Amino acid dipepetide frequency for Eremococcus coleocola ACS-139-V-Col8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.572AlaAla: 6.572 ± 0.159
0.517AlaCys: 0.517 ± 0.033
4.903AlaAsp: 4.903 ± 0.11
4.707AlaGlu: 4.707 ± 0.103
3.328AlaPhe: 3.328 ± 0.094
5.7AlaGly: 5.7 ± 0.132
1.368AlaHis: 1.368 ± 0.057
6.016AlaIle: 6.016 ± 0.111
5.236AlaLys: 5.236 ± 0.1
8.266AlaLeu: 8.266 ± 0.133
2.402AlaMet: 2.402 ± 0.07
3.459AlaAsn: 3.459 ± 0.085
2.078AlaPro: 2.078 ± 0.064
4.19AlaGln: 4.19 ± 0.105
2.801AlaArg: 2.801 ± 0.075
5.01AlaSer: 5.01 ± 0.108
3.767AlaThr: 3.767 ± 0.098
5.049AlaVal: 5.049 ± 0.101
0.704AlaTrp: 0.704 ± 0.036
3.26AlaTyr: 3.26 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.283CysAla: 0.283 ± 0.026
0.059CysCys: 0.059 ± 0.012
0.297CysAsp: 0.297 ± 0.024
0.224CysGlu: 0.224 ± 0.021
0.25CysPhe: 0.25 ± 0.024
0.513CysGly: 0.513 ± 0.037
0.226CysHis: 0.226 ± 0.026
0.351CysIle: 0.351 ± 0.027
0.203CysLys: 0.203 ± 0.02
0.739CysLeu: 0.739 ± 0.038
0.101CysMet: 0.101 ± 0.015
0.162CysAsn: 0.162 ± 0.016
0.267CysPro: 0.267 ± 0.028
0.384CysGln: 0.384 ± 0.028
0.254CysArg: 0.254 ± 0.021
0.265CysSer: 0.265 ± 0.023
0.213CysThr: 0.213 ± 0.019
0.306CysVal: 0.306 ± 0.025
0.035CysTrp: 0.035 ± 0.009
0.191CysTyr: 0.191 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.705AspAla: 3.705 ± 0.098
0.365AspCys: 0.365 ± 0.03
2.985AspAsp: 2.985 ± 0.078
3.831AspGlu: 3.831 ± 0.102
3.285AspPhe: 3.285 ± 0.086
3.537AspGly: 3.537 ± 0.098
1.576AspHis: 1.576 ± 0.064
4.364AspIle: 4.364 ± 0.092
3.81AspLys: 3.81 ± 0.096
7.265AspLeu: 7.265 ± 0.142
1.559AspMet: 1.559 ± 0.06
2.359AspAsn: 2.359 ± 0.072
2.398AspPro: 2.398 ± 0.107
5.141AspGln: 5.141 ± 0.123
2.571AspArg: 2.571 ± 0.065
3.229AspSer: 3.229 ± 0.087
2.727AspThr: 2.727 ± 0.073
3.352AspVal: 3.352 ± 0.088
0.7AspTrp: 0.7 ± 0.038
3.408AspTyr: 3.408 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
6.016GluAla: 6.016 ± 0.145
0.246GluCys: 0.246 ± 0.021
4.196GluAsp: 4.196 ± 0.107
5.232GluGlu: 5.232 ± 0.148
2.441GluPhe: 2.441 ± 0.074
3.915GluGly: 3.915 ± 0.101
0.899GluHis: 0.899 ± 0.043
5.271GluIle: 5.271 ± 0.11
4.469GluLys: 4.469 ± 0.112
6.256GluLeu: 6.256 ± 0.118
1.931GluMet: 1.931 ± 0.057
3.437GluAsn: 3.437 ± 0.095
1.627GluPro: 1.627 ± 0.061
2.359GluGln: 2.359 ± 0.07
2.509GluArg: 2.509 ± 0.075
3.796GluSer: 3.796 ± 0.091
3.326GluThr: 3.326 ± 0.098
4.475GluVal: 4.475 ± 0.101
0.562GluTrp: 0.562 ± 0.031
1.886GluTyr: 1.886 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.149PheAla: 3.149 ± 0.08
0.302PheCys: 0.302 ± 0.023
2.928PheAsp: 2.928 ± 0.076
2.694PheGlu: 2.694 ± 0.073
2.0PhePhe: 2.0 ± 0.074
3.008PheGly: 3.008 ± 0.086
0.753PheHis: 0.753 ± 0.039
3.344PheIle: 3.344 ± 0.097
2.747PheLys: 2.747 ± 0.077
4.13PheLeu: 4.13 ± 0.112
1.19PheMet: 1.19 ± 0.048
2.243PheAsn: 2.243 ± 0.074
1.389PhePro: 1.389 ± 0.058
1.672PheGln: 1.672 ± 0.059
1.354PheArg: 1.354 ± 0.052
2.649PheSer: 2.649 ± 0.077
2.224PheThr: 2.224 ± 0.069
2.889PheVal: 2.889 ± 0.083
0.402PheTrp: 0.402 ± 0.029
1.785PheTyr: 1.785 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.555GlyAla: 4.555 ± 0.122
0.392GlyCys: 0.392 ± 0.031
3.578GlyAsp: 3.578 ± 0.094
3.157GlyGlu: 3.157 ± 0.106
3.006GlyPhe: 3.006 ± 0.071
4.282GlyGly: 4.282 ± 0.117
1.627GlyHis: 1.627 ± 0.057
5.092GlyIle: 5.092 ± 0.103
4.155GlyLys: 4.155 ± 0.091
7.263GlyLeu: 7.263 ± 0.133
1.826GlyMet: 1.826 ± 0.065
2.485GlyAsn: 2.485 ± 0.063
1.793GlyPro: 1.793 ± 0.065
4.493GlyGln: 4.493 ± 0.105
2.917GlyArg: 2.917 ± 0.077
3.81GlySer: 3.81 ± 0.099
3.217GlyThr: 3.217 ± 0.08
4.337GlyVal: 4.337 ± 0.096
0.585GlyTrp: 0.585 ± 0.035
2.692GlyTyr: 2.692 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.227HisAla: 1.227 ± 0.057
0.133HisCys: 0.133 ± 0.016
1.128HisAsp: 1.128 ± 0.046
1.161HisGlu: 1.161 ± 0.05
1.018HisPhe: 1.018 ± 0.036
1.313HisGly: 1.313 ± 0.059
0.737HisHis: 0.737 ± 0.044
1.35HisIle: 1.35 ± 0.052
0.934HisLys: 0.934 ± 0.046
2.267HisLeu: 2.267 ± 0.068
0.439HisMet: 0.439 ± 0.028
0.786HisAsn: 0.786 ± 0.04
1.085HisPro: 1.085 ± 0.048
1.147HisGln: 1.147 ± 0.052
0.86HisArg: 0.86 ± 0.042
1.022HisSer: 1.022 ± 0.048
0.931HisThr: 0.931 ± 0.042
1.133HisVal: 1.133 ± 0.045
0.17HisTrp: 0.17 ± 0.021
1.014HisTyr: 1.014 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.925IleAla: 5.925 ± 0.103
0.54IleCys: 0.54 ± 0.03
4.945IleAsp: 4.945 ± 0.094
5.248IleGlu: 5.248 ± 0.111
3.186IlePhe: 3.186 ± 0.087
4.928IleGly: 4.928 ± 0.1
1.479IleHis: 1.479 ± 0.05
5.739IleIle: 5.739 ± 0.117
4.553IleLys: 4.553 ± 0.095
7.427IleLeu: 7.427 ± 0.16
1.842IleMet: 1.842 ± 0.072
3.5IleAsn: 3.5 ± 0.088
3.098IlePro: 3.098 ± 0.082
3.467IleGln: 3.467 ± 0.077
2.803IleArg: 2.803 ± 0.077
4.485IleSer: 4.485 ± 0.113
3.668IleThr: 3.668 ± 0.089
4.743IleVal: 4.743 ± 0.102
0.613IleTrp: 0.613 ± 0.035
2.735IleTyr: 2.735 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.135LysAla: 5.135 ± 0.107
0.191LysCys: 0.191 ± 0.022
4.161LysAsp: 4.161 ± 0.099
5.162LysGlu: 5.162 ± 0.128
1.857LysPhe: 1.857 ± 0.056
3.67LysGly: 3.67 ± 0.094
1.094LysHis: 1.094 ± 0.048
4.206LysIle: 4.206 ± 0.102
3.833LysLys: 3.833 ± 0.119
5.513LysLeu: 5.513 ± 0.111
1.742LysMet: 1.742 ± 0.059
2.915LysAsn: 2.915 ± 0.082
1.968LysPro: 1.968 ± 0.063
2.918LysGln: 2.918 ± 0.096
2.552LysArg: 2.552 ± 0.072
3.299LysSer: 3.299 ± 0.085
3.112LysThr: 3.112 ± 0.073
4.405LysVal: 4.405 ± 0.108
0.474LysTrp: 0.474 ± 0.031
2.296LysTyr: 2.296 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
9.631LeuAla: 9.631 ± 0.147
0.56LeuCys: 0.56 ± 0.034
6.9LeuAsp: 6.9 ± 0.124
6.475LeuGlu: 6.475 ± 0.119
4.284LeuPhe: 4.284 ± 0.101
6.803LeuGly: 6.803 ± 0.136
1.498LeuHis: 1.498 ± 0.054
7.741LeuIle: 7.741 ± 0.157
6.479LeuLys: 6.479 ± 0.11
9.745LeuLeu: 9.745 ± 0.188
2.696LeuMet: 2.696 ± 0.085
5.033LeuAsn: 5.033 ± 0.1
3.952LeuPro: 3.952 ± 0.093
3.556LeuGln: 3.556 ± 0.09
3.365LeuArg: 3.365 ± 0.087
7.199LeuSer: 7.199 ± 0.138
5.404LeuThr: 5.404 ± 0.112
7.343LeuVal: 7.343 ± 0.135
0.759LeuTrp: 0.759 ± 0.036
3.065LeuTyr: 3.065 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.439MetAla: 2.439 ± 0.072
0.088MetCys: 0.088 ± 0.012
1.721MetAsp: 1.721 ± 0.057
1.658MetGlu: 1.658 ± 0.067
0.87MetPhe: 0.87 ± 0.051
1.808MetGly: 1.808 ± 0.061
0.377MetHis: 0.377 ± 0.027
2.099MetIle: 2.099 ± 0.071
1.81MetLys: 1.81 ± 0.062
2.035MetLeu: 2.035 ± 0.067
0.73MetMet: 0.73 ± 0.043
1.329MetAsn: 1.329 ± 0.054
1.036MetPro: 1.036 ± 0.043
1.1MetGln: 1.1 ± 0.041
0.919MetArg: 0.919 ± 0.038
1.697MetSer: 1.697 ± 0.055
2.046MetThr: 2.046 ± 0.066
2.06MetVal: 2.06 ± 0.057
0.162MetTrp: 0.162 ± 0.016
0.681MetTyr: 0.681 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.632AsnAla: 2.632 ± 0.086
0.218AsnCys: 0.218 ± 0.025
2.47AsnAsp: 2.47 ± 0.066
2.778AsnGlu: 2.778 ± 0.071
2.089AsnPhe: 2.089 ± 0.066
2.675AsnGly: 2.675 ± 0.077
1.278AsnHis: 1.278 ± 0.049
3.225AsnIle: 3.225 ± 0.081
2.675AsnLys: 2.675 ± 0.079
4.743AsnLeu: 4.743 ± 0.1
1.19AsnMet: 1.19 ± 0.047
2.023AsnAsn: 2.023 ± 0.08
2.331AsnPro: 2.331 ± 0.073
3.369AsnGln: 3.369 ± 0.099
2.058AsnArg: 2.058 ± 0.062
2.156AsnSer: 2.156 ± 0.072
2.002AsnThr: 2.002 ± 0.068
2.511AsnVal: 2.511 ± 0.07
0.451AsnTrp: 0.451 ± 0.031
2.175AsnTyr: 2.175 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.647ProAla: 2.647 ± 0.074
0.142ProCys: 0.142 ± 0.018
2.378ProAsp: 2.378 ± 0.072
2.727ProGlu: 2.727 ± 0.075
1.643ProPhe: 1.643 ± 0.055
2.165ProGly: 2.165 ± 0.077
0.667ProHis: 0.667 ± 0.04
2.665ProIle: 2.665 ± 0.077
2.041ProLys: 2.041 ± 0.067
3.41ProLeu: 3.41 ± 0.082
0.853ProMet: 0.853 ± 0.039
1.766ProAsn: 1.766 ± 0.065
0.64ProPro: 0.64 ± 0.035
1.818ProGln: 1.818 ± 0.057
1.102ProArg: 1.102 ± 0.052
2.281ProSer: 2.281 ± 0.071
1.82ProThr: 1.82 ± 0.086
2.684ProVal: 2.684 ± 0.081
0.318ProTrp: 0.318 ± 0.027
1.399ProTyr: 1.399 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
6.959GlnAla: 6.959 ± 0.158
0.14GlnCys: 0.14 ± 0.016
3.293GlnAsp: 3.293 ± 0.069
4.075GlnGlu: 4.075 ± 0.091
1.617GlnPhe: 1.617 ± 0.054
3.295GlnGly: 3.295 ± 0.092
0.782GlnHis: 0.782 ± 0.04
3.744GlnIle: 3.744 ± 0.085
2.647GlnLys: 2.647 ± 0.079
4.824GlnLeu: 4.824 ± 0.092
1.364GlnMet: 1.364 ± 0.055
1.955GlnAsn: 1.955 ± 0.058
1.457GlnPro: 1.457 ± 0.06
1.807GlnGln: 1.807 ± 0.069
1.91GlnArg: 1.91 ± 0.057
2.885GlnSer: 2.885 ± 0.08
2.879GlnThr: 2.879 ± 0.075
4.824GlnVal: 4.824 ± 0.115
0.48GlnTrp: 0.48 ± 0.033
1.434GlnTyr: 1.434 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.431ArgAla: 2.431 ± 0.079
0.189ArgCys: 0.189 ± 0.019
2.087ArgAsp: 2.087 ± 0.075
2.359ArgGlu: 2.359 ± 0.074
1.795ArgPhe: 1.795 ± 0.064
2.13ArgGly: 2.13 ± 0.071
0.89ArgHis: 0.89 ± 0.042
2.967ArgIle: 2.967 ± 0.084
2.507ArgLys: 2.507 ± 0.081
4.239ArgLeu: 4.239 ± 0.089
1.139ArgMet: 1.139 ± 0.049
1.549ArgAsn: 1.549 ± 0.05
1.567ArgPro: 1.567 ± 0.059
2.48ArgGln: 2.48 ± 0.083
1.953ArgArg: 1.953 ± 0.072
2.013ArgSer: 2.013 ± 0.064
1.883ArgThr: 1.883 ± 0.054
2.571ArgVal: 2.571 ± 0.076
0.32ArgTrp: 0.32 ± 0.024
1.426ArgTyr: 1.426 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.679SerAla: 3.679 ± 0.088
0.25SerCys: 0.25 ± 0.024
3.556SerAsp: 3.556 ± 0.082
3.474SerGlu: 3.474 ± 0.094
2.901SerPhe: 2.901 ± 0.089
4.169SerGly: 4.169 ± 0.093
1.344SerHis: 1.344 ± 0.051
4.22SerIle: 4.22 ± 0.097
3.461SerLys: 3.461 ± 0.092
6.968SerLeu: 6.968 ± 0.132
1.457SerMet: 1.457 ± 0.054
2.716SerAsn: 2.716 ± 0.08
2.084SerPro: 2.084 ± 0.064
4.218SerGln: 4.218 ± 0.113
2.442SerArg: 2.442 ± 0.074
3.592SerSer: 3.592 ± 0.11
2.602SerThr: 2.602 ± 0.074
3.514SerVal: 3.514 ± 0.096
0.546SerTrp: 0.546 ± 0.035
2.279SerTyr: 2.279 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.658ThrAla: 3.658 ± 0.084
0.254ThrCys: 0.254 ± 0.022
3.141ThrAsp: 3.141 ± 0.121
2.907ThrGlu: 2.907 ± 0.091
2.111ThrPhe: 2.111 ± 0.066
3.757ThrGly: 3.757 ± 0.083
1.018ThrHis: 1.018 ± 0.042
4.206ThrIle: 4.206 ± 0.091
2.581ThrLys: 2.581 ± 0.077
5.232ThrLeu: 5.232 ± 0.107
1.338ThrMet: 1.338 ± 0.047
2.199ThrAsn: 2.199 ± 0.067
2.121ThrPro: 2.121 ± 0.061
2.15ThrGln: 2.15 ± 0.06
1.744ThrArg: 1.744 ± 0.06
3.174ThrSer: 3.174 ± 0.086
2.478ThrThr: 2.478 ± 0.084
3.697ThrVal: 3.697 ± 0.083
0.574ThrTrp: 0.574 ± 0.035
2.243ThrTyr: 2.243 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
5.607ValAla: 5.607 ± 0.114
0.4ValCys: 0.4 ± 0.03
4.547ValAsp: 4.547 ± 0.103
4.343ValGlu: 4.343 ± 0.115
2.844ValPhe: 2.844 ± 0.079
4.622ValGly: 4.622 ± 0.109
1.055ValHis: 1.055 ± 0.048
5.209ValIle: 5.209 ± 0.099
4.052ValLys: 4.052 ± 0.078
6.496ValLeu: 6.496 ± 0.117
1.818ValMet: 1.818 ± 0.057
3.153ValAsn: 3.153 ± 0.08
2.415ValPro: 2.415 ± 0.073
2.585ValGln: 2.585 ± 0.061
2.288ValArg: 2.288 ± 0.068
4.245ValSer: 4.245 ± 0.091
4.003ValThr: 4.003 ± 0.102
4.688ValVal: 4.688 ± 0.124
0.538ValTrp: 0.538 ± 0.032
2.437ValTyr: 2.437 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.595TrpAla: 0.595 ± 0.029
0.059TrpCys: 0.059 ± 0.011
0.507TrpAsp: 0.507 ± 0.031
0.378TrpGlu: 0.378 ± 0.028
0.39TrpPhe: 0.39 ± 0.026
0.521TrpGly: 0.521 ± 0.033
0.191TrpHis: 0.191 ± 0.02
0.642TrpIle: 0.642 ± 0.036
0.425TrpLys: 0.425 ± 0.024
1.194TrpLeu: 1.194 ± 0.051
0.271TrpMet: 0.271 ± 0.024
0.359TrpAsn: 0.359 ± 0.026
0.324TrpPro: 0.324 ± 0.025
0.624TrpGln: 0.624 ± 0.037
0.343TrpArg: 0.343 ± 0.025
0.515TrpSer: 0.515 ± 0.031
0.488TrpThr: 0.488 ± 0.029
0.603TrpVal: 0.603 ± 0.032
0.09TrpTrp: 0.09 ± 0.014
0.297TrpTyr: 0.297 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.489TyrAla: 2.489 ± 0.076
0.279TyrCys: 0.279 ± 0.027
2.444TyrAsp: 2.444 ± 0.076
2.261TyrGlu: 2.261 ± 0.061
1.937TyrPhe: 1.937 ± 0.072
2.45TyrGly: 2.45 ± 0.07
0.995TyrHis: 0.995 ± 0.05
2.472TyrIle: 2.472 ± 0.071
1.885TyrLys: 1.885 ± 0.063
4.477TyrLeu: 4.477 ± 0.112
0.774TyrMet: 0.774 ± 0.035
1.621TyrAsn: 1.621 ± 0.057
1.537TyrPro: 1.537 ± 0.062
2.895TyrGln: 2.895 ± 0.068
1.748TyrArg: 1.748 ± 0.062
2.15TyrSer: 2.15 ± 0.067
1.793TyrThr: 1.793 ± 0.062
2.162TyrVal: 2.162 ± 0.07
0.334TyrTrp: 0.334 ± 0.026
1.771TyrTyr: 1.771 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1720 proteins (512594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski