Amino acid dipepetide frequency for Marinobacter vulgaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.803AlaAla: 9.803 ± 0.114	0.983AlaCys: 0.983 ± 0.03	5.682AlaAsp: 5.682 ± 0.075	6.579AlaGlu: 6.579 ± 0.089	3.612AlaPhe: 3.612 ± 0.064	8.596AlaGly: 8.596 ± 0.093	1.792AlaHis: 1.792 ± 0.043	5.569AlaIle: 5.569 ± 0.073	3.046AlaLys: 3.046 ± 0.059	11.223AlaLeu: 11.223 ± 0.126	3.022AlaMet: 3.022 ± 0.057	2.826AlaAsn: 2.826 ± 0.049	3.934AlaPro: 3.934 ± 0.056	3.154AlaGln: 3.154 ± 0.05	6.67AlaArg: 6.67 ± 0.089	5.884AlaSer: 5.884 ± 0.077	4.688AlaThr: 4.688 ± 0.07	7.177AlaVal: 7.177 ± 0.087	1.377AlaTrp: 1.377 ± 0.039	2.226AlaTyr: 2.226 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.767CysAla: 0.767 ± 0.027	0.135CysCys: 0.135 ± 0.011	0.561CysAsp: 0.561 ± 0.023	0.584CysGlu: 0.584 ± 0.023	0.355CysPhe: 0.355 ± 0.017	0.879CysGly: 0.879 ± 0.031	0.32CysHis: 0.32 ± 0.019	0.451CysIle: 0.451 ± 0.02	0.29CysLys: 0.29 ± 0.018	0.904CysLeu: 0.904 ± 0.03	0.199CysMet: 0.199 ± 0.012	0.265CysAsn: 0.265 ± 0.015	0.499CysPro: 0.499 ± 0.025	0.383CysGln: 0.383 ± 0.019	0.684CysArg: 0.684 ± 0.027	0.583CysSer: 0.583 ± 0.022	0.423CysThr: 0.423 ± 0.022	0.607CysVal: 0.607 ± 0.023	0.121CysTrp: 0.121 ± 0.01	0.251CysTyr: 0.251 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.194AspAla: 5.194 ± 0.07	0.506AspCys: 0.506 ± 0.023	3.664AspAsp: 3.664 ± 0.07	4.318AspGlu: 4.318 ± 0.067	2.265AspPhe: 2.265 ± 0.054	4.548AspGly: 4.548 ± 0.078	1.356AspHis: 1.356 ± 0.032	3.482AspIle: 3.482 ± 0.055	1.971AspLys: 1.971 ± 0.048	5.781AspLeu: 5.781 ± 0.076	1.529AspMet: 1.529 ± 0.04	2.013AspAsn: 2.013 ± 0.051	2.846AspPro: 2.846 ± 0.052	2.429AspGln: 2.429 ± 0.053	4.025AspArg: 4.025 ± 0.063	3.247AspSer: 3.247 ± 0.056	3.018AspThr: 3.018 ± 0.055	4.053AspVal: 4.053 ± 0.066	0.964AspTrp: 0.964 ± 0.035	1.829AspTyr: 1.829 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.742GluAla: 6.742 ± 0.077	0.449GluCys: 0.449 ± 0.023	3.587GluAsp: 3.587 ± 0.062	4.461GluGlu: 4.461 ± 0.079	2.254GluPhe: 2.254 ± 0.045	4.686GluGly: 4.686 ± 0.061	1.593GluHis: 1.593 ± 0.038	3.44GluIle: 3.44 ± 0.062	3.058GluLys: 3.058 ± 0.065	7.109GluLeu: 7.109 ± 0.089	1.687GluMet: 1.687 ± 0.037	2.257GluAsn: 2.257 ± 0.04	2.971GluPro: 2.971 ± 0.067	3.522GluGln: 3.522 ± 0.068	4.605GluArg: 4.605 ± 0.065	3.761GluSer: 3.761 ± 0.058	3.542GluThr: 3.542 ± 0.058	4.517GluVal: 4.517 ± 0.072	0.835GluTrp: 0.835 ± 0.025	1.4GluTyr: 1.4 ± 0.032	0.001GluXaa: 0.001 ± 0.001
