Amino acid dipepetide frequency for Callorhinchus milii (Ghost shark)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.154AlaAla: 5.154 ± 0.022	1.257AlaCys: 1.257 ± 0.007	2.986AlaAsp: 2.986 ± 0.011	4.359AlaGlu: 4.359 ± 0.016	2.472AlaPhe: 2.472 ± 0.011	3.747AlaGly: 3.747 ± 0.015	1.391AlaHis: 1.391 ± 0.008	3.191AlaIle: 3.191 ± 0.011	3.543AlaLys: 3.543 ± 0.016	6.267AlaLeu: 6.267 ± 0.019	1.583AlaMet: 1.583 ± 0.011	2.357AlaAsn: 2.357 ± 0.009	2.737AlaPro: 2.737 ± 0.014	2.752AlaGln: 2.752 ± 0.012	3.008AlaArg: 3.008 ± 0.011	4.833AlaSer: 4.833 ± 0.016	3.333AlaThr: 3.333 ± 0.011	4.621AlaVal: 4.621 ± 0.015	0.664AlaTrp: 0.664 ± 0.006	1.556AlaTyr: 1.556 ± 0.008	0.001AlaXaa: 0.001 ± 0.0
Cys	1.235CysAla: 1.235 ± 0.009	0.646CysCys: 0.646 ± 0.005	1.147CysAsp: 1.147 ± 0.012	1.336CysGlu: 1.336 ± 0.009	0.982CysPhe: 0.982 ± 0.006	1.464CysGly: 1.464 ± 0.011	0.641CysHis: 0.641 ± 0.005	1.226CysIle: 1.226 ± 0.008	1.286CysLys: 1.286 ± 0.009	2.277CysLeu: 2.277 ± 0.011	0.466CysMet: 0.466 ± 0.004	0.96CysAsn: 0.96 ± 0.008	1.183CysPro: 1.183 ± 0.009	1.051CysGln: 1.051 ± 0.008	1.248CysArg: 1.248 ± 0.008	2.008CysSer: 2.008 ± 0.011	1.25CysThr: 1.25 ± 0.008	1.56CysVal: 1.56 ± 0.012	0.29CysTrp: 0.29 ± 0.003	0.64CysTyr: 0.64 ± 0.005	0.001CysXaa: 0.001 ± 0.0
Asp	2.753AspAla: 2.753 ± 0.01	1.18AspCys: 1.18 ± 0.01	2.919AspAsp: 2.919 ± 0.016	3.784AspGlu: 3.784 ± 0.014	2.18AspPhe: 2.18 ± 0.008	3.447AspGly: 3.447 ± 0.018	1.193AspHis: 1.193 ± 0.006	3.027AspIle: 3.027 ± 0.011	2.868AspLys: 2.868 ± 0.011	5.165AspLeu: 5.165 ± 0.014	1.186AspMet: 1.186 ± 0.007	2.077AspAsn: 2.077 ± 0.01	2.627AspPro: 2.627 ± 0.012	2.009AspGln: 2.009 ± 0.01	2.556AspArg: 2.556 ± 0.011	4.077AspSer: 4.077 ± 0.012	2.582AspThr: 2.582 ± 0.009	3.382AspVal: 3.382 ± 0.012	0.694AspTrp: 0.694 ± 0.005	1.718AspTyr: 1.718 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	4.482GluAla: 4.482 ± 0.017	1.365GluCys: 1.365 ± 0.011	4.179GluAsp: 4.179 ± 0.013	7.009GluGlu: 7.009 ± 0.03	2.3GluPhe: 2.3 ± 0.01	3.803GluGly: 3.803 ± 0.012	1.569GluHis: 1.569 ± 0.008	3.646GluIle: 3.646 ± 0.013	5.148GluLys: 5.148 ± 0.021	6.449GluLeu: 6.449 ± 0.021	1.883GluMet: 1.883 ± 0.008	3.272GluAsn: 3.272 ± 0.012	2.467GluPro: 2.467 ± 0.012	3.192GluGln: 3.192 ± 0.013	3.979GluArg: 3.979 ± 0.016	4.395GluSer: 4.395 ± 0.016	3.556GluThr: 3.556 ± 0.013	4.207GluVal: 4.207 ± 0.013	0.755GluTrp: 0.755 ± 0.005	1.851GluTyr: 1.851 ± 0.008	0.001GluXaa: 0.001 ± 0.0
Phe	2.24PheAla: 2.24 ± 0.009	1.011PheCys: 1.011 ± 0.007	1.997PheAsp: 1.997 ± 0.008	2.21PheGlu: 2.21 ± 0.009	1.701PhePhe: 1.701 ± 0.01	2.317PheGly: 2.317 ± 0.011	1.108PheHis: 1.108 ± 0.006	2.17PheIle: 2.17 ± 0.011	2.048PheLys: 2.048 ± 0.008	4.107PheLeu: 4.107 ± 0.015	0.835PheMet: 0.835 ± 0.006	1.69PheAsn: 1.69 ± 0.008	1.894PhePro: 1.894 ± 0.009	1.806PheGln: 1.806 ± 0.008	1.951PheArg: 1.951 ± 0.009	3.297PheSer: 3.297 ± 0.012	2.358PheThr: 2.358 ± 0.01	2.439PheVal: 2.439 ± 0.009	0.511PheTrp: 0.511 ± 0.005	1.32PheTyr: 1.32 ± 0.008	0.001PheXaa: 0.001 ± 0.0
Gly	3.433GlyAla: 3.433 ± 0.015	1.207GlyCys: 1.207 ± 0.009	3.019GlyAsp: 3.019 ± 0.012	3.714GlyGlu: 3.714 ± 0.014	2.441GlyPhe: 2.441 ± 0.011	4.105GlyGly: 4.105 ± 0.017	1.528GlyHis: 1.528 ± 0.008	3.166GlyIle: 3.166 ± 0.013	3.908GlyLys: 3.908 ± 0.012	5.206GlyLeu: 5.206 ± 0.014	1.417GlyMet: 1.417 ± 0.008	2.668GlyAsn: 2.668 ± 0.011	2.522GlyPro: 2.522 ± 0.019	2.522GlyGln: 2.522 ± 0.01	3.243GlyArg: 3.243 ± 0.015	5.043GlySer: 5.043 ± 0.016	3.458GlyThr: 3.458 ± 0.013	3.579GlyVal: 3.579 ± 0.013	0.776GlyTrp: 0.776 ± 0.006	1.904GlyTyr: 1.904 ± 0.011	0.001GlyXaa: 0.001 ± 0.0
His	1.219HisAla: 1.219 ± 0.006	0.761HisCys: 0.761 ± 0.006	1.011HisAsp: 1.011 ± 0.005	1.351HisGlu: 1.351 ± 0.007	1.131HisPhe: 1.131 ± 0.006	1.462HisGly: 1.462 ± 0.008	0.892HisHis: 0.892 ± 0.006	1.422HisIle: 1.422 ± 0.007	1.365HisLys: 1.365 ± 0.007	2.782HisLeu: 2.782 ± 0.01	0.586HisMet: 0.586 ± 0.004	1.07HisAsn: 1.07 ± 0.006	1.48HisPro: 1.48 ± 0.008	1.236HisGln: 1.236 ± 0.008	1.516HisArg: 1.516 ± 0.008	2.368HisSer: 2.368 ± 0.014	1.51HisThr: 1.51 ± 0.011	1.545HisVal: 1.545 ± 0.008	0.36HisTrp: 0.36 ± 0.003	0.899HisTyr: 0.899 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	3.134IleAla: 3.134 ± 0.01	1.271IleCys: 1.271 ± 0.007	2.647IleAsp: 2.647 ± 0.01	3.138IleGlu: 3.138 ± 0.012	2.22IlePhe: 2.22 ± 0.012	2.721IleGly: 2.721 ± 0.011	1.445IleHis: 1.445 ± 0.008	3.086IleIle: 3.086 ± 0.013	3.093IleLys: 3.093 ± 0.011	5.164IleLeu: 5.164 ± 0.015	1.176IleMet: 1.176 ± 0.006	2.458IleAsn: 2.458 ± 0.009	2.798IlePro: 2.798 ± 0.01	2.582IleGln: 2.582 ± 0.011	2.713IleArg: 2.713 ± 0.01	4.194IleSer: 4.194 ± 0.013	3.07IleThr: 3.07 ± 0.015	3.228IleVal: 3.228 ± 0.013	0.587IleTrp: 0.587 ± 0.004	1.649IleTyr: 1.649 ± 0.009	0.001IleXaa: 0.001 ± 0.0
Lys	3.887LysAla: 3.887 ± 0.017	1.246LysCys: 1.246 ± 0.009	3.421LysAsp: 3.421 ± 0.012	5.109LysGlu: 5.109 ± 0.019	1.931LysPhe: 1.931 ± 0.009	3.246LysGly: 3.246 ± 0.015	1.556LysHis: 1.556 ± 0.008	3.231LysIle: 3.231 ± 0.012	4.602LysLys: 4.602 ± 0.021	5.894LysLeu: 5.894 ± 0.018	1.579LysMet: 1.579 ± 0.008	2.651LysAsn: 2.651 ± 0.012	2.824LysPro: 2.824 ± 0.012	2.902LysGln: 2.902 ± 0.012	3.455LysArg: 3.455 ± 0.013	4.096LysSer: 4.096 ± 0.017	3.228LysThr: 3.228 ± 0.012	3.808LysVal: 3.808 ± 0.013	0.689LysTrp: 0.689 ± 0.005	1.841LysTyr: 1.841 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.011LeuAla: 6.011 ± 0.018	2.29LeuCys: 2.29 ± 0.012	4.948LeuAsp: 4.948 ± 0.014	6.805LeuGlu: 6.805 ± 0.022	3.787LeuPhe: 3.787 ± 0.015	5.07LeuGly: 5.07 ± 0.016	2.785LeuHis: 2.785 ± 0.011	4.568LeuIle: 4.568 ± 0.015	6.289LeuLys: 6.289 ± 0.017	10.091LeuLeu: 10.091 ± 0.032	2.2LeuMet: 2.2 ± 0.01	4.185LeuAsn: 4.185 ± 0.012	5.031LeuPro: 5.031 ± 0.015	5.634LeuGln: 5.634 ± 0.02	5.321LeuArg: 5.321 ± 0.017	8.018LeuSer: 8.018 ± 0.025	5.371LeuThr: 5.371 ± 0.015	5.522LeuVal: 5.522 ± 0.016	1.112LeuTrp: 1.112 ± 0.008	2.873LeuTyr: 2.873 ± 0.011	0.001LeuXaa: 0.001 ± 0.0
Met	1.713MetAla: 1.713 ± 0.008	0.507MetCys: 0.507 ± 0.004	1.38MetAsp: 1.38 ± 0.006	1.907MetGlu: 1.907 ± 0.008	0.926MetPhe: 0.926 ± 0.006	1.304MetGly: 1.304 ± 0.008	0.526MetHis: 0.526 ± 0.004	1.078MetIle: 1.078 ± 0.007	1.612MetLys: 1.612 ± 0.008	2.159MetLeu: 2.159 ± 0.01	0.639MetMet: 0.639 ± 0.005	1.08MetAsn: 1.08 ± 0.007	1.032MetPro: 1.032 ± 0.01	1.047MetGln: 1.047 ± 0.007	1.109MetArg: 1.109 ± 0.006	1.676MetSer: 1.676 ± 0.007	1.222MetThr: 1.222 ± 0.006	1.533MetVal: 1.533 ± 0.008	0.269MetTrp: 0.269 ± 0.003	0.713MetTyr: 0.713 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.396AsnAla: 2.396 ± 0.009	1.047AsnCys: 1.047 ± 0.009	1.934AsnAsp: 1.934 ± 0.009	2.646AsnGlu: 2.646 ± 0.011	1.687AsnPhe: 1.687 ± 0.008	2.84AsnGly: 2.84 ± 0.014	1.065AsnHis: 1.065 ± 0.006	2.698AsnIle: 2.698 ± 0.01	2.65AsnLys: 2.65 ± 0.011	4.276AsnLeu: 4.276 ± 0.013	1.064AsnMet: 1.064 ± 0.006	2.042AsnAsn: 2.042 ± 0.01	2.373AsnPro: 2.373 ± 0.012	1.883AsnGln: 1.883 ± 0.009	2.161AsnArg: 2.161 ± 0.009	3.5AsnSer: 3.5 ± 0.013	2.372AsnThr: 2.372 ± 0.009	2.741AsnVal: 2.741 ± 0.01	0.523AsnTrp: 0.523 ± 0.005	1.358AsnTyr: 1.358 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	3.235ProAla: 3.235 ± 0.013	0.979ProCys: 0.979 ± 0.008	2.621ProAsp: 2.621 ± 0.012	3.556ProGlu: 3.556 ± 0.013	1.845ProPhe: 1.845 ± 0.009	3.529ProGly: 3.529 ± 0.027	1.334ProHis: 1.334 ± 0.009	2.168ProIle: 2.168 ± 0.009	2.545ProLys: 2.545 ± 0.01	4.408ProLeu: 4.408 ± 0.015	0.947ProMet: 0.947 ± 0.006	2.011ProAsn: 2.011 ± 0.009	4.003ProPro: 4.003 ± 0.026	2.23ProGln: 2.23 ± 0.011	2.404ProArg: 2.404 ± 0.011	4.611ProSer: 4.611 ± 0.016	2.861ProThr: 2.861 ± 0.011	3.396ProVal: 3.396 ± 0.014	0.536ProTrp: 0.536 ± 0.004	1.366ProTyr: 1.366 ± 0.008	0.002ProXaa: 0.002 ± 0.0
Gln	3.017GlnAla: 3.017 ± 0.013	1.045GlnCys: 1.045 ± 0.008	2.237GlnAsp: 2.237 ± 0.009	3.49GlnGlu: 3.49 ± 0.014	1.57GlnPhe: 1.57 ± 0.007	2.457GlnGly: 2.457 ± 0.011	1.322GlnHis: 1.322 ± 0.007	2.4GlnIle: 2.4 ± 0.008	2.867GlnLys: 2.867 ± 0.013	4.729GlnLeu: 4.729 ± 0.017	1.21GlnMet: 1.21 ± 0.007	2.045GlnAsn: 2.045 ± 0.009	2.297GlnPro: 2.297 ± 0.013	3.135GlnGln: 3.135 ± 0.021	2.729GlnArg: 2.729 ± 0.011	3.299GlnSer: 3.299 ± 0.013	2.531GlnThr: 2.531 ± 0.01	2.809GlnVal: 2.809 ± 0.01	0.582GlnTrp: 0.582 ± 0.005	1.364GlnTyr: 1.364 ± 0.007	0.001GlnXaa: 0.001 ± 0.0
Arg	3.108ArgAla: 3.108 ± 0.012	1.205ArgCys: 1.205 ± 0.009	2.725ArgAsp: 2.725 ± 0.011	3.739ArgGlu: 3.739 ± 0.016	1.987ArgPhe: 1.987 ± 0.009	2.963ArgGly: 2.963 ± 0.012	1.427ArgHis: 1.427 ± 0.008	2.744ArgIle: 2.744 ± 0.01	3.695ArgLys: 3.695 ± 0.013	5.113ArgLeu: 5.113 ± 0.014	1.272ArgMet: 1.272 ± 0.006	2.388ArgAsn: 2.388 ± 0.009	2.421ArgPro: 2.421 ± 0.011	2.514ArgGln: 2.514 ± 0.011	3.594ArgArg: 3.594 ± 0.015	3.998ArgSer: 3.998 ± 0.014	2.799ArgThr: 2.799 ± 0.009	3.087ArgVal: 3.087 ± 0.012	0.661ArgTrp: 0.661 ± 0.006	1.596ArgTyr: 1.596 ± 0.007	0.001ArgXaa: 0.001 ± 0.0
Ser	4.918SerAla: 4.918 ± 0.016	1.77SerCys: 1.77 ± 0.01	4.063SerAsp: 4.063 ± 0.016	4.965SerGlu: 4.965 ± 0.018	3.093SerPhe: 3.093 ± 0.012	5.028SerGly: 5.028 ± 0.016	2.13SerHis: 2.13 ± 0.016	3.862SerIle: 3.862 ± 0.014	4.297SerLys: 4.297 ± 0.015	8.046SerLeu: 8.046 ± 0.025	1.682SerMet: 1.682 ± 0.007	3.29SerAsn: 3.29 ± 0.011	4.931SerPro: 4.931 ± 0.02	3.554SerGln: 3.554 ± 0.013	4.034SerArg: 4.034 ± 0.015	8.136SerSer: 8.136 ± 0.032	4.589SerThr: 4.589 ± 0.016	5.16SerVal: 5.16 ± 0.013	0.92SerTrp: 0.92 ± 0.006	2.132SerTyr: 2.132 ± 0.01	0.001SerXaa: 0.001 ± 0.0
Thr	3.784ThrAla: 3.784 ± 0.011	1.361ThrCys: 1.361 ± 0.012	2.884ThrAsp: 2.884 ± 0.011	3.79ThrGlu: 3.79 ± 0.014	2.285ThrPhe: 2.285 ± 0.009	3.574ThrGly: 3.574 ± 0.013	1.38ThrHis: 1.38 ± 0.011	2.919ThrIle: 2.919 ± 0.011	2.928ThrLys: 2.928 ± 0.01	5.435ThrLeu: 5.435 ± 0.017	1.195ThrMet: 1.195 ± 0.007	2.152ThrAsn: 2.152 ± 0.009	3.121ThrPro: 3.121 ± 0.013	2.267ThrGln: 2.267 ± 0.01	2.445ThrArg: 2.445 ± 0.01	4.638ThrSer: 4.638 ± 0.016	3.088ThrThr: 3.088 ± 0.016	4.152ThrVal: 4.152 ± 0.016	0.676ThrTrp: 0.676 ± 0.006	1.546ThrTyr: 1.546 ± 0.008	0.0ThrXaa: 0.0 ± 0.0
Val	3.99ValAla: 3.99 ± 0.014	1.693ValCys: 1.693 ± 0.011	3.173ValAsp: 3.173 ± 0.011	4.051ValGlu: 4.051 ± 0.011	2.578ValPhe: 2.578 ± 0.01	3.415ValGly: 3.415 ± 0.011	1.568ValHis: 1.568 ± 0.007	3.354ValIle: 3.354 ± 0.012	3.882ValLys: 3.882 ± 0.012	6.161ValLeu: 6.161 ± 0.018	1.473ValMet: 1.473 ± 0.008	2.821ValAsn: 2.821 ± 0.011	3.095ValPro: 3.095 ± 0.012	2.937ValGln: 2.937 ± 0.01	3.208ValArg: 3.208 ± 0.011	5.099ValSer: 5.099 ± 0.015	3.987ValThr: 3.987 ± 0.015	4.079ValVal: 4.079 ± 0.015	0.775ValTrp: 0.775 ± 0.005	1.896ValTyr: 1.896 ± 0.009	0.001ValXaa: 0.001 ± 0.0
Trp	0.66TrpAla: 0.66 ± 0.005	0.273TrpCys: 0.273 ± 0.003	0.663TrpAsp: 0.663 ± 0.005	0.78TrpGlu: 0.78 ± 0.005	0.476TrpPhe: 0.476 ± 0.004	0.656TrpGly: 0.656 ± 0.006	0.285TrpHis: 0.285 ± 0.003	0.667TrpIle: 0.667 ± 0.005	0.846TrpLys: 0.846 ± 0.005	1.225TrpLeu: 1.225 ± 0.008	0.333TrpMet: 0.333 ± 0.004	0.625TrpAsn: 0.625 ± 0.005	0.437TrpPro: 0.437 ± 0.004	0.558TrpGln: 0.558 ± 0.005	0.667TrpArg: 0.667 ± 0.006	0.899TrpSer: 0.899 ± 0.006	0.708TrpThr: 0.708 ± 0.006	0.683TrpVal: 0.683 ± 0.006	0.211TrpTrp: 0.211 ± 0.003	0.372TrpTyr: 0.372 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.439TyrAla: 1.439 ± 0.007	0.782TyrCys: 0.782 ± 0.006	1.468TyrAsp: 1.468 ± 0.008	1.768TyrGlu: 1.768 ± 0.009	1.418TyrPhe: 1.418 ± 0.007	1.711TyrGly: 1.711 ± 0.007	0.82TyrHis: 0.82 ± 0.005	1.753TyrIle: 1.753 ± 0.008	1.725TyrLys: 1.725 ± 0.011	2.959TyrLeu: 2.959 ± 0.012	0.707TyrMet: 0.707 ± 0.005	1.412TyrAsn: 1.412 ± 0.007	1.312TyrPro: 1.312 ± 0.009	1.324TyrGln: 1.324 ± 0.006	1.694TyrArg: 1.694 ± 0.009	2.416TyrSer: 2.416 ± 0.01	1.747TyrThr: 1.747 ± 0.009	1.703TyrVal: 1.703 ± 0.007	0.436TyrTrp: 0.436 ± 0.006	1.104TyrTyr: 1.104 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.402XaaXaa: 0.402 ± 0.044

Statistics based on 49245 proteins (31969766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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