Amino acid dipepetide frequency for Mycobacterium bohemicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.365AlaAla: 21.365 ± 0.213
1.056AlaCys: 1.056 ± 0.026
8.412AlaAsp: 8.412 ± 0.088
7.744AlaGlu: 7.744 ± 0.087
3.481AlaPhe: 3.481 ± 0.052
13.155AlaGly: 13.155 ± 0.263
2.653AlaHis: 2.653 ± 0.042
5.123AlaIle: 5.123 ± 0.06
2.857AlaLys: 2.857 ± 0.052
13.245AlaLeu: 13.245 ± 0.112
2.928AlaMet: 2.928 ± 0.042
2.678AlaAsn: 2.678 ± 0.046
6.756AlaPro: 6.756 ± 0.091
4.014AlaGln: 4.014 ± 0.051
9.289AlaArg: 9.289 ± 0.108
6.084AlaSer: 6.084 ± 0.075
6.964AlaThr: 6.964 ± 0.074
11.754AlaVal: 11.754 ± 0.103
1.736AlaTrp: 1.736 ± 0.032
2.353AlaTyr: 2.353 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.138CysAla: 1.138 ± 0.03
0.092CysCys: 0.092 ± 0.008
0.577CysAsp: 0.577 ± 0.021
0.412CysGlu: 0.412 ± 0.016
0.24CysPhe: 0.24 ± 0.012
0.984CysGly: 0.984 ± 0.027
0.179CysHis: 0.179 ± 0.01
0.267CysIle: 0.267 ± 0.013
0.123CysLys: 0.123 ± 0.01
0.675CysLeu: 0.675 ± 0.021
0.125CysMet: 0.125 ± 0.009
0.171CysAsn: 0.171 ± 0.012
0.582CysPro: 0.582 ± 0.021
0.222CysGln: 0.222 ± 0.012
0.607CysArg: 0.607 ± 0.022
0.47CysSer: 0.47 ± 0.021
0.487CysThr: 0.487 ± 0.017
0.71CysVal: 0.71 ± 0.021
0.137CysTrp: 0.137 ± 0.01
0.2CysTyr: 0.2 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.809AspAla: 7.809 ± 0.086
0.47AspCys: 0.47 ± 0.015
4.147AspAsp: 4.147 ± 0.061
3.971AspGlu: 3.971 ± 0.061
1.86AspPhe: 1.86 ± 0.036
5.814AspGly: 5.814 ± 0.065
1.418AspHis: 1.418 ± 0.034
2.493AspIle: 2.493 ± 0.039
1.248AspLys: 1.248 ± 0.033
5.974AspLeu: 5.974 ± 0.068
1.049AspMet: 1.049 ± 0.025
1.165AspAsn: 1.165 ± 0.029
4.477AspPro: 4.477 ± 0.058
1.618AspGln: 1.618 ± 0.031
4.593AspArg: 4.593 ± 0.064
2.618AspSer: 2.618 ± 0.043
2.99AspThr: 2.99 ± 0.043
5.286AspVal: 5.286 ± 0.07
0.988AspTrp: 0.988 ± 0.027
1.477AspTyr: 1.477 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.248GluAla: 6.248 ± 0.079
0.39GluCys: 0.39 ± 0.016
2.412GluAsp: 2.412 ± 0.045
2.484GluGlu: 2.484 ± 0.049
1.824GluPhe: 1.824 ± 0.032
3.434GluGly: 3.434 ± 0.053
1.469GluHis: 1.469 ± 0.035
2.543GluIle: 2.543 ± 0.042
1.244GluLys: 1.244 ± 0.032
6.355GluLeu: 6.355 ± 0.076
1.086GluMet: 1.086 ± 0.029
1.038GluAsn: 1.038 ± 0.023
3.077GluPro: 3.077 ± 0.058
2.028GluGln: 2.028 ± 0.04
4.628GluArg: 4.628 ± 0.065
2.593GluSer: 2.593 ± 0.048
2.507GluThr: 2.507 ± 0.044
4.291GluVal: 4.291 ± 0.052
0.74GluTrp: 0.74 ± 0.023
1.086GluTyr: 1.086 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.135PheAla: 4.135 ± 0.054
0.347PheCys: 0.347 ± 0.015
2.41PheAsp: 2.41 ± 0.042
1.556PheGlu: 1.556 ± 0.034
1.043PhePhe: 1.043 ± 0.028
3.546PheGly: 3.546 ± 0.057
0.638PheHis: 0.638 ± 0.019
1.002PheIle: 1.002 ± 0.031
0.524PheLys: 0.524 ± 0.018
2.553PheLeu: 2.553 ± 0.038
0.509PheMet: 0.509 ± 0.017
0.75PheAsn: 0.75 ± 0.026
1.527PhePro: 1.527 ± 0.028
0.679PheGln: 0.679 ± 0.019
1.737PheArg: 1.737 ± 0.031
1.713PheSer: 1.713 ± 0.037
1.973PheThr: 1.973 ± 0.038
2.601PheVal: 2.601 ± 0.046
0.456PheTrp: 0.456 ± 0.019
0.736PheTyr: 0.736 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
11.23GlyAla: 11.23 ± 0.231
0.835GlyCys: 0.835 ± 0.027
5.139GlyAsp: 5.139 ± 0.064
4.475GlyGlu: 4.475 ± 0.06
3.135GlyPhe: 3.135 ± 0.048
9.33GlyGly: 9.33 ± 0.529
2.161GlyHis: 2.161 ± 0.038
4.002GlyIle: 4.002 ± 0.052
2.27GlyLys: 2.27 ± 0.038
8.86GlyLeu: 8.86 ± 0.093
2.211GlyMet: 2.211 ± 0.04
2.31GlyAsn: 2.31 ± 0.203
5.028GlyPro: 5.028 ± 0.062
2.91GlyGln: 2.91 ± 0.063
6.788GlyArg: 6.788 ± 0.066
5.355GlySer: 5.355 ± 0.093
5.295GlyThr: 5.295 ± 0.176
7.797GlyVal: 7.797 ± 0.083
1.652GlyTrp: 1.652 ± 0.039
2.491GlyTyr: 2.491 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.597HisAla: 2.597 ± 0.039
0.238HisCys: 0.238 ± 0.013
1.355HisAsp: 1.355 ± 0.029
1.061HisGlu: 1.061 ± 0.028
0.686HisPhe: 0.686 ± 0.021
2.188HisGly: 2.188 ± 0.035
0.692HisHis: 0.692 ± 0.022
0.795HisIle: 0.795 ± 0.024
0.367HisLys: 0.367 ± 0.017
2.183HisLeu: 2.183 ± 0.039
0.343HisMet: 0.343 ± 0.017
0.51HisAsn: 0.51 ± 0.018
1.736HisPro: 1.736 ± 0.038
0.623HisGln: 0.623 ± 0.02
1.976HisArg: 1.976 ± 0.043
1.074HisSer: 1.074 ± 0.027
1.186HisThr: 1.186 ± 0.026
1.736HisVal: 1.736 ± 0.03
0.399HisTrp: 0.399 ± 0.017
0.584HisTyr: 0.584 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.092IleAla: 6.092 ± 0.071
0.382IleCys: 0.382 ± 0.017
3.2IleAsp: 3.2 ± 0.041
2.47IleGlu: 2.47 ± 0.041
1.039IlePhe: 1.039 ± 0.024
4.294IleGly: 4.294 ± 0.059
0.806IleHis: 0.806 ± 0.024
1.306IleIle: 1.306 ± 0.031
0.867IleLys: 0.867 ± 0.027
2.864IleLeu: 2.864 ± 0.047
0.613IleMet: 0.613 ± 0.019
1.113IleAsn: 1.113 ± 0.028
2.402IlePro: 2.402 ± 0.043
0.879IleGln: 0.879 ± 0.025
2.608IleArg: 2.608 ± 0.041
2.19IleSer: 2.19 ± 0.036
2.62IleThr: 2.62 ± 0.038
3.541IleVal: 3.541 ± 0.05
0.455IleTrp: 0.455 ± 0.016
0.776IleTyr: 0.776 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.62LysAla: 2.62 ± 0.057
0.126LysCys: 0.126 ± 0.009
1.058LysAsp: 1.058 ± 0.024
0.905LysGlu: 0.905 ± 0.028
0.605LysPhe: 0.605 ± 0.018
1.503LysGly: 1.503 ± 0.031
0.483LysHis: 0.483 ± 0.02
0.98LysIle: 0.98 ± 0.027
0.591LysLys: 0.591 ± 0.025
2.089LysLeu: 2.089 ± 0.042
0.449LysMet: 0.449 ± 0.016
0.494LysAsn: 0.494 ± 0.02
1.434LysPro: 1.434 ± 0.034
0.647LysGln: 0.647 ± 0.021
1.569LysArg: 1.569 ± 0.035
1.19LysSer: 1.19 ± 0.033
1.273LysThr: 1.273 ± 0.031
1.904LysVal: 1.904 ± 0.04
0.282LysTrp: 0.282 ± 0.014
0.455LysTyr: 0.455 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.331LeuAla: 14.331 ± 0.109
0.832LeuCys: 0.832 ± 0.024
6.371LeuAsp: 6.371 ± 0.064
4.427LeuGlu: 4.427 ± 0.058
2.678LeuPhe: 2.678 ± 0.045
8.95LeuGly: 8.95 ± 0.081
2.116LeuHis: 2.116 ± 0.036
3.978LeuIle: 3.978 ± 0.055
1.758LeuLys: 1.758 ± 0.039
9.669LeuLeu: 9.669 ± 0.112
1.77LeuMet: 1.77 ± 0.037
2.18LeuAsn: 2.18 ± 0.038
5.988LeuPro: 5.988 ± 0.081
2.508LeuGln: 2.508 ± 0.041
7.895LeuArg: 7.895 ± 0.086
5.617LeuSer: 5.617 ± 0.068
6.065LeuThr: 6.065 ± 0.066
8.243LeuVal: 8.243 ± 0.094
1.184LeuTrp: 1.184 ± 0.03
1.726LeuTyr: 1.726 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
2.64MetAla: 2.64 ± 0.041
0.19MetCys: 0.19 ± 0.011
0.906MetAsp: 0.906 ± 0.024
0.682MetGlu: 0.682 ± 0.02
0.654MetPhe: 0.654 ± 0.018
1.542MetGly: 1.542 ± 0.035
0.444MetHis: 0.444 ± 0.018
0.873MetIle: 0.873 ± 0.025
0.43MetLys: 0.43 ± 0.018
2.095MetLeu: 2.095 ± 0.033
0.425MetMet: 0.425 ± 0.018
0.485MetAsn: 0.485 ± 0.019
1.255MetPro: 1.255 ± 0.031
0.535MetGln: 0.535 ± 0.019
1.603MetArg: 1.603 ± 0.031
1.501MetSer: 1.501 ± 0.03
1.788MetThr: 1.788 ± 0.032
1.651MetVal: 1.651 ± 0.033
0.263MetTrp: 0.263 ± 0.012
0.346MetTyr: 0.346 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.798AsnAla: 2.798 ± 0.048
0.179AsnCys: 0.179 ± 0.011
1.216AsnAsp: 1.216 ± 0.029
0.957AsnGlu: 0.957 ± 0.024
0.748AsnPhe: 0.748 ± 0.025
2.477AsnGly: 2.477 ± 0.231
0.455AsnHis: 0.455 ± 0.017
0.902AsnIle: 0.902 ± 0.028
0.434AsnLys: 0.434 ± 0.02
2.127AsnLeu: 2.127 ± 0.039
0.427AsnMet: 0.427 ± 0.015
0.586AsnAsn: 0.586 ± 0.023
1.787AsnPro: 1.787 ± 0.036
0.671AsnGln: 0.671 ± 0.021
1.558AsnArg: 1.558 ± 0.033
1.172AsnSer: 1.172 ± 0.04
1.281AsnThr: 1.281 ± 0.036
1.775AsnVal: 1.775 ± 0.034
0.386AsnTrp: 0.386 ± 0.016
0.57AsnTyr: 0.57 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.879ProAla: 7.879 ± 0.094
0.309ProCys: 0.309 ± 0.016
4.497ProAsp: 4.497 ± 0.056
3.752ProGlu: 3.752 ± 0.053
1.669ProPhe: 1.669 ± 0.034
6.304ProGly: 6.304 ± 0.073
1.273ProHis: 1.273 ± 0.033
2.138ProIle: 2.138 ± 0.039
1.274ProLys: 1.274 ± 0.03
5.111ProLeu: 5.111 ± 0.053
1.212ProMet: 1.212 ± 0.027
1.342ProAsn: 1.342 ± 0.033
4.217ProPro: 4.217 ± 0.101
1.883ProGln: 1.883 ± 0.04
3.783ProArg: 3.783 ± 0.051
3.073ProSer: 3.073 ± 0.052
3.363ProThr: 3.363 ± 0.051
5.084ProVal: 5.084 ± 0.066
0.908ProTrp: 0.908 ± 0.024
1.239ProTyr: 1.239 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.67GlnAla: 3.67 ± 0.055
0.216GlnCys: 0.216 ± 0.012
1.195GlnAsp: 1.195 ± 0.027
1.069GlnGlu: 1.069 ± 0.026
0.97GlnPhe: 0.97 ± 0.023
2.06GlnGly: 2.06 ± 0.049
0.736GlnHis: 0.736 ± 0.023
1.365GlnIle: 1.365 ± 0.03
0.59GlnLys: 0.59 ± 0.019
3.456GlnLeu: 3.456 ± 0.048
0.669GlnMet: 0.669 ± 0.021
0.635GlnAsn: 0.635 ± 0.023
1.93GlnPro: 1.93 ± 0.047
1.24GlnGln: 1.24 ± 0.036
2.764GlnArg: 2.764 ± 0.039
1.463GlnSer: 1.463 ± 0.029
1.506GlnThr: 1.506 ± 0.032
2.452GlnVal: 2.452 ± 0.041
0.554GlnTrp: 0.554 ± 0.019
0.638GlnTyr: 0.638 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
8.987ArgAla: 8.987 ± 0.114
0.645ArgCys: 0.645 ± 0.023
4.353ArgAsp: 4.353 ± 0.061
3.902ArgGlu: 3.902 ± 0.059
2.537ArgPhe: 2.537 ± 0.037
5.564ArgGly: 5.564 ± 0.066
1.927ArgHis: 1.927 ± 0.039
3.333ArgIle: 3.333 ± 0.047
1.517ArgLys: 1.517 ± 0.034
7.981ArgLeu: 7.981 ± 0.084
1.826ArgMet: 1.826 ± 0.033
1.604ArgAsn: 1.604 ± 0.036
4.362ArgPro: 4.362 ± 0.062
2.373ArgGln: 2.373 ± 0.038
7.143ArgArg: 7.143 ± 0.094
3.924ArgSer: 3.924 ± 0.052
3.865ArgThr: 3.865 ± 0.054
5.884ArgVal: 5.884 ± 0.065
1.414ArgTrp: 1.414 ± 0.03
1.969ArgTyr: 1.969 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.998SerAla: 6.998 ± 0.072
0.401SerCys: 0.401 ± 0.017
3.032SerAsp: 3.032 ± 0.049
2.428SerGlu: 2.428 ± 0.043
1.643SerPhe: 1.643 ± 0.03
5.797SerGly: 5.797 ± 0.109
1.093SerHis: 1.093 ± 0.026
2.101SerIle: 2.101 ± 0.039
1.113SerLys: 1.113 ± 0.028
4.769SerLeu: 4.769 ± 0.059
1.253SerMet: 1.253 ± 0.028
1.133SerAsn: 1.133 ± 0.03
3.198SerPro: 3.198 ± 0.047
1.439SerGln: 1.439 ± 0.031
3.612SerArg: 3.612 ± 0.052
2.965SerSer: 2.965 ± 0.055
3.088SerThr: 3.088 ± 0.048
4.449SerVal: 4.449 ± 0.05
0.911SerTrp: 0.911 ± 0.025
1.23SerTyr: 1.23 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
7.509ThrAla: 7.509 ± 0.079
0.428ThrCys: 0.428 ± 0.019
3.379ThrAsp: 3.379 ± 0.051
2.918ThrGlu: 2.918 ± 0.044
1.731ThrPhe: 1.731 ± 0.035
5.982ThrGly: 5.982 ± 0.131
1.102ThrHis: 1.102 ± 0.024
2.237ThrIle: 2.237 ± 0.039
1.158ThrLys: 1.158 ± 0.029
5.419ThrLeu: 5.419 ± 0.071
1.214ThrMet: 1.214 ± 0.028
1.266ThrAsn: 1.266 ± 0.041
3.717ThrPro: 3.717 ± 0.051
1.461ThrGln: 1.461 ± 0.031
3.568ThrArg: 3.568 ± 0.052
2.915ThrSer: 2.915 ± 0.05
3.553ThrThr: 3.553 ± 0.054
5.438ThrVal: 5.438 ± 0.061
0.801ThrTrp: 0.801 ± 0.023
1.273ThrTyr: 1.273 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
11.519ValAla: 11.519 ± 0.113
0.833ValCys: 0.833 ± 0.027
5.644ValAsp: 5.644 ± 0.065
4.484ValGlu: 4.484 ± 0.054
2.58ValPhe: 2.58 ± 0.045
7.188ValGly: 7.188 ± 0.07
1.816ValHis: 1.816 ± 0.038
3.858ValIle: 3.858 ± 0.052
1.625ValLys: 1.625 ± 0.037
8.801ValLeu: 8.801 ± 0.089
1.576ValMet: 1.576 ± 0.036
2.104ValAsn: 2.104 ± 0.037
4.655ValPro: 4.655 ± 0.057
2.132ValGln: 2.132 ± 0.037
6.091ValArg: 6.091 ± 0.075
4.635ValSer: 4.635 ± 0.06
5.276ValThr: 5.276 ± 0.058
8.369ValVal: 8.369 ± 0.094
1.031ValTrp: 1.031 ± 0.026
1.573ValTyr: 1.573 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.594TrpAla: 1.594 ± 0.036
0.164TrpCys: 0.164 ± 0.01
0.797TrpAsp: 0.797 ± 0.023
0.71TrpGlu: 0.71 ± 0.024
0.511TrpPhe: 0.511 ± 0.02
1.065TrpGly: 1.065 ± 0.031
0.36TrpHis: 0.36 ± 0.016
0.591TrpIle: 0.591 ± 0.02
0.315TrpLys: 0.315 ± 0.015
1.762TrpLeu: 1.762 ± 0.033
0.326TrpMet: 0.326 ± 0.013
0.425TrpAsn: 0.425 ± 0.019
0.857TrpPro: 0.857 ± 0.022
0.597TrpGln: 0.597 ± 0.018
1.336TrpArg: 1.336 ± 0.03
0.948TrpSer: 0.948 ± 0.025
0.857TrpThr: 0.857 ± 0.025
1.14TrpVal: 1.14 ± 0.028
0.341TrpTrp: 0.341 ± 0.016
0.318TrpTyr: 0.318 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.489TyrAla: 2.489 ± 0.039
0.262TyrCys: 0.262 ± 0.012
1.365TyrAsp: 1.365 ± 0.029
1.072TyrGlu: 1.072 ± 0.031
0.803TyrPhe: 0.803 ± 0.023
2.104TyrGly: 2.104 ± 0.045
0.504TyrHis: 0.504 ± 0.018
0.629TyrIle: 0.629 ± 0.018
0.353TyrLys: 0.353 ± 0.015
2.297TyrLeu: 2.297 ± 0.044
0.295TyrMet: 0.295 ± 0.013
0.514TyrAsn: 0.514 ± 0.02
1.327TyrPro: 1.327 ± 0.035
0.719TyrGln: 0.719 ± 0.02
1.961TyrArg: 1.961 ± 0.041
1.152TyrSer: 1.152 ± 0.025
1.132TyrThr: 1.132 ± 0.028
1.686TyrVal: 1.686 ± 0.037
0.376TyrTrp: 0.376 ± 0.016
0.529TyrTyr: 0.529 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4677 proteins (1557375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski