Amino acid dipepetide frequency for Loktanella atrilutea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.724AlaAla: 18.724 ± 0.233	1.252AlaCys: 1.252 ± 0.033	8.343AlaAsp: 8.343 ± 0.105	7.157AlaGlu: 7.157 ± 0.098	4.31AlaPhe: 4.31 ± 0.058	11.085AlaGly: 11.085 ± 0.128	2.241AlaHis: 2.241 ± 0.041	6.187AlaIle: 6.187 ± 0.074	3.435AlaLys: 3.435 ± 0.075	13.92AlaLeu: 13.92 ± 0.139	4.041AlaMet: 4.041 ± 0.061	2.794AlaAsn: 2.794 ± 0.044	6.208AlaPro: 6.208 ± 0.078	4.758AlaGln: 4.758 ± 0.063	9.058AlaArg: 9.058 ± 0.115	5.397AlaSer: 5.397 ± 0.068	7.357AlaThr: 7.357 ± 0.088	9.14AlaVal: 9.14 ± 0.098	1.424AlaTrp: 1.424 ± 0.037	2.495AlaTyr: 2.495 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.035	0.103CysCys: 0.103 ± 0.01	0.662CysAsp: 0.662 ± 0.025	0.383CysGlu: 0.383 ± 0.018	0.278CysPhe: 0.278 ± 0.015	0.961CysGly: 0.961 ± 0.032	0.292CysHis: 0.292 ± 0.017	0.425CysIle: 0.425 ± 0.018	0.203CysLys: 0.203 ± 0.013	0.814CysLeu: 0.814 ± 0.026	0.163CysMet: 0.163 ± 0.011	0.208CysAsn: 0.208 ± 0.013	0.472CysPro: 0.472 ± 0.022	0.22CysGln: 0.22 ± 0.014	0.554CysArg: 0.554 ± 0.022	0.367CysSer: 0.367 ± 0.018	0.485CysThr: 0.485 ± 0.021	0.623CysVal: 0.623 ± 0.022	0.107CysTrp: 0.107 ± 0.01	0.189CysTyr: 0.189 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.684AspAla: 8.684 ± 0.106	0.516AspCys: 0.516 ± 0.021	4.235AspAsp: 4.235 ± 0.09	2.839AspGlu: 2.839 ± 0.056	2.356AspPhe: 2.356 ± 0.048	6.378AspGly: 6.378 ± 0.087	1.548AspHis: 1.548 ± 0.037	3.197AspIle: 3.197 ± 0.056	1.578AspLys: 1.578 ± 0.039	7.035AspLeu: 7.035 ± 0.074	1.921AspMet: 1.921 ± 0.045	1.457AspAsn: 1.457 ± 0.039	4.025AspPro: 4.025 ± 0.072	1.984AspGln: 1.984 ± 0.048	5.37AspArg: 5.37 ± 0.073	2.287AspSer: 2.287 ± 0.042	3.788AspThr: 3.788 ± 0.086	4.779AspVal: 4.779 ± 0.066	1.244AspTrp: 1.244 ± 0.039	1.665AspTyr: 1.665 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.687GluAla: 6.687 ± 0.087	0.276GluCys: 0.276 ± 0.015	2.982GluAsp: 2.982 ± 0.05	2.662GluGlu: 2.662 ± 0.057	1.309GluPhe: 1.309 ± 0.03	4.088GluGly: 4.088 ± 0.059	0.896GluHis: 0.896 ± 0.028	2.948GluIle: 2.948 ± 0.052	1.617GluLys: 1.617 ± 0.044	4.015GluLeu: 4.015 ± 0.064	1.586GluMet: 1.586 ± 0.042	1.381GluAsn: 1.381 ± 0.034	1.974GluPro: 1.974 ± 0.044	1.55GluGln: 1.55 ± 0.039	3.443GluArg: 3.443 ± 0.066	2.004GluSer: 2.004 ± 0.041	3.234GluThr: 3.234 ± 0.055	3.835GluVal: 3.835 ± 0.057	0.522GluTrp: 0.522 ± 0.02	0.834GluTyr: 0.834 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.566PheAla: 4.566 ± 0.062	0.394PheCys: 0.394 ± 0.017	2.933PheAsp: 2.933 ± 0.043	1.777PheGlu: 1.777 ± 0.038	1.281PhePhe: 1.281 ± 0.041	3.664PheGly: 3.664 ± 0.057	0.733PheHis: 0.733 ± 0.027	1.634PheIle: 1.634 ± 0.039	0.894PheLys: 0.894 ± 0.025	3.055PheLeu: 3.055 ± 0.057	0.839PheMet: 0.839 ± 0.027	0.989PheAsn: 0.989 ± 0.03	1.574PhePro: 1.574 ± 0.036	0.962PheGln: 0.962 ± 0.029	2.066PheArg: 2.066 ± 0.047	1.806PheSer: 1.806 ± 0.045	2.099PheThr: 2.099 ± 0.044	2.672PheVal: 2.672 ± 0.05	0.53PheTrp: 0.53 ± 0.025	0.903PheTyr: 0.903 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.896GlyAla: 9.896 ± 0.114	0.822GlyCys: 0.822 ± 0.025	5.371GlyAsp: 5.371 ± 0.111	3.982GlyGlu: 3.982 ± 0.065	3.52GlyPhe: 3.52 ± 0.064	7.66GlyGly: 7.66 ± 0.142	1.956GlyHis: 1.956 ± 0.045	4.557GlyIle: 4.557 ± 0.062	2.721GlyLys: 2.721 ± 0.052	9.236GlyLeu: 9.236 ± 0.099	2.556GlyMet: 2.556 ± 0.053	2.266GlyAsn: 2.266 ± 0.086	3.952GlyPro: 3.952 ± 0.075	3.369GlyGln: 3.369 ± 0.057	5.936GlyArg: 5.936 ± 0.072	4.207GlySer: 4.207 ± 0.067	5.469GlyThr: 5.469 ± 0.076	6.333GlyVal: 6.333 ± 0.08	1.49GlyTrp: 1.49 ± 0.038	2.253GlyTyr: 2.253 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.547HisAla: 2.547 ± 0.053	0.225HisCys: 0.225 ± 0.014	1.553HisAsp: 1.553 ± 0.036	0.818HisGlu: 0.818 ± 0.026	0.794HisPhe: 0.794 ± 0.028	1.942HisGly: 1.942 ± 0.042	0.588HisHis: 0.588 ± 0.023	0.953HisIle: 0.953 ± 0.03	0.449HisLys: 0.449 ± 0.019	2.098HisLeu: 2.098 ± 0.043	0.565HisMet: 0.565 ± 0.022	0.442HisAsn: 0.442 ± 0.02	1.406HisPro: 1.406 ± 0.034	0.519HisGln: 0.519 ± 0.023	1.45HisArg: 1.45 ± 0.04	0.764HisSer: 0.764 ± 0.024	0.899HisThr: 0.899 ± 0.031	1.566HisVal: 1.566 ± 0.035	0.356HisTrp: 0.356 ± 0.016	0.531HisTyr: 0.531 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.525IleAla: 7.525 ± 0.084	0.558IleCys: 0.558 ± 0.022	3.736IleAsp: 3.736 ± 0.065	2.786IleGlu: 2.786 ± 0.052	1.726IlePhe: 1.726 ± 0.039	4.81IleGly: 4.81 ± 0.08	0.963IleHis: 0.963 ± 0.032	2.144IleIle: 2.144 ± 0.051	1.282IleLys: 1.282 ± 0.031	4.689IleLeu: 4.689 ± 0.064	1.183IleMet: 1.183 ± 0.033	1.361IleAsn: 1.361 ± 0.032	2.367IlePro: 2.367 ± 0.045	1.153IleGln: 1.153 ± 0.029	3.209IleArg: 3.209 ± 0.055	2.568IleSer: 2.568 ± 0.048	2.957IleThr: 2.957 ± 0.053	4.208IleVal: 4.208 ± 0.062	0.709IleTrp: 0.709 ± 0.024	1.199IleTyr: 1.199 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.588LysAla: 3.588 ± 0.067	0.146LysCys: 0.146 ± 0.011	1.757LysAsp: 1.757 ± 0.044	1.163LysGlu: 1.163 ± 0.039	0.798LysPhe: 0.798 ± 0.029	2.441LysGly: 2.441 ± 0.051	0.498LysHis: 0.498 ± 0.023	1.441LysIle: 1.441 ± 0.036	0.943LysLys: 0.943 ± 0.035	2.525LysLeu: 2.525 ± 0.053	0.781LysMet: 0.781 ± 0.026	0.678LysAsn: 0.678 ± 0.028	1.582LysPro: 1.582 ± 0.035	0.751LysGln: 0.751 ± 0.025	1.893LysArg: 1.893 ± 0.04	1.551LysSer: 1.551 ± 0.036	1.86LysThr: 1.86 ± 0.042	2.072LysVal: 2.072 ± 0.045	0.324LysTrp: 0.324 ± 0.017	0.561LysTyr: 0.561 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.97LeuAla: 12.97 ± 0.136	0.953LeuCys: 0.953 ± 0.026	6.316LeuAsp: 6.316 ± 0.078	4.056LeuGlu: 4.056 ± 0.064	3.311LeuPhe: 3.311 ± 0.058	8.088LeuGly: 8.088 ± 0.089	1.991LeuHis: 1.991 ± 0.043	5.295LeuIle: 5.295 ± 0.079	2.825LeuLys: 2.825 ± 0.055	9.138LeuLeu: 9.138 ± 0.117	2.66LeuMet: 2.66 ± 0.052	2.615LeuAsn: 2.615 ± 0.049	5.595LeuPro: 5.595 ± 0.081	3.066LeuGln: 3.066 ± 0.051	7.279LeuArg: 7.279 ± 0.091	6.331LeuSer: 6.331 ± 0.077	7.063LeuThr: 7.063 ± 0.083	6.737LeuVal: 6.737 ± 0.095	1.287LeuTrp: 1.287 ± 0.034	1.915LeuTyr: 1.915 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.695MetAla: 3.695 ± 0.061	0.183MetCys: 0.183 ± 0.011	1.555MetAsp: 1.555 ± 0.036	1.17MetGlu: 1.17 ± 0.029	0.818MetPhe: 0.818 ± 0.027	2.293MetGly: 2.293 ± 0.046	0.475MetHis: 0.475 ± 0.019	1.612MetIle: 1.612 ± 0.038	1.025MetLys: 1.025 ± 0.031	2.588MetLeu: 2.588 ± 0.046	0.839MetMet: 0.839 ± 0.032	0.866MetAsn: 0.866 ± 0.027	1.649MetPro: 1.649 ± 0.035	0.995MetGln: 0.995 ± 0.031	1.861MetArg: 1.861 ± 0.04	1.608MetSer: 1.608 ± 0.04	2.647MetThr: 2.647 ± 0.053	1.861MetVal: 1.861 ± 0.04	0.241MetTrp: 0.241 ± 0.015	0.332MetTyr: 0.332 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.056	0.242AsnCys: 0.242 ± 0.014	1.656AsnAsp: 1.656 ± 0.069	1.035AsnGlu: 1.035 ± 0.031	0.924AsnPhe: 0.924 ± 0.033	2.34AsnGly: 2.34 ± 0.055	0.489AsnHis: 0.489 ± 0.019	1.299AsnIle: 1.299 ± 0.036	0.592AsnLys: 0.592 ± 0.023	2.45AsnLeu: 2.45 ± 0.049	0.705AsnMet: 0.705 ± 0.024	0.604AsnAsn: 0.604 ± 0.023	1.783AsnPro: 1.783 ± 0.04	0.688AsnGln: 0.688 ± 0.025	1.69AsnArg: 1.69 ± 0.037	0.992AsnSer: 0.992 ± 0.032	1.36AsnThr: 1.36 ± 0.037	1.905AsnVal: 1.905 ± 0.043	0.421AsnTrp: 0.421 ± 0.019	0.623AsnTyr: 0.623 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.728ProAla: 6.728 ± 0.082	0.348ProCys: 0.348 ± 0.017	4.519ProAsp: 4.519 ± 0.07	3.204ProGlu: 3.204 ± 0.055	1.932ProPhe: 1.932 ± 0.039	4.5ProGly: 4.5 ± 0.07	1.085ProHis: 1.085 ± 0.031	2.134ProIle: 2.134 ± 0.039	1.462ProLys: 1.462 ± 0.042	4.875ProLeu: 4.875 ± 0.062	1.351ProMet: 1.351 ± 0.032	1.152ProAsn: 1.152 ± 0.032	2.44ProPro: 2.44 ± 0.053	1.953ProGln: 1.953 ± 0.038	3.032ProArg: 3.032 ± 0.056	2.303ProSer: 2.303 ± 0.046	2.717ProThr: 2.717 ± 0.049	4.618ProVal: 4.618 ± 0.071	0.696ProTrp: 0.696 ± 0.024	1.156ProTyr: 1.156 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.389GlnAla: 4.389 ± 0.062	0.199GlnCys: 0.199 ± 0.013	2.018GlnAsp: 2.018 ± 0.04	1.329GlnGlu: 1.329 ± 0.033	1.021GlnPhe: 1.021 ± 0.028	2.614GlnGly: 2.614 ± 0.049	0.601GlnHis: 0.601 ± 0.022	2.129GlnIle: 2.129 ± 0.047	0.886GlnLys: 0.886 ± 0.028	2.761GlnLeu: 2.761 ± 0.051	1.087GlnMet: 1.087 ± 0.03	0.881GlnAsn: 0.881 ± 0.028	1.745GlnPro: 1.745 ± 0.038	1.106GlnGln: 1.106 ± 0.039	2.302GlnArg: 2.302 ± 0.039	1.808GlnSer: 1.808 ± 0.041	2.176GlnThr: 2.176 ± 0.043	2.542GlnVal: 2.542 ± 0.049	0.404GlnTrp: 0.404 ± 0.017	0.534GlnTyr: 0.534 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.297ArgAla: 8.297 ± 0.106	0.476ArgCys: 0.476 ± 0.02	4.942ArgAsp: 4.942 ± 0.068	3.091ArgGlu: 3.091 ± 0.059	2.511ArgPhe: 2.511 ± 0.046	4.895ArgGly: 4.895 ± 0.067	1.682ArgHis: 1.682 ± 0.042	4.033ArgIle: 4.033 ± 0.06	1.89ArgLys: 1.89 ± 0.05	7.404ArgLeu: 7.404 ± 0.095	2.149ArgMet: 2.149 ± 0.046	1.833ArgAsn: 1.833 ± 0.04	3.407ArgPro: 3.407 ± 0.056	2.505ArgGln: 2.505 ± 0.055	5.295ArgArg: 5.295 ± 0.081	3.216ArgSer: 3.216 ± 0.056	3.725ArgThr: 3.725 ± 0.055	4.773ArgVal: 4.773 ± 0.061	0.955ArgTrp: 0.955 ± 0.027	1.5ArgTyr: 1.5 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.419SerAla: 5.419 ± 0.069	0.415SerCys: 0.415 ± 0.02	3.34SerAsp: 3.34 ± 0.057	2.234SerGlu: 2.234 ± 0.043	2.083SerPhe: 2.083 ± 0.042	4.879SerGly: 4.879 ± 0.074	1.088SerHis: 1.088 ± 0.027	2.353SerIle: 2.353 ± 0.043	1.228SerLys: 1.228 ± 0.032	4.859SerLeu: 4.859 ± 0.069	1.283SerMet: 1.283 ± 0.031	1.231SerAsn: 1.231 ± 0.032	2.49SerPro: 2.49 ± 0.047	1.528SerGln: 1.528 ± 0.04	3.202SerArg: 3.202 ± 0.05	2.347SerSer: 2.347 ± 0.051	2.522SerThr: 2.522 ± 0.047	3.648SerVal: 3.648 ± 0.058	0.643SerTrp: 0.643 ± 0.023	1.216SerTyr: 1.216 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.579ThrAla: 7.579 ± 0.082	0.527ThrCys: 0.527 ± 0.024	4.174ThrAsp: 4.174 ± 0.067	2.915ThrGlu: 2.915 ± 0.045	2.312ThrPhe: 2.312 ± 0.042	6.191ThrGly: 6.191 ± 0.082	1.206ThrHis: 1.206 ± 0.031	2.897ThrIle: 2.897 ± 0.054	1.41ThrLys: 1.41 ± 0.037	6.835ThrLeu: 6.835 ± 0.088	1.41ThrMet: 1.41 ± 0.034	1.248ThrAsn: 1.248 ± 0.031	3.887ThrPro: 3.887 ± 0.061	1.803ThrGln: 1.803 ± 0.035	3.772ThrArg: 3.772 ± 0.064	2.792ThrSer: 2.792 ± 0.048	3.601ThrThr: 3.601 ± 0.064	4.934ThrVal: 4.934 ± 0.065	0.766ThrTrp: 0.766 ± 0.027	1.343ThrTyr: 1.343 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.57ValAla: 9.57 ± 0.116	0.642ValCys: 0.642 ± 0.02	4.309ValAsp: 4.309 ± 0.061	3.729ValGlu: 3.729 ± 0.055	2.742ValPhe: 2.742 ± 0.054	5.639ValGly: 5.639 ± 0.074	1.327ValHis: 1.327 ± 0.039	4.215ValIle: 4.215 ± 0.07	2.009ValLys: 2.009 ± 0.04	7.443ValLeu: 7.443 ± 0.091	2.286ValMet: 2.286 ± 0.047	2.043ValAsn: 2.043 ± 0.04	3.85ValPro: 3.85 ± 0.054	2.311ValGln: 2.311 ± 0.046	4.494ValArg: 4.494 ± 0.062	3.902ValSer: 3.902 ± 0.056	5.556ValThr: 5.556 ± 0.074	5.857ValVal: 5.857 ± 0.075	1.066ValTrp: 1.066 ± 0.032	1.44ValTyr: 1.44 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.381TrpAla: 1.381 ± 0.037	0.154TrpCys: 0.154 ± 0.01	0.8TrpAsp: 0.8 ± 0.027	0.519TrpGlu: 0.519 ± 0.02	0.558TrpPhe: 0.558 ± 0.021	0.979TrpGly: 0.979 ± 0.03	0.328TrpHis: 0.328 ± 0.016	0.724TrpIle: 0.724 ± 0.024	0.397TrpLys: 0.397 ± 0.018	1.571TrpLeu: 1.571 ± 0.04	0.406TrpMet: 0.406 ± 0.018	0.414TrpAsn: 0.414 ± 0.018	0.742TrpPro: 0.742 ± 0.028	0.643TrpGln: 0.643 ± 0.023	1.082TrpArg: 1.082 ± 0.028	0.775TrpSer: 0.775 ± 0.027	0.914TrpThr: 0.914 ± 0.029	0.871TrpVal: 0.871 ± 0.029	0.215TrpTrp: 0.215 ± 0.013	0.264TrpTyr: 0.264 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.723TyrAla: 2.723 ± 0.046	0.182TyrCys: 0.182 ± 0.011	1.686TyrAsp: 1.686 ± 0.038	0.995TyrGlu: 0.995 ± 0.029	0.784TyrPhe: 0.784 ± 0.025	2.106TyrGly: 2.106 ± 0.053	0.479TyrHis: 0.479 ± 0.02	0.957TyrIle: 0.957 ± 0.027	0.507TyrLys: 0.507 ± 0.023	2.184TyrLeu: 2.184 ± 0.045	0.498TyrMet: 0.498 ± 0.021	0.587TyrAsn: 0.587 ± 0.024	1.059TyrPro: 1.059 ± 0.029	0.668TyrGln: 0.668 ± 0.022	1.59TyrArg: 1.59 ± 0.033	0.984TyrSer: 0.984 ± 0.031	1.174TyrThr: 1.174 ± 0.032	1.456TyrVal: 1.456 ± 0.035	0.338TyrTrp: 0.338 ± 0.018	0.551TyrTyr: 0.551 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4069 proteins (1257508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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