Amino acid dipepetide frequency for Zostera marina (Eelgrass)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.796AlaAla: 4.796 ± 0.034	1.127AlaCys: 1.127 ± 0.014	2.817AlaAsp: 2.817 ± 0.021	3.436AlaGlu: 3.436 ± 0.034	2.504AlaPhe: 2.504 ± 0.018	3.592AlaGly: 3.592 ± 0.025	1.149AlaHis: 1.149 ± 0.012	3.806AlaIle: 3.806 ± 0.025	3.533AlaLys: 3.533 ± 0.05	5.573AlaLeu: 5.573 ± 0.032	1.755AlaMet: 1.755 ± 0.015	2.422AlaAsn: 2.422 ± 0.024	2.245AlaPro: 2.245 ± 0.021	1.674AlaGln: 1.674 ± 0.016	2.913AlaArg: 2.913 ± 0.022	5.354AlaSer: 5.354 ± 0.027	3.341AlaThr: 3.341 ± 0.024	4.391AlaVal: 4.391 ± 0.027	0.643AlaTrp: 0.643 ± 0.009	1.619AlaTyr: 1.619 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.908CysAla: 0.908 ± 0.01	0.52CysCys: 0.52 ± 0.01	0.923CysAsp: 0.923 ± 0.013	0.834CysGlu: 0.834 ± 0.01	0.916CysPhe: 0.916 ± 0.011	1.355CysGly: 1.355 ± 0.016	0.494CysHis: 0.494 ± 0.009	1.11CysIle: 1.11 ± 0.013	1.133CysLys: 1.133 ± 0.015	1.815CysLeu: 1.815 ± 0.017	0.462CysMet: 0.462 ± 0.008	0.938CysAsn: 0.938 ± 0.015	0.861CysPro: 0.861 ± 0.012	0.606CysGln: 0.606 ± 0.01	1.12CysArg: 1.12 ± 0.012	1.917CysSer: 1.917 ± 0.018	0.878CysThr: 0.878 ± 0.011	1.114CysVal: 1.114 ± 0.012	0.23CysTrp: 0.23 ± 0.006	0.568CysTyr: 0.568 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.278AspAla: 3.278 ± 0.023	1.008AspCys: 1.008 ± 0.013	4.176AspAsp: 4.176 ± 0.032	4.063AspGlu: 4.063 ± 0.028	2.542AspPhe: 2.542 ± 0.019	4.076AspGly: 4.076 ± 0.028	1.39AspHis: 1.39 ± 0.013	3.522AspIle: 3.522 ± 0.022	2.803AspLys: 2.803 ± 0.02	5.22AspLeu: 5.22 ± 0.025	1.437AspMet: 1.437 ± 0.013	2.346AspAsn: 2.346 ± 0.019	2.471AspPro: 2.471 ± 0.017	1.687AspGln: 1.687 ± 0.016	2.595AspArg: 2.595 ± 0.022	4.43AspSer: 4.43 ± 0.026	2.354AspThr: 2.354 ± 0.016	4.055AspVal: 4.055 ± 0.024	0.711AspTrp: 0.711 ± 0.009	1.581AspTyr: 1.581 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	3.909GluAla: 3.909 ± 0.036	0.908GluCys: 0.908 ± 0.012	3.959GluAsp: 3.959 ± 0.03	6.002GluGlu: 6.002 ± 0.044	2.416GluPhe: 2.416 ± 0.017	3.204GluGly: 3.204 ± 0.024	1.24GluHis: 1.24 ± 0.013	4.252GluIle: 4.252 ± 0.027	4.944GluLys: 4.944 ± 0.033	5.263GluLeu: 5.263 ± 0.03	1.909GluMet: 1.909 ± 0.02	3.465GluAsn: 3.465 ± 0.027	1.734GluPro: 1.734 ± 0.017	1.927GluGln: 1.927 ± 0.019	3.128GluArg: 3.128 ± 0.025	4.492GluSer: 4.492 ± 0.029	3.037GluThr: 3.037 ± 0.019	3.844GluVal: 3.844 ± 0.026	0.684GluTrp: 0.684 ± 0.01	1.695GluTyr: 1.695 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	2.377PheAla: 2.377 ± 0.02	0.944PheCys: 0.944 ± 0.012	2.584PheAsp: 2.584 ± 0.019	2.301PheGlu: 2.301 ± 0.019	2.29PhePhe: 2.29 ± 0.019	3.063PheGly: 3.063 ± 0.026	1.214PheHis: 1.214 ± 0.013	2.444PheIle: 2.444 ± 0.02	2.242PheLys: 2.242 ± 0.018	4.514PheLeu: 4.514 ± 0.028	0.999PheMet: 0.999 ± 0.012	1.921PheAsn: 1.921 ± 0.014	2.105PhePro: 2.105 ± 0.017	1.607PheGln: 1.607 ± 0.015	2.153PheArg: 2.153 ± 0.016	4.306PheSer: 4.306 ± 0.024	2.118PheThr: 2.118 ± 0.016	2.779PheVal: 2.779 ± 0.021	0.563PheTrp: 0.563 ± 0.009	1.348PheTyr: 1.348 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.213GlyAla: 3.213 ± 0.023	1.283GlyCys: 1.283 ± 0.015	3.443GlyAsp: 3.443 ± 0.025	3.401GlyGlu: 3.401 ± 0.022	3.174GlyPhe: 3.174 ± 0.024	5.465GlyGly: 5.465 ± 0.051	1.456GlyHis: 1.456 ± 0.015	3.929GlyIle: 3.929 ± 0.025	4.125GlyLys: 4.125 ± 0.022	5.386GlyLeu: 5.386 ± 0.034	1.6GlyMet: 1.6 ± 0.016	3.198GlyAsn: 3.198 ± 0.024	1.9GlyPro: 1.9 ± 0.015	1.754GlyGln: 1.754 ± 0.018	3.634GlyArg: 3.634 ± 0.026	5.687GlySer: 5.687 ± 0.036	3.079GlyThr: 3.079 ± 0.02	4.1GlyVal: 4.1 ± 0.027	0.841GlyTrp: 0.841 ± 0.01	2.058GlyTyr: 2.058 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.327HisAla: 1.327 ± 0.013	0.517HisCys: 0.517 ± 0.009	1.212HisAsp: 1.212 ± 0.012	1.201HisGlu: 1.201 ± 0.015	1.065HisPhe: 1.065 ± 0.012	1.729HisGly: 1.729 ± 0.017	1.062HisHis: 1.062 ± 0.018	1.366HisIle: 1.366 ± 0.013	1.126HisLys: 1.126 ± 0.012	2.449HisLeu: 2.449 ± 0.021	0.581HisMet: 0.581 ± 0.009	1.065HisAsn: 1.065 ± 0.012	1.388HisPro: 1.388 ± 0.015	1.046HisGln: 1.046 ± 0.012	1.528HisArg: 1.528 ± 0.015	2.128HisSer: 2.128 ± 0.018	1.097HisThr: 1.097 ± 0.011	1.542HisVal: 1.542 ± 0.015	0.298HisTrp: 0.298 ± 0.007	0.729HisTyr: 0.729 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.744IleAla: 3.744 ± 0.023	1.229IleCys: 1.229 ± 0.013	3.549IleAsp: 3.549 ± 0.023	3.544IleGlu: 3.544 ± 0.024	2.827IlePhe: 2.827 ± 0.023	3.83IleGly: 3.83 ± 0.023	1.609IleHis: 1.609 ± 0.014	3.562IleIle: 3.562 ± 0.027	3.429IleLys: 3.429 ± 0.022	5.915IleLeu: 5.915 ± 0.028	1.327IleMet: 1.327 ± 0.013	2.672IleAsn: 2.672 ± 0.019	3.264IlePro: 3.264 ± 0.023	2.244IleGln: 2.244 ± 0.018	2.915IleArg: 2.915 ± 0.02	5.828IleSer: 5.828 ± 0.031	3.168IleThr: 3.168 ± 0.021	3.862IleVal: 3.862 ± 0.022	0.723IleTrp: 0.723 ± 0.011	1.717IleTyr: 1.717 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.481LysAla: 3.481 ± 0.04	1.028LysCys: 1.028 ± 0.012	3.412LysAsp: 3.412 ± 0.023	4.584LysGlu: 4.584 ± 0.031	2.282LysPhe: 2.282 ± 0.016	3.265LysGly: 3.265 ± 0.024	1.441LysHis: 1.441 ± 0.015	4.11LysIle: 4.11 ± 0.024	5.713LysLys: 5.713 ± 0.041	5.853LysLeu: 5.853 ± 0.03	1.823LysMet: 1.823 ± 0.017	3.417LysAsn: 3.417 ± 0.026	2.49LysPro: 2.49 ± 0.021	2.204LysGln: 2.204 ± 0.018	3.566LysArg: 3.566 ± 0.026	5.066LysSer: 5.066 ± 0.029	3.312LysThr: 3.312 ± 0.023	3.676LysVal: 3.676 ± 0.02	0.803LysTrp: 0.803 ± 0.011	1.807LysTyr: 1.807 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	5.576LeuAla: 5.576 ± 0.026	1.782LeuCys: 1.782 ± 0.016	5.104LeuAsp: 5.104 ± 0.03	5.814LeuGlu: 5.814 ± 0.033	4.07LeuPhe: 4.07 ± 0.026	5.289LeuGly: 5.289 ± 0.028	2.572LeuHis: 2.572 ± 0.019	5.072LeuIle: 5.072 ± 0.032	6.097LeuLys: 6.097 ± 0.027	9.724LeuLeu: 9.724 ± 0.05	2.19LeuMet: 2.19 ± 0.018	4.149LeuAsn: 4.149 ± 0.025	4.867LeuPro: 4.867 ± 0.032	3.956LeuGln: 3.956 ± 0.027	5.09LeuArg: 5.09 ± 0.03	8.325LeuSer: 8.325 ± 0.034	4.4LeuThr: 4.4 ± 0.026	5.987LeuVal: 5.987 ± 0.03	1.06LeuTrp: 1.06 ± 0.011	2.442LeuTyr: 2.442 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	1.958MetAla: 1.958 ± 0.016	0.375MetCys: 0.375 ± 0.007	1.652MetAsp: 1.652 ± 0.016	2.136MetGlu: 2.136 ± 0.016	0.97MetPhe: 0.97 ± 0.012	1.603MetGly: 1.603 ± 0.015	0.554MetHis: 0.554 ± 0.008	1.538MetIle: 1.538 ± 0.016	1.848MetLys: 1.848 ± 0.015	2.193MetLeu: 2.193 ± 0.018	0.821MetMet: 0.821 ± 0.011	1.226MetAsn: 1.226 ± 0.014	1.026MetPro: 1.026 ± 0.012	0.904MetGln: 0.904 ± 0.011	1.202MetArg: 1.202 ± 0.012	1.982MetSer: 1.982 ± 0.015	1.272MetThr: 1.272 ± 0.013	1.85MetVal: 1.85 ± 0.016	0.264MetTrp: 0.264 ± 0.007	0.692MetTyr: 0.692 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.653AsnAla: 2.653 ± 0.027	0.906AsnCys: 0.906 ± 0.012	2.609AsnAsp: 2.609 ± 0.019	2.715AsnGlu: 2.715 ± 0.022	2.023AsnPhe: 2.023 ± 0.016	3.27AsnGly: 3.27 ± 0.023	1.308AsnHis: 1.308 ± 0.014	3.166AsnIle: 3.166 ± 0.023	2.747AsnLys: 2.747 ± 0.021	4.741AsnLeu: 4.741 ± 0.03	1.311AsnMet: 1.311 ± 0.014	2.735AsnAsn: 2.735 ± 0.024	2.454AsnPro: 2.454 ± 0.02	1.787AsnGln: 1.787 ± 0.017	2.238AsnArg: 2.238 ± 0.018	4.357AsnSer: 4.357 ± 0.026	2.468AsnThr: 2.468 ± 0.018	2.99AsnVal: 2.99 ± 0.021	0.578AsnTrp: 0.578 ± 0.009	1.433AsnTyr: 1.433 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	2.305ProAla: 2.305 ± 0.019	0.742ProCys: 0.742 ± 0.011	2.388ProAsp: 2.388 ± 0.022	2.732ProGlu: 2.732 ± 0.019	1.972ProPhe: 1.972 ± 0.017	2.256ProGly: 2.256 ± 0.017	1.023ProHis: 1.023 ± 0.013	2.657ProIle: 2.657 ± 0.019	2.6ProLys: 2.6 ± 0.02	3.992ProLeu: 3.992 ± 0.028	1.025ProMet: 1.025 ± 0.013	2.392ProAsn: 2.392 ± 0.023	3.541ProPro: 3.541 ± 0.056	1.541ProGln: 1.541 ± 0.018	2.109ProArg: 2.109 ± 0.018	4.938ProSer: 4.938 ± 0.038	2.745ProThr: 2.745 ± 0.023	2.813ProVal: 2.813 ± 0.019	0.567ProTrp: 0.567 ± 0.009	1.248ProTyr: 1.248 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	1.896GlnAla: 1.896 ± 0.015	0.571GlnCys: 0.571 ± 0.009	1.538GlnAsp: 1.538 ± 0.014	2.041GlnGlu: 2.041 ± 0.019	1.397GlnPhe: 1.397 ± 0.012	1.788GlnGly: 1.788 ± 0.015	0.942GlnHis: 0.942 ± 0.012	2.252GlnIle: 2.252 ± 0.017	2.425GlnLys: 2.425 ± 0.016	3.225GlnLeu: 3.225 ± 0.022	1.017GlnMet: 1.017 ± 0.012	1.91GlnAsn: 1.91 ± 0.018	1.518GlnPro: 1.518 ± 0.018	1.931GlnGln: 1.931 ± 0.032	1.951GlnArg: 1.951 ± 0.016	2.795GlnSer: 2.795 ± 0.022	1.867GlnThr: 1.867 ± 0.017	2.101GlnVal: 2.101 ± 0.019	0.43GlnTrp: 0.43 ± 0.007	0.914GlnTyr: 0.914 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	2.612ArgAla: 2.612 ± 0.019	1.042ArgCys: 1.042 ± 0.012	2.594ArgAsp: 2.594 ± 0.021	3.107ArgGlu: 3.107 ± 0.028	2.354ArgPhe: 2.354 ± 0.019	2.962ArgGly: 2.962 ± 0.024	1.299ArgHis: 1.299 ± 0.014	3.189ArgIle: 3.189 ± 0.02	3.916ArgLys: 3.916 ± 0.027	4.803ArgLeu: 4.803 ± 0.026	1.402ArgMet: 1.402 ± 0.015	2.745ArgAsn: 2.745 ± 0.021	2.105ArgPro: 2.105 ± 0.02	1.79ArgGln: 1.79 ± 0.018	4.195ArgArg: 4.195 ± 0.035	4.589ArgSer: 4.589 ± 0.028	2.454ArgThr: 2.454 ± 0.019	2.993ArgVal: 2.993 ± 0.022	0.741ArgTrp: 0.741 ± 0.01	1.534ArgTyr: 1.534 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	4.914SerAla: 4.914 ± 0.027	1.689SerCys: 1.689 ± 0.014	4.941SerAsp: 4.941 ± 0.027	4.874SerGlu: 4.874 ± 0.028	4.152SerPhe: 4.152 ± 0.024	5.797SerGly: 5.797 ± 0.039	2.018SerHis: 2.018 ± 0.018	5.447SerIle: 5.447 ± 0.028	5.277SerLys: 5.277 ± 0.028	8.376SerLeu: 8.376 ± 0.037	2.3SerMet: 2.3 ± 0.017	4.479SerAsn: 4.479 ± 0.03	4.4SerPro: 4.4 ± 0.044	2.914SerGln: 2.914 ± 0.021	4.353SerArg: 4.353 ± 0.029	11.678SerSer: 11.678 ± 0.057	5.334SerThr: 5.334 ± 0.03	5.456SerVal: 5.456 ± 0.027	1.077SerTrp: 1.077 ± 0.013	2.378SerTyr: 2.378 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	3.325ThrAla: 3.325 ± 0.023	0.989ThrCys: 0.989 ± 0.011	2.6ThrAsp: 2.6 ± 0.019	2.779ThrGlu: 2.779 ± 0.019	2.152ThrPhe: 2.152 ± 0.015	3.344ThrGly: 3.344 ± 0.022	1.156ThrHis: 1.156 ± 0.012	3.237ThrIle: 3.237 ± 0.019	2.935ThrLys: 2.935 ± 0.018	4.603ThrLeu: 4.603 ± 0.025	1.349ThrMet: 1.349 ± 0.015	2.439ThrAsn: 2.439 ± 0.02	2.616ThrPro: 2.616 ± 0.023	1.559ThrGln: 1.559 ± 0.015	2.362ThrArg: 2.362 ± 0.018	5.074ThrSer: 5.074 ± 0.027	3.619ThrThr: 3.619 ± 0.027	3.536ThrVal: 3.536 ± 0.022	0.62ThrTrp: 0.62 ± 0.009	1.46ThrTyr: 1.46 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.141ValAla: 4.141 ± 0.026	1.188ValCys: 1.188 ± 0.013	3.996ValAsp: 3.996 ± 0.022	4.255ValGlu: 4.255 ± 0.027	2.906ValPhe: 2.906 ± 0.021	4.12ValGly: 4.12 ± 0.025	1.48ValHis: 1.48 ± 0.015	3.828ValIle: 3.828 ± 0.024	3.878ValLys: 3.878 ± 0.023	6.035ValLeu: 6.035 ± 0.031	1.605ValMet: 1.605 ± 0.017	2.751ValAsn: 2.751 ± 0.019	2.939ValPro: 2.939 ± 0.021	2.068ValGln: 2.068 ± 0.016	3.08ValArg: 3.08 ± 0.022	5.522ValSer: 5.522 ± 0.027	3.204ValThr: 3.204 ± 0.019	5.078ValVal: 5.078 ± 0.033	0.722ValTrp: 0.722 ± 0.01	1.866ValTyr: 1.866 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.674TrpAla: 0.674 ± 0.01	0.216TrpCys: 0.216 ± 0.004	0.65TrpAsp: 0.65 ± 0.01	0.684TrpGlu: 0.684 ± 0.01	0.527TrpPhe: 0.527 ± 0.009	0.678TrpGly: 0.678 ± 0.011	0.271TrpHis: 0.271 ± 0.007	0.786TrpIle: 0.786 ± 0.011	0.978TrpLys: 0.978 ± 0.01	1.074TrpLeu: 1.074 ± 0.011	0.363TrpMet: 0.363 ± 0.007	0.785TrpAsn: 0.785 ± 0.013	0.431TrpPro: 0.431 ± 0.007	0.372TrpGln: 0.372 ± 0.007	0.762TrpArg: 0.762 ± 0.011	0.974TrpSer: 0.974 ± 0.011	0.616TrpThr: 0.616 ± 0.008	0.75TrpVal: 0.75 ± 0.01	0.221TrpTrp: 0.221 ± 0.006	0.344TrpTyr: 0.344 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.606TyrAla: 1.606 ± 0.017	0.639TyrCys: 0.639 ± 0.011	1.598TyrAsp: 1.598 ± 0.016	1.509TyrGlu: 1.509 ± 0.015	1.334TyrPhe: 1.334 ± 0.013	2.043TyrGly: 2.043 ± 0.019	0.779TyrHis: 0.779 ± 0.011	1.682TyrIle: 1.682 ± 0.016	1.585TyrLys: 1.585 ± 0.016	2.81TyrLeu: 2.81 ± 0.022	0.79TyrMet: 0.79 ± 0.011	1.435TyrAsn: 1.435 ± 0.015	1.232TyrPro: 1.232 ± 0.014	0.936TyrGln: 0.936 ± 0.012	1.53TyrArg: 1.53 ± 0.015	2.409TyrSer: 2.409 ± 0.017	1.393TyrThr: 1.393 ± 0.014	1.745TyrVal: 1.745 ± 0.015	0.379TyrTrp: 0.379 ± 0.008	0.998TyrTyr: 0.998 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20559 proteins (7987506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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