Amino acid dipepetide frequency for Candidatus Jettenia caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.546AlaAla: 4.546 ± 0.078
0.883AlaCys: 0.883 ± 0.03
3.273AlaAsp: 3.273 ± 0.06
4.335AlaGlu: 4.335 ± 0.067
2.979AlaPhe: 2.979 ± 0.056
4.803AlaGly: 4.803 ± 0.083
1.469AlaHis: 1.469 ± 0.035
5.748AlaIle: 5.748 ± 0.083
4.156AlaLys: 4.156 ± 0.073
6.433AlaLeu: 6.433 ± 0.077
1.71AlaMet: 1.71 ± 0.039
2.473AlaAsn: 2.473 ± 0.049
1.964AlaPro: 1.964 ± 0.039
2.159AlaGln: 2.159 ± 0.045
3.16AlaArg: 3.16 ± 0.062
3.94AlaSer: 3.94 ± 0.069
3.161AlaThr: 3.161 ± 0.062
4.389AlaVal: 4.389 ± 0.073
0.674AlaTrp: 0.674 ± 0.025
2.279AlaTyr: 2.279 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.805CysAla: 0.805 ± 0.029
0.2CysCys: 0.2 ± 0.013
0.637CysAsp: 0.637 ± 0.027
0.684CysGlu: 0.684 ± 0.026
0.633CysPhe: 0.633 ± 0.024
1.095CysGly: 1.095 ± 0.033
0.558CysHis: 0.558 ± 0.046
1.105CysIle: 1.105 ± 0.033
0.83CysLys: 0.83 ± 0.03
1.132CysLeu: 1.132 ± 0.031
0.334CysMet: 0.334 ± 0.02
0.635CysAsn: 0.635 ± 0.029
0.661CysPro: 0.661 ± 0.029
0.346CysGln: 0.346 ± 0.018
0.593CysArg: 0.593 ± 0.025
0.772CysSer: 0.772 ± 0.024
0.626CysThr: 0.626 ± 0.025
0.762CysVal: 0.762 ± 0.027
0.122CysTrp: 0.122 ± 0.009
0.464CysTyr: 0.464 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.534AspAla: 3.534 ± 0.072
0.632AspCys: 0.632 ± 0.026
2.549AspAsp: 2.549 ± 0.077
3.669AspGlu: 3.669 ± 0.058
2.464AspPhe: 2.464 ± 0.052
3.544AspGly: 3.544 ± 0.094
0.974AspHis: 0.974 ± 0.033
5.213AspIle: 5.213 ± 0.069
3.739AspLys: 3.739 ± 0.056
4.613AspLeu: 4.613 ± 0.066
1.291AspMet: 1.291 ± 0.038
2.17AspAsn: 2.17 ± 0.045
2.099AspPro: 2.099 ± 0.048
1.334AspGln: 1.334 ± 0.041
2.394AspArg: 2.394 ± 0.051
2.663AspSer: 2.663 ± 0.046
3.238AspThr: 3.238 ± 0.066
3.533AspVal: 3.533 ± 0.053
0.619AspTrp: 0.619 ± 0.021
2.129AspTyr: 2.129 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.442GluAla: 4.442 ± 0.076
0.656GluCys: 0.656 ± 0.025
3.358GluAsp: 3.358 ± 0.06
5.561GluGlu: 5.561 ± 0.113
2.663GluPhe: 2.663 ± 0.055
4.23GluGly: 4.23 ± 0.068
1.415GluHis: 1.415 ± 0.036
6.452GluIle: 6.452 ± 0.094
6.587GluLys: 6.587 ± 0.092
6.012GluLeu: 6.012 ± 0.086
1.744GluMet: 1.744 ± 0.037
3.306GluAsn: 3.306 ± 0.065
1.795GluPro: 1.795 ± 0.046
2.201GluGln: 2.201 ± 0.054
3.717GluArg: 3.717 ± 0.055
3.568GluSer: 3.568 ± 0.059
3.235GluThr: 3.235 ± 0.053
4.323GluVal: 4.323 ± 0.067
0.707GluTrp: 0.707 ± 0.026
2.269GluTyr: 2.269 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
2.594PheAla: 2.594 ± 0.058
0.703PheCys: 0.703 ± 0.027
2.519PheAsp: 2.519 ± 0.047
2.606PheGlu: 2.606 ± 0.047
2.366PhePhe: 2.366 ± 0.052
3.122PheGly: 3.122 ± 0.058
1.152PheHis: 1.152 ± 0.031
3.728PheIle: 3.728 ± 0.081
2.575PheLys: 2.575 ± 0.058
4.628PheLeu: 4.628 ± 0.082
1.028PheMet: 1.028 ± 0.03
1.877PheAsn: 1.877 ± 0.043
1.795PhePro: 1.795 ± 0.043
1.333PheGln: 1.333 ± 0.037
1.978PheArg: 1.978 ± 0.049
3.299PheSer: 3.299 ± 0.063
2.565PheThr: 2.565 ± 0.05
2.729PheVal: 2.729 ± 0.05
0.522PheTrp: 0.522 ± 0.024
1.729PheTyr: 1.729 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.29GlyAla: 4.29 ± 0.064
0.983GlyCys: 0.983 ± 0.03
3.292GlyAsp: 3.292 ± 0.062
4.109GlyGlu: 4.109 ± 0.064
3.179GlyPhe: 3.179 ± 0.071
4.47GlyGly: 4.47 ± 0.079
1.391GlyHis: 1.391 ± 0.037
6.717GlyIle: 6.717 ± 0.088
5.522GlyLys: 5.522 ± 0.08
5.864GlyLeu: 5.864 ± 0.077
1.92GlyMet: 1.92 ± 0.046
3.215GlyAsn: 3.215 ± 0.06
1.733GlyPro: 1.733 ± 0.044
1.909GlyGln: 1.909 ± 0.037
3.147GlyArg: 3.147 ± 0.059
3.981GlySer: 3.981 ± 0.075
3.99GlyThr: 3.99 ± 0.12
4.436GlyVal: 4.436 ± 0.078
0.782GlyTrp: 0.782 ± 0.034
2.722GlyTyr: 2.722 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.476HisAla: 1.476 ± 0.036
0.346HisCys: 0.346 ± 0.019
1.164HisAsp: 1.164 ± 0.032
1.461HisGlu: 1.461 ± 0.04
0.982HisPhe: 0.982 ± 0.035
1.665HisGly: 1.665 ± 0.045
0.605HisHis: 0.605 ± 0.027
2.021HisIle: 2.021 ± 0.046
1.346HisLys: 1.346 ± 0.035
2.02HisLeu: 2.02 ± 0.047
0.479HisMet: 0.479 ± 0.021
0.968HisAsn: 0.968 ± 0.033
1.148HisPro: 1.148 ± 0.036
0.664HisGln: 0.664 ± 0.022
1.055HisArg: 1.055 ± 0.029
1.199HisSer: 1.199 ± 0.031
1.335HisThr: 1.335 ± 0.041
1.309HisVal: 1.309 ± 0.038
0.27HisTrp: 0.27 ± 0.017
0.899HisTyr: 0.899 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.042IleAla: 6.042 ± 0.078
1.109IleCys: 1.109 ± 0.034
4.753IleAsp: 4.753 ± 0.081
5.666IleGlu: 5.666 ± 0.08
3.703IlePhe: 3.703 ± 0.071
5.47IleGly: 5.47 ± 0.093
2.097IleHis: 2.097 ± 0.053
6.809IleIle: 6.809 ± 0.091
5.85IleLys: 5.85 ± 0.076
8.041IleLeu: 8.041 ± 0.092
1.744IleMet: 1.744 ± 0.038
3.535IleAsn: 3.535 ± 0.051
4.231IlePro: 4.231 ± 0.056
3.039IleGln: 3.039 ± 0.041
4.02IleArg: 4.02 ± 0.061
5.751IleSer: 5.751 ± 0.08
5.094IleThr: 5.094 ± 0.087
5.473IleVal: 5.473 ± 0.076
0.709IleTrp: 0.709 ± 0.028
2.553IleTyr: 2.553 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.486LysAla: 4.486 ± 0.073
0.719LysCys: 0.719 ± 0.028
4.438LysAsp: 4.438 ± 0.077
6.583LysGlu: 6.583 ± 0.096
2.264LysPhe: 2.264 ± 0.045
4.833LysGly: 4.833 ± 0.069
1.363LysHis: 1.363 ± 0.035
6.221LysIle: 6.221 ± 0.082
6.677LysLys: 6.677 ± 0.11
5.979LysLeu: 5.979 ± 0.083
1.84LysMet: 1.84 ± 0.044
3.945LysAsn: 3.945 ± 0.064
2.592LysPro: 2.592 ± 0.054
2.491LysGln: 2.491 ± 0.049
3.925LysArg: 3.925 ± 0.066
3.955LysSer: 3.955 ± 0.065
4.007LysThr: 4.007 ± 0.067
4.461LysVal: 4.461 ± 0.062
0.591LysTrp: 0.591 ± 0.025
2.654LysTyr: 2.654 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
6.261LeuAla: 6.261 ± 0.083
1.278LeuCys: 1.278 ± 0.035
4.656LeuAsp: 4.656 ± 0.073
6.113LeuGlu: 6.113 ± 0.084
4.33LeuPhe: 4.33 ± 0.077
6.032LeuGly: 6.032 ± 0.08
2.041LeuHis: 2.041 ± 0.047
6.9LeuIle: 6.9 ± 0.079
7.209LeuLys: 7.209 ± 0.081
8.869LeuLeu: 8.869 ± 0.107
2.087LeuMet: 2.087 ± 0.046
3.988LeuAsn: 3.988 ± 0.067
4.195LeuPro: 4.195 ± 0.067
3.116LeuGln: 3.116 ± 0.063
4.812LeuArg: 4.812 ± 0.078
6.908LeuSer: 6.908 ± 0.084
4.862LeuThr: 4.862 ± 0.074
5.16LeuVal: 5.16 ± 0.072
0.987LeuTrp: 0.987 ± 0.033
3.139LeuTyr: 3.139 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.798MetAla: 1.798 ± 0.039
0.263MetCys: 0.263 ± 0.016
1.212MetAsp: 1.212 ± 0.035
1.586MetGlu: 1.586 ± 0.04
0.756MetPhe: 0.756 ± 0.031
1.713MetGly: 1.713 ± 0.032
0.479MetHis: 0.479 ± 0.02
1.815MetIle: 1.815 ± 0.042
2.055MetLys: 2.055 ± 0.046
2.064MetLeu: 2.064 ± 0.044
0.549MetMet: 0.549 ± 0.025
1.189MetAsn: 1.189 ± 0.034
1.015MetPro: 1.015 ± 0.032
0.772MetGln: 0.772 ± 0.027
1.322MetArg: 1.322 ± 0.034
1.436MetSer: 1.436 ± 0.034
1.152MetThr: 1.152 ± 0.036
1.691MetVal: 1.691 ± 0.039
0.207MetTrp: 0.207 ± 0.015
0.705MetTyr: 0.705 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.941AsnAla: 2.941 ± 0.067
0.572AsnCys: 0.572 ± 0.026
2.042AsnAsp: 2.042 ± 0.046
2.596AsnGlu: 2.596 ± 0.049
1.9AsnPhe: 1.9 ± 0.043
2.739AsnGly: 2.739 ± 0.055
0.967AsnHis: 0.967 ± 0.029
4.169AsnIle: 4.169 ± 0.068
3.169AsnLys: 3.169 ± 0.057
4.343AsnLeu: 4.343 ± 0.059
0.92AsnMet: 0.92 ± 0.028
2.286AsnAsn: 2.286 ± 0.058
2.452AsnPro: 2.452 ± 0.051
1.419AsnGln: 1.419 ± 0.048
2.168AsnArg: 2.168 ± 0.044
2.413AsnSer: 2.413 ± 0.048
2.746AsnThr: 2.746 ± 0.052
2.613AsnVal: 2.613 ± 0.052
0.5AsnTrp: 0.5 ± 0.02
1.715AsnTyr: 1.715 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.447ProAla: 2.447 ± 0.055
0.523ProCys: 0.523 ± 0.024
2.598ProAsp: 2.598 ± 0.049
3.19ProGlu: 3.19 ± 0.059
2.036ProPhe: 2.036 ± 0.045
2.795ProGly: 2.795 ± 0.058
0.966ProHis: 0.966 ± 0.028
2.843ProIle: 2.843 ± 0.059
2.439ProLys: 2.439 ± 0.047
3.621ProLeu: 3.621 ± 0.062
0.836ProMet: 0.836 ± 0.032
1.551ProAsn: 1.551 ± 0.043
1.647ProPro: 1.647 ± 0.07
1.281ProGln: 1.281 ± 0.037
1.513ProArg: 1.513 ± 0.04
2.391ProSer: 2.391 ± 0.05
1.904ProThr: 1.904 ± 0.05
3.067ProVal: 3.067 ± 0.057
0.448ProTrp: 0.448 ± 0.019
1.48ProTyr: 1.48 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.076GlnAla: 2.076 ± 0.053
0.385GlnCys: 0.385 ± 0.02
1.502GlnAsp: 1.502 ± 0.041
2.512GlnGlu: 2.512 ± 0.064
1.262GlnPhe: 1.262 ± 0.034
1.998GlnGly: 1.998 ± 0.039
0.685GlnHis: 0.685 ± 0.025
2.642GlnIle: 2.642 ± 0.047
2.863GlnLys: 2.863 ± 0.053
2.684GlnLeu: 2.684 ± 0.045
0.842GlnMet: 0.842 ± 0.031
1.501GlnAsn: 1.501 ± 0.038
1.174GlnPro: 1.174 ± 0.034
1.194GlnGln: 1.194 ± 0.039
1.76GlnArg: 1.76 ± 0.045
1.755GlnSer: 1.755 ± 0.045
1.678GlnThr: 1.678 ± 0.042
1.935GlnVal: 1.935 ± 0.039
0.401GlnTrp: 0.401 ± 0.021
1.115GlnTyr: 1.115 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.742ArgAla: 2.742 ± 0.053
0.635ArgCys: 0.635 ± 0.024
2.475ArgAsp: 2.475 ± 0.049
3.759ArgGlu: 3.759 ± 0.062
2.336ArgPhe: 2.336 ± 0.044
2.891ArgGly: 2.891 ± 0.061
1.041ArgHis: 1.041 ± 0.031
4.425ArgIle: 4.425 ± 0.065
3.828ArgLys: 3.828 ± 0.065
4.709ArgLeu: 4.709 ± 0.08
1.353ArgMet: 1.353 ± 0.034
2.288ArgAsn: 2.288 ± 0.044
1.625ArgPro: 1.625 ± 0.043
1.675ArgGln: 1.675 ± 0.039
2.509ArgArg: 2.509 ± 0.056
2.583ArgSer: 2.583 ± 0.056
2.254ArgThr: 2.254 ± 0.05
3.027ArgVal: 3.027 ± 0.053
0.592ArgTrp: 0.592 ± 0.025
1.977ArgTyr: 1.977 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.591SerAla: 3.591 ± 0.069
0.781SerCys: 0.781 ± 0.026
3.157SerAsp: 3.157 ± 0.059
3.705SerGlu: 3.705 ± 0.062
3.132SerPhe: 3.132 ± 0.071
4.607SerGly: 4.607 ± 0.094
1.419SerHis: 1.419 ± 0.034
5.072SerIle: 5.072 ± 0.079
3.985SerLys: 3.985 ± 0.055
6.315SerLeu: 6.315 ± 0.08
1.466SerMet: 1.466 ± 0.034
2.506SerAsn: 2.506 ± 0.058
2.679SerPro: 2.679 ± 0.05
1.969SerGln: 1.969 ± 0.042
2.824SerArg: 2.824 ± 0.054
3.841SerSer: 3.841 ± 0.069
3.098SerThr: 3.098 ± 0.058
3.899SerVal: 3.899 ± 0.054
0.726SerTrp: 0.726 ± 0.029
2.178SerTyr: 2.178 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.55ThrAla: 3.55 ± 0.089
0.693ThrCys: 0.693 ± 0.026
2.755ThrAsp: 2.755 ± 0.053
3.269ThrGlu: 3.269 ± 0.053
2.446ThrPhe: 2.446 ± 0.047
4.48ThrGly: 4.48 ± 0.073
1.26ThrHis: 1.26 ± 0.028
4.829ThrIle: 4.829 ± 0.074
3.235ThrLys: 3.235 ± 0.055
5.28ThrLeu: 5.28 ± 0.088
1.161ThrMet: 1.161 ± 0.032
2.15ThrAsn: 2.15 ± 0.058
2.457ThrPro: 2.457 ± 0.047
1.559ThrGln: 1.559 ± 0.034
2.274ThrArg: 2.274 ± 0.047
3.37ThrSer: 3.37 ± 0.063
3.07ThrThr: 3.07 ± 0.072
3.865ThrVal: 3.865 ± 0.089
0.628ThrTrp: 0.628 ± 0.031
1.91ThrTyr: 1.91 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.057ValAla: 4.057 ± 0.067
0.956ValCys: 0.956 ± 0.03
3.438ValAsp: 3.438 ± 0.086
3.955ValGlu: 3.955 ± 0.075
3.105ValPhe: 3.105 ± 0.055
3.916ValGly: 3.916 ± 0.063
1.297ValHis: 1.297 ± 0.04
5.419ValIle: 5.419 ± 0.078
4.673ValLys: 4.673 ± 0.067
5.765ValLeu: 5.765 ± 0.079
1.526ValMet: 1.526 ± 0.037
2.862ValAsn: 2.862 ± 0.055
2.403ValPro: 2.403 ± 0.048
1.83ValGln: 1.83 ± 0.041
2.982ValArg: 2.982 ± 0.052
4.437ValSer: 4.437 ± 0.089
3.773ValThr: 3.773 ± 0.062
4.423ValVal: 4.423 ± 0.069
0.67ValTrp: 0.67 ± 0.025
2.151ValTyr: 2.151 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.613TrpAla: 0.613 ± 0.026
0.134TrpCys: 0.134 ± 0.011
0.563TrpAsp: 0.563 ± 0.023
0.707TrpGlu: 0.707 ± 0.029
0.51TrpPhe: 0.51 ± 0.024
0.731TrpGly: 0.731 ± 0.033
0.272TrpHis: 0.272 ± 0.016
0.931TrpIle: 0.931 ± 0.031
0.799TrpLys: 0.799 ± 0.028
1.034TrpLeu: 1.034 ± 0.037
0.296TrpMet: 0.296 ± 0.015
0.563TrpAsn: 0.563 ± 0.026
0.317TrpPro: 0.317 ± 0.019
0.411TrpGln: 0.411 ± 0.019
0.568TrpArg: 0.568 ± 0.023
0.603TrpSer: 0.603 ± 0.025
0.492TrpThr: 0.492 ± 0.022
0.633TrpVal: 0.633 ± 0.028
0.161TrpTrp: 0.161 ± 0.011
0.399TrpTyr: 0.399 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.242TyrAla: 2.242 ± 0.051
0.543TyrCys: 0.543 ± 0.022
2.019TyrAsp: 2.019 ± 0.046
2.175TyrGlu: 2.175 ± 0.054
1.801TyrPhe: 1.801 ± 0.045
2.519TyrGly: 2.519 ± 0.053
0.961TyrHis: 0.961 ± 0.031
2.631TyrIle: 2.631 ± 0.06
2.491TyrLys: 2.491 ± 0.047
3.536TyrLeu: 3.536 ± 0.069
0.65TyrMet: 0.65 ± 0.025
1.66TyrAsn: 1.66 ± 0.05
1.595TyrPro: 1.595 ± 0.04
1.262TyrGln: 1.262 ± 0.037
2.004TyrArg: 2.004 ± 0.041
2.086TyrSer: 2.086 ± 0.043
1.961TyrThr: 1.961 ± 0.051
1.911TyrVal: 1.911 ± 0.044
0.42TyrTrp: 0.42 ± 0.021
1.511TyrTyr: 1.511 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3545 proteins (1108176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski