Amino acid dipepetide frequency for Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.197AlaAla: 5.197 ± 0.06	1.204AlaCys: 1.204 ± 0.022	3.175AlaAsp: 3.175 ± 0.028	4.258AlaGlu: 4.258 ± 0.041	2.54AlaPhe: 2.54 ± 0.03	3.043AlaGly: 3.043 ± 0.031	1.355AlaHis: 1.355 ± 0.021	4.124AlaIle: 4.124 ± 0.033	3.714AlaLys: 3.714 ± 0.033	6.008AlaLeu: 6.008 ± 0.053	1.556AlaMet: 1.556 ± 0.02	2.95AlaAsn: 2.95 ± 0.029	2.38AlaPro: 2.38 ± 0.03	2.423AlaGln: 2.423 ± 0.028	3.128AlaArg: 3.128 ± 0.029	4.77AlaSer: 4.77 ± 0.043	3.724AlaThr: 3.724 ± 0.034	4.613AlaVal: 4.613 ± 0.033	0.583AlaTrp: 0.583 ± 0.013	1.801AlaTyr: 1.801 ± 0.021	0.001AlaXaa: 0.001 ± 0.0
Cys	1.321CysAla: 1.321 ± 0.021	0.61CysCys: 0.61 ± 0.016	1.282CysAsp: 1.282 ± 0.034	1.298CysGlu: 1.298 ± 0.024	0.941CysPhe: 0.941 ± 0.016	1.335CysGly: 1.335 ± 0.025	0.556CysHis: 0.556 ± 0.013	1.422CysIle: 1.422 ± 0.024	1.193CysLys: 1.193 ± 0.023	1.891CysLeu: 1.891 ± 0.024	0.486CysMet: 0.486 ± 0.011	1.055CysAsn: 1.055 ± 0.019	1.079CysPro: 1.079 ± 0.026	0.806CysGln: 0.806 ± 0.017	1.27CysArg: 1.27 ± 0.019	1.908CysSer: 1.908 ± 0.028	1.122CysThr: 1.122 ± 0.018	1.204CysVal: 1.204 ± 0.02	0.251CysTrp: 0.251 ± 0.008	0.677CysTyr: 0.677 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.271AspAla: 3.271 ± 0.029	1.128AspCys: 1.128 ± 0.02	4.408AspAsp: 4.408 ± 0.056	4.825AspGlu: 4.825 ± 0.042	2.38AspPhe: 2.38 ± 0.023	3.509AspGly: 3.509 ± 0.039	1.115AspHis: 1.115 ± 0.015	3.666AspIle: 3.666 ± 0.03	2.926AspLys: 2.926 ± 0.032	4.823AspLeu: 4.823 ± 0.039	1.291AspMet: 1.291 ± 0.019	2.667AspAsn: 2.667 ± 0.026	2.085AspPro: 2.085 ± 0.023	1.821AspGln: 1.821 ± 0.023	2.84AspArg: 2.84 ± 0.034	4.122AspSer: 4.122 ± 0.036	2.481AspThr: 2.481 ± 0.025	3.471AspVal: 3.471 ± 0.029	0.647AspTrp: 0.647 ± 0.014	1.834AspTyr: 1.834 ± 0.021	0.003AspXaa: 0.003 ± 0.001
Glu	3.985GluAla: 3.985 ± 0.041	1.339GluCys: 1.339 ± 0.026	3.37GluAsp: 3.37 ± 0.034	5.689GluGlu: 5.689 ± 0.062	2.253GluPhe: 2.253 ± 0.023	2.823GluGly: 2.823 ± 0.032	1.507GluHis: 1.507 ± 0.02	4.561GluIle: 4.561 ± 0.039	5.531GluLys: 5.531 ± 0.061	6.107GluLeu: 6.107 ± 0.051	2.084GluMet: 2.084 ± 0.02	3.967GluAsn: 3.967 ± 0.035	2.103GluPro: 2.103 ± 0.028	3.225GluGln: 3.225 ± 0.032	4.23GluArg: 4.23 ± 0.041	4.558GluSer: 4.558 ± 0.039	3.55GluThr: 3.55 ± 0.035	3.583GluVal: 3.583 ± 0.029	0.771GluTrp: 0.771 ± 0.014	1.984GluTyr: 1.984 ± 0.024	0.001GluXaa: 0.001 ± 0.001
Phe	2.682PheAla: 2.682 ± 0.027	1.031PheCys: 1.031 ± 0.016	2.518PheAsp: 2.518 ± 0.026	2.516PheGlu: 2.516 ± 0.028	1.742PhePhe: 1.742 ± 0.024	2.606PheGly: 2.606 ± 0.031	1.038PheHis: 1.038 ± 0.017	2.739PheIle: 2.739 ± 0.03	1.905PheLys: 1.905 ± 0.021	3.806PheLeu: 3.806 ± 0.037	0.996PheMet: 0.996 ± 0.017	1.789PheAsn: 1.789 ± 0.021	1.734PhePro: 1.734 ± 0.021	1.379PheGln: 1.379 ± 0.018	2.2PheArg: 2.2 ± 0.023	3.237PheSer: 3.237 ± 0.031	2.307PheThr: 2.307 ± 0.024	2.659PheVal: 2.659 ± 0.025	0.503PheTrp: 0.503 ± 0.011	1.425PheTyr: 1.425 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	2.969GlyAla: 2.969 ± 0.033	1.101GlyCys: 1.101 ± 0.02	2.853GlyAsp: 2.853 ± 0.032	3.162GlyGlu: 3.162 ± 0.029	2.201GlyPhe: 2.201 ± 0.031	3.243GlyGly: 3.243 ± 0.052	1.231GlyHis: 1.231 ± 0.019	3.533GlyIle: 3.533 ± 0.033	3.235GlyLys: 3.235 ± 0.033	4.08GlyLeu: 4.08 ± 0.052	1.288GlyMet: 1.288 ± 0.019	2.727GlyAsn: 2.727 ± 0.03	2.04GlyPro: 2.04 ± 0.045	1.993GlyGln: 1.993 ± 0.026	3.157GlyArg: 3.157 ± 0.038	4.279GlySer: 4.279 ± 0.04	3.142GlyThr: 3.142 ± 0.031	2.867GlyVal: 2.867 ± 0.032	0.622GlyTrp: 0.622 ± 0.014	1.815GlyTyr: 1.815 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.33HisAla: 1.33 ± 0.018	0.639HisCys: 0.639 ± 0.013	1.125HisAsp: 1.125 ± 0.015	1.404HisGlu: 1.404 ± 0.019	1.223HisPhe: 1.223 ± 0.017	1.256HisGly: 1.256 ± 0.018	0.77HisHis: 0.77 ± 0.015	1.585HisIle: 1.585 ± 0.019	1.127HisLys: 1.127 ± 0.016	2.438HisLeu: 2.438 ± 0.025	0.566HisMet: 0.566 ± 0.011	1.053HisAsn: 1.053 ± 0.014	1.138HisPro: 1.138 ± 0.016	1.001HisGln: 1.001 ± 0.017	1.482HisArg: 1.482 ± 0.022	2.017HisSer: 2.017 ± 0.024	1.104HisThr: 1.104 ± 0.015	1.36HisVal: 1.36 ± 0.018	0.314HisTrp: 0.314 ± 0.008	0.897HisTyr: 0.897 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.514IleAla: 4.514 ± 0.038	1.605IleCys: 1.605 ± 0.028	3.941IleAsp: 3.941 ± 0.031	4.114IleGlu: 4.114 ± 0.041	2.751IlePhe: 2.751 ± 0.033	3.485IleGly: 3.485 ± 0.031	1.507IleHis: 1.507 ± 0.022	4.279IleIle: 4.279 ± 0.048	3.392IleLys: 3.392 ± 0.033	5.662IleLeu: 5.662 ± 0.042	1.413IleMet: 1.413 ± 0.018	3.181IleAsn: 3.181 ± 0.032	3.119IlePro: 3.119 ± 0.028	2.323IleGln: 2.323 ± 0.022	3.73IleArg: 3.73 ± 0.033	5.694IleSer: 5.694 ± 0.039	3.792IleThr: 3.792 ± 0.03	3.952IleVal: 3.952 ± 0.031	0.706IleTrp: 0.706 ± 0.013	2.069IleTyr: 2.069 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.446LysAla: 3.446 ± 0.036	1.363LysCys: 1.363 ± 0.025	3.03LysAsp: 3.03 ± 0.032	4.597LysGlu: 4.597 ± 0.047	2.257LysPhe: 2.257 ± 0.027	2.619LysGly: 2.619 ± 0.035	1.497LysHis: 1.497 ± 0.019	4.093LysIle: 4.093 ± 0.036	5.151LysLys: 5.151 ± 0.053	5.827LysLeu: 5.827 ± 0.048	1.731LysMet: 1.731 ± 0.021	3.334LysAsn: 3.334 ± 0.031	2.349LysPro: 2.349 ± 0.03	2.824LysGln: 2.824 ± 0.029	4.091LysArg: 4.091 ± 0.037	4.301LysSer: 4.301 ± 0.044	3.253LysThr: 3.253 ± 0.032	3.154LysVal: 3.154 ± 0.026	0.757LysTrp: 0.757 ± 0.013	2.041LysTyr: 2.041 ± 0.024	0.001LysXaa: 0.001 ± 0.0
Leu	5.741LeuAla: 5.741 ± 0.04	2.029LeuCys: 2.029 ± 0.027	4.641LeuAsp: 4.641 ± 0.038	5.846LeuGlu: 5.846 ± 0.049	3.861LeuPhe: 3.861 ± 0.038	3.759LeuGly: 3.759 ± 0.032	2.432LeuHis: 2.432 ± 0.026	5.744LeuIle: 5.744 ± 0.048	6.054LeuLys: 6.054 ± 0.046	9.596LeuLeu: 9.596 ± 0.083	2.269LeuMet: 2.269 ± 0.021	4.613LeuAsn: 4.613 ± 0.035	4.623LeuPro: 4.623 ± 0.049	4.249LeuGln: 4.249 ± 0.038	5.619LeuArg: 5.619 ± 0.041	7.731LeuSer: 7.731 ± 0.049	4.874LeuThr: 4.874 ± 0.037	4.654LeuVal: 4.654 ± 0.04	0.984LeuTrp: 0.984 ± 0.016	2.796LeuTyr: 2.796 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.582MetAla: 1.582 ± 0.023	0.449MetCys: 0.449 ± 0.01	1.478MetAsp: 1.478 ± 0.021	1.905MetGlu: 1.905 ± 0.022	0.893MetPhe: 0.893 ± 0.015	1.09MetGly: 1.09 ± 0.017	0.637MetHis: 0.637 ± 0.012	1.575MetIle: 1.575 ± 0.021	1.863MetLys: 1.863 ± 0.023	2.345MetLeu: 2.345 ± 0.024	0.716MetMet: 0.716 ± 0.017	1.406MetAsn: 1.406 ± 0.018	1.082MetPro: 1.082 ± 0.017	1.191MetGln: 1.191 ± 0.017	1.419MetArg: 1.419 ± 0.019	1.758MetSer: 1.758 ± 0.022	1.272MetThr: 1.272 ± 0.014	1.337MetVal: 1.337 ± 0.017	0.231MetTrp: 0.231 ± 0.007	0.643MetTyr: 0.643 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.274AsnAla: 3.274 ± 0.028	1.121AsnCys: 1.121 ± 0.019	3.463AsnAsp: 3.463 ± 0.031	3.911AsnGlu: 3.911 ± 0.037	2.11AsnPhe: 2.11 ± 0.029	3.294AsnGly: 3.294 ± 0.036	1.064AsnHis: 1.064 ± 0.017	3.467AsnIle: 3.467 ± 0.032	2.657AsnLys: 2.657 ± 0.03	4.297AsnLeu: 4.297 ± 0.028	1.206AsnMet: 1.206 ± 0.018	2.859AsnAsn: 2.859 ± 0.034	1.939AsnPro: 1.939 ± 0.022	1.769AsnGln: 1.769 ± 0.023	2.734AsnArg: 2.734 ± 0.03	4.148AsnSer: 4.148 ± 0.042	2.526AsnThr: 2.526 ± 0.027	3.208AsnVal: 3.208 ± 0.029	0.544AsnTrp: 0.544 ± 0.012	1.684AsnTyr: 1.684 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	2.376ProAla: 2.376 ± 0.03	0.771ProCys: 0.771 ± 0.019	2.15ProAsp: 2.15 ± 0.023	2.77ProGlu: 2.77 ± 0.029	1.84ProPhe: 1.84 ± 0.02	2.441ProGly: 2.441 ± 0.096	0.958ProHis: 0.958 ± 0.017	2.677ProIle: 2.677 ± 0.028	2.396ProLys: 2.396 ± 0.027	3.873ProLeu: 3.873 ± 0.034	0.912ProMet: 0.912 ± 0.015	2.128ProAsn: 2.128 ± 0.025	3.186ProPro: 3.186 ± 0.065	1.718ProGln: 1.718 ± 0.023	2.042ProArg: 2.042 ± 0.026	4.016ProSer: 4.016 ± 0.037	2.612ProThr: 2.612 ± 0.028	2.729ProVal: 2.729 ± 0.029	0.411ProTrp: 0.411 ± 0.011	1.419ProTyr: 1.419 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	2.209GlnAla: 2.209 ± 0.029	0.969GlnCys: 0.969 ± 0.022	1.438GlnAsp: 1.438 ± 0.019	2.345GlnGlu: 2.345 ± 0.029	1.691GlnPhe: 1.691 ± 0.021	1.495GlnGly: 1.495 ± 0.021	1.14GlnHis: 1.14 ± 0.018	2.74GlnIle: 2.74 ± 0.026	2.841GlnLys: 2.841 ± 0.029	4.439GlnLeu: 4.439 ± 0.042	1.271GlnMet: 1.271 ± 0.019	2.216GlnAsn: 2.216 ± 0.024	1.726GlnPro: 1.726 ± 0.028	3.522GlnGln: 3.522 ± 0.084	2.601GlnArg: 2.601 ± 0.029	3.037GlnSer: 3.037 ± 0.032	2.148GlnThr: 2.148 ± 0.024	1.928GlnVal: 1.928 ± 0.023	0.519GlnTrp: 0.519 ± 0.011	1.388GlnTyr: 1.388 ± 0.019	0.005GlnXaa: 0.005 ± 0.001
Arg	3.088ArgAla: 3.088 ± 0.026	1.35ArgCys: 1.35 ± 0.023	2.758ArgAsp: 2.758 ± 0.033	3.619ArgGlu: 3.619 ± 0.041	2.371ArgPhe: 2.371 ± 0.025	2.597ArgGly: 2.597 ± 0.038	1.498ArgHis: 1.498 ± 0.022	3.887ArgIle: 3.887 ± 0.034	4.242ArgLys: 4.242 ± 0.04	5.402ArgLeu: 5.402 ± 0.044	1.462ArgMet: 1.462 ± 0.018	3.269ArgAsn: 3.269 ± 0.024	2.211ArgPro: 2.211 ± 0.029	2.501ArgGln: 2.501 ± 0.029	4.427ArgArg: 4.427 ± 0.043	4.514ArgSer: 4.514 ± 0.042	3.007ArgThr: 3.007 ± 0.029	2.846ArgVal: 2.846 ± 0.024	0.68ArgTrp: 0.68 ± 0.012	1.909ArgTyr: 1.909 ± 0.023	0.001ArgXaa: 0.001 ± 0.0
Ser	5.125SerAla: 5.125 ± 0.041	1.617SerCys: 1.617 ± 0.026	4.643SerAsp: 4.643 ± 0.04	4.902SerGlu: 4.902 ± 0.036	3.322SerPhe: 3.322 ± 0.03	4.583SerGly: 4.583 ± 0.04	1.781SerHis: 1.781 ± 0.022	4.811SerIle: 4.811 ± 0.037	4.459SerLys: 4.459 ± 0.043	7.304SerLeu: 7.304 ± 0.051	1.834SerMet: 1.834 ± 0.021	4.242SerAsn: 4.242 ± 0.038	3.519SerPro: 3.519 ± 0.04	2.972SerGln: 2.972 ± 0.03	4.298SerArg: 4.298 ± 0.041	9.082SerSer: 9.082 ± 0.097	5.127SerThr: 5.127 ± 0.046	5.01SerVal: 5.01 ± 0.035	0.793SerTrp: 0.793 ± 0.015	2.233SerTyr: 2.233 ± 0.025	0.002SerXaa: 0.002 ± 0.001
Thr	4.014ThrAla: 4.014 ± 0.038	1.098ThrCys: 1.098 ± 0.023	3.071ThrAsp: 3.071 ± 0.03	3.468ThrGlu: 3.468 ± 0.033	2.249ThrPhe: 2.249 ± 0.027	2.991ThrGly: 2.991 ± 0.029	1.137ThrHis: 1.137 ± 0.019	3.623ThrIle: 3.623 ± 0.036	3.066ThrLys: 3.066 ± 0.027	4.844ThrLeu: 4.844 ± 0.035	1.259ThrMet: 1.259 ± 0.016	2.779ThrAsn: 2.779 ± 0.03	2.536ThrPro: 2.536 ± 0.031	1.799ThrGln: 1.799 ± 0.025	2.494ThrArg: 2.494 ± 0.024	4.985ThrSer: 4.985 ± 0.047	4.085ThrThr: 4.085 ± 0.068	4.158ThrVal: 4.158 ± 0.035	0.484ThrTrp: 0.484 ± 0.012	1.555ThrTyr: 1.555 ± 0.02	0.003ThrXaa: 0.003 ± 0.001
Val	3.972ValAla: 3.972 ± 0.031	1.243ValCys: 1.243 ± 0.023	3.498ValAsp: 3.498 ± 0.031	4.058ValGlu: 4.058 ± 0.036	2.262ValPhe: 2.262 ± 0.025	2.95ValGly: 2.95 ± 0.029	1.44ValHis: 1.44 ± 0.019	4.0ValIle: 4.0 ± 0.036	3.484ValLys: 3.484 ± 0.033	5.363ValLeu: 5.363 ± 0.038	1.417ValMet: 1.417 ± 0.019	2.85ValAsn: 2.85 ± 0.03	2.78ValPro: 2.78 ± 0.025	2.442ValGln: 2.442 ± 0.025	3.212ValArg: 3.212 ± 0.026	4.346ValSer: 4.346 ± 0.036	3.429ValThr: 3.429 ± 0.038	3.89ValVal: 3.89 ± 0.041	0.61ValTrp: 0.61 ± 0.013	1.746ValTyr: 1.746 ± 0.02	0.001ValXaa: 0.001 ± 0.001
Trp	0.552TrpAla: 0.552 ± 0.011	0.231TrpCys: 0.231 ± 0.008	0.567TrpAsp: 0.567 ± 0.012	0.581TrpGlu: 0.581 ± 0.011	0.475TrpPhe: 0.475 ± 0.01	0.423TrpGly: 0.423 ± 0.013	0.286TrpHis: 0.286 ± 0.009	0.793TrpIle: 0.793 ± 0.014	0.857TrpLys: 0.857 ± 0.016	1.106TrpLeu: 1.106 ± 0.018	0.33TrpMet: 0.33 ± 0.01	0.692TrpAsn: 0.692 ± 0.012	0.438TrpPro: 0.438 ± 0.011	0.454TrpGln: 0.454 ± 0.01	0.695TrpArg: 0.695 ± 0.012	0.845TrpSer: 0.845 ± 0.017	0.648TrpThr: 0.648 ± 0.015	0.476TrpVal: 0.476 ± 0.011	0.163TrpTrp: 0.163 ± 0.006	0.364TrpTyr: 0.364 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.899TyrAla: 1.899 ± 0.024	0.807TyrCys: 0.807 ± 0.016	1.905TyrAsp: 1.905 ± 0.022	1.952TyrGlu: 1.952 ± 0.022	1.449TyrPhe: 1.449 ± 0.02	1.992TyrGly: 1.992 ± 0.026	0.879TyrHis: 0.879 ± 0.016	1.908TyrIle: 1.908 ± 0.026	1.622TyrLys: 1.622 ± 0.02	2.904TyrLeu: 2.904 ± 0.027	0.786TyrMet: 0.786 ± 0.013	1.497TyrAsn: 1.497 ± 0.02	1.361TyrPro: 1.361 ± 0.019	1.252TyrGln: 1.252 ± 0.019	1.971TyrArg: 1.971 ± 0.021	2.308TyrSer: 2.308 ± 0.025	1.495TyrThr: 1.495 ± 0.022	1.894TyrVal: 1.894 ± 0.02	0.402TyrTrp: 0.402 ± 0.01	1.233TyrTyr: 1.233 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.005XaaGln: 0.005 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.231XaaXaa: 0.231 ± 0.035

Statistics based on 10007 proteins (4369685 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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