Amino acid dipepetide frequency for Mycoplasma citelli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.238AlaAla: 2.238 ± 0.105
0.181AlaCys: 0.181 ± 0.023
2.417AlaAsp: 2.417 ± 0.103
2.414AlaGlu: 2.414 ± 0.105
2.698AlaPhe: 2.698 ± 0.098
2.279AlaGly: 2.279 ± 0.089
0.808AlaHis: 0.808 ± 0.052
4.791AlaIle: 4.791 ± 0.124
6.002AlaLys: 6.002 ± 0.17
6.007AlaLeu: 6.007 ± 0.156
0.716AlaMet: 0.716 ± 0.048
4.09AlaAsn: 4.09 ± 0.187
1.557AlaPro: 1.557 ± 0.075
3.263AlaGln: 3.263 ± 0.137
1.533AlaArg: 1.533 ± 0.077
3.939AlaSer: 3.939 ± 0.11
3.204AlaThr: 3.204 ± 0.143
2.447AlaVal: 2.447 ± 0.087
0.395AlaTrp: 0.395 ± 0.034
2.093AlaTyr: 2.093 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.16CysAla: 0.16 ± 0.024
0.035CysCys: 0.035 ± 0.01
0.208CysAsp: 0.208 ± 0.031
0.195CysGlu: 0.195 ± 0.022
0.262CysPhe: 0.262 ± 0.038
0.23CysGly: 0.23 ± 0.028
0.062CysHis: 0.062 ± 0.014
0.216CysIle: 0.216 ± 0.026
0.254CysLys: 0.254 ± 0.027
0.319CysLeu: 0.319 ± 0.033
0.046CysMet: 0.046 ± 0.011
0.154CysAsn: 0.154 ± 0.02
0.103CysPro: 0.103 ± 0.019
0.127CysGln: 0.127 ± 0.017
0.065CysArg: 0.065 ± 0.013
0.341CysSer: 0.341 ± 0.033
0.146CysThr: 0.146 ± 0.018
0.246CysVal: 0.246 ± 0.029
0.038CysTrp: 0.038 ± 0.01
0.146CysTyr: 0.146 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.006AspAla: 3.006 ± 0.123
0.132AspCys: 0.132 ± 0.023
2.506AspAsp: 2.506 ± 0.094
3.563AspGlu: 3.563 ± 0.128
3.974AspPhe: 3.974 ± 0.117
2.025AspGly: 2.025 ± 0.082
0.695AspHis: 0.695 ± 0.042
4.088AspIle: 4.088 ± 0.103
5.621AspLys: 5.621 ± 0.153
6.469AspLeu: 6.469 ± 0.155
0.527AspMet: 0.527 ± 0.037
4.066AspAsn: 4.066 ± 0.119
1.741AspPro: 1.741 ± 0.071
2.566AspGln: 2.566 ± 0.078
1.008AspArg: 1.008 ± 0.053
3.566AspSer: 3.566 ± 0.117
2.647AspThr: 2.647 ± 0.119
2.787AspVal: 2.787 ± 0.099
0.487AspTrp: 0.487 ± 0.036
2.79AspTyr: 2.79 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
3.374GluAla: 3.374 ± 0.112
0.138GluCys: 0.138 ± 0.02
3.123GluAsp: 3.123 ± 0.112
4.569GluGlu: 4.569 ± 0.141
3.512GluPhe: 3.512 ± 0.113
2.03GluGly: 2.03 ± 0.081
0.933GluHis: 0.933 ± 0.06
6.945GluIle: 6.945 ± 0.151
7.097GluLys: 7.097 ± 0.182
6.664GluLeu: 6.664 ± 0.179
1.044GluMet: 1.044 ± 0.067
5.931GluAsn: 5.931 ± 0.13
1.2GluPro: 1.2 ± 0.062
3.771GluGln: 3.771 ± 0.116
1.495GluArg: 1.495 ± 0.069
3.244GluSer: 3.244 ± 0.105
3.158GluThr: 3.158 ± 0.098
3.736GluVal: 3.736 ± 0.104
0.395GluTrp: 0.395 ± 0.033
2.985GluTyr: 2.985 ± 0.113
0.0GluXaa: 0.0 ± 0.0
Phe
2.95PheAla: 2.95 ± 0.096
0.208PheCys: 0.208 ± 0.024
3.734PheAsp: 3.734 ± 0.116
3.85PheGlu: 3.85 ± 0.1
2.752PhePhe: 2.752 ± 0.118
2.533PheGly: 2.533 ± 0.096
0.535PheHis: 0.535 ± 0.042
4.472PheIle: 4.472 ± 0.184
5.599PheLys: 5.599 ± 0.16
5.588PheLeu: 5.588 ± 0.183
0.649PheMet: 0.649 ± 0.046
4.647PheAsn: 4.647 ± 0.127
1.154PhePro: 1.154 ± 0.063
1.492PheGln: 1.492 ± 0.069
1.273PheArg: 1.273 ± 0.057
3.877PheSer: 3.877 ± 0.133
2.633PheThr: 2.633 ± 0.091
3.144PheVal: 3.144 ± 0.108
0.622PheTrp: 0.622 ± 0.042
2.474PheTyr: 2.474 ± 0.09
0.0PheXaa: 0.0 ± 0.0
Gly
2.303GlyAla: 2.303 ± 0.101
0.138GlyCys: 0.138 ± 0.02
2.095GlyAsp: 2.095 ± 0.081
2.287GlyGlu: 2.287 ± 0.083
2.649GlyPhe: 2.649 ± 0.084
2.403GlyGly: 2.403 ± 0.109
0.67GlyHis: 0.67 ± 0.042
3.882GlyIle: 3.882 ± 0.134
3.72GlyLys: 3.72 ± 0.117
3.631GlyLeu: 3.631 ± 0.109
0.662GlyMet: 0.662 ± 0.051
2.482GlyAsn: 2.482 ± 0.083
0.954GlyPro: 0.954 ± 0.059
1.53GlyGln: 1.53 ± 0.081
1.279GlyArg: 1.279 ± 0.06
2.909GlySer: 2.909 ± 0.098
2.633GlyThr: 2.633 ± 0.101
2.628GlyVal: 2.628 ± 0.102
0.503GlyTrp: 0.503 ± 0.035
1.928GlyTyr: 1.928 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.727HisAla: 0.727 ± 0.05
0.084HisCys: 0.084 ± 0.014
0.552HisAsp: 0.552 ± 0.041
0.662HisGlu: 0.662 ± 0.043
0.887HisPhe: 0.887 ± 0.047
0.649HisGly: 0.649 ± 0.047
0.219HisHis: 0.219 ± 0.024
1.003HisIle: 1.003 ± 0.054
1.195HisLys: 1.195 ± 0.068
1.465HisLeu: 1.465 ± 0.068
0.2HisMet: 0.2 ± 0.024
0.984HisAsn: 0.984 ± 0.05
0.546HisPro: 0.546 ± 0.044
0.63HisGln: 0.63 ± 0.042
0.346HisArg: 0.346 ± 0.032
1.027HisSer: 1.027 ± 0.046
0.692HisThr: 0.692 ± 0.046
0.533HisVal: 0.533 ± 0.042
0.143HisTrp: 0.143 ± 0.024
0.6HisTyr: 0.6 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
4.988IleAla: 4.988 ± 0.13
0.335IleCys: 0.335 ± 0.034
5.166IleAsp: 5.166 ± 0.132
5.356IleGlu: 5.356 ± 0.147
4.785IlePhe: 4.785 ± 0.183
3.525IleGly: 3.525 ± 0.134
1.057IleHis: 1.057 ± 0.055
7.172IleIle: 7.172 ± 0.197
9.084IleLys: 9.084 ± 0.196
8.408IleLeu: 8.408 ± 0.196
1.0IleMet: 1.0 ± 0.06
8.259IleAsn: 8.259 ± 0.162
2.525IlePro: 2.525 ± 0.089
3.471IleGln: 3.471 ± 0.107
2.211IleArg: 2.211 ± 0.085
7.034IleSer: 7.034 ± 0.151
4.677IleThr: 4.677 ± 0.118
4.377IleVal: 4.377 ± 0.151
0.673IleTrp: 0.673 ± 0.048
3.174IleTyr: 3.174 ± 0.113
0.0IleXaa: 0.0 ± 0.0
Lys
5.683LysAla: 5.683 ± 0.165
0.262LysCys: 0.262 ± 0.03
6.378LysAsp: 6.378 ± 0.135
8.311LysGlu: 8.311 ± 0.171
4.577LysPhe: 4.577 ± 0.111
3.504LysGly: 3.504 ± 0.109
1.317LysHis: 1.317 ± 0.065
9.922LysIle: 9.922 ± 0.197
8.705LysLys: 8.705 ± 0.218
10.054LysLeu: 10.054 ± 0.171
1.903LysMet: 1.903 ± 0.079
9.738LysAsn: 9.738 ± 0.188
2.263LysPro: 2.263 ± 0.108
4.255LysGln: 4.255 ± 0.137
2.793LysArg: 2.793 ± 0.107
6.077LysSer: 6.077 ± 0.138
5.994LysThr: 5.994 ± 0.142
5.204LysVal: 5.204 ± 0.118
0.944LysTrp: 0.944 ± 0.052
4.547LysTyr: 4.547 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
5.588LeuAla: 5.588 ± 0.149
0.335LeuCys: 0.335 ± 0.038
5.726LeuAsp: 5.726 ± 0.138
7.121LeuGlu: 7.121 ± 0.15
5.296LeuPhe: 5.296 ± 0.149
3.931LeuGly: 3.931 ± 0.134
1.254LeuHis: 1.254 ± 0.054
8.9LeuIle: 8.9 ± 0.181
11.541LeuLys: 11.541 ± 0.21
8.757LeuLeu: 8.757 ± 0.203
1.406LeuMet: 1.406 ± 0.066
9.811LeuAsn: 9.811 ± 0.236
2.525LeuPro: 2.525 ± 0.093
4.207LeuGln: 4.207 ± 0.15
2.779LeuArg: 2.779 ± 0.091
8.108LeuSer: 8.108 ± 0.198
5.399LeuThr: 5.399 ± 0.155
5.375LeuVal: 5.375 ± 0.138
0.833LeuTrp: 0.833 ± 0.06
3.423LeuTyr: 3.423 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
0.57MetAla: 0.57 ± 0.046
0.084MetCys: 0.084 ± 0.015
0.662MetAsp: 0.662 ± 0.05
0.698MetGlu: 0.698 ± 0.048
0.887MetPhe: 0.887 ± 0.049
0.568MetGly: 0.568 ± 0.043
0.211MetHis: 0.211 ± 0.023
1.157MetIle: 1.157 ± 0.07
1.449MetLys: 1.449 ± 0.071
1.546MetLeu: 1.546 ± 0.064
0.262MetMet: 0.262 ± 0.026
1.119MetAsn: 1.119 ± 0.061
0.378MetPro: 0.378 ± 0.036
0.673MetGln: 0.673 ± 0.047
0.346MetArg: 0.346 ± 0.03
1.006MetSer: 1.006 ± 0.063
0.589MetThr: 0.589 ± 0.042
0.725MetVal: 0.725 ± 0.047
0.111MetTrp: 0.111 ± 0.017
0.449MetTyr: 0.449 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
4.155AsnAla: 4.155 ± 0.202
0.227AsnCys: 0.227 ± 0.028
4.496AsnAsp: 4.496 ± 0.156
5.526AsnGlu: 5.526 ± 0.153
4.434AsnPhe: 4.434 ± 0.138
3.15AsnGly: 3.15 ± 0.097
1.027AsnHis: 1.027 ± 0.057
6.626AsnIle: 6.626 ± 0.17
8.689AsnLys: 8.689 ± 0.175
9.797AsnLeu: 9.797 ± 0.222
0.871AsnMet: 0.871 ± 0.05
7.391AsnAsn: 7.391 ± 0.254
3.109AsnPro: 3.109 ± 0.125
4.623AsnGln: 4.623 ± 0.152
1.849AsnArg: 1.849 ± 0.068
6.715AsnSer: 6.715 ± 0.204
4.063AsnThr: 4.063 ± 0.173
3.898AsnVal: 3.898 ± 0.111
0.989AsnTrp: 0.989 ± 0.069
3.801AsnTyr: 3.801 ± 0.107
0.0AsnXaa: 0.0 ± 0.0
Pro
1.33ProAla: 1.33 ± 0.091
0.059ProCys: 0.059 ± 0.013
1.306ProAsp: 1.306 ± 0.063
1.957ProGlu: 1.957 ± 0.082
1.308ProPhe: 1.308 ± 0.055
1.122ProGly: 1.122 ± 0.065
0.435ProHis: 0.435 ± 0.035
2.255ProIle: 2.255 ± 0.073
2.547ProLys: 2.547 ± 0.112
2.463ProLeu: 2.463 ± 0.088
0.308ProMet: 0.308 ± 0.033
2.257ProAsn: 2.257 ± 0.096
0.554ProPro: 0.554 ± 0.045
1.457ProGln: 1.457 ± 0.078
0.576ProArg: 0.576 ± 0.039
1.976ProSer: 1.976 ± 0.078
1.695ProThr: 1.695 ± 0.068
1.536ProVal: 1.536 ± 0.071
0.203ProTrp: 0.203 ± 0.024
1.298ProTyr: 1.298 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.787GlnAla: 2.787 ± 0.127
0.116GlnCys: 0.116 ± 0.019
1.874GlnAsp: 1.874 ± 0.068
3.174GlnGlu: 3.174 ± 0.11
1.69GlnPhe: 1.69 ± 0.067
1.906GlnGly: 1.906 ± 0.095
0.462GlnHis: 0.462 ± 0.033
4.682GlnIle: 4.682 ± 0.148
5.572GlnLys: 5.572 ± 0.139
4.32GlnLeu: 4.32 ± 0.16
0.703GlnMet: 0.703 ± 0.048
4.539GlnAsn: 4.539 ± 0.156
0.906GlnPro: 0.906 ± 0.052
1.903GlnGln: 1.903 ± 0.09
1.427GlnArg: 1.427 ± 0.059
2.944GlnSer: 2.944 ± 0.11
2.29GlnThr: 2.29 ± 0.083
2.263GlnVal: 2.263 ± 0.089
0.368GlnTrp: 0.368 ± 0.032
1.844GlnTyr: 1.844 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
1.233ArgAla: 1.233 ± 0.056
0.076ArgCys: 0.076 ± 0.016
1.482ArgAsp: 1.482 ± 0.073
1.819ArgGlu: 1.819 ± 0.077
1.381ArgPhe: 1.381 ± 0.064
1.2ArgGly: 1.2 ± 0.057
0.373ArgHis: 0.373 ± 0.031
2.46ArgIle: 2.46 ± 0.083
2.576ArgLys: 2.576 ± 0.085
2.222ArgLeu: 2.222 ± 0.073
0.533ArgMet: 0.533 ± 0.038
2.052ArgAsn: 2.052 ± 0.07
0.63ArgPro: 0.63 ± 0.044
0.887ArgGln: 0.887 ± 0.047
0.9ArgArg: 0.9 ± 0.054
1.506ArgSer: 1.506 ± 0.069
1.2ArgThr: 1.2 ± 0.063
1.409ArgVal: 1.409 ± 0.065
0.316ArgTrp: 0.316 ± 0.04
1.1ArgTyr: 1.1 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.601SerAla: 3.601 ± 0.129
0.373SerCys: 0.373 ± 0.033
4.131SerAsp: 4.131 ± 0.108
4.728SerGlu: 4.728 ± 0.127
3.961SerPhe: 3.961 ± 0.121
3.428SerGly: 3.428 ± 0.107
0.9SerHis: 0.9 ± 0.048
5.891SerIle: 5.891 ± 0.143
6.88SerLys: 6.88 ± 0.157
8.086SerLeu: 8.086 ± 0.182
0.876SerMet: 0.876 ± 0.062
5.375SerAsn: 5.375 ± 0.145
1.779SerPro: 1.779 ± 0.072
3.455SerGln: 3.455 ± 0.112
1.671SerArg: 1.671 ± 0.062
5.802SerSer: 5.802 ± 0.192
3.69SerThr: 3.69 ± 0.107
3.688SerVal: 3.688 ± 0.125
0.576SerTrp: 0.576 ± 0.036
2.63SerTyr: 2.63 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
2.433ThrAla: 2.433 ± 0.141
0.114ThrCys: 0.114 ± 0.02
2.287ThrAsp: 2.287 ± 0.085
2.731ThrGlu: 2.731 ± 0.111
2.941ThrPhe: 2.941 ± 0.087
2.328ThrGly: 2.328 ± 0.095
0.795ThrHis: 0.795 ± 0.056
4.255ThrIle: 4.255 ± 0.096
5.58ThrLys: 5.58 ± 0.14
6.161ThrLeu: 6.161 ± 0.174
0.554ThrMet: 0.554 ± 0.039
4.393ThrAsn: 4.393 ± 0.154
2.144ThrPro: 2.144 ± 0.099
3.023ThrGln: 3.023 ± 0.146
1.238ThrArg: 1.238 ± 0.061
3.788ThrSer: 3.788 ± 0.135
3.312ThrThr: 3.312 ± 0.112
2.201ThrVal: 2.201 ± 0.084
0.438ThrTrp: 0.438 ± 0.038
2.009ThrTyr: 2.009 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
3.685ValAla: 3.685 ± 0.123
0.243ValCys: 0.243 ± 0.029
3.233ValAsp: 3.233 ± 0.105
3.187ValGlu: 3.187 ± 0.113
3.077ValPhe: 3.077 ± 0.109
2.29ValGly: 2.29 ± 0.092
0.681ValHis: 0.681 ± 0.051
4.509ValIle: 4.509 ± 0.139
4.974ValLys: 4.974 ± 0.104
4.934ValLeu: 4.934 ± 0.124
0.619ValMet: 0.619 ± 0.041
4.09ValAsn: 4.09 ± 0.121
1.387ValPro: 1.387 ± 0.066
1.855ValGln: 1.855 ± 0.076
1.211ValArg: 1.211 ± 0.059
4.039ValSer: 4.039 ± 0.109
2.268ValThr: 2.268 ± 0.093
3.014ValVal: 3.014 ± 0.105
0.37ValTrp: 0.37 ± 0.029
2.12ValTyr: 2.12 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.354TrpAla: 0.354 ± 0.028
0.049TrpCys: 0.049 ± 0.025
0.543TrpAsp: 0.543 ± 0.045
0.654TrpGlu: 0.654 ± 0.044
0.56TrpPhe: 0.56 ± 0.042
0.427TrpGly: 0.427 ± 0.035
0.095TrpHis: 0.095 ± 0.017
0.949TrpIle: 0.949 ± 0.055
1.062TrpLys: 1.062 ± 0.066
0.695TrpLeu: 0.695 ± 0.048
0.189TrpMet: 0.189 ± 0.024
0.814TrpAsn: 0.814 ± 0.061
0.165TrpPro: 0.165 ± 0.022
0.23TrpGln: 0.23 ± 0.028
0.26TrpArg: 0.26 ± 0.029
0.419TrpSer: 0.419 ± 0.036
0.511TrpThr: 0.511 ± 0.039
0.497TrpVal: 0.497 ± 0.039
0.141TrpTrp: 0.141 ± 0.02
0.343TrpTyr: 0.343 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.906TyrAla: 1.906 ± 0.072
0.162TyrCys: 0.162 ± 0.022
2.347TyrAsp: 2.347 ± 0.078
2.541TyrGlu: 2.541 ± 0.098
2.555TyrPhe: 2.555 ± 0.1
1.76TyrGly: 1.76 ± 0.069
0.614TyrHis: 0.614 ± 0.048
3.104TyrIle: 3.104 ± 0.117
4.282TyrLys: 4.282 ± 0.149
4.726TyrLeu: 4.726 ± 0.106
0.419TyrMet: 0.419 ± 0.036
3.247TyrAsn: 3.247 ± 0.124
1.022TyrPro: 1.022 ± 0.063
2.352TyrGln: 2.352 ± 0.079
1.095TyrArg: 1.095 ± 0.047
3.204TyrSer: 3.204 ± 0.088
1.922TyrThr: 1.922 ± 0.08
2.082TyrVal: 2.082 ± 0.082
0.414TyrTrp: 0.414 ± 0.035
1.887TyrTyr: 1.887 ± 0.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 908 proteins (369893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski