Amino acid dipepetide frequency for Corynebacterium sp. 2189

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.433AlaAla: 15.433 ± 0.261	0.89AlaCys: 0.89 ± 0.043	7.316AlaAsp: 7.316 ± 0.125	9.155AlaGlu: 9.155 ± 0.128	3.477AlaPhe: 3.477 ± 0.081	10.676AlaGly: 10.676 ± 0.151	2.617AlaHis: 2.617 ± 0.064	5.323AlaIle: 5.323 ± 0.094	2.984AlaLys: 2.984 ± 0.077	11.736AlaLeu: 11.736 ± 0.148	2.392AlaMet: 2.392 ± 0.067	2.555AlaAsn: 2.555 ± 0.068	5.142AlaPro: 5.142 ± 0.144	3.999AlaGln: 3.999 ± 0.088	7.913AlaArg: 7.913 ± 0.132	5.743AlaSer: 5.743 ± 0.085	6.664AlaThr: 6.664 ± 0.095	9.678AlaVal: 9.678 ± 0.143	1.511AlaTrp: 1.511 ± 0.052	2.414AlaTyr: 2.414 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.825CysAla: 0.825 ± 0.032	0.073CysCys: 0.073 ± 0.011	0.396CysAsp: 0.396 ± 0.024	0.396CysGlu: 0.396 ± 0.029	0.208CysPhe: 0.208 ± 0.019	0.69CysGly: 0.69 ± 0.032	0.184CysHis: 0.184 ± 0.015	0.25CysIle: 0.25 ± 0.021	0.099CysLys: 0.099 ± 0.012	0.518CysLeu: 0.518 ± 0.025	0.116CysMet: 0.116 ± 0.013	0.135CysAsn: 0.135 ± 0.013	0.354CysPro: 0.354 ± 0.026	0.181CysGln: 0.181 ± 0.017	0.405CysArg: 0.405 ± 0.025	0.417CysSer: 0.417 ± 0.024	0.399CysThr: 0.399 ± 0.023	0.495CysVal: 0.495 ± 0.03	0.093CysTrp: 0.093 ± 0.011	0.126CysTyr: 0.126 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.191AspAla: 7.191 ± 0.11	0.341AspCys: 0.341 ± 0.022	4.661AspAsp: 4.661 ± 0.091	5.188AspGlu: 5.188 ± 0.095	2.0AspPhe: 2.0 ± 0.06	5.455AspGly: 5.455 ± 0.107	1.481AspHis: 1.481 ± 0.047	3.179AspIle: 3.179 ± 0.073	1.936AspLys: 1.936 ± 0.051	5.712AspLeu: 5.712 ± 0.092	1.232AspMet: 1.232 ± 0.038	2.054AspAsn: 2.054 ± 0.059	3.783AspPro: 3.783 ± 0.079	1.807AspGln: 1.807 ± 0.057	3.622AspArg: 3.622 ± 0.068	3.085AspSer: 3.085 ± 0.072	3.699AspThr: 3.699 ± 0.078	4.8AspVal: 4.8 ± 0.088	0.856AspTrp: 0.856 ± 0.041	1.835AspTyr: 1.835 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	7.556GluAla: 7.556 ± 0.127	0.338GluCys: 0.338 ± 0.023	4.067GluAsp: 4.067 ± 0.093	4.927GluGlu: 4.927 ± 0.113	2.111GluPhe: 2.111 ± 0.065	4.619GluGly: 4.619 ± 0.085	1.849GluHis: 1.849 ± 0.052	4.089GluIle: 4.089 ± 0.081	2.787GluLys: 2.787 ± 0.076	7.425GluLeu: 7.425 ± 0.117	1.38GluMet: 1.38 ± 0.048	2.035GluAsn: 2.035 ± 0.062	3.05GluPro: 3.05 ± 0.082	2.603GluGln: 2.603 ± 0.067	4.989GluArg: 4.989 ± 0.098	3.009GluSer: 3.009 ± 0.071	3.455GluThr: 3.455 ± 0.08	5.475GluVal: 5.475 ± 0.106	0.762GluTrp: 0.762 ± 0.038	1.395GluTyr: 1.395 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.805PheAla: 3.805 ± 0.076	0.248PheCys: 0.248 ± 0.019	2.392PheAsp: 2.392 ± 0.059	1.839PheGlu: 1.839 ± 0.061	1.245PhePhe: 1.245 ± 0.048	3.289PheGly: 3.289 ± 0.084	0.736PheHis: 0.736 ± 0.03	1.623PheIle: 1.623 ± 0.049	0.57PheLys: 0.57 ± 0.029	2.918PheLeu: 2.918 ± 0.071	0.584PheMet: 0.584 ± 0.03	0.885PheAsn: 0.885 ± 0.036	1.325PhePro: 1.325 ± 0.042	0.822PheGln: 0.822 ± 0.037	1.839PheArg: 1.839 ± 0.047	2.108PheSer: 2.108 ± 0.061	2.053PheThr: 2.053 ± 0.056	2.532PheVal: 2.532 ± 0.078	0.45PheTrp: 0.45 ± 0.025	0.778PheTyr: 0.778 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.831GlyAla: 8.831 ± 0.132	0.62GlyCys: 0.62 ± 0.032	4.741GlyAsp: 4.741 ± 0.09	5.876GlyGlu: 5.876 ± 0.1	3.25GlyPhe: 3.25 ± 0.074	6.883GlyGly: 6.883 ± 0.14	1.989GlyHis: 1.989 ± 0.058	4.747GlyIle: 4.747 ± 0.087	2.655GlyLys: 2.655 ± 0.059	8.387GlyLeu: 8.387 ± 0.117	2.145GlyMet: 2.145 ± 0.064	2.204GlyAsn: 2.204 ± 0.059	3.4GlyPro: 3.4 ± 0.065	2.598GlyGln: 2.598 ± 0.065	5.432GlyArg: 5.432 ± 0.093	4.694GlySer: 4.694 ± 0.08	5.246GlyThr: 5.246 ± 0.093	6.94GlyVal: 6.94 ± 0.113	1.354GlyTrp: 1.354 ± 0.048	2.257GlyTyr: 2.257 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.427HisAla: 2.427 ± 0.065	0.165HisCys: 0.165 ± 0.016	1.499HisAsp: 1.499 ± 0.05	1.38HisGlu: 1.38 ± 0.048	0.646HisPhe: 0.646 ± 0.028	2.071HisGly: 2.071 ± 0.058	0.666HisHis: 0.666 ± 0.032	1.026HisIle: 1.026 ± 0.039	0.43HisLys: 0.43 ± 0.023	2.354HisLeu: 2.354 ± 0.064	0.447HisMet: 0.447 ± 0.027	0.608HisAsn: 0.608 ± 0.028	1.63HisPro: 1.63 ± 0.054	0.663HisGln: 0.663 ± 0.029	1.755HisArg: 1.755 ± 0.052	1.225HisSer: 1.225 ± 0.045	1.414HisThr: 1.414 ± 0.056	1.661HisVal: 1.661 ± 0.052	0.282HisTrp: 0.282 ± 0.021	0.584HisTyr: 0.584 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.693IleAla: 6.693 ± 0.11	0.377IleCys: 0.377 ± 0.025	4.246IleAsp: 4.246 ± 0.089	3.218IleGlu: 3.218 ± 0.078	1.524IlePhe: 1.524 ± 0.056	4.754IleGly: 4.754 ± 0.103	1.061IleHis: 1.061 ± 0.038	2.639IleIle: 2.639 ± 0.078	1.045IleLys: 1.045 ± 0.048	4.156IleLeu: 4.156 ± 0.087	0.91IleMet: 0.91 ± 0.037	1.552IleAsn: 1.552 ± 0.052	2.549IlePro: 2.549 ± 0.063	1.1IleGln: 1.1 ± 0.043	2.791IleArg: 2.791 ± 0.066	2.867IleSer: 2.867 ± 0.059	3.644IleThr: 3.644 ± 0.083	4.282IleVal: 4.282 ± 0.09	0.525IleTrp: 0.525 ± 0.026	1.058IleTyr: 1.058 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.154LysAla: 3.154 ± 0.082	0.09LysCys: 0.09 ± 0.01	1.65LysAsp: 1.65 ± 0.055	1.759LysGlu: 1.759 ± 0.052	0.713LysPhe: 0.713 ± 0.031	1.867LysGly: 1.867 ± 0.06	0.655LysHis: 0.655 ± 0.029	1.431LysIle: 1.431 ± 0.051	1.578LysLys: 1.578 ± 0.077	2.79LysLeu: 2.79 ± 0.069	0.653LysMet: 0.653 ± 0.033	0.986LysAsn: 0.986 ± 0.041	1.414LysPro: 1.414 ± 0.06	0.955LysGln: 0.955 ± 0.037	2.073LysArg: 2.073 ± 0.067	1.343LysSer: 1.343 ± 0.052	1.636LysThr: 1.636 ± 0.052	2.192LysVal: 2.192 ± 0.06	0.334LysTrp: 0.334 ± 0.021	0.604LysTyr: 0.604 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.447LeuAla: 12.447 ± 0.159	0.566LeuCys: 0.566 ± 0.03	6.505LeuAsp: 6.505 ± 0.097	5.465LeuGlu: 5.465 ± 0.098	2.894LeuPhe: 2.894 ± 0.072	8.46LeuGly: 8.46 ± 0.132	2.111LeuHis: 2.111 ± 0.055	5.269LeuIle: 5.269 ± 0.109	2.524LeuLys: 2.524 ± 0.064	8.882LeuLeu: 8.882 ± 0.16	1.974LeuMet: 1.974 ± 0.054	2.533LeuAsn: 2.533 ± 0.056	5.082LeuPro: 5.082 ± 0.089	2.495LeuGln: 2.495 ± 0.058	6.57LeuArg: 6.57 ± 0.098	5.886LeuSer: 5.886 ± 0.101	5.94LeuThr: 5.94 ± 0.102	8.003LeuVal: 8.003 ± 0.121	1.106LeuTrp: 1.106 ± 0.043	1.814LeuTyr: 1.814 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.519MetAla: 2.519 ± 0.065	0.135MetCys: 0.135 ± 0.015	1.089MetAsp: 1.089 ± 0.036	0.958MetGlu: 0.958 ± 0.032	0.687MetPhe: 0.687 ± 0.034	1.555MetGly: 1.555 ± 0.049	0.443MetHis: 0.443 ± 0.024	1.198MetIle: 1.198 ± 0.041	0.595MetLys: 0.595 ± 0.031	2.121MetLeu: 2.121 ± 0.062	0.459MetMet: 0.459 ± 0.026	0.617MetAsn: 0.617 ± 0.029	1.151MetPro: 1.151 ± 0.044	0.659MetGln: 0.659 ± 0.034	1.399MetArg: 1.399 ± 0.042	1.704MetSer: 1.704 ± 0.047	1.71MetThr: 1.71 ± 0.044	1.581MetVal: 1.581 ± 0.05	0.266MetTrp: 0.266 ± 0.02	0.359MetTyr: 0.359 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.874AsnAla: 2.874 ± 0.071	0.2AsnCys: 0.2 ± 0.017	1.632AsnAsp: 1.632 ± 0.056	1.688AsnGlu: 1.688 ± 0.054	0.868AsnPhe: 0.868 ± 0.034	2.076AsnGly: 2.076 ± 0.064	0.602AsnHis: 0.602 ± 0.024	1.328AsnIle: 1.328 ± 0.048	0.753AsnLys: 0.753 ± 0.035	2.536AsnLeu: 2.536 ± 0.057	0.569AsnMet: 0.569 ± 0.027	0.791AsnAsn: 0.791 ± 0.039	1.92AsnPro: 1.92 ± 0.054	0.901AsnGln: 0.901 ± 0.04	1.685AsnArg: 1.685 ± 0.05	1.44AsnSer: 1.44 ± 0.044	1.515AsnThr: 1.515 ± 0.05	2.064AsnVal: 2.064 ± 0.06	0.393AsnTrp: 0.393 ± 0.02	0.798AsnTyr: 0.798 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.941ProAla: 5.941 ± 0.11	0.206ProCys: 0.206 ± 0.018	3.315ProAsp: 3.315 ± 0.074	4.684ProGlu: 4.684 ± 0.092	1.523ProPhe: 1.523 ± 0.049	4.668ProGly: 4.668 ± 0.081	1.208ProHis: 1.208 ± 0.048	1.977ProIle: 1.977 ± 0.052	1.453ProLys: 1.453 ± 0.052	4.3ProLeu: 4.3 ± 0.086	0.984ProMet: 0.984 ± 0.037	1.302ProAsn: 1.302 ± 0.048	2.016ProPro: 2.016 ± 0.068	1.801ProGln: 1.801 ± 0.052	2.915ProArg: 2.915 ± 0.067	2.626ProSer: 2.626 ± 0.067	3.117ProThr: 3.117 ± 0.073	4.487ProVal: 4.487 ± 0.085	0.621ProTrp: 0.621 ± 0.027	1.035ProTyr: 1.035 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.851GlnAla: 3.851 ± 0.094	0.151GlnCys: 0.151 ± 0.015	1.511GlnAsp: 1.511 ± 0.05	1.854GlnGlu: 1.854 ± 0.055	0.922GlnPhe: 0.922 ± 0.035	2.044GlnGly: 2.044 ± 0.058	0.66GlnHis: 0.66 ± 0.032	1.648GlnIle: 1.648 ± 0.052	1.045GlnLys: 1.045 ± 0.042	3.53GlnLeu: 3.53 ± 0.079	0.835GlnMet: 0.835 ± 0.035	0.756GlnAsn: 0.756 ± 0.037	1.575GlnPro: 1.575 ± 0.049	1.273GlnGln: 1.273 ± 0.05	2.556GlnArg: 2.556 ± 0.066	1.486GlnSer: 1.486 ± 0.053	1.463GlnThr: 1.463 ± 0.049	2.505GlnVal: 2.505 ± 0.054	0.521GlnTrp: 0.521 ± 0.028	0.61GlnTyr: 0.61 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.164ArgAla: 7.164 ± 0.114	0.392ArgCys: 0.392 ± 0.023	4.027ArgAsp: 4.027 ± 0.087	4.895ArgGlu: 4.895 ± 0.086	2.253ArgPhe: 2.253 ± 0.06	4.935ArgGly: 4.935 ± 0.087	1.629ArgHis: 1.629 ± 0.045	3.469ArgIle: 3.469 ± 0.065	2.034ArgLys: 2.034 ± 0.061	6.467ArgLeu: 6.467 ± 0.104	1.682ArgMet: 1.682 ± 0.048	1.656ArgAsn: 1.656 ± 0.052	3.34ArgPro: 3.34 ± 0.063	2.199ArgGln: 2.199 ± 0.064	6.046ArgArg: 6.046 ± 0.118	3.725ArgSer: 3.725 ± 0.075	3.899ArgThr: 3.899 ± 0.077	4.712ArgVal: 4.712 ± 0.08	0.942ArgTrp: 0.942 ± 0.037	1.688ArgTyr: 1.688 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.33SerAla: 6.33 ± 0.095	0.309SerCys: 0.309 ± 0.018	3.077SerAsp: 3.077 ± 0.071	3.493SerGlu: 3.493 ± 0.083	1.944SerPhe: 1.944 ± 0.046	5.176SerGly: 5.176 ± 0.095	1.169SerHis: 1.169 ± 0.04	2.442SerIle: 2.442 ± 0.062	1.334SerLys: 1.334 ± 0.052	5.237SerLeu: 5.237 ± 0.084	1.26SerMet: 1.26 ± 0.042	1.317SerAsn: 1.317 ± 0.042	2.784SerPro: 2.784 ± 0.066	1.836SerGln: 1.836 ± 0.055	3.619SerArg: 3.619 ± 0.071	3.583SerSer: 3.583 ± 0.08	3.625SerThr: 3.625 ± 0.075	4.294SerVal: 4.294 ± 0.081	0.859SerTrp: 0.859 ± 0.038	1.36SerTyr: 1.36 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.959ThrAla: 6.959 ± 0.098	0.376ThrCys: 0.376 ± 0.025	3.739ThrAsp: 3.739 ± 0.077	3.764ThrGlu: 3.764 ± 0.081	1.893ThrPhe: 1.893 ± 0.055	5.576ThrGly: 5.576 ± 0.09	1.335ThrHis: 1.335 ± 0.049	3.037ThrIle: 3.037 ± 0.067	1.433ThrLys: 1.433 ± 0.049	5.523ThrLeu: 5.523 ± 0.088	1.248ThrMet: 1.248 ± 0.049	1.534ThrAsn: 1.534 ± 0.052	3.738ThrPro: 3.738 ± 0.076	1.682ThrGln: 1.682 ± 0.053	3.718ThrArg: 3.718 ± 0.075	3.468ThrSer: 3.468 ± 0.079	4.022ThrThr: 4.022 ± 0.092	5.545ThrVal: 5.545 ± 0.104	0.854ThrTrp: 0.854 ± 0.034	1.489ThrTyr: 1.489 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.739ValAla: 9.739 ± 0.118	0.579ValCys: 0.579 ± 0.028	5.758ValAsp: 5.758 ± 0.097	5.259ValGlu: 5.259 ± 0.091	2.508ValPhe: 2.508 ± 0.069	6.551ValGly: 6.551 ± 0.115	1.703ValHis: 1.703 ± 0.058	4.76ValIle: 4.76 ± 0.1	1.833ValLys: 1.833 ± 0.065	7.895ValLeu: 7.895 ± 0.131	1.648ValMet: 1.648 ± 0.047	2.079ValAsn: 2.079 ± 0.062	4.057ValPro: 4.057 ± 0.07	1.859ValGln: 1.859 ± 0.056	5.124ValArg: 5.124 ± 0.09	4.532ValSer: 4.532 ± 0.084	5.483ValThr: 5.483 ± 0.086	7.625ValVal: 7.625 ± 0.146	0.946ValTrp: 0.946 ± 0.036	1.634ValTyr: 1.634 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.482TrpAla: 1.482 ± 0.052	0.113TrpCys: 0.113 ± 0.014	0.688TrpAsp: 0.688 ± 0.029	0.72TrpGlu: 0.72 ± 0.031	0.502TrpPhe: 0.502 ± 0.031	0.88TrpGly: 0.88 ± 0.039	0.318TrpHis: 0.318 ± 0.019	0.704TrpIle: 0.704 ± 0.033	0.38TrpLys: 0.38 ± 0.021	1.605TrpLeu: 1.605 ± 0.059	0.341TrpMet: 0.341 ± 0.023	0.386TrpAsn: 0.386 ± 0.024	0.645TrpPro: 0.645 ± 0.031	0.546TrpGln: 0.546 ± 0.03	0.936TrpArg: 0.936 ± 0.039	0.705TrpSer: 0.705 ± 0.034	0.671TrpThr: 0.671 ± 0.033	1.089TrpVal: 1.089 ± 0.043	0.321TrpTrp: 0.321 ± 0.023	0.293TrpTyr: 0.293 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.398TyrAla: 2.398 ± 0.057	0.189TyrCys: 0.189 ± 0.016	1.607TyrAsp: 1.607 ± 0.045	1.402TyrGlu: 1.402 ± 0.05	0.874TyrPhe: 0.874 ± 0.039	2.025TyrGly: 2.025 ± 0.059	0.52TyrHis: 0.52 ± 0.026	0.855TyrIle: 0.855 ± 0.033	0.406TyrLys: 0.406 ± 0.023	2.434TyrLeu: 2.434 ± 0.066	0.34TyrMet: 0.34 ± 0.02	0.652TyrAsn: 0.652 ± 0.032	1.225TyrPro: 1.225 ± 0.045	0.814TyrGln: 0.814 ± 0.03	1.767TyrArg: 1.767 ± 0.058	1.402TyrSer: 1.402 ± 0.049	1.28TyrThr: 1.28 ± 0.044	1.614TyrVal: 1.614 ± 0.05	0.328TyrTrp: 0.328 ± 0.021	0.576TyrTyr: 0.576 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2133 proteins (688899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---