Amino acid dipepetide frequency for Sandarakinorhabdus cyanobacteriorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.512AlaAla: 24.512 ± 0.29	1.137AlaCys: 1.137 ± 0.033	8.621AlaAsp: 8.621 ± 0.105	7.927AlaGlu: 7.927 ± 0.121	4.183AlaPhe: 4.183 ± 0.067	14.249AlaGly: 14.249 ± 0.23	2.57AlaHis: 2.57 ± 0.062	6.58AlaIle: 6.58 ± 0.085	3.76AlaLys: 3.76 ± 0.079	15.93AlaLeu: 15.93 ± 0.174	4.29AlaMet: 4.29 ± 0.069	3.438AlaAsn: 3.438 ± 0.087	7.154AlaPro: 7.154 ± 0.102	4.843AlaGln: 4.843 ± 0.077	11.242AlaArg: 11.242 ± 0.133	6.732AlaSer: 6.732 ± 0.113	6.951AlaThr: 6.951 ± 0.107	9.676AlaVal: 9.676 ± 0.103	1.974AlaTrp: 1.974 ± 0.052	2.426AlaTyr: 2.426 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	1.007CysAla: 1.007 ± 0.034	0.093CysCys: 0.093 ± 0.01	0.509CysAsp: 0.509 ± 0.019	0.322CysGlu: 0.322 ± 0.018	0.286CysPhe: 0.286 ± 0.018	0.837CysGly: 0.837 ± 0.033	0.29CysHis: 0.29 ± 0.021	0.338CysIle: 0.338 ± 0.017	0.146CysLys: 0.146 ± 0.012	0.733CysLeu: 0.733 ± 0.026	0.127CysMet: 0.127 ± 0.012	0.217CysAsn: 0.217 ± 0.016	0.481CysPro: 0.481 ± 0.024	0.276CysGln: 0.276 ± 0.017	0.607CysArg: 0.607 ± 0.025	0.411CysSer: 0.411 ± 0.021	0.382CysThr: 0.382 ± 0.02	0.511CysVal: 0.511 ± 0.022	0.119CysTrp: 0.119 ± 0.01	0.146CysTyr: 0.146 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.041AspAla: 8.041 ± 0.091	0.477AspCys: 0.477 ± 0.021	3.159AspAsp: 3.159 ± 0.059	2.83AspGlu: 2.83 ± 0.065	2.045AspPhe: 2.045 ± 0.052	5.948AspGly: 5.948 ± 0.082	1.197AspHis: 1.197 ± 0.04	2.52AspIle: 2.52 ± 0.056	1.386AspLys: 1.386 ± 0.043	5.69AspLeu: 5.69 ± 0.084	1.208AspMet: 1.208 ± 0.032	1.249AspAsn: 1.249 ± 0.035	3.6AspPro: 3.6 ± 0.065	1.751AspGln: 1.751 ± 0.043	4.357AspArg: 4.357 ± 0.075	1.987AspSer: 1.987 ± 0.041	2.34AspThr: 2.34 ± 0.05	4.165AspVal: 4.165 ± 0.06	1.284AspTrp: 1.284 ± 0.036	1.439AspTyr: 1.439 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.525GluAla: 7.525 ± 0.117	0.296GluCys: 0.296 ± 0.016	2.087GluAsp: 2.087 ± 0.053	2.149GluGlu: 2.149 ± 0.061	1.432GluPhe: 1.432 ± 0.038	3.629GluGly: 3.629 ± 0.069	0.857GluHis: 0.857 ± 0.034	2.445GluIle: 2.445 ± 0.061	1.561GluLys: 1.561 ± 0.042	4.678GluLeu: 4.678 ± 0.084	1.187GluMet: 1.187 ± 0.032	1.103GluAsn: 1.103 ± 0.035	2.358GluPro: 2.358 ± 0.054	1.908GluGln: 1.908 ± 0.045	4.123GluArg: 4.123 ± 0.082	1.735GluSer: 1.735 ± 0.041	2.818GluThr: 2.818 ± 0.06	3.311GluVal: 3.311 ± 0.062	0.692GluTrp: 0.692 ± 0.028	0.85GluTyr: 0.85 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.91PheAla: 4.91 ± 0.07	0.294PheCys: 0.294 ± 0.016	2.431PheAsp: 2.431 ± 0.054	1.612PheGlu: 1.612 ± 0.045	1.14PhePhe: 1.14 ± 0.041	3.716PheGly: 3.716 ± 0.064	0.652PheHis: 0.652 ± 0.026	1.515PheIle: 1.515 ± 0.038	0.827PheLys: 0.827 ± 0.032	2.776PheLeu: 2.776 ± 0.05	0.697PheMet: 0.697 ± 0.027	1.139PheAsn: 1.139 ± 0.046	1.5PhePro: 1.5 ± 0.031	0.954PheGln: 0.954 ± 0.03	2.12PheArg: 2.12 ± 0.051	1.793PheSer: 1.793 ± 0.044	2.109PheThr: 2.109 ± 0.048	2.352PheVal: 2.352 ± 0.046	0.506PheTrp: 0.506 ± 0.024	0.745PheTyr: 0.745 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.186GlyAla: 10.186 ± 0.174	0.834GlyCys: 0.834 ± 0.03	4.911GlyAsp: 4.911 ± 0.09	4.219GlyGlu: 4.219 ± 0.08	3.824GlyPhe: 3.824 ± 0.074	8.734GlyGly: 8.734 ± 0.353	1.983GlyHis: 1.983 ± 0.049	4.252GlyIle: 4.252 ± 0.068	3.093GlyLys: 3.093 ± 0.072	10.211GlyLeu: 10.211 ± 0.101	2.26GlyMet: 2.26 ± 0.053	2.607GlyAsn: 2.607 ± 0.137	4.479GlyPro: 4.479 ± 0.073	3.747GlyGln: 3.747 ± 0.062	7.075GlyArg: 7.075 ± 0.085	4.822GlySer: 4.822 ± 0.151	4.969GlyThr: 4.969 ± 0.214	6.45GlyVal: 6.45 ± 0.086	1.956GlyTrp: 1.956 ± 0.051	1.865GlyTyr: 1.865 ± 0.046	0.002GlyXaa: 0.002 ± 0.001
His	2.5HisAla: 2.5 ± 0.059	0.236HisCys: 0.236 ± 0.016	1.266HisAsp: 1.266 ± 0.039	0.896HisGlu: 0.896 ± 0.031	0.78HisPhe: 0.78 ± 0.028	2.119HisGly: 2.119 ± 0.054	0.577HisHis: 0.577 ± 0.028	0.885HisIle: 0.885 ± 0.03	0.422HisLys: 0.422 ± 0.019	1.902HisLeu: 1.902 ± 0.049	0.466HisMet: 0.466 ± 0.019	0.495HisAsn: 0.495 ± 0.022	1.295HisPro: 1.295 ± 0.039	0.583HisGln: 0.583 ± 0.024	1.389HisArg: 1.389 ± 0.045	0.843HisSer: 0.843 ± 0.029	0.672HisThr: 0.672 ± 0.031	1.509HisVal: 1.509 ± 0.046	0.429HisTrp: 0.429 ± 0.021	0.523HisTyr: 0.523 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.578IleAla: 7.578 ± 0.083	0.381IleCys: 0.381 ± 0.019	3.536IleAsp: 3.536 ± 0.061	2.795IleGlu: 2.795 ± 0.061	1.321IlePhe: 1.321 ± 0.041	4.681IleGly: 4.681 ± 0.068	0.908IleHis: 0.908 ± 0.029	2.48IleIle: 2.48 ± 0.055	1.225IleLys: 1.225 ± 0.037	3.597IleLeu: 3.597 ± 0.064	0.919IleMet: 0.919 ± 0.029	1.527IleAsn: 1.527 ± 0.043	2.048IlePro: 2.048 ± 0.045	0.947IleGln: 0.947 ± 0.028	2.952IleArg: 2.952 ± 0.055	2.595IleSer: 2.595 ± 0.067	2.954IleThr: 2.954 ± 0.057	3.347IleVal: 3.347 ± 0.055	0.593IleTrp: 0.593 ± 0.024	0.772IleTyr: 0.772 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.337LysAla: 4.337 ± 0.085	0.142LysCys: 0.142 ± 0.011	1.421LysAsp: 1.421 ± 0.05	1.007LysGlu: 1.007 ± 0.037	0.736LysPhe: 0.736 ± 0.029	2.555LysGly: 2.555 ± 0.057	0.423LysHis: 0.423 ± 0.02	1.146LysIle: 1.146 ± 0.039	0.897LysLys: 0.897 ± 0.041	2.992LysLeu: 2.992 ± 0.059	0.654LysMet: 0.654 ± 0.028	0.608LysAsn: 0.608 ± 0.026	1.973LysPro: 1.973 ± 0.051	0.888LysGln: 0.888 ± 0.032	1.955LysArg: 1.955 ± 0.051	1.366LysSer: 1.366 ± 0.042	1.494LysThr: 1.494 ± 0.04	1.857LysVal: 1.857 ± 0.053	0.361LysTrp: 0.361 ± 0.017	0.507LysTyr: 0.507 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	18.247LeuAla: 18.247 ± 0.189	0.825LeuCys: 0.825 ± 0.031	5.792LeuAsp: 5.792 ± 0.071	4.367LeuGlu: 4.367 ± 0.084	3.446LeuPhe: 3.446 ± 0.064	8.786LeuGly: 8.786 ± 0.098	1.896LeuHis: 1.896 ± 0.046	4.826LeuIle: 4.826 ± 0.069	3.407LeuLys: 3.407 ± 0.062	10.017LeuLeu: 10.017 ± 0.13	2.343LeuMet: 2.343 ± 0.053	2.694LeuAsn: 2.694 ± 0.081	6.575LeuPro: 6.575 ± 0.101	2.628LeuGln: 2.628 ± 0.059	6.282LeuArg: 6.282 ± 0.088	5.348LeuSer: 5.348 ± 0.087	5.34LeuThr: 5.34 ± 0.098	7.854LeuVal: 7.854 ± 0.097	1.439LeuTrp: 1.439 ± 0.041	1.797LeuTyr: 1.797 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.96MetAla: 3.96 ± 0.068	0.141MetCys: 0.141 ± 0.011	1.05MetAsp: 1.05 ± 0.034	0.908MetGlu: 0.908 ± 0.032	0.661MetPhe: 0.661 ± 0.028	1.922MetGly: 1.922 ± 0.045	0.433MetHis: 0.433 ± 0.019	1.254MetIle: 1.254 ± 0.033	0.822MetLys: 0.822 ± 0.034	2.522MetLeu: 2.522 ± 0.053	0.662MetMet: 0.662 ± 0.025	0.686MetAsn: 0.686 ± 0.025	1.464MetPro: 1.464 ± 0.037	0.732MetGln: 0.732 ± 0.03	1.617MetArg: 1.617 ± 0.038	1.217MetSer: 1.217 ± 0.033	1.508MetThr: 1.508 ± 0.038	1.657MetVal: 1.657 ± 0.043	0.203MetTrp: 0.203 ± 0.014	0.243MetTyr: 0.243 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.316AsnAla: 3.316 ± 0.088	0.247AsnCys: 0.247 ± 0.015	1.3AsnAsp: 1.3 ± 0.04	0.959AsnGlu: 0.959 ± 0.033	1.011AsnPhe: 1.011 ± 0.037	2.618AsnGly: 2.618 ± 0.114	0.521AsnHis: 0.521 ± 0.023	1.382AsnIle: 1.382 ± 0.045	0.584AsnLys: 0.584 ± 0.027	2.542AsnLeu: 2.542 ± 0.067	0.491AsnMet: 0.491 ± 0.022	0.738AsnAsn: 0.738 ± 0.05	1.94AsnPro: 1.94 ± 0.044	0.837AsnGln: 0.837 ± 0.029	2.048AsnArg: 2.048 ± 0.046	1.293AsnSer: 1.293 ± 0.062	1.06AsnThr: 1.06 ± 0.05	1.769AsnVal: 1.769 ± 0.054	0.459AsnTrp: 0.459 ± 0.019	0.571AsnTyr: 0.571 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	9.286ProAla: 9.286 ± 0.135	0.383ProCys: 0.383 ± 0.021	4.123ProAsp: 4.123 ± 0.069	3.195ProGlu: 3.195 ± 0.067	1.896ProPhe: 1.896 ± 0.043	5.848ProGly: 5.848 ± 0.08	1.084ProHis: 1.084 ± 0.036	2.238ProIle: 2.238 ± 0.046	1.44ProLys: 1.44 ± 0.037	5.411ProLeu: 5.411 ± 0.081	1.214ProMet: 1.214 ± 0.036	1.282ProAsn: 1.282 ± 0.038	3.708ProPro: 3.708 ± 0.087	1.759ProGln: 1.759 ± 0.038	3.273ProArg: 3.273 ± 0.064	2.353ProSer: 2.353 ± 0.045	2.519ProThr: 2.519 ± 0.057	4.488ProVal: 4.488 ± 0.075	0.836ProTrp: 0.836 ± 0.029	1.007ProTyr: 1.007 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.817GlnAla: 4.817 ± 0.07	0.211GlnCys: 0.211 ± 0.014	1.246GlnAsp: 1.246 ± 0.04	1.091GlnGlu: 1.091 ± 0.031	1.199GlnPhe: 1.199 ± 0.037	2.67GlnGly: 2.67 ± 0.053	0.575GlnHis: 0.575 ± 0.022	1.652GlnIle: 1.652 ± 0.04	0.837GlnLys: 0.837 ± 0.032	3.616GlnLeu: 3.616 ± 0.055	0.807GlnMet: 0.807 ± 0.026	0.7GlnAsn: 0.7 ± 0.029	2.318GlnPro: 2.318 ± 0.054	1.161GlnGln: 1.161 ± 0.035	2.763GlnArg: 2.763 ± 0.056	1.665GlnSer: 1.665 ± 0.039	1.59GlnThr: 1.59 ± 0.037	2.432GlnVal: 2.432 ± 0.05	0.495GlnTrp: 0.495 ± 0.024	0.599GlnTyr: 0.599 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.4ArgAla: 9.4 ± 0.102	0.584ArgCys: 0.584 ± 0.026	4.036ArgAsp: 4.036 ± 0.061	3.181ArgGlu: 3.181 ± 0.06	3.188ArgPhe: 3.188 ± 0.057	4.97ArgGly: 4.97 ± 0.076	1.76ArgHis: 1.76 ± 0.049	3.911ArgIle: 3.911 ± 0.072	1.651ArgLys: 1.651 ± 0.046	9.385ArgLeu: 9.385 ± 0.123	1.802ArgMet: 1.802 ± 0.05	1.653ArgAsn: 1.653 ± 0.048	4.052ArgPro: 4.052 ± 0.072	2.828ArgGln: 2.828 ± 0.063	6.07ArgArg: 6.07 ± 0.107	3.286ArgSer: 3.286 ± 0.061	3.235ArgThr: 3.235 ± 0.061	4.84ArgVal: 4.84 ± 0.072	1.398ArgTrp: 1.398 ± 0.045	1.611ArgTyr: 1.611 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.287SerAla: 6.287 ± 0.109	0.36SerCys: 0.36 ± 0.019	2.625SerAsp: 2.625 ± 0.05	1.959SerGlu: 1.959 ± 0.044	1.995SerPhe: 1.995 ± 0.041	5.186SerGly: 5.186 ± 0.137	0.971SerHis: 0.971 ± 0.029	2.472SerIle: 2.472 ± 0.065	1.062SerLys: 1.062 ± 0.037	5.184SerLeu: 5.184 ± 0.084	1.02SerMet: 1.02 ± 0.029	1.317SerAsn: 1.317 ± 0.043	2.696SerPro: 2.696 ± 0.052	1.403SerGln: 1.403 ± 0.039	3.413SerArg: 3.413 ± 0.061	2.221SerSer: 2.221 ± 0.062	2.258SerThr: 2.258 ± 0.063	3.254SerVal: 3.254 ± 0.061	0.789SerTrp: 0.789 ± 0.029	1.041SerTyr: 1.041 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.259ThrAla: 7.259 ± 0.12	0.37ThrCys: 0.37 ± 0.021	2.625ThrAsp: 2.625 ± 0.057	1.966ThrGlu: 1.966 ± 0.046	1.316ThrPhe: 1.316 ± 0.041	5.563ThrGly: 5.563 ± 0.164	0.943ThrHis: 0.943 ± 0.031	2.65ThrIle: 2.65 ± 0.056	1.144ThrLys: 1.144 ± 0.037	5.822ThrLeu: 5.822 ± 0.125	1.112ThrMet: 1.112 ± 0.033	1.267ThrAsn: 1.267 ± 0.06	3.551ThrPro: 3.551 ± 0.069	1.386ThrGln: 1.386 ± 0.039	3.591ThrArg: 3.591 ± 0.057	2.596ThrSer: 2.596 ± 0.06	2.642ThrThr: 2.642 ± 0.065	3.612ThrVal: 3.612 ± 0.071	0.625ThrTrp: 0.625 ± 0.024	0.885ThrTyr: 0.885 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.712ValAla: 10.712 ± 0.116	0.5ValCys: 0.5 ± 0.026	3.93ValAsp: 3.93 ± 0.064	3.907ValGlu: 3.907 ± 0.069	2.013ValPhe: 2.013 ± 0.052	5.456ValGly: 5.456 ± 0.088	1.299ValHis: 1.299 ± 0.039	3.372ValIle: 3.372 ± 0.053	2.181ValLys: 2.181 ± 0.057	6.805ValLeu: 6.805 ± 0.075	1.73ValMet: 1.73 ± 0.046	1.967ValAsn: 1.967 ± 0.057	4.3ValPro: 4.3 ± 0.07	2.236ValGln: 2.236 ± 0.044	4.879ValArg: 4.879 ± 0.073	3.504ValSer: 3.504 ± 0.058	4.429ValThr: 4.429 ± 0.08	5.533ValVal: 5.533 ± 0.076	0.955ValTrp: 0.955 ± 0.029	1.238ValTyr: 1.238 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	1.857TrpAla: 1.857 ± 0.046	0.142TrpCys: 0.142 ± 0.01	0.757TrpAsp: 0.757 ± 0.029	0.574TrpGlu: 0.574 ± 0.024	0.552TrpPhe: 0.552 ± 0.023	1.116TrpGly: 1.116 ± 0.037	0.404TrpHis: 0.404 ± 0.02	0.582TrpIle: 0.582 ± 0.027	0.375TrpLys: 0.375 ± 0.017	2.156TrpLeu: 2.156 ± 0.054	0.331TrpMet: 0.331 ± 0.017	0.475TrpAsn: 0.475 ± 0.024	0.95TrpPro: 0.95 ± 0.027	0.908TrpGln: 0.908 ± 0.031	1.468TrpArg: 1.468 ± 0.038	0.819TrpSer: 0.819 ± 0.028	0.773TrpThr: 0.773 ± 0.032	0.939TrpVal: 0.939 ± 0.034	0.35TrpTrp: 0.35 ± 0.02	0.262TrpTyr: 0.262 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.053	0.186TyrCys: 0.186 ± 0.013	1.247TyrAsp: 1.247 ± 0.035	0.88TyrGlu: 0.88 ± 0.029	0.765TyrPhe: 0.765 ± 0.03	1.876TyrGly: 1.876 ± 0.047	0.441TyrHis: 0.441 ± 0.021	0.656TyrIle: 0.656 ± 0.027	0.498TyrLys: 0.498 ± 0.022	1.942TyrLeu: 1.942 ± 0.048	0.34TyrMet: 0.34 ± 0.017	0.522TyrAsn: 0.522 ± 0.023	0.904TyrPro: 0.904 ± 0.031	0.669TyrGln: 0.669 ± 0.025	1.617TyrArg: 1.617 ± 0.042	0.927TyrSer: 0.927 ± 0.028	0.883TyrThr: 0.883 ± 0.033	1.391TyrVal: 1.391 ± 0.038	0.325TyrTrp: 0.325 ± 0.019	0.432TyrTyr: 0.432 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3280 proteins (1058910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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