Amino acid dipepetide frequency for Human parainfluenza virus 4a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.228AlaAla: 3.228 ± 0.875
0.807AlaCys: 0.807 ± 0.541
2.623AlaAsp: 2.623 ± 0.555
3.027AlaGlu: 3.027 ± 0.672
1.816AlaPhe: 1.816 ± 0.88
2.421AlaGly: 2.421 ± 0.613
1.412AlaHis: 1.412 ± 0.819
4.439AlaIle: 4.439 ± 0.814
3.43AlaLys: 3.43 ± 0.742
5.044AlaLeu: 5.044 ± 1.511
0.807AlaMet: 0.807 ± 0.642
3.027AlaAsn: 3.027 ± 0.557
2.623AlaPro: 2.623 ± 1.06
2.623AlaGln: 2.623 ± 0.618
2.825AlaArg: 2.825 ± 0.686
4.237AlaSer: 4.237 ± 0.782
2.825AlaThr: 2.825 ± 0.641
2.421AlaVal: 2.421 ± 1.038
0.202AlaTrp: 0.202 ± 0.259
2.018AlaTyr: 2.018 ± 0.764
0.0AlaXaa: 0.0 ± 0.0
Cys
1.412CysAla: 1.412 ± 0.579
0.605CysCys: 0.605 ± 0.339
0.807CysAsp: 0.807 ± 0.345
0.605CysGlu: 0.605 ± 0.445
1.211CysPhe: 1.211 ± 0.387
0.605CysGly: 0.605 ± 0.339
0.404CysHis: 0.404 ± 0.242
2.018CysIle: 2.018 ± 0.521
1.211CysLys: 1.211 ± 0.494
2.825CysLeu: 2.825 ± 0.647
0.404CysMet: 0.404 ± 0.357
1.412CysAsn: 1.412 ± 0.43
1.211CysPro: 1.211 ± 0.581
1.211CysGln: 1.211 ± 0.452
0.605CysArg: 0.605 ± 0.271
1.412CysSer: 1.412 ± 0.34
1.009CysThr: 1.009 ± 0.324
0.807CysVal: 0.807 ± 0.392
0.202CysTrp: 0.202 ± 0.121
0.404CysTyr: 0.404 ± 0.355
0.0CysXaa: 0.0 ± 0.0
Asp
3.43AspAla: 3.43 ± 1.161
1.211AspCys: 1.211 ± 0.417
2.623AspAsp: 2.623 ± 0.993
2.22AspGlu: 2.22 ± 0.413
1.614AspPhe: 1.614 ± 0.774
2.623AspGly: 2.623 ± 0.657
1.816AspHis: 1.816 ± 0.562
4.843AspIle: 4.843 ± 0.915
1.816AspLys: 1.816 ± 0.453
7.466AspLeu: 7.466 ± 1.634
0.202AspMet: 0.202 ± 0.23
2.825AspAsn: 2.825 ± 0.647
3.834AspPro: 3.834 ± 0.777
2.623AspGln: 2.623 ± 0.689
3.228AspArg: 3.228 ± 1.14
4.439AspSer: 4.439 ± 0.406
3.228AspThr: 3.228 ± 1.087
2.018AspVal: 2.018 ± 0.486
0.404AspTrp: 0.404 ± 0.2
2.421AspTyr: 2.421 ± 0.482
0.0AspXaa: 0.0 ± 0.0
Glu
1.614GluAla: 1.614 ± 1.018
1.211GluCys: 1.211 ± 0.544
2.623GluAsp: 2.623 ± 0.423
3.43GluGlu: 3.43 ± 1.362
2.22GluPhe: 2.22 ± 0.752
2.623GluGly: 2.623 ± 0.644
0.807GluHis: 0.807 ± 0.47
5.65GluIle: 5.65 ± 0.838
2.825GluLys: 2.825 ± 0.669
4.641GluLeu: 4.641 ± 0.98
0.807GluMet: 0.807 ± 0.326
3.834GluAsn: 3.834 ± 0.412
1.412GluPro: 1.412 ± 0.582
2.421GluGln: 2.421 ± 0.631
2.421GluArg: 2.421 ± 0.541
5.044GluSer: 5.044 ± 1.038
3.027GluThr: 3.027 ± 0.498
3.228GluVal: 3.228 ± 0.741
0.404GluTrp: 0.404 ± 0.278
1.211GluTyr: 1.211 ± 0.601
0.0GluXaa: 0.0 ± 0.0
Phe
1.816PheAla: 1.816 ± 0.476
0.807PheCys: 0.807 ± 0.374
1.009PheAsp: 1.009 ± 0.4
2.421PheGlu: 2.421 ± 0.738
2.018PhePhe: 2.018 ± 0.541
2.018PheGly: 2.018 ± 0.583
0.807PheHis: 0.807 ± 0.284
2.623PheIle: 2.623 ± 0.919
2.623PheLys: 2.623 ± 0.769
4.843PheLeu: 4.843 ± 0.668
0.605PheMet: 0.605 ± 0.282
2.22PheAsn: 2.22 ± 0.558
1.412PhePro: 1.412 ± 0.864
1.211PheGln: 1.211 ± 0.414
1.211PheArg: 1.211 ± 0.544
2.825PheSer: 2.825 ± 0.638
2.623PheThr: 2.623 ± 0.556
1.816PheVal: 1.816 ± 0.612
0.202PheTrp: 0.202 ± 0.121
1.412PheTyr: 1.412 ± 0.824
0.0PheXaa: 0.0 ± 0.0
Gly
2.623GlyAla: 2.623 ± 0.692
1.816GlyCys: 1.816 ± 0.873
4.036GlyAsp: 4.036 ± 1.071
1.009GlyGlu: 1.009 ± 0.392
1.816GlyPhe: 1.816 ± 0.56
1.816GlyGly: 1.816 ± 0.577
0.807GlyHis: 0.807 ± 0.352
3.228GlyIle: 3.228 ± 0.919
2.825GlyLys: 2.825 ± 0.618
5.65GlyLeu: 5.65 ± 1.07
0.202GlyMet: 0.202 ± 0.23
3.027GlyAsn: 3.027 ± 1.128
1.412GlyPro: 1.412 ± 1.419
1.009GlyGln: 1.009 ± 0.581
3.228GlyArg: 3.228 ± 0.831
4.237GlySer: 4.237 ± 1.08
2.421GlyThr: 2.421 ± 1.219
2.825GlyVal: 2.825 ± 0.492
1.009GlyTrp: 1.009 ± 0.421
1.009GlyTyr: 1.009 ± 0.402
0.0GlyXaa: 0.0 ± 0.0
His
2.018HisAla: 2.018 ± 0.558
0.605HisCys: 0.605 ± 0.245
0.605HisAsp: 0.605 ± 0.245
1.009HisGlu: 1.009 ± 0.445
0.0HisPhe: 0.0 ± 0.0
1.412HisGly: 1.412 ± 0.561
0.202HisHis: 0.202 ± 0.121
1.614HisIle: 1.614 ± 0.343
0.605HisLys: 0.605 ± 0.363
2.623HisLeu: 2.623 ± 0.58
0.0HisMet: 0.0 ± 0.0
2.623HisAsn: 2.623 ± 0.413
1.412HisPro: 1.412 ± 0.507
1.211HisGln: 1.211 ± 0.465
0.605HisArg: 0.605 ± 0.32
1.009HisSer: 1.009 ± 0.505
1.614HisThr: 1.614 ± 0.327
1.009HisVal: 1.009 ± 0.332
0.404HisTrp: 0.404 ± 0.2
0.404HisTyr: 0.404 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
3.632IleAla: 3.632 ± 0.696
1.412IleCys: 1.412 ± 0.43
4.237IleAsp: 4.237 ± 0.736
5.65IleGlu: 5.65 ± 1.099
3.027IlePhe: 3.027 ± 0.575
3.027IleGly: 3.027 ± 0.902
3.43IleHis: 3.43 ± 1.005
7.264IleIle: 7.264 ± 1.497
5.044IleLys: 5.044 ± 1.006
8.878IleLeu: 8.878 ± 1.772
3.43IleMet: 3.43 ± 0.565
5.448IleAsn: 5.448 ± 0.904
3.632IlePro: 3.632 ± 1.045
4.237IleGln: 4.237 ± 1.436
4.439IleArg: 4.439 ± 1.503
8.071IleSer: 8.071 ± 1.244
6.86IleThr: 6.86 ± 1.497
3.43IleVal: 3.43 ± 0.833
1.009IleTrp: 1.009 ± 0.4
2.421IleTyr: 2.421 ± 0.899
0.0IleXaa: 0.0 ± 0.0
Lys
2.421LysAla: 2.421 ± 0.565
1.211LysCys: 1.211 ± 0.376
4.036LysAsp: 4.036 ± 1.239
3.834LysGlu: 3.834 ± 0.624
2.623LysPhe: 2.623 ± 0.787
1.614LysGly: 1.614 ± 0.602
1.412LysHis: 1.412 ± 0.559
6.457LysIle: 6.457 ± 1.153
2.825LysLys: 2.825 ± 0.655
5.448LysLeu: 5.448 ± 1.448
0.807LysMet: 0.807 ± 0.392
3.834LysAsn: 3.834 ± 0.879
2.018LysPro: 2.018 ± 0.639
3.228LysGln: 3.228 ± 0.82
2.22LysArg: 2.22 ± 0.58
4.439LysSer: 4.439 ± 0.583
3.632LysThr: 3.632 ± 0.761
2.22LysVal: 2.22 ± 0.478
0.404LysTrp: 0.404 ± 0.254
2.421LysTyr: 2.421 ± 0.334
0.0LysXaa: 0.0 ± 0.0
Leu
5.246LeuAla: 5.246 ± 1.06
1.816LeuCys: 1.816 ± 0.526
6.659LeuAsp: 6.659 ± 1.12
5.851LeuGlu: 5.851 ± 1.121
2.421LeuPhe: 2.421 ± 0.453
5.448LeuGly: 5.448 ± 0.627
1.412LeuHis: 1.412 ± 0.448
9.685LeuIle: 9.685 ± 1.177
6.659LeuLys: 6.659 ± 1.041
10.291LeuLeu: 10.291 ± 1.792
3.027LeuMet: 3.027 ± 0.65
9.08LeuAsn: 9.08 ± 0.97
3.632LeuPro: 3.632 ± 0.353
4.237LeuGln: 4.237 ± 0.624
4.843LeuArg: 4.843 ± 0.896
9.887LeuSer: 9.887 ± 1.463
9.08LeuThr: 9.08 ± 1.748
4.237LeuVal: 4.237 ± 0.687
0.807LeuTrp: 0.807 ± 0.507
4.237LeuTyr: 4.237 ± 1.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.412MetAla: 1.412 ± 0.512
0.202MetCys: 0.202 ± 0.121
0.404MetAsp: 0.404 ± 0.374
1.211MetGlu: 1.211 ± 0.41
0.202MetPhe: 0.202 ± 0.121
1.211MetGly: 1.211 ± 0.419
0.202MetHis: 0.202 ± 0.23
2.421MetIle: 2.421 ± 0.528
1.614MetLys: 1.614 ± 0.429
2.018MetLeu: 2.018 ± 0.73
0.202MetMet: 0.202 ± 0.222
1.412MetAsn: 1.412 ± 0.482
0.605MetPro: 0.605 ± 0.294
0.807MetGln: 0.807 ± 0.631
1.614MetArg: 1.614 ± 0.705
1.816MetSer: 1.816 ± 0.877
1.009MetThr: 1.009 ± 0.23
1.816MetVal: 1.816 ± 0.808
0.404MetTrp: 0.404 ± 0.242
0.404MetTyr: 0.404 ± 0.242
0.0MetXaa: 0.0 ± 0.0
Asn
2.623AsnAla: 2.623 ± 0.686
0.807AsnCys: 0.807 ± 0.778
5.448AsnAsp: 5.448 ± 0.943
3.632AsnGlu: 3.632 ± 1.202
3.43AsnPhe: 3.43 ± 0.886
2.421AsnGly: 2.421 ± 0.541
2.018AsnHis: 2.018 ± 0.851
6.255AsnIle: 6.255 ± 0.649
3.834AsnLys: 3.834 ± 0.784
8.273AsnLeu: 8.273 ± 1.366
0.605AsnMet: 0.605 ± 0.408
3.027AsnAsn: 3.027 ± 0.597
4.641AsnPro: 4.641 ± 0.632
3.43AsnGln: 3.43 ± 1.155
2.22AsnArg: 2.22 ± 1.015
3.834AsnSer: 3.834 ± 0.93
2.825AsnThr: 2.825 ± 0.573
2.421AsnVal: 2.421 ± 0.819
1.412AsnTrp: 1.412 ± 0.658
3.027AsnTyr: 3.027 ± 0.396
0.0AsnXaa: 0.0 ± 0.0
Pro
2.22ProAla: 2.22 ± 0.969
0.404ProCys: 0.404 ± 0.278
2.623ProAsp: 2.623 ± 0.476
2.22ProGlu: 2.22 ± 0.714
1.614ProPhe: 1.614 ± 0.552
2.825ProGly: 2.825 ± 0.917
0.807ProHis: 0.807 ± 0.4
3.228ProIle: 3.228 ± 1.346
2.018ProLys: 2.018 ± 0.421
4.439ProLeu: 4.439 ± 0.762
0.605ProMet: 0.605 ± 0.322
3.228ProAsn: 3.228 ± 0.882
2.421ProPro: 2.421 ± 0.454
2.421ProGln: 2.421 ± 0.605
3.43ProArg: 3.43 ± 0.7
5.044ProSer: 5.044 ± 1.166
3.632ProThr: 3.632 ± 0.775
2.22ProVal: 2.22 ± 0.72
0.202ProTrp: 0.202 ± 0.121
1.816ProTyr: 1.816 ± 0.558
0.0ProXaa: 0.0 ± 0.0
Gln
2.421GlnAla: 2.421 ± 0.558
0.807GlnCys: 0.807 ± 0.33
2.421GlnAsp: 2.421 ± 1.135
2.22GlnGlu: 2.22 ± 0.419
2.825GlnPhe: 2.825 ± 0.783
2.22GlnGly: 2.22 ± 0.827
0.605GlnHis: 0.605 ± 0.245
5.448GlnIle: 5.448 ± 1.57
3.228GlnLys: 3.228 ± 0.786
3.632GlnLeu: 3.632 ± 0.622
1.614GlnMet: 1.614 ± 0.391
3.228GlnAsn: 3.228 ± 0.568
1.412GlnPro: 1.412 ± 0.821
2.22GlnGln: 2.22 ± 0.685
1.816GlnArg: 1.816 ± 0.6
3.027GlnSer: 3.027 ± 0.913
3.027GlnThr: 3.027 ± 0.558
2.825GlnVal: 2.825 ± 0.443
0.202GlnTrp: 0.202 ± 0.121
1.412GlnTyr: 1.412 ± 0.341
0.0GlnXaa: 0.0 ± 0.0
Arg
1.816ArgAla: 1.816 ± 1.218
1.009ArgCys: 1.009 ± 0.355
3.834ArgAsp: 3.834 ± 1.287
1.614ArgGlu: 1.614 ± 0.442
1.614ArgPhe: 1.614 ± 0.959
2.421ArgGly: 2.421 ± 0.764
1.009ArgHis: 1.009 ± 0.527
4.843ArgIle: 4.843 ± 0.705
3.632ArgLys: 3.632 ± 0.846
5.044ArgLeu: 5.044 ± 1.005
1.412ArgMet: 1.412 ± 0.385
3.027ArgAsn: 3.027 ± 0.824
1.816ArgPro: 1.816 ± 0.314
2.623ArgGln: 2.623 ± 0.535
3.43ArgArg: 3.43 ± 0.558
4.237ArgSer: 4.237 ± 1.251
2.22ArgThr: 2.22 ± 0.655
1.412ArgVal: 1.412 ± 0.461
0.404ArgTrp: 0.404 ± 0.203
1.412ArgTyr: 1.412 ± 0.661
0.0ArgXaa: 0.0 ± 0.0
Ser
4.439SerAla: 4.439 ± 0.793
1.816SerCys: 1.816 ± 0.855
3.43SerAsp: 3.43 ± 0.888
4.439SerGlu: 4.439 ± 0.533
1.816SerPhe: 1.816 ± 0.536
3.43SerGly: 3.43 ± 1.263
1.412SerHis: 1.412 ± 0.463
5.851SerIle: 5.851 ± 1.541
4.641SerLys: 4.641 ± 0.967
9.08SerLeu: 9.08 ± 1.401
2.825SerMet: 2.825 ± 0.601
4.843SerAsn: 4.843 ± 0.818
4.036SerPro: 4.036 ± 0.85
3.43SerGln: 3.43 ± 0.611
3.632SerArg: 3.632 ± 0.712
5.65SerSer: 5.65 ± 0.621
5.246SerThr: 5.246 ± 0.831
4.641SerVal: 4.641 ± 0.985
1.412SerTrp: 1.412 ± 0.579
2.825SerTyr: 2.825 ± 0.663
0.0SerXaa: 0.0 ± 0.0
Thr
5.044ThrAla: 5.044 ± 1.153
1.211ThrCys: 1.211 ± 0.49
2.825ThrAsp: 2.825 ± 0.514
3.228ThrGlu: 3.228 ± 0.81
1.816ThrPhe: 1.816 ± 0.618
3.027ThrGly: 3.027 ± 0.816
0.807ThrHis: 0.807 ± 0.453
6.86ThrIle: 6.86 ± 1.331
3.228ThrLys: 3.228 ± 0.982
7.869ThrLeu: 7.869 ± 0.53
2.018ThrMet: 2.018 ± 0.671
4.439ThrAsn: 4.439 ± 0.738
3.632ThrPro: 3.632 ± 0.674
3.027ThrGln: 3.027 ± 1.027
2.825ThrArg: 2.825 ± 0.605
3.43ThrSer: 3.43 ± 0.558
4.237ThrThr: 4.237 ± 1.11
1.816ThrVal: 1.816 ± 0.941
0.605ThrTrp: 0.605 ± 0.245
2.22ThrTyr: 2.22 ± 1.035
0.0ThrXaa: 0.0 ± 0.0
Val
2.018ValAla: 2.018 ± 1.131
1.614ValCys: 1.614 ± 0.437
3.228ValAsp: 3.228 ± 0.627
2.421ValGlu: 2.421 ± 1.017
2.22ValPhe: 2.22 ± 0.58
2.421ValGly: 2.421 ± 0.85
1.009ValHis: 1.009 ± 0.316
2.018ValIle: 2.018 ± 0.617
2.421ValLys: 2.421 ± 0.525
5.246ValLeu: 5.246 ± 0.839
0.807ValMet: 0.807 ± 0.302
2.623ValAsn: 2.623 ± 0.774
3.43ValPro: 3.43 ± 0.75
1.614ValGln: 1.614 ± 0.617
2.22ValArg: 2.22 ± 0.645
3.228ValSer: 3.228 ± 1.012
2.421ValThr: 2.421 ± 0.639
1.412ValVal: 1.412 ± 0.604
0.404ValTrp: 0.404 ± 0.357
1.614ValTyr: 1.614 ± 0.547
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.282
0.404TrpCys: 0.404 ± 0.348
0.202TrpAsp: 0.202 ± 0.23
0.404TrpGlu: 0.404 ± 0.242
0.202TrpPhe: 0.202 ± 0.121
0.605TrpGly: 0.605 ± 0.282
0.0TrpHis: 0.0 ± 0.0
1.211TrpIle: 1.211 ± 0.375
0.807TrpLys: 0.807 ± 0.324
0.404TrpLeu: 0.404 ± 0.201
0.202TrpMet: 0.202 ± 0.121
1.009TrpAsn: 1.009 ± 0.445
0.605TrpPro: 0.605 ± 0.245
0.404TrpGln: 0.404 ± 0.2
0.605TrpArg: 0.605 ± 0.245
1.211TrpSer: 1.211 ± 0.375
0.605TrpThr: 0.605 ± 0.363
1.009TrpVal: 1.009 ± 0.332
0.202TrpTrp: 0.202 ± 0.222
0.202TrpTyr: 0.202 ± 0.121
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.816TyrAla: 1.816 ± 0.809
0.605TyrCys: 0.605 ± 0.297
1.211TyrAsp: 1.211 ± 0.258
1.009TyrGlu: 1.009 ± 0.385
2.018TyrPhe: 2.018 ± 0.846
1.816TyrGly: 1.816 ± 0.265
0.605TyrHis: 0.605 ± 0.405
2.623TyrIle: 2.623 ± 0.786
1.816TyrLys: 1.816 ± 0.265
5.044TyrLeu: 5.044 ± 1.122
0.202TyrMet: 0.202 ± 0.222
2.018TyrAsn: 2.018 ± 0.623
2.22TyrPro: 2.22 ± 0.725
2.623TyrGln: 2.623 ± 0.533
1.412TyrArg: 1.412 ± 0.477
1.816TyrSer: 1.816 ± 0.432
2.623TyrThr: 2.623 ± 0.808
0.807TyrVal: 0.807 ± 0.33
0.605TyrTrp: 0.605 ± 0.363
2.421TyrTyr: 2.421 ± 0.482
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski