Amino acid dipepetide frequency for Scleroderma citrinum Foug A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.836AlaAla: 6.836 ± 0.045	1.35AlaCys: 1.35 ± 0.017	3.828AlaAsp: 3.828 ± 0.027	4.344AlaGlu: 4.344 ± 0.033	3.086AlaPhe: 3.086 ± 0.027	4.543AlaGly: 4.543 ± 0.032	2.232AlaHis: 2.232 ± 0.018	4.108AlaIle: 4.108 ± 0.03	3.555AlaLys: 3.555 ± 0.025	7.817AlaLeu: 7.817 ± 0.039	1.896AlaMet: 1.896 ± 0.023	2.667AlaAsn: 2.667 ± 0.02	4.305AlaPro: 4.305 ± 0.033	3.296AlaGln: 3.296 ± 0.024	4.689AlaArg: 4.689 ± 0.037	6.79AlaSer: 6.79 ± 0.038	4.786AlaThr: 4.786 ± 0.033	4.936AlaVal: 4.936 ± 0.031	1.187AlaTrp: 1.187 ± 0.015	2.042AlaTyr: 2.042 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.017	0.465CysCys: 0.465 ± 0.011	0.867CysAsp: 0.867 ± 0.012	0.823CysGlu: 0.823 ± 0.012	0.746CysPhe: 0.746 ± 0.011	1.131CysGly: 1.131 ± 0.014	0.598CysHis: 0.598 ± 0.012	1.038CysIle: 1.038 ± 0.013	0.789CysLys: 0.789 ± 0.012	1.693CysLeu: 1.693 ± 0.017	0.449CysMet: 0.449 ± 0.009	0.62CysAsn: 0.62 ± 0.01	1.08CysPro: 1.08 ± 0.017	0.731CysGln: 0.731 ± 0.013	1.049CysArg: 1.049 ± 0.015	1.451CysSer: 1.451 ± 0.02	1.103CysThr: 1.103 ± 0.014	1.041CysVal: 1.041 ± 0.013	0.302CysTrp: 0.302 ± 0.008	0.473CysTyr: 0.473 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.364AspAla: 4.364 ± 0.03	0.78AspCys: 0.78 ± 0.012	3.9AspAsp: 3.9 ± 0.035	4.051AspGlu: 4.051 ± 0.03	2.027AspPhe: 2.027 ± 0.019	3.929AspGly: 3.929 ± 0.028	1.55AspHis: 1.55 ± 0.016	3.242AspIle: 3.242 ± 0.024	2.229AspLys: 2.229 ± 0.019	4.976AspLeu: 4.976 ± 0.032	1.259AspMet: 1.259 ± 0.015	1.848AspAsn: 1.848 ± 0.018	3.347AspPro: 3.347 ± 0.024	1.703AspGln: 1.703 ± 0.017	2.892AspArg: 2.892 ± 0.026	3.916AspSer: 3.916 ± 0.026	3.055AspThr: 3.055 ± 0.021	3.986AspVal: 3.986 ± 0.027	0.96AspTrp: 0.96 ± 0.013	1.47AspTyr: 1.47 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.581GluAla: 4.581 ± 0.035	0.91GluCys: 0.91 ± 0.012	3.837GluAsp: 3.837 ± 0.032	4.871GluGlu: 4.871 ± 0.047	1.912GluPhe: 1.912 ± 0.018	3.517GluGly: 3.517 ± 0.026	1.576GluHis: 1.576 ± 0.017	2.769GluIle: 2.769 ± 0.021	2.821GluLys: 2.821 ± 0.025	5.314GluLeu: 5.314 ± 0.034	1.439GluMet: 1.439 ± 0.014	1.921GluAsn: 1.921 ± 0.019	2.469GluPro: 2.469 ± 0.021	2.181GluGln: 2.181 ± 0.019	3.877GluArg: 3.877 ± 0.029	3.823GluSer: 3.823 ± 0.024	2.831GluThr: 2.831 ± 0.027	3.682GluVal: 3.682 ± 0.028	1.039GluTrp: 1.039 ± 0.014	1.529GluTyr: 1.529 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.787PheAla: 2.787 ± 0.022	0.729PheCys: 0.729 ± 0.011	2.141PheAsp: 2.141 ± 0.018	1.935PheGlu: 1.935 ± 0.017	1.566PhePhe: 1.566 ± 0.017	2.54PheGly: 2.54 ± 0.024	1.213PheHis: 1.213 ± 0.016	1.89PheIle: 1.89 ± 0.02	1.548PheLys: 1.548 ± 0.019	3.547PheLeu: 3.547 ± 0.025	0.811PheMet: 0.811 ± 0.011	1.39PheAsn: 1.39 ± 0.015	2.138PhePro: 2.138 ± 0.021	1.313PheGln: 1.313 ± 0.015	2.01PheArg: 2.01 ± 0.017	3.244PheSer: 3.244 ± 0.026	2.223PheThr: 2.223 ± 0.022	2.512PheVal: 2.512 ± 0.02	0.628PheTrp: 0.628 ± 0.01	1.033PheTyr: 1.033 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.275GlyAla: 4.275 ± 0.028	1.11GlyCys: 1.11 ± 0.015	3.406GlyAsp: 3.406 ± 0.03	3.309GlyGlu: 3.309 ± 0.023	2.318GlyPhe: 2.318 ± 0.021	4.474GlyGly: 4.474 ± 0.042	1.985GlyHis: 1.985 ± 0.02	3.228GlyIle: 3.228 ± 0.025	3.147GlyLys: 3.147 ± 0.025	5.425GlyLeu: 5.425 ± 0.028	1.591GlyMet: 1.591 ± 0.016	2.325GlyAsn: 2.325 ± 0.019	3.144GlyPro: 3.144 ± 0.023	2.265GlyGln: 2.265 ± 0.024	3.717GlyArg: 3.717 ± 0.026	5.254GlySer: 5.254 ± 0.033	3.841GlyThr: 3.841 ± 0.025	4.073GlyVal: 4.073 ± 0.03	1.092GlyTrp: 1.092 ± 0.014	1.703GlyTyr: 1.703 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.317HisAla: 2.317 ± 0.021	0.626HisCys: 0.626 ± 0.012	1.591HisAsp: 1.591 ± 0.016	1.461HisGlu: 1.461 ± 0.017	1.19HisPhe: 1.19 ± 0.012	1.867HisGly: 1.867 ± 0.018	1.138HisHis: 1.138 ± 0.017	1.651HisIle: 1.651 ± 0.016	1.118HisLys: 1.118 ± 0.012	2.984HisLeu: 2.984 ± 0.026	0.645HisMet: 0.645 ± 0.01	1.007HisAsn: 1.007 ± 0.014	2.206HisPro: 2.206 ± 0.023	1.155HisGln: 1.155 ± 0.015	1.962HisArg: 1.962 ± 0.018	2.494HisSer: 2.494 ± 0.027	1.829HisThr: 1.829 ± 0.02	1.876HisVal: 1.876 ± 0.017	0.458HisTrp: 0.458 ± 0.01	0.829HisTyr: 0.829 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.017IleAla: 4.017 ± 0.027	0.944IleCys: 0.944 ± 0.013	2.805IleAsp: 2.805 ± 0.021	2.607IleGlu: 2.607 ± 0.022	1.974IlePhe: 1.974 ± 0.021	2.907IleGly: 2.907 ± 0.025	1.592IleHis: 1.592 ± 0.016	2.564IleIle: 2.564 ± 0.021	2.117IleLys: 2.117 ± 0.02	4.879IleLeu: 4.879 ± 0.032	1.068IleMet: 1.068 ± 0.012	1.816IleAsn: 1.816 ± 0.019	3.433IlePro: 3.433 ± 0.022	1.991IleGln: 1.991 ± 0.021	2.924IleArg: 2.924 ± 0.026	4.09IleSer: 4.09 ± 0.028	2.894IleThr: 2.894 ± 0.021	3.311IleVal: 3.311 ± 0.027	0.756IleTrp: 0.756 ± 0.011	1.378IleTyr: 1.378 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.753LysAla: 3.753 ± 0.028	0.75LysCys: 0.75 ± 0.011	2.509LysAsp: 2.509 ± 0.022	3.002LysGlu: 3.002 ± 0.027	1.47LysPhe: 1.47 ± 0.015	2.812LysGly: 2.812 ± 0.022	1.308LysHis: 1.308 ± 0.013	2.045LysIle: 2.045 ± 0.02	2.812LysLys: 2.812 ± 0.03	4.004LysLeu: 4.004 ± 0.028	1.035LysMet: 1.035 ± 0.013	1.481LysAsn: 1.481 ± 0.017	2.376LysPro: 2.376 ± 0.023	1.726LysGln: 1.726 ± 0.02	3.232LysArg: 3.232 ± 0.026	3.207LysSer: 3.207 ± 0.027	2.426LysThr: 2.426 ± 0.025	2.792LysVal: 2.792 ± 0.024	0.716LysTrp: 0.716 ± 0.011	1.309LysTyr: 1.309 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.65LeuAla: 7.65 ± 0.037	1.806LeuCys: 1.806 ± 0.02	5.343LeuAsp: 5.343 ± 0.035	5.429LeuGlu: 5.429 ± 0.034	3.522LeuPhe: 3.522 ± 0.027	5.542LeuGly: 5.542 ± 0.031	3.058LeuHis: 3.058 ± 0.028	4.112LeuIle: 4.112 ± 0.026	4.097LeuLys: 4.097 ± 0.031	9.003LeuLeu: 9.003 ± 0.051	2.032LeuMet: 2.032 ± 0.018	3.073LeuAsn: 3.073 ± 0.025	6.111LeuPro: 6.111 ± 0.04	4.05LeuGln: 4.05 ± 0.027	5.915LeuArg: 5.915 ± 0.034	8.148LeuSer: 8.148 ± 0.041	5.355LeuThr: 5.355 ± 0.033	5.927LeuVal: 5.927 ± 0.033	1.35LeuTrp: 1.35 ± 0.016	2.425LeuTyr: 2.425 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.004MetAla: 2.004 ± 0.019	0.359MetCys: 0.359 ± 0.007	1.466MetAsp: 1.466 ± 0.017	1.367MetGlu: 1.367 ± 0.015	0.794MetPhe: 0.794 ± 0.011	1.298MetGly: 1.298 ± 0.015	0.656MetHis: 0.656 ± 0.012	0.993MetIle: 0.993 ± 0.013	1.08MetLys: 1.08 ± 0.014	2.051MetLeu: 2.051 ± 0.021	0.559MetMet: 0.559 ± 0.01	0.779MetAsn: 0.779 ± 0.011	1.312MetPro: 1.312 ± 0.014	0.976MetGln: 0.976 ± 0.013	1.311MetArg: 1.311 ± 0.015	2.12MetSer: 2.12 ± 0.018	1.391MetThr: 1.391 ± 0.016	1.433MetVal: 1.433 ± 0.017	0.351MetTrp: 0.351 ± 0.008	0.599MetTyr: 0.599 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.883AsnAla: 2.883 ± 0.02	0.561AsnCys: 0.561 ± 0.011	1.887AsnAsp: 1.887 ± 0.019	1.88AsnGlu: 1.88 ± 0.016	1.288AsnPhe: 1.288 ± 0.016	2.444AsnGly: 2.444 ± 0.02	0.981AsnHis: 0.981 ± 0.013	2.026AsnIle: 2.026 ± 0.02	1.481AsnLys: 1.481 ± 0.014	3.182AsnLeu: 3.182 ± 0.022	0.824AsnMet: 0.824 ± 0.013	1.363AsnAsn: 1.363 ± 0.014	2.215AsnPro: 2.215 ± 0.02	1.203AsnGln: 1.203 ± 0.013	1.817AsnArg: 1.817 ± 0.019	2.63AsnSer: 2.63 ± 0.023	2.2AsnThr: 2.2 ± 0.021	2.5AsnVal: 2.5 ± 0.02	0.554AsnTrp: 0.554 ± 0.009	0.946AsnTyr: 0.946 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.634ProAla: 4.634 ± 0.036	0.956ProCys: 0.956 ± 0.016	3.161ProAsp: 3.161 ± 0.027	3.279ProGlu: 3.279 ± 0.024	2.168ProPhe: 2.168 ± 0.02	3.546ProGly: 3.546 ± 0.029	1.831ProHis: 1.831 ± 0.018	2.695ProIle: 2.695 ± 0.024	2.35ProLys: 2.35 ± 0.023	5.475ProLeu: 5.475 ± 0.039	1.19ProMet: 1.19 ± 0.014	2.131ProAsn: 2.131 ± 0.021	5.909ProPro: 5.909 ± 0.057	2.425ProGln: 2.425 ± 0.026	3.553ProArg: 3.553 ± 0.03	7.144ProSer: 7.144 ± 0.047	4.221ProThr: 4.221 ± 0.028	3.778ProVal: 3.778 ± 0.032	0.778ProTrp: 0.778 ± 0.013	1.545ProTyr: 1.545 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.132GlnAla: 3.132 ± 0.024	0.765GlnCys: 0.765 ± 0.013	1.929GlnAsp: 1.929 ± 0.017	2.318GlnGlu: 2.318 ± 0.02	1.276GlnPhe: 1.276 ± 0.016	2.323GlnGly: 2.323 ± 0.023	1.256GlnHis: 1.256 ± 0.015	1.832GlnIle: 1.832 ± 0.018	1.771GlnLys: 1.771 ± 0.018	3.741GlnLeu: 3.741 ± 0.025	0.921GlnMet: 0.921 ± 0.014	1.34GlnAsn: 1.34 ± 0.015	2.426GlnPro: 2.426 ± 0.026	2.048GlnGln: 2.048 ± 0.027	2.579GlnArg: 2.579 ± 0.022	3.08GlnSer: 3.08 ± 0.022	2.22GlnThr: 2.22 ± 0.022	2.443GlnVal: 2.443 ± 0.02	0.688GlnTrp: 0.688 ± 0.011	1.102GlnTyr: 1.102 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.665ArgAla: 4.665 ± 0.037	1.089ArgCys: 1.089 ± 0.014	3.22ArgAsp: 3.22 ± 0.028	3.52ArgGlu: 3.52 ± 0.025	2.145ArgPhe: 2.145 ± 0.019	3.514ArgGly: 3.514 ± 0.024	1.852ArgHis: 1.852 ± 0.018	3.025ArgIle: 3.025 ± 0.022	3.178ArgLys: 3.178 ± 0.027	5.603ArgLeu: 5.603 ± 0.026	1.459ArgMet: 1.459 ± 0.015	2.144ArgAsn: 2.144 ± 0.019	3.502ArgPro: 3.502 ± 0.033	2.425ArgGln: 2.425 ± 0.021	4.845ArgArg: 4.845 ± 0.035	5.064ArgSer: 5.064 ± 0.034	3.538ArgThr: 3.538 ± 0.027	3.722ArgVal: 3.722 ± 0.025	1.055ArgTrp: 1.055 ± 0.014	1.65ArgTyr: 1.65 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.428SerAla: 6.428 ± 0.039	1.451SerCys: 1.451 ± 0.019	4.394SerAsp: 4.394 ± 0.032	3.978SerGlu: 3.978 ± 0.028	3.123SerPhe: 3.123 ± 0.023	5.415SerGly: 5.415 ± 0.034	2.524SerHis: 2.524 ± 0.022	4.186SerIle: 4.186 ± 0.028	3.492SerLys: 3.492 ± 0.025	8.036SerLeu: 8.036 ± 0.044	1.853SerMet: 1.853 ± 0.019	2.976SerAsn: 2.976 ± 0.021	6.184SerPro: 6.184 ± 0.051	3.278SerGln: 3.278 ± 0.025	5.143SerArg: 5.143 ± 0.035	9.357SerSer: 9.357 ± 0.079	5.954SerThr: 5.954 ± 0.038	5.078SerVal: 5.078 ± 0.031	1.136SerTrp: 1.136 ± 0.014	1.956SerTyr: 1.956 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	4.631ThrAla: 4.631 ± 0.031	1.097ThrCys: 1.097 ± 0.013	2.867ThrAsp: 2.867 ± 0.023	2.799ThrGlu: 2.799 ± 0.022	2.348ThrPhe: 2.348 ± 0.02	3.699ThrGly: 3.699 ± 0.03	1.76ThrHis: 1.76 ± 0.019	3.151ThrIle: 3.151 ± 0.025	2.455ThrLys: 2.455 ± 0.021	5.847ThrLeu: 5.847 ± 0.034	1.35ThrMet: 1.35 ± 0.016	2.071ThrAsn: 2.071 ± 0.021	4.307ThrPro: 4.307 ± 0.03	2.182ThrGln: 2.182 ± 0.02	3.438ThrArg: 3.438 ± 0.025	5.794ThrSer: 5.794 ± 0.04	4.297ThrThr: 4.297 ± 0.037	3.75ThrVal: 3.75 ± 0.026	0.908ThrTrp: 0.908 ± 0.011	1.612ThrTyr: 1.612 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.989ValAla: 4.989 ± 0.031	1.092ValCys: 1.092 ± 0.013	3.876ValAsp: 3.876 ± 0.029	3.691ValGlu: 3.691 ± 0.024	2.476ValPhe: 2.476 ± 0.021	3.704ValGly: 3.704 ± 0.028	1.95ValHis: 1.95 ± 0.016	3.251ValIle: 3.251 ± 0.028	2.817ValLys: 2.817 ± 0.024	6.161ValLeu: 6.161 ± 0.034	1.444ValMet: 1.444 ± 0.015	2.204ValAsn: 2.204 ± 0.021	4.051ValPro: 4.051 ± 0.027	2.647ValGln: 2.647 ± 0.022	3.604ValArg: 3.604 ± 0.024	5.074ValSer: 5.074 ± 0.033	3.671ValThr: 3.671 ± 0.025	4.514ValVal: 4.514 ± 0.035	1.013ValTrp: 1.013 ± 0.014	1.72ValTyr: 1.72 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.144TrpAla: 1.144 ± 0.014	0.327TrpCys: 0.327 ± 0.007	0.918TrpAsp: 0.918 ± 0.015	0.871TrpGlu: 0.871 ± 0.011	0.607TrpPhe: 0.607 ± 0.011	0.812TrpGly: 0.812 ± 0.013	0.485TrpHis: 0.485 ± 0.009	0.784TrpIle: 0.784 ± 0.012	0.857TrpLys: 0.857 ± 0.012	1.464TrpLeu: 1.464 ± 0.018	0.462TrpMet: 0.462 ± 0.009	0.646TrpAsn: 0.646 ± 0.01	0.717TrpPro: 0.717 ± 0.01	0.599TrpGln: 0.599 ± 0.01	1.044TrpArg: 1.044 ± 0.013	1.215TrpSer: 1.215 ± 0.012	1.001TrpThr: 1.001 ± 0.013	0.941TrpVal: 0.941 ± 0.013	0.352TrpTrp: 0.352 ± 0.009	0.461TrpTyr: 0.461 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.976TyrAla: 1.976 ± 0.017	0.508TyrCys: 0.508 ± 0.009	1.541TyrAsp: 1.541 ± 0.017	1.363TyrGlu: 1.363 ± 0.014	1.162TyrPhe: 1.162 ± 0.014	1.666TyrGly: 1.666 ± 0.019	0.86TyrHis: 0.86 ± 0.01	1.473TyrIle: 1.473 ± 0.015	1.05TyrLys: 1.05 ± 0.011	2.747TyrLeu: 2.747 ± 0.021	0.612TyrMet: 0.612 ± 0.01	1.063TyrAsn: 1.063 ± 0.014	1.536TyrPro: 1.536 ± 0.016	0.995TyrGln: 0.995 ± 0.013	1.614TyrArg: 1.614 ± 0.017	2.048TyrSer: 2.048 ± 0.018	1.528TyrThr: 1.528 ± 0.017	1.655TyrVal: 1.655 ± 0.018	0.386TyrTrp: 0.386 ± 0.008	0.89TyrTyr: 0.89 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20903 proteins (6241616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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