Thauera sp. K11

Taxonomy: cellular organisms; Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Zoogloeaceae; Thauera; unclassified Thauera

Average proteome isoelectric point is 6.68

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 4391 proteins (isoelectric point calculated using IPC2_protein)

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Summary statistics related to proteome-wise predictions


    

Protein with the lowest isoelectric point:
>tr|A0A290ZMC1|A0A290ZMC1_9RHOO AAA domain-containing protein OS=Thauera sp. K11 OX=2005884 GN=CCZ27_09455 PE=4 SV=1
MM1 pKa = 7.95PIAIEE6 pKa = 4.2EE7 pKa = 4.78PINTYY12 pKa = 8.04TVGNQVEE19 pKa = 4.25PEE21 pKa = 4.13IVVLADD27 pKa = 3.33GGYY30 pKa = 9.39VVMWQSSGQDD40 pKa = 3.34GSGGGIYY47 pKa = 9.85GQRR50 pKa = 11.84FTSNGTPLGAEE61 pKa = 3.9FRR63 pKa = 11.84INDD66 pKa = 3.83VVSGTQEE73 pKa = 3.72QPRR76 pKa = 11.84AAALSDD82 pKa = 3.25GGFVVVWQDD91 pKa = 2.83TGGADD96 pKa = 3.29GSGYY100 pKa = 10.85GVIGQRR106 pKa = 11.84FAADD110 pKa = 3.6GSTLGGNFVANTTTSSTQYY129 pKa = 10.3AGAVAAYY136 pKa = 9.3DD137 pKa = 3.18GGYY140 pKa = 10.3AVVWSSSQSGGNSFDD155 pKa = 4.23IYY157 pKa = 8.77VQRR160 pKa = 11.84YY161 pKa = 5.43TNAGTPVGAEE171 pKa = 4.04DD172 pKa = 4.21RR173 pKa = 11.84VSTVPGAATAQPGAQYY189 pKa = 10.65QPDD192 pKa = 3.93VATLQDD198 pKa = 3.03GRR200 pKa = 11.84LIVVWNDD207 pKa = 3.11SNGNDD212 pKa = 3.66GNGDD216 pKa = 3.73GVFGRR221 pKa = 11.84LFDD224 pKa = 4.3PATGAFGDD232 pKa = 3.97TFLVNTTTAGSQSSSSAGYY251 pKa = 9.23GPRR254 pKa = 11.84VAALADD260 pKa = 3.7GGFVAVWPANGQDD273 pKa = 3.35GSGWGVFGQRR283 pKa = 11.84FNADD287 pKa = 2.71GSKK290 pKa = 10.67AGGEE294 pKa = 4.0FLVNQSTNGGQYY306 pKa = 9.89QADD309 pKa = 3.76VTALSTGGFVVTWYY323 pKa = 10.69NDD325 pKa = 3.22NYY327 pKa = 10.73DD328 pKa = 3.41VSGSGTSADD337 pKa = 3.47VYY339 pKa = 10.82VRR341 pKa = 11.84EE342 pKa = 4.37FGGDD346 pKa = 3.53GLPAGDD352 pKa = 3.76QRR354 pKa = 11.84KK355 pKa = 8.88LLSATNSTEE364 pKa = 3.92YY365 pKa = 10.73QPAIADD371 pKa = 4.18LGNGNYY377 pKa = 9.03IVAYY381 pKa = 9.73ADD383 pKa = 3.55YY384 pKa = 11.09VSTANGGDD392 pKa = 3.13NSYY395 pKa = 10.81EE396 pKa = 3.47IRR398 pKa = 11.84QQIFGDD404 pKa = 3.46EE405 pKa = 3.9ADD407 pKa = 4.7FFRR410 pKa = 11.84QANPEE415 pKa = 4.23LGDD418 pKa = 3.53FTGSVTFAEE427 pKa = 4.35NLVNATPQVIDD438 pKa = 3.72AAVSFHH444 pKa = 7.23DD445 pKa = 4.14VDD447 pKa = 4.43SADD450 pKa = 3.54FDD452 pKa = 4.08GGVIDD457 pKa = 6.13LFYY460 pKa = 9.91TQYY463 pKa = 11.73GEE465 pKa = 4.27TTDD468 pKa = 3.52QLGVRR473 pKa = 11.84HH474 pKa = 5.83QGSAPGHH481 pKa = 6.16IGVAGSTVTYY491 pKa = 10.06GGVAIGTISGGQNGSNLSIALNANATAAAVEE522 pKa = 4.05ALIQNLTYY530 pKa = 10.97ASTSQSPAASRR541 pKa = 11.84TVGIRR546 pKa = 11.84VSDD549 pKa = 3.78GDD551 pKa = 3.88GGASASSQVTINVTLEE567 pKa = 3.8LDD569 pKa = 3.92GAPEE573 pKa = 3.71VHH575 pKa = 5.54TAEE578 pKa = 5.59RR579 pKa = 11.84INTYY583 pKa = 9.27TGNQQYY589 pKa = 10.05EE590 pKa = 4.19PEE592 pKa = 4.32IVVLADD598 pKa = 3.52GSYY601 pKa = 9.88VVVWQSGGQDD611 pKa = 3.24GSGDD615 pKa = 3.75GIYY618 pKa = 10.55GQRR621 pKa = 11.84FTSNGTPLGAEE632 pKa = 3.9FRR634 pKa = 11.84INDD637 pKa = 3.83VVSGTQEE644 pKa = 3.72QPRR647 pKa = 11.84AAALSDD653 pKa = 3.25GGFVVVWQDD662 pKa = 2.83TGGADD667 pKa = 3.29GSGYY671 pKa = 10.85GVIGQRR677 pKa = 11.84FAADD681 pKa = 4.25GSALGGNFVANTTTSSTQYY700 pKa = 10.3AGAVAAYY707 pKa = 9.3DD708 pKa = 3.18GGYY711 pKa = 10.3AVVWSSSQSGGNSFDD726 pKa = 4.23IYY728 pKa = 8.77VQRR731 pKa = 11.84YY732 pKa = 5.43TNAGTPVGAEE742 pKa = 4.04DD743 pKa = 4.21RR744 pKa = 11.84VSTVPGAATAQPGAQYY760 pKa = 10.65QPDD763 pKa = 3.93VATLQDD769 pKa = 3.03GRR771 pKa = 11.84LIVVWNDD778 pKa = 3.11SNGNDD783 pKa = 3.66GNGDD787 pKa = 3.73GVFGRR792 pKa = 11.84LFDD795 pKa = 4.3PATGAFGDD803 pKa = 3.97TFLVNTTTAGSQSSSSAGYY822 pKa = 9.08GLRR825 pKa = 11.84VAALADD831 pKa = 3.58GGFVVVWPDD840 pKa = 3.02NGQDD844 pKa = 3.4GSGWGVFGQRR854 pKa = 11.84FNADD858 pKa = 2.71GSKK861 pKa = 10.67AGGEE865 pKa = 3.9FRR867 pKa = 11.84INEE870 pKa = 4.39STTSSQYY877 pKa = 9.4QASVTALSTGGFVVAWHH894 pKa = 6.44NDD896 pKa = 3.21GYY898 pKa = 11.01GVSGSGSYY906 pKa = 10.71NDD908 pKa = 3.51VYY910 pKa = 10.81IRR912 pKa = 11.84EE913 pKa = 4.03YY914 pKa = 11.01DD915 pKa = 3.59GAGVPVDD922 pKa = 4.07GEE924 pKa = 4.37RR925 pKa = 11.84KK926 pKa = 8.45LTGPSSTGSNQVFQPAIADD945 pKa = 3.77LGDD948 pKa = 3.55GNFVVVYY955 pKa = 9.93SAYY958 pKa = 10.42QPTANGGNNTYY969 pKa = 10.57EE970 pKa = 3.65IFQNVFGDD978 pKa = 4.04AAALARR984 pKa = 11.84TSAAPVLTDD993 pKa = 3.91LAATVSFGEE1002 pKa = 4.73VAASTAPQLIDD1013 pKa = 3.29AAVSLVDD1020 pKa = 5.43LDD1022 pKa = 3.89STDD1025 pKa = 3.77FGGGRR1030 pKa = 11.84LDD1032 pKa = 3.93LFYY1035 pKa = 11.13VQYY1038 pKa = 11.52GEE1040 pKa = 4.64ATDD1043 pKa = 3.64QLGVRR1048 pKa = 11.84HH1049 pKa = 6.36EE1050 pKa = 4.68GNGAGQIGVAGNTVSYY1066 pKa = 10.35GGIVIGTIAAGADD1079 pKa = 3.57GADD1082 pKa = 3.68GANLAVLFNAAATVDD1097 pKa = 3.59AVEE1100 pKa = 5.41ALIQNLTYY1108 pKa = 10.09ATTADD1113 pKa = 3.7KK1114 pKa = 10.69PGQTRR1119 pKa = 11.84TIGLRR1124 pKa = 11.84IADD1127 pKa = 3.69GDD1129 pKa = 4.17GGVSAARR1136 pKa = 11.84TVNINIALDD1145 pKa = 4.01LDD1147 pKa = 3.92TAAAVHH1153 pKa = 6.11GEE1155 pKa = 3.99EE1156 pKa = 4.29RR1157 pKa = 11.84VNSYY1161 pKa = 10.78VEE1163 pKa = 4.43STQSEE1168 pKa = 4.5PEE1170 pKa = 4.0IVVLADD1176 pKa = 3.33GGYY1179 pKa = 9.39VVMWQSSGQDD1189 pKa = 3.35GSGDD1193 pKa = 3.66GIYY1196 pKa = 10.55GQRR1199 pKa = 11.84FTSNGTPLGAEE1210 pKa = 4.02FRR1212 pKa = 11.84INDD1215 pKa = 3.98AVSGMQEE1222 pKa = 3.85QPRR1225 pKa = 11.84AAALSDD1231 pKa = 3.25GGFVVVWQDD1240 pKa = 2.83TGGADD1245 pKa = 3.44GSGWGIIGQRR1255 pKa = 11.84FAADD1259 pKa = 4.29GSALGSNFVANTTTNGNQSGGAVAAYY1285 pKa = 9.9DD1286 pKa = 3.24GGYY1289 pKa = 10.3AVVWSSSQSGGSSFDD1304 pKa = 3.24IYY1306 pKa = 10.0VQRR1309 pKa = 11.84FTNAGTPAGGEE1320 pKa = 4.32TRR1322 pKa = 11.84VSTVPGAATAQPGAQYY1338 pKa = 10.68QPDD1341 pKa = 3.39VAARR1345 pKa = 11.84AGGDD1349 pKa = 4.53LIVVWNDD1356 pKa = 2.71SGSNDD1361 pKa = 3.13GSGDD1365 pKa = 3.66GVFGRR1370 pKa = 11.84IYY1372 pKa = 10.97DD1373 pKa = 3.84SATGTFGSTFLVNTTTAGSQSSSSGGNGPHH1403 pKa = 6.53VATLVDD1409 pKa = 3.56GGFVVIWPANGQDD1422 pKa = 3.36GSGWGVFGQRR1432 pKa = 11.84FNADD1436 pKa = 2.71GSKK1439 pKa = 10.67AGGEE1443 pKa = 4.0FLVNQSTNGGQYY1455 pKa = 9.89QADD1458 pKa = 3.76VTALSTGGFVVTWYY1472 pKa = 10.69NDD1474 pKa = 3.22NYY1476 pKa = 10.73DD1477 pKa = 3.47VSGSGTTGDD1486 pKa = 3.34VYY1488 pKa = 11.08LRR1490 pKa = 11.84EE1491 pKa = 4.13YY1492 pKa = 10.55GATGLPVDD1500 pKa = 4.98DD1501 pKa = 4.44EE1502 pKa = 5.03RR1503 pKa = 11.84KK1504 pKa = 10.06LSSATNSTEE1513 pKa = 3.83YY1514 pKa = 10.7QPAVADD1520 pKa = 4.48LGNGNYY1526 pKa = 9.37VVVYY1530 pKa = 10.52ADD1532 pKa = 3.75YY1533 pKa = 8.53GTSAGGGNGYY1543 pKa = 9.8DD1544 pKa = 2.86IRR1546 pKa = 11.84QQIFGDD1552 pKa = 3.37AADD1555 pKa = 4.4FVRR1558 pKa = 11.84NSAAPLIDD1566 pKa = 4.15DD1567 pKa = 3.89VRR1569 pKa = 11.84TLLTLTSDD1577 pKa = 3.69AASPLYY1583 pKa = 10.55AGNAQIIDD1591 pKa = 3.58GDD1593 pKa = 4.27VAVMDD1598 pKa = 3.98VDD1600 pKa = 3.97SADD1603 pKa = 3.41FAGGQLAVQLLNGASAGEE1621 pKa = 3.96ALAIRR1626 pKa = 11.84HH1627 pKa = 5.57QGNGAGQIGVAGNTVSYY1644 pKa = 9.94GGTVIGTFSGGGSGAATLLVSLNANAGAAAVRR1676 pKa = 11.84ALIEE1680 pKa = 4.03NVSYY1684 pKa = 11.09QNSTPPTGTTDD1695 pKa = 2.89RR1696 pKa = 11.84YY1697 pKa = 10.37LAFRR1701 pKa = 11.84LFDD1704 pKa = 4.2GDD1706 pKa = 4.34GGVSDD1711 pKa = 3.99ATTVQIRR1718 pKa = 11.84IQSSSPSLPALVLDD1732 pKa = 4.76DD1733 pKa = 5.45VEE1735 pKa = 4.57TTLQIGEE1742 pKa = 4.38SQAQAGVLIDD1752 pKa = 3.64GAVALDD1758 pKa = 3.85YY1759 pKa = 11.28NGSNGFDD1766 pKa = 3.32GGKK1769 pKa = 8.48LTVGYY1774 pKa = 9.93LSSTGRR1780 pKa = 11.84VDD1782 pKa = 3.44DD1783 pKa = 3.59QLGIRR1788 pKa = 11.84NQGSGAGEE1796 pKa = 4.07VGLSGSTVLYY1806 pKa = 8.74EE1807 pKa = 4.05GSVIGTVSAGLDD1819 pKa = 3.59GVNGAGLEE1827 pKa = 4.19IVFNGAATAQAIEE1840 pKa = 4.14RR1841 pKa = 11.84VIEE1844 pKa = 3.85NLVYY1848 pKa = 10.93SNTSDD1853 pKa = 3.41GPNPNRR1859 pKa = 11.84TIRR1862 pKa = 11.84INVRR1866 pKa = 11.84DD1867 pKa = 3.84AANVASGNSDD1877 pKa = 3.33VVIQIAPEE1885 pKa = 4.13ADD1887 pKa = 3.14PAAPQFLLGQQQSNGYY1903 pKa = 8.71EE1904 pKa = 4.06AGDD1907 pKa = 3.52QGSPAVGRR1915 pKa = 11.84LFGANDD1921 pKa = 3.77GGYY1924 pKa = 9.99VIAWVSAGGQDD1935 pKa = 3.79GSGQGVFAQRR1945 pKa = 11.84YY1946 pKa = 7.53AADD1949 pKa = 4.06GSAIGPEE1956 pKa = 4.18FQVNSHH1962 pKa = 5.84TLNEE1966 pKa = 4.23QNQPTVAGLQNGGFVVVWASSNQDD1990 pKa = 2.61GSGYY1994 pKa = 10.43GVYY1997 pKa = 10.08AQRR2000 pKa = 11.84YY2001 pKa = 7.42GADD2004 pKa = 3.55GTPQSGEE2011 pKa = 4.03FQVNTSTSSTQDD2023 pKa = 2.94EE2024 pKa = 4.43PAVLGLADD2032 pKa = 3.93GSFVIAYY2039 pKa = 9.7SSYY2042 pKa = 9.71YY2043 pKa = 10.3NNTGGSYY2050 pKa = 10.86YY2051 pKa = 10.7DD2052 pKa = 3.5VLGQRR2057 pKa = 11.84YY2058 pKa = 8.34AADD2061 pKa = 3.71GTPLGGEE2068 pKa = 4.18FTLNTQVSNTQSQPRR2083 pKa = 11.84LAALEE2088 pKa = 4.31GGGFVAIWTDD2098 pKa = 3.21SSGDD2102 pKa = 3.31ASGYY2106 pKa = 10.58GIVAQRR2112 pKa = 11.84FAADD2116 pKa = 3.74GSKK2119 pKa = 10.56LGGEE2123 pKa = 4.1IKK2125 pKa = 11.06VNTTEE2130 pKa = 4.24TGNQQGPDD2138 pKa = 3.43VAGLPGGGFVAVWHH2152 pKa = 6.17YY2153 pKa = 11.41NSAVYY2158 pKa = 9.7AQRR2161 pKa = 11.84FDD2163 pKa = 3.59ASGGKK2168 pKa = 9.97AGGEE2172 pKa = 4.13LLVSTADD2179 pKa = 3.33TSSNYY2184 pKa = 10.07SNHH2187 pKa = 5.68ARR2189 pKa = 11.84VAVVGDD2195 pKa = 3.79GFVVTWDD2202 pKa = 3.34SYY2204 pKa = 10.63YY2205 pKa = 11.2SLGGSGYY2212 pKa = 10.55DD2213 pKa = 3.21IVAQKK2218 pKa = 10.85FDD2220 pKa = 3.65FAGNKK2225 pKa = 9.03IDD2227 pKa = 4.03GTFLVNSTTDD2237 pKa = 3.01STQYY2241 pKa = 10.6QPAIAALGGSNFVVAWAGYY2260 pKa = 7.39NQEE2263 pKa = 4.15QGGTASTYY2271 pKa = 11.0GVFHH2275 pKa = 6.38QLLGEE2280 pKa = 4.39AGSITRR2286 pKa = 11.84SAAPEE2291 pKa = 4.08LLDD2294 pKa = 4.1LASSVTFGEE2303 pKa = 4.25ALVNAAPQIIDD2314 pKa = 3.76PGVNLIDD2321 pKa = 4.53ADD2323 pKa = 3.9SANFDD2328 pKa = 4.06GGSLWVSVVSGYY2340 pKa = 11.52GSITYY2345 pKa = 9.58AQLPEE2350 pKa = 4.75DD2351 pKa = 4.94VPAQDD2356 pKa = 3.38QLGIRR2361 pKa = 11.84HH2362 pKa = 5.91QGSGADD2368 pKa = 3.63QIGVAGNTVSYY2379 pKa = 9.94GGTVIGTILSAGANGADD2396 pKa = 3.5LVIRR2400 pKa = 11.84FNASATPTAVEE2411 pKa = 4.3KK2412 pKa = 10.84LIEE2415 pKa = 4.32SLTYY2419 pKa = 11.03ANTSSAPVASRR2430 pKa = 11.84SIAISVSDD2438 pKa = 3.89GAGGTSVPKK2447 pKa = 10.25IVTINVTPDD2456 pKa = 3.07ADD2458 pKa = 3.9GAQPLFANEE2467 pKa = 3.93RR2468 pKa = 11.84VNTFEE2473 pKa = 6.22PGTQDD2478 pKa = 2.6EE2479 pKa = 4.31AAIARR2484 pKa = 11.84LADD2487 pKa = 3.55GGYY2490 pKa = 9.28VVVWTSSGQDD2500 pKa = 2.77GWGDD2504 pKa = 3.66GVHH2507 pKa = 6.0GQRR2510 pKa = 11.84YY2511 pKa = 7.42DD2512 pKa = 3.33AKK2514 pKa = 8.78GVPVGSEE2521 pKa = 3.99FQVNSYY2527 pKa = 8.84TPNGQSAPAVAGLGDD2542 pKa = 3.77GGYY2545 pKa = 10.24VVLWQSSGQDD2555 pKa = 3.3GSSWGVFGQRR2565 pKa = 11.84FDD2567 pKa = 3.75ASGVPAGGEE2576 pKa = 4.06FQVNTGAQNEE2586 pKa = 4.15QSAVAVAGLADD2597 pKa = 3.88GFVATWYY2604 pKa = 10.47SYY2606 pKa = 10.68YY2607 pKa = 10.45QDD2609 pKa = 2.84GTYY2612 pKa = 10.45QDD2614 pKa = 4.67VYY2616 pKa = 10.43FQRR2619 pKa = 11.84FDD2621 pKa = 3.18AAGNKK2626 pKa = 9.57LGAEE2630 pKa = 4.24TRR2632 pKa = 11.84ANTSAGYY2639 pKa = 9.35EE2640 pKa = 3.85NSYY2643 pKa = 10.93QGTPAITAFADD2654 pKa = 4.14GSFVIVWRR2662 pKa = 11.84GDD2664 pKa = 3.1GGQDD2668 pKa = 3.02GSGYY2672 pKa = 10.76GVFGQRR2678 pKa = 11.84YY2679 pKa = 7.97AADD2682 pKa = 4.14GSALGAEE2689 pKa = 4.6FQVNSHH2695 pKa = 6.14GADD2698 pKa = 3.15NQYY2701 pKa = 10.99EE2702 pKa = 4.08PDD2704 pKa = 3.7VAVLADD2710 pKa = 3.54GGFVVVWRR2718 pKa = 11.84SDD2720 pKa = 3.49SQDD2723 pKa = 2.83GSGAGVFGQRR2733 pKa = 11.84YY2734 pKa = 7.96DD2735 pKa = 3.28ASGNAVGAEE2744 pKa = 3.71FRR2746 pKa = 11.84VNTGTSGNQYY2756 pKa = 9.76QPSVSALSHH2765 pKa = 6.19GGFVVAWNDD2774 pKa = 3.3DD2775 pKa = 3.34SRR2777 pKa = 11.84TYY2779 pKa = 10.86AQQFDD2784 pKa = 3.65AAGARR2789 pKa = 11.84IDD2791 pKa = 3.4HH2792 pKa = 7.01PLRR2795 pKa = 11.84VDD2797 pKa = 3.44TLDD2800 pKa = 3.64NNSNANLPAVLGLDD2814 pKa = 2.82NGAFVTVWRR2823 pKa = 11.84DD2824 pKa = 3.05YY2825 pKa = 11.42DD2826 pKa = 3.86YY2827 pKa = 10.58GTGSHH2832 pKa = 6.51NVYY2835 pKa = 9.89QQLFGSPGDD2844 pKa = 3.94FAHH2847 pKa = 6.65SANPEE2852 pKa = 4.14LVDD2855 pKa = 3.46VATSVVFRR2863 pKa = 11.84EE2864 pKa = 3.95NLINTAPQLIDD2875 pKa = 3.61PSVGLFDD2882 pKa = 5.87ADD2884 pKa = 3.84SADD2887 pKa = 3.53FDD2889 pKa = 4.32GGILEE2894 pKa = 4.11VDD2896 pKa = 3.71YY2897 pKa = 9.96LTGYY2901 pKa = 9.74GALDD2905 pKa = 3.4QLGLEE2910 pKa = 4.7GLDD2913 pKa = 3.82HH2914 pKa = 6.99QDD2916 pKa = 2.96QLGIRR2921 pKa = 11.84NQGAGTNEE2929 pKa = 3.82IGVSGTTVSFEE2940 pKa = 3.79GTIIGTIVSNGQNGAKK2956 pKa = 8.42LTVMFNANATSEE2968 pKa = 4.04AVEE2971 pKa = 3.89RR2972 pKa = 11.84VIEE2975 pKa = 4.05NLTYY2979 pKa = 11.2ANTVSNPIASRR2990 pKa = 11.84TVSIRR2995 pKa = 11.84VTDD2998 pKa = 3.92GDD3000 pKa = 3.71GGASVARR3007 pKa = 11.84TVRR3010 pKa = 11.84IDD3012 pKa = 3.42VVAEE3016 pKa = 3.59TDD3018 pKa = 3.57GAVPHH3023 pKa = 6.4GLEE3026 pKa = 4.01KK3027 pKa = 10.23TVNTTVANEE3036 pKa = 3.84QSAPAVAVLADD3047 pKa = 3.71GGYY3050 pKa = 8.95VVVWQSYY3057 pKa = 8.64GQDD3060 pKa = 3.2ATSTWGVYY3068 pKa = 7.09GQRR3071 pKa = 11.84YY3072 pKa = 8.86DD3073 pKa = 5.19ADD3075 pKa = 4.3DD3076 pKa = 4.2NPVGGEE3082 pKa = 3.81FRR3084 pKa = 11.84VNTTTAGGQYY3094 pKa = 8.65EE3095 pKa = 4.24AQVVGLAGGGYY3106 pKa = 9.39AVVWRR3111 pKa = 11.84SDD3113 pKa = 3.43GQDD3116 pKa = 2.95GSGAGVYY3123 pKa = 7.78GQRR3126 pKa = 11.84YY3127 pKa = 8.12AADD3130 pKa = 3.87GSAIGGEE3137 pKa = 4.1FRR3139 pKa = 11.84INTTTSSNQYY3149 pKa = 9.3QPSIAADD3156 pKa = 3.64ADD3158 pKa = 3.98DD3159 pKa = 4.75GFVVAWYY3166 pKa = 10.05HH3167 pKa = 6.46DD3168 pKa = 4.26AYY3170 pKa = 11.21SAGNTEE3176 pKa = 3.85YY3177 pKa = 11.52ADD3179 pKa = 3.92IFFQRR3184 pKa = 11.84YY3185 pKa = 8.39DD3186 pKa = 3.2AGGNPAGAEE3195 pKa = 4.01TRR3197 pKa = 11.84ANPSLGSTFIYY3208 pKa = 10.2QSQPDD3213 pKa = 4.2ITWLDD3218 pKa = 3.12NGGFVVVWTDD3228 pKa = 3.05TSGTDD3233 pKa = 3.59GNGQGVFGQVFDD3245 pKa = 4.32ASGNAVGGAFQANAYY3260 pKa = 7.5ITGAQQNPAVAALKK3274 pKa = 10.79DD3275 pKa = 3.48GGFVVVWEE3283 pKa = 4.82SEE3285 pKa = 4.17GQDD3288 pKa = 3.42LSSTGIYY3295 pKa = 9.27GQRR3298 pKa = 11.84FDD3300 pKa = 4.48AAGAKK3305 pKa = 9.91LGAEE3309 pKa = 4.05FRR3311 pKa = 11.84VNTTVSSTQYY3321 pKa = 10.28QPDD3324 pKa = 3.72VVGLEE3329 pKa = 3.81NGGWVVTWTDD3339 pKa = 3.02AYY3341 pKa = 9.98GASSGGYY3348 pKa = 9.77DD3349 pKa = 4.15VFVQQYY3355 pKa = 9.09DD3356 pKa = 3.42AAGRR3360 pKa = 11.84AVDD3363 pKa = 4.29GEE3365 pKa = 4.59TRR3367 pKa = 11.84VNNYY3371 pKa = 8.09TPSTQYY3377 pKa = 10.71EE3378 pKa = 4.1PAIAATPDD3386 pKa = 2.95GGFVVAYY3393 pKa = 10.04SGYY3396 pKa = 9.04TYY3398 pKa = 10.95SGDD3401 pKa = 3.68GNGDD3405 pKa = 3.6GVPDD3409 pKa = 4.63GGSDD3413 pKa = 3.31SYY3415 pKa = 11.52DD3416 pKa = 2.73IRR3418 pKa = 11.84LQRR3421 pKa = 11.84FSNTAPEE3428 pKa = 4.11ITDD3431 pKa = 3.15VSVNGLEE3438 pKa = 4.13EE3439 pKa = 3.97AVIVLDD3445 pKa = 3.64YY3446 pKa = 11.61ALFEE3450 pKa = 5.13AGFSDD3455 pKa = 4.97EE3456 pKa = 5.75DD3457 pKa = 4.06GQSLQAIRR3465 pKa = 11.84ITTLPANGILRR3476 pKa = 11.84LDD3478 pKa = 3.78GVAIVPGQEE3487 pKa = 3.62IGLSALQGGLLTYY3500 pKa = 10.47QGEE3503 pKa = 4.4TDD3505 pKa = 5.4FFGLDD3510 pKa = 3.14QFLWTGSDD3518 pKa = 3.38GVAFAATPVATNITLANVNDD3538 pKa = 4.49GPRR3541 pKa = 11.84LEE3543 pKa = 5.68AGANDD3548 pKa = 3.76TAAEE3552 pKa = 4.42GTWFYY3557 pKa = 10.35HH3558 pKa = 6.37TIAIGDD3564 pKa = 4.26PDD3566 pKa = 4.3PEE3568 pKa = 4.26GHH3570 pKa = 6.55RR3571 pKa = 11.84VTVSWGDD3578 pKa = 3.56GSPDD3582 pKa = 3.53TVFSTSSANPGISHH3596 pKa = 7.0VYY3598 pKa = 10.6ADD3600 pKa = 4.32DD3601 pKa = 3.88GSYY3604 pKa = 9.65TVTVTVDD3611 pKa = 3.5DD3612 pKa = 3.99QQGQANSIEE3621 pKa = 4.11TDD3623 pKa = 3.4SFDD3626 pKa = 3.53VAVANVAPTIAPFGGNSVVQGEE3648 pKa = 5.12VYY3650 pKa = 10.3TLGLGTPYY3658 pKa = 11.01DD3659 pKa = 4.26PGTDD3663 pKa = 2.89TVTEE3667 pKa = 3.91YY3668 pKa = 10.89RR3669 pKa = 11.84IDD3671 pKa = 3.49WGDD3674 pKa = 3.34GSDD3677 pKa = 3.76PQIIAAAEE3685 pKa = 4.05LPPGGIVTHH3694 pKa = 6.93SYY3696 pKa = 8.95TAAGGKK3702 pKa = 7.31TIRR3705 pKa = 11.84VTLVDD3710 pKa = 3.58EE3711 pKa = 5.46DD3712 pKa = 4.7GVHH3715 pKa = 6.55SNAGTKK3721 pKa = 10.19SITVAAPAEE3730 pKa = 4.72VITVDD3735 pKa = 3.19AGNDD3739 pKa = 3.38VTVLEE3744 pKa = 4.5GSYY3747 pKa = 9.53FQKK3750 pKa = 10.43IISFDD3755 pKa = 3.76DD3756 pKa = 3.73PTDD3759 pKa = 3.09QGAAGRR3765 pKa = 11.84SYY3767 pKa = 10.51TVTWGDD3773 pKa = 3.46GQTTSGYY3780 pKa = 9.27VAAGQSSFVIGHH3792 pKa = 6.65TYY3794 pKa = 11.04ADD3796 pKa = 3.72DD3797 pKa = 3.84AAGYY3801 pKa = 8.23EE3802 pKa = 4.33VTVTVDD3808 pKa = 4.33DD3809 pKa = 5.4DD3810 pKa = 4.23GQQGSDD3816 pKa = 3.06SFTVQVNNVAPTISLGGNPSVAEE3839 pKa = 4.14GSPYY3843 pKa = 11.15ALTLFTPSDD3852 pKa = 3.69PGADD3856 pKa = 2.91TVQQYY3861 pKa = 9.06VIRR3864 pKa = 11.84WGDD3867 pKa = 3.34GSEE3870 pKa = 3.98QTIAAADD3877 pKa = 3.88LPADD3881 pKa = 4.74RR3882 pKa = 11.84IVTHH3886 pKa = 6.51VYY3888 pKa = 11.19ADD3890 pKa = 3.43GDD3892 pKa = 4.05ANQTIEE3898 pKa = 4.19VDD3900 pKa = 4.43LVDD3903 pKa = 5.72EE3904 pKa = 5.34DD3905 pKa = 4.56GTWVNAGSRR3914 pKa = 11.84GVHH3917 pKa = 5.77VYY3919 pKa = 10.49DD3920 pKa = 4.39VAPTLALAGAGSVDD3934 pKa = 3.45EE3935 pKa = 4.5GSPYY3939 pKa = 10.15TLEE3942 pKa = 4.65LGAIADD3948 pKa = 4.23PGLDD3952 pKa = 2.6TVTQYY3957 pKa = 11.15RR3958 pKa = 11.84IDD3960 pKa = 3.63WGDD3963 pKa = 3.33GTVEE3967 pKa = 4.06NFTAAEE3973 pKa = 3.96IAAQSARR3980 pKa = 11.84THH3982 pKa = 6.51VYY3984 pKa = 9.94QDD3986 pKa = 3.3GGAGGTDD3993 pKa = 3.48YY3994 pKa = 10.59TISVALVDD4002 pKa = 4.63EE4003 pKa = 5.67DD4004 pKa = 3.97GTHH4007 pKa = 6.92ANAGSKK4013 pKa = 8.74TLTVANVAPVLALSGADD4030 pKa = 4.71DD4031 pKa = 3.65IDD4033 pKa = 3.95EE4034 pKa = 4.72GGSYY4038 pKa = 10.75VLAIAATDD4046 pKa = 3.64PAGAADD4052 pKa = 4.12PLSYY4056 pKa = 10.59TIDD4059 pKa = 3.48WGDD4062 pKa = 3.3GSAVQTLTAAEE4073 pKa = 4.0LAALGGNVAHH4083 pKa = 6.67VFADD4087 pKa = 4.4DD4088 pKa = 3.5EE4089 pKa = 4.91DD4090 pKa = 6.12GPVNATARR4098 pKa = 11.84SIVVTVSDD4106 pKa = 4.28GDD4108 pKa = 4.04GGSHH4112 pKa = 6.43SLAKK4116 pKa = 10.37AVTVHH4121 pKa = 6.08NVAPTVALGGAGSVDD4136 pKa = 3.26EE4137 pKa = 4.54GSPYY4141 pKa = 10.15TLEE4144 pKa = 4.44LGAIVDD4150 pKa = 4.18PGLDD4154 pKa = 2.67TVTQYY4159 pKa = 11.15RR4160 pKa = 11.84IDD4162 pKa = 3.63WGDD4165 pKa = 3.33GTVEE4169 pKa = 4.06NFTAAEE4175 pKa = 3.96IAAQSARR4182 pKa = 11.84THH4184 pKa = 6.55VYY4186 pKa = 10.17QDD4188 pKa = 3.26GGTGGTDD4195 pKa = 3.4YY4196 pKa = 10.94AISVALVDD4204 pKa = 4.73EE4205 pKa = 5.67DD4206 pKa = 3.97GTHH4209 pKa = 6.92ANAGSKK4215 pKa = 9.43TITVANVAPVLALSGADD4232 pKa = 4.71DD4233 pKa = 3.65IDD4235 pKa = 3.94EE4236 pKa = 4.76GGSYY4240 pKa = 10.88LLAIAATDD4248 pKa = 3.63PAGAADD4254 pKa = 4.12PLSYY4258 pKa = 10.59TIDD4261 pKa = 3.48WGDD4264 pKa = 3.3GSAVQTLTAAEE4275 pKa = 4.0LAALGGNVAHH4285 pKa = 6.67VFADD4289 pKa = 4.4DD4290 pKa = 3.5EE4291 pKa = 4.91DD4292 pKa = 6.12GPVNATARR4300 pKa = 11.84TITVTASDD4308 pKa = 3.83GDD4310 pKa = 3.87GGVAQQSRR4318 pKa = 11.84SVTVHH4323 pKa = 5.73NVAPTLALSGAAGQVQGTAYY4343 pKa = 10.64ALTLGAVSDD4352 pKa = 4.47PGLDD4356 pKa = 2.99TVTAYY4361 pKa = 10.69VVDD4364 pKa = 3.85WGDD4367 pKa = 3.32GTVGVFDD4374 pKa = 3.79SAGEE4378 pKa = 4.22VTHH4381 pKa = 7.05TYY4383 pKa = 10.95AGTGDD4388 pKa = 3.63YY4389 pKa = 9.62TISVSLADD4397 pKa = 4.24EE4398 pKa = 5.44DD4399 pKa = 4.14GTHH4402 pKa = 6.79AGVATRR4408 pKa = 11.84TVSITAPTATLSFEE4422 pKa = 4.48AGADD4426 pKa = 3.5ASIDD4430 pKa = 3.42EE4431 pKa = 5.07GEE4433 pKa = 4.32TFTRR4437 pKa = 11.84NIVFSDD4443 pKa = 4.07GEE4445 pKa = 4.48DD4446 pKa = 3.1NGAAGWSYY4454 pKa = 11.3SIDD4457 pKa = 3.7YY4458 pKa = 11.26GDD4460 pKa = 3.72GTVVTGTTPVRR4471 pKa = 11.84SIEE4474 pKa = 4.01LSHH4477 pKa = 7.19RR4478 pKa = 11.84YY4479 pKa = 9.71ADD4481 pKa = 3.72GDD4483 pKa = 3.5ATRR4486 pKa = 11.84TVTVTLTDD4494 pKa = 3.43EE4495 pKa = 4.77AGEE4498 pKa = 4.36SVSDD4502 pKa = 3.82SFDD4505 pKa = 3.24VTVANVAPTVALSGAGSVDD4524 pKa = 3.19EE4525 pKa = 4.47GSAYY4529 pKa = 10.62VLSFGALVDD4538 pKa = 4.6PGADD4542 pKa = 2.79TATAYY4547 pKa = 9.64TLDD4550 pKa = 3.71WGDD4553 pKa = 3.44GTVQSFTAAEE4563 pKa = 4.23FAALGGNASHH4573 pKa = 7.19VYY4575 pKa = 10.81ADD4577 pKa = 4.24DD4578 pKa = 3.88GSYY4581 pKa = 11.24GITLGVTDD4589 pKa = 4.51EE4590 pKa = 5.21DD4591 pKa = 4.63GSFIAGSKK4599 pKa = 8.16TVAVANVAPVLALSGADD4616 pKa = 4.71DD4617 pKa = 3.65IDD4619 pKa = 3.94EE4620 pKa = 4.76GGSYY4624 pKa = 10.88LLAIAATDD4632 pKa = 3.63PAGAADD4638 pKa = 4.12PLSYY4642 pKa = 10.59TIDD4645 pKa = 3.48WGDD4648 pKa = 3.3GSAVQTLTAAEE4659 pKa = 4.0LAALGGNVAHH4669 pKa = 6.67VFADD4673 pKa = 4.4DD4674 pKa = 3.5EE4675 pKa = 4.91DD4676 pKa = 6.12GPVNATARR4684 pKa = 11.84SIVVTVSDD4692 pKa = 4.28GDD4694 pKa = 4.04GGSHH4698 pKa = 6.43SLAKK4702 pKa = 10.37AVTVHH4707 pKa = 6.08NVAPTVALGGAGSVDD4722 pKa = 3.31EE4723 pKa = 4.55GSAYY4727 pKa = 10.69VLNFGALVDD4736 pKa = 4.8PGADD4740 pKa = 2.79TATAYY4745 pKa = 9.64TLDD4748 pKa = 3.71WGDD4751 pKa = 3.44GTVQSFTAAEE4761 pKa = 4.23FAALGGNASHH4771 pKa = 7.39TYY4773 pKa = 11.07ADD4775 pKa = 4.29DD4776 pKa = 3.86GNYY4779 pKa = 10.69GITLSVTDD4787 pKa = 3.83EE4788 pKa = 4.85DD4789 pKa = 4.81GSFVAGSKK4797 pKa = 10.36SVTVANVAPVLALSGADD4814 pKa = 4.71DD4815 pKa = 3.65IDD4817 pKa = 3.94EE4818 pKa = 4.76GGSYY4822 pKa = 10.88LLAIAATDD4830 pKa = 3.63PAGAADD4836 pKa = 4.12PLSYY4840 pKa = 10.59TIDD4843 pKa = 3.48WGDD4846 pKa = 3.3GSAVQTLTAAEE4857 pKa = 4.0LAALGGNVAHH4867 pKa = 6.67VFADD4871 pKa = 4.4DD4872 pKa = 3.5EE4873 pKa = 4.91DD4874 pKa = 6.12GPVNATARR4882 pKa = 11.84TITVTASDD4890 pKa = 3.83GDD4892 pKa = 3.87GGVAQQSRR4900 pKa = 11.84SVTVHH4905 pKa = 5.73NVAPTLALSGAAGQVQGTAYY4925 pKa = 10.64ALTLGAVSDD4934 pKa = 4.47PGLDD4938 pKa = 2.99TVTAYY4943 pKa = 10.69VVDD4946 pKa = 3.85WGDD4949 pKa = 3.32GTVGVFDD4956 pKa = 3.79SAGEE4960 pKa = 4.22VTHH4963 pKa = 7.05TYY4965 pKa = 10.95AGTGDD4970 pKa = 3.63YY4971 pKa = 9.62TISVSLADD4979 pKa = 4.24EE4980 pKa = 5.44DD4981 pKa = 4.14GTHH4984 pKa = 6.79AGVATRR4990 pKa = 11.84TVSITAPTATLSFEE5004 pKa = 4.53AGADD5008 pKa = 3.49AAIDD5012 pKa = 3.48EE5013 pKa = 5.21GEE5015 pKa = 4.21TFTRR5019 pKa = 11.84SIVFSDD5025 pKa = 4.41GEE5027 pKa = 4.48DD5028 pKa = 3.1NGAAGWSYY5036 pKa = 11.3SIDD5039 pKa = 3.7YY5040 pKa = 11.26GDD5042 pKa = 3.72GTVVTGTTPVRR5053 pKa = 11.84SIEE5056 pKa = 4.01LSHH5059 pKa = 7.19RR5060 pKa = 11.84YY5061 pKa = 9.71ADD5063 pKa = 3.72GDD5065 pKa = 3.5ATRR5068 pKa = 11.84TVTVTLTDD5076 pKa = 3.43EE5077 pKa = 4.77AGEE5080 pKa = 4.36SVSDD5084 pKa = 3.82SFDD5087 pKa = 3.24VTVANVAPTVALSGAGSVDD5106 pKa = 3.19EE5107 pKa = 4.47GSAYY5111 pKa = 10.62VLSFGALVDD5120 pKa = 4.6PGADD5124 pKa = 2.79TATAYY5129 pKa = 9.64TLDD5132 pKa = 3.71WGDD5135 pKa = 3.44GTVQSFTAAEE5145 pKa = 4.23FAALGGNASHH5155 pKa = 7.19VYY5157 pKa = 10.81ADD5159 pKa = 4.24DD5160 pKa = 3.88GSYY5163 pKa = 11.24GITLGVTDD5171 pKa = 4.51EE5172 pKa = 5.21DD5173 pKa = 4.63GSFIAGSKK5181 pKa = 8.55TVTVANVAPVLALSGADD5198 pKa = 4.71DD5199 pKa = 3.65IDD5201 pKa = 3.95EE5202 pKa = 4.72GGSYY5206 pKa = 10.75VLAIAATDD5214 pKa = 3.64PAGAADD5220 pKa = 4.12PLSYY5224 pKa = 10.59TIDD5227 pKa = 3.48WGDD5230 pKa = 3.3GSAVQTLTAAEE5241 pKa = 4.0LAALGGNVAHH5251 pKa = 6.67VFADD5255 pKa = 4.4DD5256 pKa = 3.5EE5257 pKa = 4.91DD5258 pKa = 6.12GPVNATARR5266 pKa = 11.84SIVVTVSDD5274 pKa = 4.28GDD5276 pKa = 4.04GGSHH5280 pKa = 6.43SLAKK5284 pKa = 10.37AVTVHH5289 pKa = 6.08NVAPTVALGGAGSVDD5304 pKa = 3.31EE5305 pKa = 4.55GSAYY5309 pKa = 10.69VLNFGALVDD5318 pKa = 4.64PGADD5322 pKa = 2.71TVTAYY5327 pKa = 9.82TLDD5330 pKa = 3.59WGDD5333 pKa = 3.44GTVQSFTATEE5343 pKa = 4.53FAALGGNASHH5353 pKa = 7.39TYY5355 pKa = 11.07ADD5357 pKa = 4.29DD5358 pKa = 3.86GNYY5361 pKa = 10.69GITLSVTDD5369 pKa = 3.83EE5370 pKa = 4.85DD5371 pKa = 4.81GSFVAGSKK5379 pKa = 10.34SVTVEE5384 pKa = 4.09GNVLPPEE5391 pKa = 4.09TVRR5394 pKa = 11.84IGEE5397 pKa = 4.08APTRR5401 pKa = 11.84VTSGNPNAIADD5412 pKa = 3.54AWLGDD5417 pKa = 3.68KK5418 pKa = 10.86VSAIVHH5424 pKa = 6.17KK5425 pKa = 10.94ADD5427 pKa = 3.35ATDD5430 pKa = 4.72AGEE5433 pKa = 3.98AWSAVNFSGTNATTLAGVDD5452 pKa = 4.32HH5453 pKa = 6.68YY5454 pKa = 11.7SGDD5457 pKa = 3.93LGVSGQSAATSSVRR5471 pKa = 11.84QEE5473 pKa = 3.26IDD5475 pKa = 2.77GRR5477 pKa = 11.84EE5478 pKa = 3.92VLRR5481 pKa = 11.84IEE5483 pKa = 4.87LGQAASKK5490 pKa = 9.14VTVDD5494 pKa = 4.38LSRR5497 pKa = 11.84FYY5499 pKa = 11.49LNDD5502 pKa = 4.42DD5503 pKa = 3.76GTLHH5507 pKa = 6.83AEE5509 pKa = 4.18SGRR5512 pKa = 11.84LRR5514 pKa = 11.84LLDD5517 pKa = 3.59ASGNVVDD5524 pKa = 4.77EE5525 pKa = 4.51ATFVADD5531 pKa = 3.43STTGGKK5537 pKa = 7.55TVSLDD5542 pKa = 3.25STADD5546 pKa = 3.55FTAVEE5551 pKa = 4.61ISAGAYY5557 pKa = 10.13DD5558 pKa = 3.51GTDD5561 pKa = 3.68FVFGAYY5567 pKa = 9.81AGAGGGFATGVYY5579 pKa = 10.49ADD5581 pKa = 3.71GAGLHH5586 pKa = 6.57GSDD5589 pKa = 5.3FLVNWVEE5596 pKa = 5.45FEE5598 pKa = 4.02FQPVGTLQPNPLDD5611 pKa = 3.64LL5612 pKa = 5.66

Molecular weight:
570.36 kDa
Isoelectric point according different methods:






Protein with the highest isoelectric point:
>tr|A0A290ZSI5|A0A290ZSI5_9RHOO LysR family transcriptional regulator OS=Thauera sp. K11 OX=2005884 GN=CCZ27_20345 PE=3 SV=1
MM1 pKa = 7.35KK2 pKa = 9.36RR3 pKa = 11.84TYY5 pKa = 9.97QPSVVRR11 pKa = 11.84RR12 pKa = 11.84KK13 pKa = 8.6RR14 pKa = 11.84THH16 pKa = 5.75GFLVRR21 pKa = 11.84MKK23 pKa = 9.7TRR25 pKa = 11.84GGRR28 pKa = 11.84AVIRR32 pKa = 11.84ARR34 pKa = 11.84RR35 pKa = 11.84AKK37 pKa = 9.91GRR39 pKa = 11.84HH40 pKa = 4.92RR41 pKa = 11.84LAVV44 pKa = 3.37

Molecular weight:
5.22 kDa
Isoelectric point according different methods:






Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

4391

0

4391

1522155

24

7685

346.7

37.59

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

13.209 ± 0.058

0.932 ± 0.013

5.636 ± 0.027

5.691 ± 0.039

3.492 ± 0.022

8.869 ± 0.053

2.244 ± 0.02

4.374 ± 0.031

2.743 ± 0.031

10.727 ± 0.046

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.194 ± 0.021

2.475 ± 0.027

5.213 ± 0.035

3.338 ± 0.023

7.83 ± 0.045

4.968 ± 0.031

4.902 ± 0.047

7.476 ± 0.037

1.408 ± 0.015

2.279 ± 0.018

Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski