Amino acid dipepetide frequency for Thauera sp. K11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.036AlaAla: 20.036 ± 0.192
1.36AlaCys: 1.36 ± 0.038
7.492AlaAsp: 7.492 ± 0.09
7.639AlaGlu: 7.639 ± 0.095
4.067AlaPhe: 4.067 ± 0.052
13.079AlaGly: 13.079 ± 0.162
2.679AlaHis: 2.679 ± 0.046
5.269AlaIle: 5.269 ± 0.077
2.955AlaLys: 2.955 ± 0.054
14.803AlaLeu: 14.803 ± 0.128
3.09AlaMet: 3.09 ± 0.052
2.808AlaAsn: 2.808 ± 0.06
6.06AlaPro: 6.06 ± 0.1
4.574AlaGln: 4.574 ± 0.092
10.532AlaArg: 10.532 ± 0.101
6.163AlaSer: 6.163 ± 0.08
5.767AlaThr: 5.767 ± 0.095
9.143AlaVal: 9.143 ± 0.086
1.96AlaTrp: 1.96 ± 0.035
2.616AlaTyr: 2.616 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.188CysAla: 1.188 ± 0.03
0.15CysCys: 0.15 ± 0.01
0.525CysAsp: 0.525 ± 0.021
0.548CysGlu: 0.548 ± 0.022
0.318CysPhe: 0.318 ± 0.016
1.008CysGly: 1.008 ± 0.03
0.286CysHis: 0.286 ± 0.016
0.409CysIle: 0.409 ± 0.017
0.204CysLys: 0.204 ± 0.011
0.826CysLeu: 0.826 ± 0.023
0.198CysMet: 0.198 ± 0.013
0.218CysAsn: 0.218 ± 0.011
0.53CysPro: 0.53 ± 0.022
0.235CysGln: 0.235 ± 0.013
0.719CysArg: 0.719 ± 0.023
0.486CysSer: 0.486 ± 0.02
0.459CysThr: 0.459 ± 0.019
0.652CysVal: 0.652 ± 0.021
0.145CysTrp: 0.145 ± 0.011
0.215CysTyr: 0.215 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.74AspAla: 7.74 ± 0.086
0.483AspCys: 0.483 ± 0.02
3.259AspAsp: 3.259 ± 0.047
3.703AspGlu: 3.703 ± 0.055
2.187AspPhe: 2.187 ± 0.037
5.651AspGly: 5.651 ± 0.108
1.177AspHis: 1.177 ± 0.027
2.56AspIle: 2.56 ± 0.041
1.491AspLys: 1.491 ± 0.034
5.551AspLeu: 5.551 ± 0.073
1.162AspMet: 1.162 ± 0.032
1.261AspAsn: 1.261 ± 0.049
3.168AspPro: 3.168 ± 0.058
1.307AspGln: 1.307 ± 0.033
3.927AspArg: 3.927 ± 0.053
2.19AspSer: 2.19 ± 0.039
2.698AspThr: 2.698 ± 0.052
4.267AspVal: 4.267 ± 0.059
1.03AspTrp: 1.03 ± 0.029
1.55AspTyr: 1.55 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.911GluAla: 7.911 ± 0.103
0.421GluCys: 0.421 ± 0.02
2.583GluAsp: 2.583 ± 0.047
2.81GluGlu: 2.81 ± 0.054
1.852GluPhe: 1.852 ± 0.036
4.241GluGly: 4.241 ± 0.059
1.466GluHis: 1.466 ± 0.032
2.997GluIle: 2.997 ± 0.049
1.794GluLys: 1.794 ± 0.043
6.232GluLeu: 6.232 ± 0.097
1.229GluMet: 1.229 ± 0.029
1.352GluAsn: 1.352 ± 0.03
2.734GluPro: 2.734 ± 0.052
2.367GluGln: 2.367 ± 0.057
5.508GluArg: 5.508 ± 0.079
2.58GluSer: 2.58 ± 0.045
2.804GluThr: 2.804 ± 0.045
4.107GluVal: 4.107 ± 0.055
0.749GluTrp: 0.749 ± 0.024