Phe	3.501PheAla: 3.501 ± 0.052	0.448PheCys: 0.448 ± 0.021	2.467PheAsp: 2.467 ± 0.05	2.365PheGlu: 2.365 ± 0.05	1.586PhePhe: 1.586 ± 0.039	3.248PheGly: 3.248 ± 0.056	0.835PheHis: 0.835 ± 0.024	2.014PheIle: 2.014 ± 0.046	1.027PheLys: 1.027 ± 0.032	3.633PheLeu: 3.633 ± 0.063	0.935PheMet: 0.935 ± 0.032	1.34PheAsn: 1.34 ± 0.041	1.664PhePro: 1.664 ± 0.04	1.221PheGln: 1.221 ± 0.029	2.521PheArg: 2.521 ± 0.049	2.761PheSer: 2.761 ± 0.056	2.074PheThr: 2.074 ± 0.05	2.712PheVal: 2.712 ± 0.05	0.531PheTrp: 0.531 ± 0.024	1.113PheTyr: 1.113 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.681GlyAla: 6.681 ± 0.087	0.899GlyCys: 0.899 ± 0.028	4.565GlyAsp: 4.565 ± 0.074	5.221GlyGlu: 5.221 ± 0.077	3.6GlyPhe: 3.6 ± 0.059	6.017GlyGly: 6.017 ± 0.093	1.898GlyHis: 1.898 ± 0.04	4.803GlyIle: 4.803 ± 0.073	3.435GlyLys: 3.435 ± 0.061	8.39GlyLeu: 8.39 ± 0.11	2.371GlyMet: 2.371 ± 0.046	2.447GlyAsn: 2.447 ± 0.048	2.591GlyPro: 2.591 ± 0.053	3.156GlyGln: 3.156 ± 0.059	4.865GlyArg: 4.865 ± 0.064	4.633GlySer: 4.633 ± 0.06	3.92GlyThr: 3.92 ± 0.058	5.861GlyVal: 5.861 ± 0.087	1.241GlyTrp: 1.241 ± 0.032	2.501GlyTyr: 2.501 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.859HisAla: 1.859 ± 0.036	0.292HisCys: 0.292 ± 0.016	1.144HisAsp: 1.144 ± 0.034	1.252HisGlu: 1.252 ± 0.035	0.925HisPhe: 0.925 ± 0.026	1.802HisGly: 1.802 ± 0.04	0.722HisHis: 0.722 ± 0.027	1.136HisIle: 1.136 ± 0.036	0.739HisLys: 0.739 ± 0.028	2.25HisLeu: 2.25 ± 0.04	0.522HisMet: 0.522 ± 0.022	0.729HisAsn: 0.729 ± 0.026	1.361HisPro: 1.361 ± 0.033	1.017HisGln: 1.017 ± 0.026	1.624HisArg: 1.624 ± 0.042	1.266HisSer: 1.266 ± 0.033	1.032HisThr: 1.032 ± 0.031	1.319HisVal: 1.319 ± 0.033	0.409HisTrp: 0.409 ± 0.019	0.785HisTyr: 0.785 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.739IleAla: 5.739 ± 0.085	0.514IleCys: 0.514 ± 0.022	3.397IleAsp: 3.397 ± 0.062	3.702IleGlu: 3.702 ± 0.066	1.706IlePhe: 1.706 ± 0.043	4.418IleGly: 4.418 ± 0.061	1.223IleHis: 1.223 ± 0.029	2.672IleIle: 2.672 ± 0.053	1.826IleLys: 1.826 ± 0.04	4.961IleLeu: 4.961 ± 0.086	1.178IleMet: 1.178 ± 0.034	2.017IleAsn: 2.017 ± 0.043	2.678IlePro: 2.678 ± 0.054	1.697IleGln: 1.697 ± 0.041	3.785IleArg: 3.785 ± 0.059	3.353IleSer: 3.353 ± 0.06	3.103IleThr: 3.103 ± 0.06	3.719IleVal: 3.719 ± 0.066	0.554IleTrp: 0.554 ± 0.024	1.231IleTyr: 1.231 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.875LysAla: 3.875 ± 0.067	0.205LysCys: 0.205 ± 0.014	1.976LysAsp: 1.976 ± 0.043	2.259LysGlu: 2.259 ± 0.053	0.899LysPhe: 0.899 ± 0.028	2.651LysGly: 2.651 ± 0.055	0.815LysHis: 0.815 ± 0.029	1.715LysIle: 1.715 ± 0.045	1.68LysLys: 1.68 ± 0.049	3.655LysLeu: 3.655 ± 0.058	0.841LysMet: 0.841 ± 0.027	1.126LysAsn: 1.126 ± 0.034	2.084LysPro: 2.084 ± 0.047	1.545LysGln: 1.545 ± 0.037	2.356LysArg: 2.356 ± 0.052	2.029LysSer: 2.029 ± 0.043	2.066LysThr: 2.066 ± 0.043	2.636LysVal: 2.636 ± 0.048	0.364LysTrp: 0.364 ± 0.018	0.799LysTyr: 0.799 ± 0.026	0.001LysXaa: 0.001 ± 0.001
Leu	11.808LeuAla: 11.808 ± 0.125	0.992LeuCys: 0.992 ± 0.032	6.194LeuAsp: 6.194 ± 0.085	7.005LeuGlu: 7.005 ± 0.094	4.034LeuPhe: 4.034 ± 0.069	8.033LeuGly: 8.033 ± 0.094	1.997LeuHis: 1.997 ± 0.048	5.438LeuIle: 5.438 ± 0.08	4.123LeuLys: 4.123 ± 0.068	10.666LeuLeu: 10.666 ± 0.139	2.832LeuMet: 2.832 ± 0.051	3.457LeuAsn: 3.457 ± 0.059	5.273LeuPro: 5.273 ± 0.075	3.63LeuGln: 3.63 ± 0.059	6.437LeuArg: 6.437 ± 0.087	6.782LeuSer: 6.782 ± 0.082	5.726LeuThr: 5.726 ± 0.077	7.914LeuVal: 7.914 ± 0.096	1.266LeuTrp: 1.266 ± 0.036	2.265LeuTyr: 2.265 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.132MetAla: 3.132 ± 0.056	0.18MetCys: 0.18 ± 0.012	1.469MetAsp: 1.469 ± 0.036	1.539MetGlu: 1.539 ± 0.038	0.778MetPhe: 0.778 ± 0.027	2.043MetGly: 2.043 ± 0.039	0.47MetHis: 0.47 ± 0.021	1.396MetIle: 1.396 ± 0.033	1.141MetLys: 1.141 ± 0.034	2.666MetLeu: 2.666 ± 0.053	0.716MetMet: 0.716 ± 0.029	0.956MetAsn: 0.956 ± 0.026	1.411MetPro: 1.411 ± 0.031	0.907MetGln: 0.907 ± 0.029	1.404MetArg: 1.404 ± 0.034	1.749MetSer: 1.749 ± 0.043	1.743MetThr: 1.743 ± 0.037	1.914MetVal: 1.914 ± 0.044	0.178MetTrp: 0.178 ± 0.012	0.449MetTyr: 0.449 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.945AsnAla: 2.945 ± 0.049	0.301AsnCys: 0.301 ± 0.015	1.794AsnAsp: 1.794 ± 0.043	1.917AsnGlu: 1.917 ± 0.037	1.068AsnPhe: 1.068 ± 0.031	2.565AsnGly: 2.565 ± 0.045	0.784AsnHis: 0.784 ± 0.024	1.704AsnIle: 1.704 ± 0.038	0.998AsnLys: 0.998 ± 0.03	3.362AsnLeu: 3.362 ± 0.053	0.75AsnMet: 0.75 ± 0.026	1.12AsnAsn: 1.12 ± 0.029	2.049AsnPro: 2.049 ± 0.045	1.315AsnGln: 1.315 ± 0.036	2.399AsnArg: 2.399 ± 0.052	1.781AsnSer: 1.781 ± 0.05	1.717AsnThr: 1.717 ± 0.039	2.019AsnVal: 2.019 ± 0.041	0.501AsnTrp: 0.501 ± 0.021	0.858AsnTyr: 0.858 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.811ProAla: 4.811 ± 0.085	0.323ProCys: 0.323 ± 0.016	3.684ProAsp: 3.684 ± 0.059	4.517ProGlu: 4.517 ± 0.069	1.816ProPhe: 1.816 ± 0.043	4.173ProGly: 4.173 ± 0.069	0.956ProHis: 0.956 ± 0.029	1.971ProIle: 1.971 ± 0.043	1.399ProLys: 1.399 ± 0.035	4.662ProLeu: 4.662 ± 0.071	1.188ProMet: 1.188 ± 0.032	1.173ProAsn: 1.173 ± 0.03	1.889ProPro: 1.889 ± 0.049	1.556ProGln: 1.556 ± 0.038	2.363ProArg: 2.363 ± 0.05	2.467ProSer: 2.467 ± 0.052	1.939ProThr: 1.939 ± 0.038	4.313ProVal: 4.313 ± 0.064	0.75ProTrp: 0.75 ± 0.027	1.096ProTyr: 1.096 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.219GlnAla: 4.219 ± 0.055	0.302GlnCys: 0.302 ± 0.018	1.842GlnAsp: 1.842 ± 0.035	2.275GlnGlu: 2.275 ± 0.055	1.349GlnPhe: 1.349 ± 0.034	2.84GlnGly: 2.84 ± 0.054	0.872GlnHis: 0.872 ± 0.028	1.887GlnIle: 1.887 ± 0.037	1.457GlnLys: 1.457 ± 0.036	4.086GlnLeu: 4.086 ± 0.066	1.011GlnMet: 1.011 ± 0.034	1.163GlnAsn: 1.163 ± 0.034	1.949GlnPro: 1.949 ± 0.042	2.076GlnGln: 2.076 ± 0.049	2.73GlnArg: 2.73 ± 0.051	2.227GlnSer: 2.227 ± 0.048	1.924GlnThr: 1.924 ± 0.041	2.853GlnVal: 2.853 ± 0.051	0.644GlnTrp: 0.644 ± 0.02	0.897GlnTyr: 0.897 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.513ArgAla: 5.513 ± 0.079	0.591ArgCys: 0.591 ± 0.023	3.827ArgAsp: 3.827 ± 0.059	4.851ArgGlu: 4.851 ± 0.079	2.882ArgPhe: 2.882 ± 0.054	3.982ArgGly: 3.982 ± 0.06	1.721ArgHis: 1.721 ± 0.039	3.787ArgIle: 3.787 ± 0.057	2.846ArgLys: 2.846 ± 0.053	7.545ArgLeu: 7.545 ± 0.091	1.734ArgMet: 1.734 ± 0.04	2.258ArgAsn: 2.258 ± 0.05	2.76ArgPro: 2.76 ± 0.051	3.13ArgGln: 3.13 ± 0.064	4.616ArgArg: 4.616 ± 0.072	3.43ArgSer: 3.43 ± 0.054	2.9ArgThr: 2.9 ± 0.051	4.797ArgVal: 4.797 ± 0.072	1.03ArgTrp: 1.03 ± 0.03	2.029ArgTyr: 2.029 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.715SerAla: 5.715 ± 0.074	0.477SerCys: 0.477 ± 0.021	3.603SerAsp: 3.603 ± 0.069	3.774SerGlu: 3.774 ± 0.061	2.278SerPhe: 2.278 ± 0.054	5.628SerGly: 5.628 ± 0.075	1.306SerHis: 1.306 ± 0.033	2.939SerIle: 2.939 ± 0.055	1.806SerLys: 1.806 ± 0.042	6.504SerLeu: 6.504 ± 0.088	1.573SerMet: 1.573 ± 0.038	1.697SerAsn: 1.697 ± 0.045	2.892SerPro: 2.892 ± 0.05	2.183SerGln: 2.183 ± 0.044	4.179SerArg: 4.179 ± 0.064	3.58SerSer: 3.58 ± 0.058	2.716SerThr: 2.716 ± 0.045	4.325SerVal: 4.325 ± 0.071	0.822SerTrp: 0.822 ± 0.027	1.461SerTyr: 1.461 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.987ThrAla: 4.987 ± 0.071	0.478ThrCys: 0.478 ± 0.024	3.103ThrAsp: 3.103 ± 0.058	3.121ThrGlu: 3.121 ± 0.061	1.901ThrPhe: 1.901 ± 0.035	4.951ThrGly: 4.951 ± 0.071	1.007ThrHis: 1.007 ± 0.032	2.671ThrIle: 2.671 ± 0.048	1.147ThrLys: 1.147 ± 0.03	6.145ThrLeu: 6.145 ± 0.072	1.163ThrMet: 1.163 ± 0.03	1.421ThrAsn: 1.421 ± 0.043	2.862ThrPro: 2.862 ± 0.06	1.513ThrGln: 1.513 ± 0.037	3.31ThrArg: 3.31 ± 0.053	2.939ThrSer: 2.939 ± 0.046	2.649ThrThr: 2.649 ± 0.06	4.14ThrVal: 4.14 ± 0.062	0.672ThrTrp: 0.672 ± 0.024	1.168ThrTyr: 1.168 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.482ValAla: 7.482 ± 0.085	0.757ValCys: 0.757 ± 0.027	4.31ValAsp: 4.31 ± 0.063	4.569ValGlu: 4.569 ± 0.069	3.01ValPhe: 3.01 ± 0.054	5.048ValGly: 5.048 ± 0.06	1.482ValHis: 1.482 ± 0.038	4.544ValIle: 4.544 ± 0.073	2.41ValLys: 2.41 ± 0.056	7.428ValLeu: 7.428 ± 0.09	2.101ValMet: 2.101 ± 0.045	2.443ValAsn: 2.443 ± 0.048	3.349ValPro: 3.349 ± 0.059	2.155ValGln: 2.155 ± 0.044	4.525ValArg: 4.525 ± 0.059	4.754ValSer: 4.754 ± 0.072	4.32ValThr: 4.32 ± 0.072	5.996ValVal: 5.996 ± 0.086	0.886ValTrp: 0.886 ± 0.032	1.758ValTyr: 1.758 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.013TrpAla: 1.013 ± 0.032	0.157TrpCys: 0.157 ± 0.012	0.663TrpAsp: 0.663 ± 0.022	0.664TrpGlu: 0.664 ± 0.024	0.636TrpPhe: 0.636 ± 0.025	0.905TrpGly: 0.905 ± 0.032	0.409TrpHis: 0.409 ± 0.018	0.728TrpIle: 0.728 ± 0.024	0.43TrpLys: 0.43 ± 0.02	1.975TrpLeu: 1.975 ± 0.046	0.363TrpMet: 0.363 ± 0.018	0.462TrpAsn: 0.462 ± 0.021	0.661TrpPro: 0.661 ± 0.025	0.826TrpGln: 0.826 ± 0.029	1.012TrpArg: 1.012 ± 0.027	0.754TrpSer: 0.754 ± 0.027	0.627TrpThr: 0.627 ± 0.027	0.929TrpVal: 0.929 ± 0.028	0.228TrpTrp: 0.228 ± 0.015	0.346TrpTyr: 0.346 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.054TyrAla: 2.054 ± 0.037	0.274TyrCys: 0.274 ± 0.015	1.508TyrAsp: 1.508 ± 0.038	1.503TyrGlu: 1.503 ± 0.038	1.041TyrPhe: 1.041 ± 0.032	2.082TyrGly: 2.082 ± 0.044	0.626TyrHis: 0.626 ± 0.023	1.126TyrIle: 1.126 ± 0.033	0.747TyrLys: 0.747 ± 0.027	2.926TyrLeu: 2.926 ± 0.052	0.528TyrMet: 0.528 ± 0.02	0.778TyrAsn: 0.778 ± 0.028	1.323TyrPro: 1.323 ± 0.033	1.187TyrGln: 1.187 ± 0.031	2.12TyrArg: 2.12 ± 0.044	1.478TyrSer: 1.478 ± 0.037	1.223TyrThr: 1.223 ± 0.037	1.525TyrVal: 1.525 ± 0.035	0.412TyrTrp: 0.412 ± 0.018	0.735TyrTyr: 0.735 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3437 proteins (1140680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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