Amino acid dipepetide frequency for Nakamurella flava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.656AlaAla: 23.656 ± 0.196	0.916AlaCys: 0.916 ± 0.027	9.95AlaAsp: 9.95 ± 0.086	7.283AlaGlu: 7.283 ± 0.09	3.395AlaPhe: 3.395 ± 0.053	14.286AlaGly: 14.286 ± 0.124	2.344AlaHis: 2.344 ± 0.045	4.631AlaIle: 4.631 ± 0.068	2.071AlaLys: 2.071 ± 0.049	13.561AlaLeu: 13.561 ± 0.121	2.449AlaMet: 2.449 ± 0.047	2.014AlaAsn: 2.014 ± 0.047	7.197AlaPro: 7.197 ± 0.093	3.754AlaGln: 3.754 ± 0.062	9.412AlaArg: 9.412 ± 0.097	5.862AlaSer: 5.862 ± 0.072	8.188AlaThr: 8.188 ± 0.095	13.883AlaVal: 13.883 ± 0.131	1.729AlaTrp: 1.729 ± 0.039	2.086AlaTyr: 2.086 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.859CysAla: 0.859 ± 0.023	0.08CysCys: 0.08 ± 0.008	0.385CysAsp: 0.385 ± 0.017	0.307CysGlu: 0.307 ± 0.016	0.191CysPhe: 0.191 ± 0.011	0.829CysGly: 0.829 ± 0.028	0.146CysHis: 0.146 ± 0.009	0.191CysIle: 0.191 ± 0.012	0.058CysLys: 0.058 ± 0.007	0.649CysLeu: 0.649 ± 0.022	0.088CysMet: 0.088 ± 0.008	0.103CysAsn: 0.103 ± 0.011	0.454CysPro: 0.454 ± 0.018	0.175CysGln: 0.175 ± 0.011	0.557CysArg: 0.557 ± 0.02	0.434CysSer: 0.434 ± 0.016	0.425CysThr: 0.425 ± 0.016	0.582CysVal: 0.582 ± 0.021	0.114CysTrp: 0.114 ± 0.009	0.131CysTyr: 0.131 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.001AspAla: 8.001 ± 0.082	0.386AspCys: 0.386 ± 0.02	4.274AspAsp: 4.274 ± 0.059	3.786AspGlu: 3.786 ± 0.056	1.487AspPhe: 1.487 ± 0.036	6.961AspGly: 6.961 ± 0.081	1.512AspHis: 1.512 ± 0.036	2.076AspIle: 2.076 ± 0.036	0.927AspLys: 0.927 ± 0.031	7.079AspLeu: 7.079 ± 0.074	0.757AspMet: 0.757 ± 0.023	0.887AspAsn: 0.887 ± 0.027	5.298AspPro: 5.298 ± 0.07	1.979AspGln: 1.979 ± 0.036	5.644AspArg: 5.644 ± 0.071	2.465AspSer: 2.465 ± 0.042	3.131AspThr: 3.131 ± 0.051	5.493AspVal: 5.493 ± 0.071	0.952AspTrp: 0.952 ± 0.026	1.109AspTyr: 1.109 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.218GluAla: 5.218 ± 0.072	0.272GluCys: 0.272 ± 0.015	2.11GluAsp: 2.11 ± 0.041	1.886GluGlu: 1.886 ± 0.043	1.439GluPhe: 1.439 ± 0.029	2.905GluGly: 2.905 ± 0.051	1.238GluHis: 1.238 ± 0.03	2.324GluIle: 2.324 ± 0.041	1.035GluLys: 1.035 ± 0.03	5.8GluLeu: 5.8 ± 0.063	0.85GluMet: 0.85 ± 0.023	0.943GluAsn: 0.943 ± 0.031	3.009GluPro: 3.009 ± 0.055	2.174GluGln: 2.174 ± 0.045	4.46GluArg: 4.46 ± 0.067	2.289GluSer: 2.289 ± 0.045	2.424GluThr: 2.424 ± 0.036	4.085GluVal: 4.085 ± 0.056	0.672GluTrp: 0.672 ± 0.021	0.984GluTyr: 0.984 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.834PheAla: 3.834 ± 0.053	0.248PheCys: 0.248 ± 0.013	2.036PheAsp: 2.036 ± 0.038	1.152PheGlu: 1.152 ± 0.027	0.892PhePhe: 0.892 ± 0.031	3.166PheGly: 3.166 ± 0.06	0.538PheHis: 0.538 ± 0.018	0.768PheIle: 0.768 ± 0.024	0.367PheLys: 0.367 ± 0.016	2.581PheLeu: 2.581 ± 0.051	0.346PheMet: 0.346 ± 0.016	0.524PheAsn: 0.524 ± 0.019	1.392PhePro: 1.392 ± 0.033	0.628PheGln: 0.628 ± 0.02	1.752PheArg: 1.752 ± 0.036	1.498PheSer: 1.498 ± 0.032	1.993PheThr: 1.993 ± 0.04	2.539PheVal: 2.539 ± 0.045	0.422PheTrp: 0.422 ± 0.016	0.573PheTyr: 0.573 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.337GlyAla: 11.337 ± 0.101	0.724GlyCys: 0.724 ± 0.025	5.244GlyAsp: 5.244 ± 0.07	4.162GlyGlu: 4.162 ± 0.06	2.912GlyPhe: 2.912 ± 0.048	8.811GlyGly: 8.811 ± 0.105	2.012GlyHis: 2.012 ± 0.041	3.785GlyIle: 3.785 ± 0.062	1.776GlyLys: 1.776 ± 0.044	9.754GlyLeu: 9.754 ± 0.099	1.898GlyMet: 1.898 ± 0.036	1.638GlyAsn: 1.638 ± 0.039	5.873GlyPro: 5.873 ± 0.071	3.058GlyGln: 3.058 ± 0.05	8.147GlyArg: 8.147 ± 0.089	6.021GlySer: 6.021 ± 0.073	6.192GlyThr: 6.192 ± 0.072	8.358GlyVal: 8.358 ± 0.081	1.84GlyTrp: 1.84 ± 0.045	2.167GlyTyr: 2.167 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.202HisAla: 2.202 ± 0.043	0.182HisCys: 0.182 ± 0.011	1.211HisAsp: 1.211 ± 0.029	0.925HisGlu: 0.925 ± 0.024	0.523HisPhe: 0.523 ± 0.019	1.887HisGly: 1.887 ± 0.043	0.624HisHis: 0.624 ± 0.021	0.521HisIle: 0.521 ± 0.02	0.228HisLys: 0.228 ± 0.013	2.294HisLeu: 2.294 ± 0.045	0.231HisMet: 0.231 ± 0.012	0.274HisAsn: 0.274 ± 0.013	1.678HisPro: 1.678 ± 0.035	0.57HisGln: 0.57 ± 0.02	2.072HisArg: 2.072 ± 0.04	0.906HisSer: 0.906 ± 0.027	1.035HisThr: 1.035 ± 0.028	1.477HisVal: 1.477 ± 0.035	0.311HisTrp: 0.311 ± 0.014	0.39HisTyr: 0.39 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.626IleAla: 5.626 ± 0.072	0.273IleCys: 0.273 ± 0.016	2.858IleAsp: 2.858 ± 0.046	1.938IleGlu: 1.938 ± 0.042	0.839IlePhe: 0.839 ± 0.029	4.247IleGly: 4.247 ± 0.067	0.539IleHis: 0.539 ± 0.02	1.109IleIle: 1.109 ± 0.038	0.651IleLys: 0.651 ± 0.023	2.685IleLeu: 2.685 ± 0.062	0.474IleMet: 0.474 ± 0.021	0.788IleAsn: 0.788 ± 0.024	1.993IlePro: 1.993 ± 0.036	0.729IleGln: 0.729 ± 0.025	2.349IleArg: 2.349 ± 0.037	1.939IleSer: 1.939 ± 0.039	2.587IleThr: 2.587 ± 0.039	3.544IleVal: 3.544 ± 0.053	0.42IleTrp: 0.42 ± 0.019	0.591IleTyr: 0.591 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.095LysAla: 2.095 ± 0.051	0.08LysCys: 0.08 ± 0.008	0.898LysAsp: 0.898 ± 0.031	0.685LysGlu: 0.685 ± 0.029	0.417LysPhe: 0.417 ± 0.017	1.234LysGly: 1.234 ± 0.031	0.279LysHis: 0.279 ± 0.014	0.746LysIle: 0.746 ± 0.027	0.445LysLys: 0.445 ± 0.022	1.473LysLeu: 1.473 ± 0.04	0.299LysMet: 0.299 ± 0.015	0.361LysAsn: 0.361 ± 0.017	0.935LysPro: 0.935 ± 0.029	0.508LysGln: 0.508 ± 0.02	0.985LysArg: 0.985 ± 0.031	0.93LysSer: 0.93 ± 0.027	0.963LysThr: 0.963 ± 0.027	1.503LysVal: 1.503 ± 0.035	0.211LysTrp: 0.211 ± 0.014	0.376LysTyr: 0.376 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.092LeuAla: 15.092 ± 0.147	0.659LeuCys: 0.659 ± 0.024	6.789LeuAsp: 6.789 ± 0.081	3.728LeuGlu: 3.728 ± 0.064	2.609LeuPhe: 2.609 ± 0.05	9.157LeuGly: 9.157 ± 0.093	1.969LeuHis: 1.969 ± 0.038	3.758LeuIle: 3.758 ± 0.065	1.239LeuLys: 1.239 ± 0.036	11.308LeuLeu: 11.308 ± 0.139	1.399LeuMet: 1.399 ± 0.036	1.526LeuAsn: 1.526 ± 0.033	6.239LeuPro: 6.239 ± 0.069	2.759LeuGln: 2.759 ± 0.046	7.957LeuArg: 7.957 ± 0.098	5.642LeuSer: 5.642 ± 0.068	7.015LeuThr: 7.015 ± 0.078	9.702LeuVal: 9.702 ± 0.089	1.244LeuTrp: 1.244 ± 0.031	1.516LeuTyr: 1.516 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.045	0.108MetCys: 0.108 ± 0.009	0.799MetAsp: 0.799 ± 0.028	0.529MetGlu: 0.529 ± 0.022	0.414MetPhe: 0.414 ± 0.018	1.315MetGly: 1.315 ± 0.029	0.277MetHis: 0.277 ± 0.014	0.738MetIle: 0.738 ± 0.022	0.335MetLys: 0.335 ± 0.017	1.595MetLeu: 1.595 ± 0.035	0.261MetMet: 0.261 ± 0.015	0.392MetAsn: 0.392 ± 0.016	0.975MetPro: 0.975 ± 0.024	0.436MetGln: 0.436 ± 0.016	1.153MetArg: 1.153 ± 0.03	1.288MetSer: 1.288 ± 0.029	1.765MetThr: 1.765 ± 0.035	1.426MetVal: 1.426 ± 0.037	0.165MetTrp: 0.165 ± 0.01	0.238MetTyr: 0.238 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.093AsnAla: 2.093 ± 0.037	0.125AsnCys: 0.125 ± 0.009	0.974AsnAsp: 0.974 ± 0.029	0.715AsnGlu: 0.715 ± 0.023	0.473AsnPhe: 0.473 ± 0.023	1.806AsnGly: 1.806 ± 0.043	0.311AsnHis: 0.311 ± 0.014	0.616AsnIle: 0.616 ± 0.023	0.337AsnLys: 0.337 ± 0.016	1.697AsnLeu: 1.697 ± 0.039	0.262AsnMet: 0.262 ± 0.016	0.397AsnAsn: 0.397 ± 0.019	1.417AsnPro: 1.417 ± 0.035	0.535AsnGln: 0.535 ± 0.024	1.213AsnArg: 1.213 ± 0.034	0.854AsnSer: 0.854 ± 0.028	1.01AsnThr: 1.01 ± 0.029	1.385AsnVal: 1.385 ± 0.035	0.299AsnTrp: 0.299 ± 0.015	0.369AsnTyr: 0.369 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	9.448ProAla: 9.448 ± 0.101	0.272ProCys: 0.272 ± 0.014	5.032ProAsp: 5.032 ± 0.06	3.342ProGlu: 3.342 ± 0.055	1.639ProPhe: 1.639 ± 0.033	6.759ProGly: 6.759 ± 0.08	1.138ProHis: 1.138 ± 0.028	1.806ProIle: 1.806 ± 0.035	0.771ProLys: 0.771 ± 0.024	5.093ProLeu: 5.093 ± 0.066	0.959ProMet: 0.959 ± 0.029	0.922ProAsn: 0.922 ± 0.027	3.795ProPro: 3.795 ± 0.072	1.621ProGln: 1.621 ± 0.039	3.773ProArg: 3.773 ± 0.06	3.659ProSer: 3.659 ± 0.055	4.416ProThr: 4.416 ± 0.073	6.197ProVal: 6.197 ± 0.071	0.99ProTrp: 0.99 ± 0.027	1.01ProTyr: 1.01 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.936GlnAla: 3.936 ± 0.056	0.152GlnCys: 0.152 ± 0.011	1.456GlnAsp: 1.456 ± 0.035	1.135GlnGlu: 1.135 ± 0.03	0.834GlnPhe: 0.834 ± 0.025	2.083GlnGly: 2.083 ± 0.043	0.593GlnHis: 0.593 ± 0.018	1.293GlnIle: 1.293 ± 0.033	0.423GlnLys: 0.423 ± 0.019	3.097GlnLeu: 3.097 ± 0.046	0.501GlnMet: 0.501 ± 0.018	0.543GlnAsn: 0.543 ± 0.02	1.718GlnPro: 1.718 ± 0.037	1.364GlnGln: 1.364 ± 0.038	2.522GlnArg: 2.522 ± 0.054	1.452GlnSer: 1.452 ± 0.032	1.593GlnThr: 1.593 ± 0.035	2.914GlnVal: 2.914 ± 0.045	0.526GlnTrp: 0.526 ± 0.02	0.618GlnTyr: 0.618 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.202ArgAla: 9.202 ± 0.096	0.545ArgCys: 0.545 ± 0.021	4.281ArgAsp: 4.281 ± 0.062	3.635ArgGlu: 3.635 ± 0.061	2.197ArgPhe: 2.197 ± 0.04	5.512ArgGly: 5.512 ± 0.072	1.687ArgHis: 1.687 ± 0.032	3.17ArgIle: 3.17 ± 0.046	1.137ArgLys: 1.137 ± 0.032	7.972ArgLeu: 7.972 ± 0.092	1.764ArgMet: 1.764 ± 0.032	1.257ArgAsn: 1.257 ± 0.035	5.473ArgPro: 5.473 ± 0.082	2.361ArgGln: 2.361 ± 0.042	8.339ArgArg: 8.339 ± 0.096	4.911ArgSer: 4.911 ± 0.065	4.952ArgThr: 4.952 ± 0.064	6.104ArgVal: 6.104 ± 0.074	1.605ArgTrp: 1.605 ± 0.034	1.587ArgTyr: 1.587 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.542SerAla: 7.542 ± 0.082	0.37SerCys: 0.37 ± 0.017	3.112SerAsp: 3.112 ± 0.049	2.231SerGlu: 2.231 ± 0.044	1.53SerPhe: 1.53 ± 0.035	6.38SerGly: 6.38 ± 0.086	0.901SerHis: 0.901 ± 0.023	1.885SerIle: 1.885 ± 0.037	0.804SerLys: 0.804 ± 0.028	4.708SerLeu: 4.708 ± 0.068	1.145SerMet: 1.145 ± 0.027	0.883SerAsn: 0.883 ± 0.026	3.447SerPro: 3.447 ± 0.054	1.246SerGln: 1.246 ± 0.031	3.777SerArg: 3.777 ± 0.056	3.657SerSer: 3.657 ± 0.083	3.985SerThr: 3.985 ± 0.062	4.635SerVal: 4.635 ± 0.059	0.903SerTrp: 0.903 ± 0.03	1.017SerTyr: 1.017 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.578ThrAla: 9.578 ± 0.092	0.385ThrCys: 0.385 ± 0.016	4.184ThrAsp: 4.184 ± 0.06	2.886ThrGlu: 2.886 ± 0.044	1.771ThrPhe: 1.771 ± 0.035	7.094ThrGly: 7.094 ± 0.082	1.014ThrHis: 1.014 ± 0.028	2.278ThrIle: 2.278 ± 0.045	0.905ThrLys: 0.905 ± 0.026	5.702ThrLeu: 5.702 ± 0.071	0.905ThrMet: 0.905 ± 0.027	1.042ThrAsn: 1.042 ± 0.029	4.272ThrPro: 4.272 ± 0.067	1.392ThrGln: 1.392 ± 0.035	3.915ThrArg: 3.915 ± 0.05	3.598ThrSer: 3.598 ± 0.057	4.731ThrThr: 4.731 ± 0.082	7.217ThrVal: 7.217 ± 0.082	0.959ThrTrp: 0.959 ± 0.026	1.148ThrTyr: 1.148 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	12.791ValAla: 12.791 ± 0.115	0.684ValCys: 0.684 ± 0.023	6.574ValAsp: 6.574 ± 0.071	4.343ValGlu: 4.343 ± 0.061	2.502ValPhe: 2.502 ± 0.041	8.322ValGly: 8.322 ± 0.097	1.82ValHis: 1.82 ± 0.038	3.479ValIle: 3.479 ± 0.056	1.364ValLys: 1.364 ± 0.035	10.447ValLeu: 10.447 ± 0.112	1.369ValMet: 1.369 ± 0.03	1.648ValAsn: 1.648 ± 0.039	5.535ValPro: 5.535 ± 0.079	2.331ValGln: 2.331 ± 0.042	6.772ValArg: 6.772 ± 0.085	4.717ValSer: 4.717 ± 0.055	6.502ValThr: 6.502 ± 0.08	10.158ValVal: 10.158 ± 0.103	1.113ValTrp: 1.113 ± 0.028	1.484ValTyr: 1.484 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.805TrpAla: 1.805 ± 0.035	0.141TrpCys: 0.141 ± 0.01	0.812TrpAsp: 0.812 ± 0.023	0.58TrpGlu: 0.58 ± 0.02	0.568TrpPhe: 0.568 ± 0.02	1.091TrpGly: 1.091 ± 0.032	0.309TrpHis: 0.309 ± 0.015	0.564TrpIle: 0.564 ± 0.022	0.267TrpLys: 0.267 ± 0.014	1.652TrpLeu: 1.652 ± 0.041	0.308TrpMet: 0.308 ± 0.015	0.385TrpAsn: 0.385 ± 0.02	0.863TrpPro: 0.863 ± 0.025	0.533TrpGln: 0.533 ± 0.018	1.216TrpArg: 1.216 ± 0.032	1.114TrpSer: 1.114 ± 0.029	1.037TrpThr: 1.037 ± 0.031	1.244TrpVal: 1.244 ± 0.03	0.462TrpTrp: 0.462 ± 0.019	0.286TrpTyr: 0.286 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.041	0.159TyrCys: 0.159 ± 0.011	1.222TyrAsp: 1.222 ± 0.034	0.869TyrGlu: 0.869 ± 0.029	0.617TyrPhe: 0.617 ± 0.021	1.868TyrGly: 1.868 ± 0.045	0.293TyrHis: 0.293 ± 0.015	0.439TyrIle: 0.439 ± 0.02	0.282TyrLys: 0.282 ± 0.015	2.16TyrLeu: 2.16 ± 0.044	0.189TyrMet: 0.189 ± 0.011	0.357TyrAsn: 0.357 ± 0.018	1.08TyrPro: 1.08 ± 0.034	0.601TyrGln: 0.601 ± 0.022	1.676TyrArg: 1.676 ± 0.035	0.925TyrSer: 0.925 ± 0.027	1.032TyrThr: 1.032 ± 0.031	1.508TyrVal: 1.508 ± 0.032	0.295TyrTrp: 0.295 ± 0.014	0.402TyrTyr: 0.402 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4268 proteins (1432224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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