033	0.747ProTrp: 0.747 ± 0.012	1.508ProTyr: 1.508 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.713GlnAla: 3.713 ± 0.033	0.426GlnCys: 0.426 ± 0.012	2.089GlnAsp: 2.089 ± 0.023	2.374GlnGlu: 2.374 ± 0.028	1.312GlnPhe: 1.312 ± 0.02	2.49GlnGly: 2.49 ± 0.028	1.108GlnHis: 1.108 ± 0.019	1.784GlnIle: 1.784 ± 0.02	1.898GlnLys: 1.898 ± 0.023	3.608GlnLeu: 3.608 ± 0.033	0.893GlnMet: 0.893 ± 0.015	1.357GlnAsn: 1.357 ± 0.016	2.663GlnPro: 2.663 ± 0.034	2.918GlnGln: 2.918 ± 0.067	2.715GlnArg: 2.715 ± 0.026	2.958GlnSer: 2.958 ± 0.029	2.226GlnThr: 2.226 ± 0.024	2.199GlnVal: 2.199 ± 0.024	0.578GlnTrp: 0.578 ± 0.012	1.106GlnTyr: 1.106 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.946ArgAla: 4.946 ± 0.036	0.729ArgCys: 0.729 ± 0.013	3.562ArgAsp: 3.562 ± 0.039	3.969ArgGlu: 3.969 ± 0.043	2.189ArgPhe: 2.189 ± 0.023	3.854ArgGly: 3.854 ± 0.034	1.646ArgHis: 1.646 ± 0.022	2.963ArgIle: 2.963 ± 0.029	3.353ArgLys: 3.353 ± 0.031	5.76ArgLeu: 5.76 ± 0.045	1.332ArgMet: 1.332 ± 0.016	2.183ArgAsn: 2.183 ± 0.024	3.631ArgPro: 3.631 ± 0.041	2.689ArgGln: 2.689 ± 0.024	5.339ArgArg: 5.339 ± 0.057	4.65ArgSer: 4.65 ± 0.044	3.138ArgThr: 3.138 ± 0.029	3.413ArgVal: 3.413 ± 0.028	0.927ArgTrp: 0.927 ± 0.015	1.668ArgTyr: 1.668 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.845SerAla: 6.845 ± 0.047	0.874SerCys: 0.874 ± 0.014	4.161SerAsp: 4.161 ± 0.033	3.927SerGlu: 3.927 ± 0.034	2.955SerPhe: 2.955 ± 0.025	5.517SerGly: 5.517 ± 0.042	1.938SerHis: 1.938 ± 0.027	3.82SerIle: 3.82 ± 0.038	3.64SerLys: 3.64 ± 0.03	7.19SerLeu: 7.19 ± 0.047	1.688SerMet: 1.688 ± 0.02	2.735SerAsn: 2.735 ± 0.029	5.396SerPro: 5.396 ± 0.057	3.218SerGln: 3.218 ± 0.032	5.108SerArg: 5.108 ± 0.047	9.148SerSer: 9.148 ± 0.095	5.073SerThr: 5.073 ± 0.048	4.499SerVal: 4.499 ± 0.026	1.136SerTrp: 1.136 ± 0.017	2.019SerTyr: 2.019 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.32ThrAla: 5.32 ± 0.037	0.729ThrCys: 0.729 ± 0.014	2.707ThrAsp: 2.707 ± 0.026	2.916ThrGlu: 2.916 ± 0.025	2.128ThrPhe: 2.128 ± 0.024	4.02ThrGly: 4.02 ± 0.038	1.216ThrHis: 1.216 ± 0.018	2.91ThrIle: 2.91 ± 0.027	2.514ThrLys: 2.514 ± 0.026	5.018ThrLeu: 5.018 ± 0.042	1.173ThrMet: 1.173 ± 0.016	1.922ThrAsn: 1.922 ± 0.026	4.109ThrPro: 4.109 ± 0.044	1.972ThrGln: 1.972 ± 0.021	3.049ThrArg: 3.049 ± 0.027	4.876ThrSer: 4.876 ± 0.044	4.194ThrThr: 4.194 ± 0.079	3.651ThrVal: 3.651 ± 0.03	0.825ThrTrp: 0.825 ± 0.016	1.56ThrTyr: 1.56 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.633ValAla: 5.633 ± 0.039	0.834ValCys: 0.834 ± 0.017	3.842ValAsp: 3.842 ± 0.031	3.852ValGlu: 3.852 ± 0.029	2.476ValPhe: 2.476 ± 0.026	3.958ValGly: 3.958 ± 0.033	1.394ValHis: 1.394 ± 0.017	2.935ValIle: 2.935 ± 0.034	2.912ValLys: 2.912 ± 0.026	5.7ValLeu: 5.7 ± 0.037	1.349ValMet: 1.349 ± 0.017	2.19ValAsn: 2.19 ± 0.021	3.625ValPro: 3.625 ± 0.032	2.332ValGln: 2.332 ± 0.021	3.493ValArg: 3.493 ± 0.029	4.551ValSer: 4.551 ± 0.038	3.512ValThr: 3.512 ± 0.031	4.447ValVal: 4.447 ± 0.041	0.875ValTrp: 0.875 ± 0.016	1.727ValTyr: 1.727 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.204TrpAla: 1.204 ± 0.02	0.195TrpCys: 0.195 ± 0.006	0.948TrpAsp: 0.948 ± 0.019	0.857TrpGlu: 0.857 ± 0.015	0.544TrpPhe: 0.544 ± 0.012	0.926TrpGly: 0.926 ± 0.016	0.365TrpHis: 0.365 ± 0.009	0.753TrpIle: 0.753 ± 0.012	0.782TrpLys: 0.782 ± 0.015	1.366TrpLeu: 1.366 ± 0.019	0.371TrpMet: 0.371 ± 0.009	0.616TrpAsn: 0.616 ± 0.012	0.608TrpPro: 0.608 ± 0.013	0.588TrpGln: 0.588 ± 0.012	0.973TrpArg: 0.973 ± 0.014	1.029TrpSer: 1.029 ± 0.016	0.919TrpThr: 0.919 ± 0.015	0.885TrpVal: 0.885 ± 0.018	0.29TrpTrp: 0.29 ± 0.008	0.41TrpTyr: 0.41 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.185TyrAla: 2.185 ± 0.026	0.42TyrCys: 0.42 ± 0.011	1.682TyrAsp: 1.682 ± 0.021	1.539TyrGlu: 1.539 ± 0.018	1.169TyrPhe: 1.169 ± 0.019	2.075TyrGly: 2.075 ± 0.024	0.743TyrHis: 0.743 ± 0.014	1.347TyrIle: 1.347 ± 0.018	1.115TyrLys: 1.115 ± 0.018	2.602TyrLeu: 2.602 ± 0.027	0.618TyrMet: 0.618 ± 0.014	1.067TyrAsn: 1.067 ± 0.018	1.436TyrPro: 1.436 ± 0.02	1.039TyrGln: 1.039 ± 0.017	1.65TyrArg: 1.65 ± 0.022	1.96TyrSer: 1.96 ± 0.021	1.502TyrThr: 1.502 ± 0.017	1.635TyrVal: 1.635 ± 0.021	0.433TyrTrp: 0.433 ± 0.01	0.929TyrTyr: 0.929 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9114 proteins (4490027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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