1.169GluTyr: 1.169 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.415PheAla: 4.415 ± 0.061
0.391PheCys: 0.391 ± 0.016
2.656PheAsp: 2.656 ± 0.046
2.17PheGlu: 2.17 ± 0.037
1.325PhePhe: 1.325 ± 0.033
3.515PheGly: 3.515 ± 0.053
0.811PheHis: 0.811 ± 0.021
1.442PheIle: 1.442 ± 0.034
0.849PheLys: 0.849 ± 0.022
3.077PheLeu: 3.077 ± 0.054
0.713PheMet: 0.713 ± 0.024
0.995PheAsn: 0.995 ± 0.027
1.476PhePro: 1.476 ± 0.036
0.942PheGln: 0.942 ± 0.025
2.383PheArg: 2.383 ± 0.045
1.935PheSer: 1.935 ± 0.04
1.658PheThr: 1.658 ± 0.035
2.879PheVal: 2.879 ± 0.05
0.445PheTrp: 0.445 ± 0.019
0.847PheTyr: 0.847 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.835GlyAla: 9.835 ± 0.137
0.972GlyCys: 0.972 ± 0.028
4.745GlyAsp: 4.745 ± 0.091
5.492GlyGlu: 5.492 ± 0.066
3.363GlyPhe: 3.363 ± 0.045
8.111GlyGly: 8.111 ± 0.135
1.929GlyHis: 1.929 ± 0.037
4.126GlyIle: 4.126 ± 0.061
3.008GlyLys: 3.008 ± 0.051
9.159GlyLeu: 9.159 ± 0.09
2.248GlyMet: 2.248 ± 0.041
2.494GlyAsn: 2.494 ± 0.084
3.012GlyPro: 3.012 ± 0.049
2.891GlyGln: 2.891 ± 0.054
7.294GlyArg: 7.294 ± 0.086
4.71GlySer: 4.71 ± 0.096
4.889GlyThr: 4.889 ± 0.14
6.615GlyVal: 6.615 ± 0.075
1.468GlyTrp: 1.468 ± 0.034
2.326GlyTyr: 2.326 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.935HisAla: 2.935 ± 0.048
0.233HisCys: 0.233 ± 0.013
1.304HisAsp: 1.304 ± 0.034
1.19HisGlu: 1.19 ± 0.032
0.889HisPhe: 0.889 ± 0.024
2.185HisGly: 2.185 ± 0.039
0.683HisHis: 0.683 ± 0.026
0.872HisIle: 0.872 ± 0.026
0.514HisLys: 0.514 ± 0.018
2.461HisLeu: 2.461 ± 0.05
0.42HisMet: 0.42 ± 0.018
0.467HisAsn: 0.467 ± 0.021
1.512HisPro: 1.512 ± 0.034
0.628HisGln: 0.628 ± 0.022
1.748HisArg: 1.748 ± 0.033
0.883HisSer: 0.883 ± 0.024
0.98HisThr: 0.98 ± 0.025
1.565HisVal: 1.565 ± 0.03
0.354HisTrp: 0.354 ± 0.015
0.62HisTyr: 0.62 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.085IleAla: 6.085 ± 0.077
0.399IleCys: 0.399 ± 0.015
3.303IleAsp: 3.303 ± 0.046
3.314IleGlu: 3.314 ± 0.056
1.286IlePhe: 1.286 ± 0.031
4.516IleGly: 4.516 ± 0.061
0.917IleHis: 0.917 ± 0.025
1.504IleIle: 1.504 ± 0.04
1.195IleLys: 1.195 ± 0.03
3.538IleLeu: 3.538 ± 0.053
0.665IleMet: 0.665 ± 0.025
1.328IleAsn: 1.328 ± 0.032
2.094IlePro: 2.094 ± 0.035
1.14IleGln: 1.14 ± 0.03
3.119IleArg: 3.119 ± 0.052
2.132IleSer: 2.132 ± 0.043
2.199IleThr: 2.199 ± 0.039
3.582IleVal: 3.582 ± 0.06
0.443IleTrp: 0.443 ± 0.017
0.982IleTyr: 0.982 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.379LysAla: 3.379 ± 0.057
0.158LysCys: 0.158 ± 0.01
1.428LysAsp: 1.428 ± 0.036
1.385LysGlu: 1.385 ± 0.035
0.739LysPhe: 0.739 ± 0.025
2.171LysGly: 2.171 ± 0.04
0.56LysHis: 0.56 ± 0.019
1.273LysIle: 1.273 ± 0.033
1.059LysLys: 1.059 ± 0.031
2.983LysLeu: 2.983 ± 0.053
0.62LysMet: 0.62 ± 0.023
0.788LysAsn: 0.788 ± 0.024
1.666LysPro: 1.666 ± 0.041
0.972LysGln: 0.972 ± 0.03
1.998LysArg: 1.998 ± 0.043
1.467LysSer: 1.467 ± 0.036
1.591LysThr: 1.591 ± 0.033
2.219LysVal: 2.219 ± 0.047
0.348LysTrp: 0.348 ± 0.018
0.624LysTyr: 0.624 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.932LeuAla: 15.932 ± 0.161
0.988LeuCys: 0.988 ± 0.032
6.47LeuAsp: 6.47 ± 0.088
5.712LeuGlu: 5.712 ± 0.069
3.533LeuPhe: 3.533 ± 0.056
8.885LeuGly: 8.885 ± 0.092
2.312LeuHis: 2.312 ± 0.042
4.379LeuIle: 4.379 ± 0.055
3.157LeuLys: 3.157 ± 0.051
11.103LeuLeu: 11.103 ± 0.144
2.196LeuMet: 2.196 ± 0.041
2.503LeuAsn: 2.503 ± 0.048
6.334LeuPro: 6.334 ± 0.086
3.6LeuGln: 3.6 ± 0.056
8.282LeuArg: 8.282 ± 0.083
5.765LeuSer: 5.765 ± 0.082
5.261LeuThr: 5.261 ± 0.084
7.517LeuVal: 7.517 ± 0.08
1.199LeuTrp: 1.199 ± 0.028
2.145LeuTyr: 2.145 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.624MetAla: 2.624 ± 0.047
0.159MetCys: 0.159 ± 0.01
1.087MetAsp: 1.087 ± 0.029
1.05MetGlu: 1.05 ± 0.028
0.63MetPhe: 0.63 ± 0.019
1.535MetGly: 1.535 ± 0.037
0.468MetHis: 0.468 ± 0.019
0.96MetIle: 0.96 ± 0.027
0.916MetLys: 0.916 ± 0.027
2.513MetLeu: 2.513 ± 0.052
0.54MetMet: 0.54 ± 0.018
0.746MetAsn: 0.746 ± 0.02
1.367MetPro: 1.367 ± 0.036
0.892MetGln: 0.892 ± 0.026
1.711MetArg: 1.711 ± 0.034
1.508MetSer: 1.508 ± 0.033
1.214MetThr: 1.214 ± 0.03
1.469MetVal: 1.469 ± 0.036
0.191MetTrp: 0.191 ± 0.012
0.354MetTyr: 0.354 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.025AsnAla: 3.025 ± 0.065
0.263AsnCys: 0.263 ± 0.011
1.33AsnAsp: 1.33 ± 0.038
1.165AsnGlu: 1.165 ± 0.037
0.92AsnPhe: 0.92 ± 0.027
2.297AsnGly: 2.297 ± 0.064
0.494AsnHis: 0.494 ± 0.019
1.117AsnIle: 1.117 ± 0.029
0.629AsnLys: 0.629 ± 0.02
2.667AsnLeu: 2.667 ± 0.051
0.503AsnMet: 0.503 ± 0.021
0.644AsnAsn: 0.644 ± 0.028
1.72AsnPro: 1.72 ± 0.032
0.801AsnGln: 0.801 ± 0.025
1.882AsnArg: 1.882 ± 0.051
1.017AsnSer: 1.017 ± 0.031
1.338AsnThr: 1.338 ± 0.047
1.845AsnVal: 1.845 ± 0.039
0.433AsnTrp: 0.433 ± 0.019
0.659AsnTyr: 0.659 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.765ProAla: 7.765 ± 0.099
0.39ProCys: 0.39 ± 0.017
3.334ProAsp: 3.334 ± 0.049
3.479ProGlu: 3.479 ± 0.06
1.774ProPhe: 1.774 ± 0.038
4.909ProGly: 4.909 ± 0.068
1.085ProHis: 1.085 ± 0.026
1.821ProIle: 1.821 ± 0.042
1.192ProLys: 1.192 ± 0.028
5.25ProLeu: 5.25 ± 0.076
1.081ProMet: 1.081 ± 0.028
1.162ProAsn: 1.162 ± 0.029
2.981ProPro: 2.981 ± 0.062
1.852ProGln: 1.852 ± 0.04
3.354ProArg: 3.354 ± 0.059
2.482ProSer: 2.482 ± 0.045
2.162ProThr: 2.162 ± 0.041
4.203ProVal: 4.203 ± 0.058
0.733ProTrp: 0.733 ± 0.021
1.123ProTyr: 1.123 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.713GlnAla: 4.713 ± 0.076
0.25GlnCys: 0.25 ± 0.014
1.489GlnAsp: 1.489 ± 0.042
1.573GlnGlu: 1.573 ± 0.036
1.119GlnPhe: 1.119 ± 0.034
2.564GlnGly: 2.564 ± 0.047
0.762GlnHis: 0.762 ± 0.022
1.614GlnIle: 1.614 ± 0.045
0.924GlnLys: 0.924 ± 0.027
3.24GlnLeu: 3.24 ± 0.056
0.77GlnMet: 0.77 ± 0.022
0.725GlnAsn: 0.725 ± 0.022
1.981GlnPro: 1.981 ± 0.042
1.493GlnGln: 1.493 ± 0.042
3.039GlnArg: 3.039 ± 0.06
1.573GlnSer: 1.573 ± 0.036
1.616GlnThr: 1.616 ± 0.037
2.627GlnVal: 2.627 ± 0.053
0.518GlnTrp: 0.518 ± 0.02
0.788GlnTyr: 0.788 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
8.741ArgAla: 8.741 ± 0.092
0.688ArgCys: 0.688 ± 0.022
4.18ArgAsp: 4.18 ± 0.063
4.799ArgGlu: 4.799 ± 0.073
3.222ArgPhe: 3.222 ± 0.048
5.325ArgGly: 5.325 ± 0.066
2.257ArgHis: 2.257 ± 0.045
4.19ArgIle: 4.19 ± 0.06
2.082ArgLys: 2.082 ± 0.045
9.584ArgLeu: 9.584 ± 0.124
1.991ArgMet: 1.991 ± 0.037
2.026ArgAsn: 2.026 ± 0.041
3.906ArgPro: 3.906 ± 0.056
2.854ArgGln: 2.854 ± 0.048
6.6ArgArg: 6.6 ± 0.091
3.705ArgSer: 3.705 ± 0.055
3.519ArgThr: 3.519 ± 0.055
5.378ArgVal: 5.378 ± 0.066
1.162ArgTrp: 1.162 ± 0.032
2.094ArgTyr: 2.094 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.208SerAla: 6.208 ± 0.097
0.447SerCys: 0.447 ± 0.019
2.514SerAsp: 2.514 ± 0.045
2.358SerGlu: 2.358 ± 0.044
1.897SerPhe: 1.897 ± 0.039
5.406SerGly: 5.406 ± 0.106
1.087SerHis: 1.087 ± 0.025
2.279SerIle: 2.279 ± 0.041
1.2SerLys: 1.2 ± 0.035
5.443SerLeu: 5.443 ± 0.076
1.087SerMet: 1.087 ± 0.03
1.236SerAsn: 1.236 ± 0.04
2.632SerPro: 2.632 ± 0.044
1.51SerGln: 1.51 ± 0.035
3.732SerArg: 3.732 ± 0.054
2.646SerSer: 2.646 ± 0.059
2.498SerThr: 2.498 ± 0.046
3.661SerVal: 3.661 ± 0.055
0.64SerTrp: 0.64 ± 0.019
1.196SerTyr: 1.196 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.945ThrAla: 5.945 ± 0.087
0.428ThrCys: 0.428 ± 0.017
2.541ThrAsp: 2.541 ± 0.056
2.238ThrGlu: 2.238 ± 0.045
1.616ThrPhe: 1.616 ± 0.032
4.706ThrGly: 4.706 ± 0.096
1.077ThrHis: 1.077 ± 0.028
2.071ThrIle: 2.071 ± 0.045
1.004ThrLys: 1.004 ± 0.029
6.21ThrLeu: 6.21 ± 0.109
0.946ThrMet: 0.946 ± 0.026
1.155ThrAsn: 1.155 ± 0.037
3.108ThrPro: 3.108 ± 0.048
1.466ThrGln: 1.466 ± 0.031
3.504ThrArg: 3.504 ± 0.06
2.395ThrSer: 2.395 ± 0.055
2.601ThrThr: 2.601 ± 0.069
4.136ThrVal: 4.136 ± 0.078
0.693ThrTrp: 0.693 ± 0.028
1.181ThrTyr: 1.181 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
9.671ValAla: 9.671 ± 0.094
0.717ValCys: 0.717 ± 0.021
4.115ValAsp: 4.115 ± 0.054
4.471ValGlu: 4.471 ± 0.06
2.788ValPhe: 2.788 ± 0.042
5.65ValGly: 5.65 ± 0.057
1.487ValHis: 1.487 ± 0.033
3.482ValIle: 3.482 ± 0.055
2.201ValLys: 2.201 ± 0.048
8.113ValLeu: 8.113 ± 0.095
1.706ValMet: 1.706 ± 0.038
1.804ValAsn: 1.804 ± 0.039
4.007ValPro: 4.007 ± 0.061
2.356ValGln: 2.356 ± 0.043
5.616ValArg: 5.616 ± 0.074
4.164ValSer: 4.164 ± 0.056
3.89ValThr: 3.89 ± 0.069
6.216ValVal: 6.216 ± 0.075
0.952ValTrp: 0.952 ± 0.027
1.353ValTyr: 1.353 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.292TrpAla: 1.292 ± 0.032
0.169TrpCys: 0.169 ± 0.01
0.609TrpAsp: 0.609 ± 0.022
0.646TrpGlu: 0.646 ± 0.022
0.53TrpPhe: 0.53 ± 0.021
0.866TrpGly: 0.866 ± 0.03
0.374TrpHis: 0.374 ± 0.015
0.637TrpIle: 0.637 ± 0.02
0.468TrpLys: 0.468 ± 0.019
1.995TrpLeu: 1.995 ± 0.041
0.373TrpMet: 0.373 ± 0.017
0.455TrpAsn: 0.455 ± 0.02
0.675TrpPro: 0.675 ± 0.025
0.733TrpGln: 0.733 ± 0.022
1.286TrpArg: 1.286 ± 0.031
0.774TrpSer: 0.774 ± 0.028
0.683TrpThr: 0.683 ± 0.026
0.959TrpVal: 0.959 ± 0.024
0.239TrpTrp: 0.239 ± 0.013
0.313TrpTyr: 0.313 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.652TyrAla: 2.652 ± 0.047
0.251TyrCys: 0.251 ± 0.012
1.397TyrAsp: 1.397 ± 0.056
1.165TyrGlu: 1.165 ± 0.024
0.869TyrPhe: 0.869 ± 0.022
2.066TyrGly: 2.066 ± 0.041
0.531TyrHis: 0.531 ± 0.018
0.738TyrIle: 0.738 ± 0.024
0.583TyrLys: 0.583 ± 0.022
2.524TyrLeu: 2.524 ± 0.041
0.397TyrMet: 0.397 ± 0.019
0.583TyrAsn: 0.583 ± 0.022
1.173TyrPro: 1.173 ± 0.031
0.765TyrGln: 0.765 ± 0.027
2.07TyrArg: 2.07 ± 0.038
1.1TyrSer: 1.1 ± 0.031
1.195TyrThr: 1.195 ± 0.042
1.72TyrVal: 1.72 ± 0.043
0.374TyrTrp: 0.374 ± 0.015
0.64TyrTyr: 0.64 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4391 proteins (1522155 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski