Amino acid dipepetide frequency for Halomonas aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.96AlaAla: 12.96 ± 0.152	1.268AlaCys: 1.268 ± 0.042	6.253AlaAsp: 6.253 ± 0.085	8.166AlaGlu: 8.166 ± 0.116	4.181AlaPhe: 4.181 ± 0.077	10.427AlaGly: 10.427 ± 0.127	2.418AlaHis: 2.418 ± 0.057	5.231AlaIle: 5.231 ± 0.077	2.234AlaLys: 2.234 ± 0.064	14.789AlaLeu: 14.789 ± 0.164	3.469AlaMet: 3.469 ± 0.061	2.213AlaAsn: 2.213 ± 0.063	5.31AlaPro: 5.31 ± 0.09	3.406AlaGln: 3.406 ± 0.06	9.605AlaArg: 9.605 ± 0.146	6.256AlaSer: 6.256 ± 0.071	5.451AlaThr: 5.451 ± 0.086	7.985AlaVal: 7.985 ± 0.096	2.08AlaTrp: 2.08 ± 0.051	2.266AlaTyr: 2.266 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.898CysAla: 0.898 ± 0.031	0.114CysCys: 0.114 ± 0.012	0.533CysAsp: 0.533 ± 0.023	0.51CysGlu: 0.51 ± 0.021	0.318CysPhe: 0.318 ± 0.019	0.899CysGly: 0.899 ± 0.033	0.331CysHis: 0.331 ± 0.021	0.324CysIle: 0.324 ± 0.02	0.168CysLys: 0.168 ± 0.015	1.059CysLeu: 1.059 ± 0.038	0.196CysMet: 0.196 ± 0.013	0.192CysAsn: 0.192 ± 0.012	0.526CysPro: 0.526 ± 0.026	0.312CysGln: 0.312 ± 0.017	0.855CysArg: 0.855 ± 0.031	0.408CysSer: 0.408 ± 0.02	0.38CysThr: 0.38 ± 0.021	0.573CysVal: 0.573 ± 0.025	0.129CysTrp: 0.129 ± 0.012	0.222CysTyr: 0.222 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.869AspAla: 6.869 ± 0.097	0.494AspCys: 0.494 ± 0.023	4.081AspAsp: 4.081 ± 0.084	4.432AspGlu: 4.432 ± 0.067	2.115AspPhe: 2.115 ± 0.048	5.026AspGly: 5.026 ± 0.112	1.597AspHis: 1.597 ± 0.041	2.683AspIle: 2.683 ± 0.052	1.252AspLys: 1.252 ± 0.041	6.164AspLeu: 6.164 ± 0.083	1.272AspMet: 1.272 ± 0.036	1.352AspAsn: 1.352 ± 0.039	3.494AspPro: 3.494 ± 0.07	1.948AspGln: 1.948 ± 0.042	4.298AspArg: 4.298 ± 0.074	2.521AspSer: 2.521 ± 0.081	2.982AspThr: 2.982 ± 0.08	3.812AspVal: 3.812 ± 0.07	1.112AspTrp: 1.112 ± 0.037	1.662AspTyr: 1.662 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	9.905GluAla: 9.905 ± 0.14	0.474GluCys: 0.474 ± 0.023	3.297GluAsp: 3.297 ± 0.06	4.353GluGlu: 4.353 ± 0.089	1.6GluPhe: 1.6 ± 0.042	5.722GluGly: 5.722 ± 0.081	1.749GluHis: 1.749 ± 0.042	2.921GluIle: 2.921 ± 0.062	1.663GluLys: 1.663 ± 0.058	6.844GluLeu: 6.844 ± 0.098	1.509GluMet: 1.509 ± 0.041	1.325GluAsn: 1.325 ± 0.038	2.977GluPro: 2.977 ± 0.06	2.949GluGln: 2.949 ± 0.065	6.396GluArg: 6.396 ± 0.099	2.919GluSer: 2.919 ± 0.053	3.438GluThr: 3.438 ± 0.06	5.347GluVal: 5.347 ± 0.072	0.833GluTrp: 0.833 ± 0.031	1.105GluTyr: 1.105 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.605PheAla: 3.605 ± 0.067	0.361PheCys: 0.361 ± 0.02	2.531PheAsp: 2.531 ± 0.054	2.179PheGlu: 2.179 ± 0.052	1.261PhePhe: 1.261 ± 0.045	3.218PheGly: 3.218 ± 0.064	0.851PheHis: 0.851 ± 0.029	1.518PheIle: 1.518 ± 0.044	0.747PheLys: 0.747 ± 0.03	3.374PheLeu: 3.374 ± 0.066	0.816PheMet: 0.816 ± 0.031	0.956PheAsn: 0.956 ± 0.028	1.479PhePro: 1.479 ± 0.038	1.11PheGln: 1.11 ± 0.032	2.123PheArg: 2.123 ± 0.05	2.023PheSer: 2.023 ± 0.044	1.968PheThr: 1.968 ± 0.056	2.406PheVal: 2.406 ± 0.053	0.483PheTrp: 0.483 ± 0.026	0.848PheTyr: 0.848 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.938GlyAla: 7.938 ± 0.098	0.922GlyCys: 0.922 ± 0.033	4.935GlyAsp: 4.935 ± 0.102	6.464GlyGlu: 6.464 ± 0.09	3.218GlyPhe: 3.218 ± 0.06	7.213GlyGly: 7.213 ± 0.106	2.345GlyHis: 2.345 ± 0.056	4.369GlyIle: 4.369 ± 0.08	2.444GlyLys: 2.444 ± 0.059	10.34GlyLeu: 10.34 ± 0.128	2.597GlyMet: 2.597 ± 0.065	2.034GlyAsn: 2.034 ± 0.05	3.221GlyPro: 3.221 ± 0.057	3.191GlyGln: 3.191 ± 0.058	6.516GlyArg: 6.516 ± 0.091	4.286GlySer: 4.286 ± 0.067	3.903GlyThr: 3.903 ± 0.074	6.6GlyVal: 6.6 ± 0.091	1.475GlyTrp: 1.475 ± 0.041	2.309GlyTyr: 2.309 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.595HisAla: 2.595 ± 0.054	0.294HisCys: 0.294 ± 0.016	1.666HisAsp: 1.666 ± 0.042	1.461HisGlu: 1.461 ± 0.043	1.036HisPhe: 1.036 ± 0.03	2.399HisGly: 2.399 ± 0.06	0.89HisHis: 0.89 ± 0.03	0.783HisIle: 0.783 ± 0.031	0.474HisLys: 0.474 ± 0.024	2.881HisLeu: 2.881 ± 0.046	0.437HisMet: 0.437 ± 0.025	0.5HisAsn: 0.5 ± 0.022	1.727HisPro: 1.727 ± 0.045	0.859HisGln: 0.859 ± 0.028	2.124HisArg: 2.124 ± 0.045	1.053HisSer: 1.053 ± 0.031	0.933HisThr: 0.933 ± 0.031	1.595HisVal: 1.595 ± 0.038	0.462HisTrp: 0.462 ± 0.023	0.774HisTyr: 0.774 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.316IleAla: 5.316 ± 0.076	0.356IleCys: 0.356 ± 0.02	3.263IleAsp: 3.263 ± 0.059	3.339IleGlu: 3.339 ± 0.06	1.395IlePhe: 1.395 ± 0.046	4.195IleGly: 4.195 ± 0.081	1.041IleHis: 1.041 ± 0.032	1.77IleIle: 1.77 ± 0.044	1.085IleLys: 1.085 ± 0.039	3.939IleLeu: 3.939 ± 0.078	0.848IleMet: 0.848 ± 0.03	1.286IleAsn: 1.286 ± 0.042	2.115IlePro: 2.115 ± 0.05	1.334IleGln: 1.334 ± 0.039	3.015IleArg: 3.015 ± 0.053	2.246IleSer: 2.246 ± 0.051	2.475IleThr: 2.475 ± 0.054	2.984IleVal: 2.984 ± 0.061	0.432IleTrp: 0.432 ± 0.022	0.87IleTyr: 0.87 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.894LysAla: 2.894 ± 0.072	0.139LysCys: 0.139 ± 0.011	1.139LysAsp: 1.139 ± 0.039	1.302LysGlu: 1.302 ± 0.045	0.53LysPhe: 0.53 ± 0.024	2.06LysGly: 2.06 ± 0.052	0.517LysHis: 0.517 ± 0.023	0.936LysIle: 0.936 ± 0.038	0.795LysLys: 0.795 ± 0.041	2.277LysLeu: 2.277 ± 0.052	0.537LysMet: 0.537 ± 0.027	0.493LysAsn: 0.493 ± 0.029	1.313LysPro: 1.313 ± 0.05	0.916LysGln: 0.916 ± 0.037	1.956LysArg: 1.956 ± 0.054	1.187LysSer: 1.187 ± 0.034	1.173LysThr: 1.173 ± 0.038	1.927LysVal: 1.927 ± 0.048	0.229LysTrp: 0.229 ± 0.016	0.431LysTyr: 0.431 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.459LeuAla: 16.459 ± 0.195	1.062LeuCys: 1.062 ± 0.034	7.598LeuAsp: 7.598 ± 0.094	8.153LeuGlu: 8.153 ± 0.106	3.704LeuPhe: 3.704 ± 0.073	10.037LeuGly: 10.037 ± 0.121	2.492LeuHis: 2.492 ± 0.051	4.855LeuIle: 4.855 ± 0.085	2.963LeuLys: 2.963 ± 0.067	12.638LeuLeu: 12.638 ± 0.195	2.933LeuMet: 2.933 ± 0.058	2.384LeuAsn: 2.384 ± 0.049	6.589LeuPro: 6.589 ± 0.103	3.146LeuGln: 3.146 ± 0.06	7.349LeuArg: 7.349 ± 0.107	6.443LeuSer: 6.443 ± 0.089	5.932LeuThr: 5.932 ± 0.088	9.051LeuVal: 9.051 ± 0.114	1.501LeuTrp: 1.501 ± 0.047	2.275LeuTyr: 2.275 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.262MetAla: 3.262 ± 0.068	0.161MetCys: 0.161 ± 0.015	1.153MetAsp: 1.153 ± 0.034	1.211MetGlu: 1.211 ± 0.037	0.628MetPhe: 0.628 ± 0.024	1.989MetGly: 1.989 ± 0.056	0.489MetHis: 0.489 ± 0.021	1.208MetIle: 1.208 ± 0.034	0.749MetLys: 0.749 ± 0.027	2.709MetLeu: 2.709 ± 0.06	0.681MetMet: 0.681 ± 0.035	0.723MetAsn: 0.723 ± 0.023	1.496MetPro: 1.496 ± 0.035	0.859MetGln: 0.859 ± 0.029	1.671MetArg: 1.671 ± 0.043	1.665MetSer: 1.665 ± 0.044	1.811MetThr: 1.811 ± 0.042	1.802MetVal: 1.802 ± 0.042	0.207MetTrp: 0.207 ± 0.014	0.317MetTyr: 0.317 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.61AsnAla: 2.61 ± 0.047	0.178AsnCys: 0.178 ± 0.015	1.288AsnAsp: 1.288 ± 0.053	1.17AsnGlu: 1.17 ± 0.032	0.746AsnPhe: 0.746 ± 0.033	1.873AsnGly: 1.873 ± 0.052	0.527AsnHis: 0.527 ± 0.026	1.078AsnIle: 1.078 ± 0.029	0.491AsnLys: 0.491 ± 0.022	2.549AsnLeu: 2.549 ± 0.054	0.45AsnMet: 0.45 ± 0.018	0.579AsnAsn: 0.579 ± 0.027	1.487AsnPro: 1.487 ± 0.04	0.788AsnGln: 0.788 ± 0.028	1.674AsnArg: 1.674 ± 0.045	0.881AsnSer: 0.881 ± 0.029	1.052AsnThr: 1.052 ± 0.033	1.612AsnVal: 1.612 ± 0.045	0.294AsnTrp: 0.294 ± 0.017	0.538AsnTyr: 0.538 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.964ProAla: 5.964 ± 0.095	0.374ProCys: 0.374 ± 0.021	3.722ProAsp: 3.722 ± 0.07	4.316ProGlu: 4.316 ± 0.08	1.735ProPhe: 1.735 ± 0.043	4.96ProGly: 4.96 ± 0.078	1.177ProHis: 1.177 ± 0.037	1.827ProIle: 1.827 ± 0.046	0.948ProLys: 0.948 ± 0.038	5.96ProLeu: 5.96 ± 0.095	1.316ProMet: 1.316 ± 0.036	0.953ProAsn: 0.953 ± 0.033	2.489ProPro: 2.489 ± 0.065	1.491ProGln: 1.491 ± 0.039	3.581ProArg: 3.581 ± 0.074	2.582ProSer: 2.582 ± 0.051	2.359ProThr: 2.359 ± 0.05	4.009ProVal: 4.009 ± 0.063	0.928ProTrp: 0.928 ± 0.032	1.055ProTyr: 1.055 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.202GlnAla: 5.202 ± 0.088	0.25GlnCys: 0.25 ± 0.016	1.67GlnAsp: 1.67 ± 0.042	1.997GlnGlu: 1.997 ± 0.049	0.962GlnPhe: 0.962 ± 0.034	3.166GlnGly: 3.166 ± 0.067	0.795GlnHis: 0.795 ± 0.03	1.267GlnIle: 1.267 ± 0.042	0.794GlnLys: 0.794 ± 0.032	3.644GlnLeu: 3.644 ± 0.065	0.753GlnMet: 0.753 ± 0.025	0.628GlnAsn: 0.628 ± 0.024	1.678GlnPro: 1.678 ± 0.042	1.678GlnGln: 1.678 ± 0.054	3.016GlnArg: 3.016 ± 0.063	1.555GlnSer: 1.555 ± 0.041	1.359GlnThr: 1.359 ± 0.041	2.73GlnVal: 2.73 ± 0.054	0.528GlnTrp: 0.528 ± 0.023	0.621GlnTyr: 0.621 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.221ArgAla: 7.221 ± 0.106	0.629ArgCys: 0.629 ± 0.027	4.672ArgAsp: 4.672 ± 0.084	6.008ArgGlu: 6.008 ± 0.097	3.048ArgPhe: 3.048 ± 0.06	5.244ArgGly: 5.244 ± 0.076	2.714ArgHis: 2.714 ± 0.057	3.356ArgIle: 3.356 ± 0.065	1.575ArgLys: 1.575 ± 0.043	11.426ArgLeu: 11.426 ± 0.16	1.79ArgMet: 1.79 ± 0.044	1.414ArgAsn: 1.414 ± 0.038	3.648ArgPro: 3.648 ± 0.068	3.428ArgGln: 3.428 ± 0.073	7.141ArgArg: 7.141 ± 0.134	3.04ArgSer: 3.04 ± 0.058	2.927ArgThr: 2.927 ± 0.055	5.599ArgVal: 5.599 ± 0.085	1.206ArgTrp: 1.206 ± 0.039	1.932ArgTyr: 1.932 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.113SerAla: 5.113 ± 0.068	0.374SerCys: 0.374 ± 0.019	2.638SerAsp: 2.638 ± 0.076	2.726SerGlu: 2.726 ± 0.06	1.776SerPhe: 1.776 ± 0.039	4.897SerGly: 4.897 ± 0.08	1.223SerHis: 1.223 ± 0.028	2.087SerIle: 2.087 ± 0.042	1.007SerLys: 1.007 ± 0.039	6.535SerLeu: 6.535 ± 0.091	1.265SerMet: 1.265 ± 0.035	1.044SerAsn: 1.044 ± 0.041	2.965SerPro: 2.965 ± 0.057	1.584SerGln: 1.584 ± 0.04	4.43SerArg: 4.43 ± 0.075	2.512SerSer: 2.512 ± 0.052	2.452SerThr: 2.452 ± 0.063	3.508SerVal: 3.508 ± 0.064	0.672SerTrp: 0.672 ± 0.027	1.083SerTyr: 1.083 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.1ThrAla: 5.1 ± 0.093	0.434ThrCys: 0.434 ± 0.02	2.499ThrAsp: 2.499 ± 0.075	2.534ThrGlu: 2.534 ± 0.048	1.778ThrPhe: 1.778 ± 0.044	4.471ThrGly: 4.471 ± 0.079	1.18ThrHis: 1.18 ± 0.031	1.845ThrIle: 1.845 ± 0.05	0.767ThrLys: 0.767 ± 0.033	7.332ThrLeu: 7.332 ± 0.117	0.963ThrMet: 0.963 ± 0.032	1.012ThrAsn: 1.012 ± 0.036	3.517ThrPro: 3.517 ± 0.062	1.38ThrGln: 1.38 ± 0.038	3.963ThrArg: 3.963 ± 0.06	2.449ThrSer: 2.449 ± 0.067	2.606ThrThr: 2.606 ± 0.062	3.566ThrVal: 3.566 ± 0.088	0.714ThrTrp: 0.714 ± 0.027	1.015ThrTyr: 1.015 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.616ValAla: 8.616 ± 0.11	0.646ValCys: 0.646 ± 0.026	4.427ValAsp: 4.427 ± 0.069	5.218ValGlu: 5.218 ± 0.074	2.511ValPhe: 2.511 ± 0.049	5.603ValGly: 5.603 ± 0.086	1.507ValHis: 1.507 ± 0.036	3.875ValIle: 3.875 ± 0.07	1.83ValLys: 1.83 ± 0.055	7.929ValLeu: 7.929 ± 0.093	2.171ValMet: 2.171 ± 0.051	1.922ValAsn: 1.922 ± 0.058	3.7ValPro: 3.7 ± 0.061	2.158ValGln: 2.158 ± 0.049	4.765ValArg: 4.765 ± 0.074	4.032ValSer: 4.032 ± 0.076	4.297ValThr: 4.297 ± 0.094	6.07ValVal: 6.07 ± 0.1	0.853ValTrp: 0.853 ± 0.03	1.468ValTyr: 1.468 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.213TrpAla: 1.213 ± 0.036	0.174TrpCys: 0.174 ± 0.013	0.575TrpAsp: 0.575 ± 0.027	0.708TrpGlu: 0.708 ± 0.03	0.481TrpPhe: 0.481 ± 0.022	0.995TrpGly: 0.995 ± 0.033	0.457TrpHis: 0.457 ± 0.02	0.599TrpIle: 0.599 ± 0.027	0.361TrpLys: 0.361 ± 0.018	2.442TrpLeu: 2.442 ± 0.063	0.382TrpMet: 0.382 ± 0.019	0.347TrpAsn: 0.347 ± 0.019	0.786TrpPro: 0.786 ± 0.033	0.928TrpGln: 0.928 ± 0.032	1.367TrpArg: 1.367 ± 0.043	0.746TrpSer: 0.746 ± 0.03	0.636TrpThr: 0.636 ± 0.028	0.953TrpVal: 0.953 ± 0.032	0.328TrpTrp: 0.328 ± 0.018	0.323TrpTyr: 0.323 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.228TyrAla: 2.228 ± 0.047	0.243TyrCys: 0.243 ± 0.017	1.226TyrAsp: 1.226 ± 0.038	1.082TyrGlu: 1.082 ± 0.036	0.831TyrPhe: 0.831 ± 0.032	1.925TyrGly: 1.925 ± 0.049	0.641TyrHis: 0.641 ± 0.025	0.772TyrIle: 0.772 ± 0.037	0.405TyrLys: 0.405 ± 0.021	2.734TyrLeu: 2.734 ± 0.051	0.408TyrMet: 0.408 ± 0.023	0.51TyrAsn: 0.51 ± 0.021	1.227TyrPro: 1.227 ± 0.039	0.827TyrGln: 0.827 ± 0.03	2.172TyrArg: 2.172 ± 0.054	1.087TyrSer: 1.087 ± 0.036	0.992TyrThr: 0.992 ± 0.039	1.471TyrVal: 1.471 ± 0.037	0.334TyrTrp: 0.334 ± 0.02	0.609TyrTyr: 0.609 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3147 proteins (1029740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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