Amino acid dipepetide frequency for Dermacoccus nishinomiyaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.773AlaAla: 18.773 ± 0.216
1.139AlaCys: 1.139 ± 0.046
8.294AlaAsp: 8.294 ± 0.127
7.143AlaGlu: 7.143 ± 0.122
3.805AlaPhe: 3.805 ± 0.074
11.857AlaGly: 11.857 ± 0.141
2.907AlaHis: 2.907 ± 0.064
4.861AlaIle: 4.861 ± 0.09
3.7AlaLys: 3.7 ± 0.101
13.207AlaLeu: 13.207 ± 0.17
3.204AlaMet: 3.204 ± 0.072
2.425AlaAsn: 2.425 ± 0.062
6.358AlaPro: 6.358 ± 0.125
4.296AlaGln: 4.296 ± 0.08
9.667AlaArg: 9.667 ± 0.129
7.721AlaSer: 7.721 ± 0.14
7.499AlaThr: 7.499 ± 0.112
10.475AlaVal: 10.475 ± 0.139
1.986AlaTrp: 1.986 ± 0.059
2.428AlaTyr: 2.428 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.917CysAla: 0.917 ± 0.034
0.111CysCys: 0.111 ± 0.013
0.516CysAsp: 0.516 ± 0.028
0.389CysGlu: 0.389 ± 0.026
0.235CysPhe: 0.235 ± 0.019
0.883CysGly: 0.883 ± 0.041
0.172CysHis: 0.172 ± 0.015
0.287CysIle: 0.287 ± 0.021
0.12CysLys: 0.12 ± 0.015
0.68CysLeu: 0.68 ± 0.03
0.115CysMet: 0.115 ± 0.012
0.126CysAsn: 0.126 ± 0.014
0.422CysPro: 0.422 ± 0.026
0.132CysGln: 0.132 ± 0.013
0.52CysArg: 0.52 ± 0.029
0.469CysSer: 0.469 ± 0.03
0.461CysThr: 0.461 ± 0.027
0.703CysVal: 0.703 ± 0.032
0.116CysTrp: 0.116 ± 0.012
0.166CysTyr: 0.166 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
10.367AspAla: 10.367 ± 0.144
0.313AspCys: 0.313 ± 0.021
5.53AspAsp: 5.53 ± 0.116
5.205AspGlu: 5.205 ± 0.1
1.669AspPhe: 1.669 ± 0.055
6.522AspGly: 6.522 ± 0.105
1.377AspHis: 1.377 ± 0.045
2.369AspIle: 2.369 ± 0.052
1.515AspLys: 1.515 ± 0.057
6.066AspLeu: 6.066 ± 0.096
1.112AspMet: 1.112 ± 0.039
1.03AspAsn: 1.03 ± 0.036
3.502AspPro: 3.502 ± 0.075
1.346AspGln: 1.346 ± 0.046
3.468AspArg: 3.468 ± 0.062
2.631AspSer: 2.631 ± 0.064
2.908AspThr: 2.908 ± 0.064
7.025AspVal: 7.025 ± 0.116
0.835AspTrp: 0.835 ± 0.037
1.099AspTyr: 1.099 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.462GluAla: 7.462 ± 0.119
0.422GluCys: 0.422 ± 0.025
2.721GluAsp: 2.721 ± 0.072
2.847GluGlu: 2.847 ± 0.064
1.689GluPhe: 1.689 ± 0.051
4.267GluGly: 4.267 ± 0.07
1.758GluHis: 1.758 ± 0.047
2.57GluIle: 2.57 ± 0.062
1.853GluLys: 1.853 ± 0.062
5.901GluLeu: 5.901 ± 0.097
1.239GluMet: 1.239 ± 0.044
1.438GluAsn: 1.438 ± 0.049
2.923GluPro: 2.923 ± 0.063
2.376GluGln: 2.376 ± 0.06
5.794GluArg: 5.794 ± 0.098
2.828GluSer: 2.828 ± 0.063
3.057GluThr: 3.057 ± 0.069
4.608GluVal: 4.608 ± 0.086
0.83GluTrp: 0.83 ± 0.034
1.049GluTyr: 1.049 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.94PheAla: 3.94 ± 0.065
0.272PheCys: 0.272 ± 0.019
2.485PheAsp: 2.485 ± 0.061
1.714PheGlu: 1.714 ± 0.047
0.998PhePhe: 0.998 ± 0.044
3.27PheGly: 3.27 ± 0.07
0.603PheHis: 0.603 ± 0.029
1.055PheIle: 1.055 ± 0.044
0.655PheLys: 0.655 ± 0.028
2.392PheLeu: 2.392 ± 0.057
0.546PheMet: 0.546 ± 0.028
0.622PheAsn: 0.622 ± 0.031
1.234PhePro: 1.234 ± 0.042
0.561PheGln: 0.561 ± 0.027
1.482PheArg: 1.482 ± 0.047
1.591PheSer: 1.591 ± 0.043
2.047PheThr: 2.047 ± 0.058
3.049PheVal: 3.049 ± 0.061
0.431PheTrp: 0.431 ± 0.026
0.641PheTyr: 0.641 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.749GlyAla: 10.749 ± 0.126
0.793GlyCys: 0.793 ± 0.033
5.392GlyAsp: 5.392 ± 0.081
5.438GlyGlu: 5.438 ± 0.081
3.054GlyPhe: 3.054 ± 0.071
7.841GlyGly: 7.841 ± 0.137
2.107GlyHis: 2.107 ± 0.057
3.866GlyIle: 3.866 ± 0.077
2.68GlyLys: 2.68 ± 0.073
8.458GlyLeu: 8.458 ± 0.116
2.112GlyMet: 2.112 ± 0.057
1.778GlyAsn: 1.778 ± 0.055
3.609GlyPro: 3.609 ± 0.067
2.585GlyGln: 2.585 ± 0.07
6.545GlyArg: 6.545 ± 0.106
5.4GlySer: 5.4 ± 0.09
5.13GlyThr: 5.13 ± 0.088
8.004GlyVal: 8.004 ± 0.128
1.575GlyTrp: 1.575 ± 0.047
2.134GlyTyr: 2.134 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.832HisAla: 2.832 ± 0.074
0.164HisCys: 0.164 ± 0.017
1.732HisAsp: 1.732 ± 0.05
1.479HisGlu: 1.479 ± 0.048
0.606HisPhe: 0.606 ± 0.028
2.177HisGly: 2.177 ± 0.056
0.721HisHis: 0.721 ± 0.039
0.718HisIle: 0.718 ± 0.03
0.366HisLys: 0.366 ± 0.022
2.38HisLeu: 2.38 ± 0.056
0.457HisMet: 0.457 ± 0.031
0.39HisAsn: 0.39 ± 0.023
1.61HisPro: 1.61 ± 0.045
0.59HisGln: 0.59 ± 0.031
1.542HisArg: 1.542 ± 0.05
0.938HisSer: 0.938 ± 0.039
1.225HisThr: 1.225 ± 0.044
2.099HisVal: 2.099 ± 0.052
0.338HisTrp: 0.338 ± 0.021
0.412HisTyr: 0.412 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.891IleAla: 5.891 ± 0.094
0.349IleCys: 0.349 ± 0.021
3.297IleAsp: 3.297 ± 0.064
2.677IleGlu: 2.677 ± 0.067
1.099IlePhe: 1.099 ± 0.042
4.05IleGly: 4.05 ± 0.091
0.727IleHis: 0.727 ± 0.032
1.578IleIle: 1.578 ± 0.053
1.054IleLys: 1.054 ± 0.04
2.896IleLeu: 2.896 ± 0.063
0.67IleMet: 0.67 ± 0.03
0.951IleAsn: 0.951 ± 0.037
1.838IlePro: 1.838 ± 0.053
0.774IleGln: 0.774 ± 0.032
2.233IleArg: 2.233 ± 0.055
2.051IleSer: 2.051 ± 0.053
2.594IleThr: 2.594 ± 0.065
4.002IleVal: 4.002 ± 0.081
0.383IleTrp: 0.383 ± 0.025
0.643IleTyr: 0.643 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.537LysAla: 3.537 ± 0.091
0.109LysCys: 0.109 ± 0.013
1.687LysAsp: 1.687 ± 0.063
1.292LysGlu: 1.292 ± 0.059
0.655LysPhe: 0.655 ± 0.033
2.308LysGly: 2.308 ± 0.07
0.599LysHis: 0.599 ± 0.028
1.245LysIle: 1.245 ± 0.05
1.318LysLys: 1.318 ± 0.058
2.358LysLeu: 2.358 ± 0.063
0.54LysMet: 0.54 ± 0.029
0.873LysAsn: 0.873 ± 0.041
1.524LysPro: 1.524 ± 0.056
0.978LysGln: 0.978 ± 0.041
1.807LysArg: 1.807 ± 0.051
1.498LysSer: 1.498 ± 0.053
1.582LysThr: 1.582 ± 0.051
2.175LysVal: 2.175 ± 0.063
0.308LysTrp: 0.308 ± 0.019
0.517LysTyr: 0.517 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
13.705LeuAla: 13.705 ± 0.155
0.633LeuCys: 0.633 ± 0.032
6.96LeuAsp: 6.96 ± 0.114
5.25LeuGlu: 5.25 ± 0.086
2.57LeuPhe: 2.57 ± 0.063
8.398LeuGly: 8.398 ± 0.112
1.926LeuHis: 1.926 ± 0.053
3.391LeuIle: 3.391 ± 0.068
2.227LeuLys: 2.227 ± 0.071
8.701LeuLeu: 8.701 ± 0.14
1.936LeuMet: 1.936 ± 0.057
1.677LeuAsn: 1.677 ± 0.055
5.136LeuPro: 5.136 ± 0.081
2.149LeuGln: 2.149 ± 0.055
7.085LeuArg: 7.085 ± 0.122
4.864LeuSer: 4.864 ± 0.081
6.397LeuThr: 6.397 ± 0.095
9.168LeuVal: 9.168 ± 0.136
1.12LeuTrp: 1.12 ± 0.045
1.504LeuTyr: 1.504 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.664MetAla: 2.664 ± 0.063
0.177MetCys: 0.177 ± 0.016
0.999MetAsp: 0.999 ± 0.04
0.862MetGlu: 0.862 ± 0.038
0.65MetPhe: 0.65 ± 0.033
1.676MetGly: 1.676 ± 0.051
0.382MetHis: 0.382 ± 0.024
0.849MetIle: 0.849 ± 0.038
0.663MetLys: 0.663 ± 0.031
2.17MetLeu: 2.17 ± 0.06
0.419MetMet: 0.419 ± 0.023
0.624MetAsn: 0.624 ± 0.026
1.38MetPro: 1.38 ± 0.042
0.592MetGln: 0.592 ± 0.031
1.729MetArg: 1.729 ± 0.049
1.762MetSer: 1.762 ± 0.042
2.05MetThr: 2.05 ± 0.047
1.475MetVal: 1.475 ± 0.043
0.285MetTrp: 0.285 ± 0.016
0.328MetTyr: 0.328 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 0.066
0.154AsnCys: 0.154 ± 0.014
1.251AsnAsp: 1.251 ± 0.042
1.066AsnGlu: 1.066 ± 0.035
0.617AsnPhe: 0.617 ± 0.033
1.954AsnGly: 1.954 ± 0.059
0.448AsnHis: 0.448 ± 0.025
0.824AsnIle: 0.824 ± 0.038
0.57AsnLys: 0.57 ± 0.027
1.988AsnLeu: 1.988 ± 0.055
0.416AsnMet: 0.416 ± 0.027
0.491AsnAsn: 0.491 ± 0.026
1.653AsnPro: 1.653 ± 0.048
0.469AsnGln: 0.469 ± 0.027
1.258AsnArg: 1.258 ± 0.042
1.017AsnSer: 1.017 ± 0.037
1.243AsnThr: 1.243 ± 0.041
1.894AsnVal: 1.894 ± 0.051
0.276AsnTrp: 0.276 ± 0.02
0.467AsnTyr: 0.467 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
6.557ProAla: 6.557 ± 0.12
0.289ProCys: 0.289 ± 0.02
3.724ProAsp: 3.724 ± 0.074
3.446ProGlu: 3.446 ± 0.063
1.613ProPhe: 1.613 ± 0.043
4.974ProGly: 4.974 ± 0.085
1.305ProHis: 1.305 ± 0.04
1.835ProIle: 1.835 ± 0.05
1.485ProLys: 1.485 ± 0.044
4.434ProLeu: 4.434 ± 0.074
1.164ProMet: 1.164 ± 0.041
1.12ProAsn: 1.12 ± 0.041
1.992ProPro: 1.992 ± 0.064
1.793ProGln: 1.793 ± 0.057
3.332ProArg: 3.332 ± 0.077
3.413ProSer: 3.413 ± 0.077
3.326ProThr: 3.326 ± 0.08
4.184ProVal: 4.184 ± 0.069
0.756ProTrp: 0.756 ± 0.03
1.045ProTyr: 1.045 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.629GlnAla: 3.629 ± 0.072
0.191GlnCys: 0.191 ± 0.016
1.309GlnAsp: 1.309 ± 0.041
1.213GlnGlu: 1.213 ± 0.04
0.826GlnPhe: 0.826 ± 0.029
2.198GlnGly: 2.198 ± 0.062
0.802GlnHis: 0.802 ± 0.033
1.392GlnIle: 1.392 ± 0.047
0.716GlnLys: 0.716 ± 0.04
2.957GlnLeu: 2.957 ± 0.063
0.636GlnMet: 0.636 ± 0.038
0.585GlnAsn: 0.585 ± 0.033
1.567GlnPro: 1.567 ± 0.058
1.165GlnGln: 1.165 ± 0.042
2.463GlnArg: 2.463 ± 0.064
1.247GlnSer: 1.247 ± 0.046
1.426GlnThr: 1.426 ± 0.047
2.467GlnVal: 2.467 ± 0.057
0.506GlnTrp: 0.506 ± 0.027
0.629GlnTyr: 0.629 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
8.649ArgAla: 8.649 ± 0.134
0.486ArgCys: 0.486 ± 0.026
4.698ArgAsp: 4.698 ± 0.087
4.791ArgGlu: 4.791 ± 0.109
2.203ArgPhe: 2.203 ± 0.059
5.422ArgGly: 5.422 ± 0.105
1.819ArgHis: 1.819 ± 0.048
3.055ArgIle: 3.055 ± 0.061
1.651ArgLys: 1.651 ± 0.055
7.014ArgLeu: 7.014 ± 0.102
1.826ArgMet: 1.826 ± 0.05
1.225ArgAsn: 1.225 ± 0.04
3.674ArgPro: 3.674 ± 0.076
1.992ArgGln: 1.992 ± 0.053
6.707ArgArg: 6.707 ± 0.135
4.075ArgSer: 4.075 ± 0.073
4.185ArgThr: 4.185 ± 0.092
5.999ArgVal: 5.999 ± 0.11
1.217ArgTrp: 1.217 ± 0.039
1.432ArgTyr: 1.432 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
7.163SerAla: 7.163 ± 0.106
0.378SerCys: 0.378 ± 0.022
3.573SerAsp: 3.573 ± 0.069
2.855SerGlu: 2.855 ± 0.069
1.689SerPhe: 1.689 ± 0.052
5.809SerGly: 5.809 ± 0.101
1.149SerHis: 1.149 ± 0.037
2.157SerIle: 2.157 ± 0.06
1.501SerLys: 1.501 ± 0.053
5.04SerLeu: 5.04 ± 0.086
1.397SerMet: 1.397 ± 0.045
1.266SerAsn: 1.266 ± 0.037
2.953SerPro: 2.953 ± 0.066
1.445SerGln: 1.445 ± 0.041
3.661SerArg: 3.661 ± 0.075
3.99SerSer: 3.99 ± 0.128
3.645SerThr: 3.645 ± 0.084
4.516SerVal: 4.516 ± 0.081
0.912SerTrp: 0.912 ± 0.037
1.187SerTyr: 1.187 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
6.617ThrAla: 6.617 ± 0.099
0.487ThrCys: 0.487 ± 0.027
3.468ThrAsp: 3.468 ± 0.066
2.566ThrGlu: 2.566 ± 0.064
2.009ThrPhe: 2.009 ± 0.05
5.43ThrGly: 5.43 ± 0.09
1.49ThrHis: 1.49 ± 0.047
2.52ThrIle: 2.52 ± 0.067
1.852ThrLys: 1.852 ± 0.061
5.974ThrLeu: 5.974 ± 0.097
1.361ThrMet: 1.361 ± 0.048
1.493ThrAsn: 1.493 ± 0.05
4.202ThrPro: 4.202 ± 0.078
1.751ThrGln: 1.751 ± 0.046
4.113ThrArg: 4.113 ± 0.087
4.188ThrSer: 4.188 ± 0.086
4.166ThrThr: 4.166 ± 0.093
4.769ThrVal: 4.769 ± 0.09
1.037ThrTrp: 1.037 ± 0.039
1.447ThrTyr: 1.447 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
11.572ValAla: 11.572 ± 0.168
0.712ValCys: 0.712 ± 0.032
6.022ValAsp: 6.022 ± 0.094
5.669ValGlu: 5.669 ± 0.089
2.392ValPhe: 2.392 ± 0.053
7.26ValGly: 7.26 ± 0.116
1.785ValHis: 1.785 ± 0.057
4.019ValIle: 4.019 ± 0.084
2.136ValLys: 2.136 ± 0.054
8.544ValLeu: 8.544 ± 0.146
1.965ValMet: 1.965 ± 0.057
1.698ValAsn: 1.698 ± 0.046
4.484ValPro: 4.484 ± 0.075
1.898ValGln: 1.898 ± 0.05
6.049ValArg: 6.049 ± 0.099
4.716ValSer: 4.716 ± 0.078
6.175ValThr: 6.175 ± 0.102
9.248ValVal: 9.248 ± 0.138
1.086ValTrp: 1.086 ± 0.042
1.378ValTyr: 1.378 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.745TrpAla: 1.745 ± 0.048
0.187TrpCys: 0.187 ± 0.018
0.734TrpAsp: 0.734 ± 0.033
0.558TrpGlu: 0.558 ± 0.024
0.585TrpPhe: 0.585 ± 0.032
1.059TrpGly: 1.059 ± 0.032
0.381TrpHis: 0.381 ± 0.024
0.592TrpIle: 0.592 ± 0.029
0.368TrpLys: 0.368 ± 0.025
1.643TrpLeu: 1.643 ± 0.05
0.343TrpMet: 0.343 ± 0.023
0.45TrpAsn: 0.45 ± 0.027
0.74TrpPro: 0.74 ± 0.035
0.54TrpGln: 0.54 ± 0.024
1.257TrpArg: 1.257 ± 0.051
0.924TrpSer: 0.924 ± 0.034
0.752TrpThr: 0.752 ± 0.035
1.168TrpVal: 1.168 ± 0.038
0.34TrpTrp: 0.34 ± 0.024
0.28TrpTyr: 0.28 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.365TyrAla: 2.365 ± 0.062
0.172TyrCys: 0.172 ± 0.016
1.496TyrAsp: 1.496 ± 0.047
1.172TyrGlu: 1.172 ± 0.04
0.625TyrPhe: 0.625 ± 0.029
1.895TyrGly: 1.895 ± 0.05
0.318TyrHis: 0.318 ± 0.021
0.575TyrIle: 0.575 ± 0.034
0.482TyrLys: 0.482 ± 0.027
1.995TyrLeu: 1.995 ± 0.058
0.276TyrMet: 0.276 ± 0.02
0.401TyrAsn: 0.401 ± 0.022
0.988TyrPro: 0.988 ± 0.047
0.493TyrGln: 0.493 ± 0.026
1.408TyrArg: 1.408 ± 0.046
0.965TyrSer: 0.965 ± 0.036
1.071TyrThr: 1.071 ± 0.043
1.781TyrVal: 1.781 ± 0.052
0.308TyrTrp: 0.308 ± 0.023
0.419TyrTyr: 0.419 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2255 proteins (732796 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski