Amino acid dipepetide frequency for Listeria phage LP-030-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.666AlaAla: 6.666 ± 2.375
0.397AlaCys: 0.397 ± 0.172
4.682AlaAsp: 4.682 ± 0.626
5.713AlaGlu: 5.713 ± 0.68
3.492AlaPhe: 3.492 ± 0.731
5.475AlaGly: 5.475 ± 1.344
0.873AlaHis: 0.873 ± 0.24
6.031AlaIle: 6.031 ± 0.959
8.967AlaLys: 8.967 ± 1.335
6.904AlaLeu: 6.904 ± 1.443
2.222AlaMet: 2.222 ± 0.45
5.158AlaAsn: 5.158 ± 0.931
1.27AlaPro: 1.27 ± 0.31
2.777AlaGln: 2.777 ± 0.473
2.063AlaArg: 2.063 ± 0.568
4.841AlaSer: 4.841 ± 1.163
3.65AlaThr: 3.65 ± 0.453
4.523AlaVal: 4.523 ± 1.035
0.714AlaTrp: 0.714 ± 0.186
2.301AlaTyr: 2.301 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.079CysAla: 0.079 ± 0.083
0.0CysCys: 0.0 ± 0.0
0.714CysAsp: 0.714 ± 0.367
0.635CysGlu: 0.635 ± 0.232
0.079CysPhe: 0.079 ± 0.08
0.873CysGly: 0.873 ± 0.3
0.0CysHis: 0.0 ± 0.0
0.159CysIle: 0.159 ± 0.115
0.476CysLys: 0.476 ± 0.227
0.476CysLeu: 0.476 ± 0.243
0.159CysMet: 0.159 ± 0.114
0.397CysAsn: 0.397 ± 0.152
0.317CysPro: 0.317 ± 0.197
0.079CysGln: 0.079 ± 0.066
0.555CysArg: 0.555 ± 0.223
0.238CysSer: 0.238 ± 0.115
0.159CysThr: 0.159 ± 0.122
0.397CysVal: 0.397 ± 0.177
0.079CysTrp: 0.079 ± 0.067
0.714CysTyr: 0.714 ± 0.228
0.0CysXaa: 0.0 ± 0.0
Asp
3.809AspAla: 3.809 ± 0.686
0.159AspCys: 0.159 ± 0.106
4.047AspAsp: 4.047 ± 0.715
4.682AspGlu: 4.682 ± 0.723
2.46AspPhe: 2.46 ± 0.483
4.126AspGly: 4.126 ± 0.607
0.317AspHis: 0.317 ± 0.173
4.761AspIle: 4.761 ± 0.513
5.634AspLys: 5.634 ± 0.602
5.793AspLeu: 5.793 ± 0.709
1.508AspMet: 1.508 ± 0.43
3.412AspAsn: 3.412 ± 0.496
1.19AspPro: 1.19 ± 0.309
0.873AspGln: 0.873 ± 0.201
1.349AspArg: 1.349 ± 0.255
4.285AspSer: 4.285 ± 0.794
2.619AspThr: 2.619 ± 0.432
3.015AspVal: 3.015 ± 0.43
0.397AspTrp: 0.397 ± 0.191
2.857AspTyr: 2.857 ± 0.753
0.0AspXaa: 0.0 ± 0.0
Glu
6.189GluAla: 6.189 ± 0.903
0.397GluCys: 0.397 ± 0.197
3.333GluAsp: 3.333 ± 0.744
6.269GluGlu: 6.269 ± 1.14
3.174GluPhe: 3.174 ± 0.556
2.698GluGly: 2.698 ± 0.53
1.19GluHis: 1.19 ± 0.302
5.634GluIle: 5.634 ± 0.825
8.253GluLys: 8.253 ± 0.839
7.777GluLeu: 7.777 ± 0.747
2.777GluMet: 2.777 ± 0.508
4.92GluAsn: 4.92 ± 0.673
1.428GluPro: 1.428 ± 0.415
3.095GluGln: 3.095 ± 0.594
3.333GluArg: 3.333 ± 0.617
4.602GluSer: 4.602 ± 0.564
4.92GluThr: 4.92 ± 0.662
4.999GluVal: 4.999 ± 0.82
1.349GluTrp: 1.349 ± 0.393
3.174GluTyr: 3.174 ± 0.549
0.0GluXaa: 0.0 ± 0.0
Phe
3.015PheAla: 3.015 ± 0.288
0.476PheCys: 0.476 ± 0.182
3.095PheAsp: 3.095 ± 0.661
2.936PheGlu: 2.936 ± 0.566
0.952PhePhe: 0.952 ± 0.263
1.984PheGly: 1.984 ± 0.36
0.635PheHis: 0.635 ± 0.252
3.095PheIle: 3.095 ± 0.447
3.015PheLys: 3.015 ± 0.39
3.333PheLeu: 3.333 ± 0.465
0.635PheMet: 0.635 ± 0.239
2.777PheAsn: 2.777 ± 0.312
0.794PhePro: 0.794 ± 0.218
1.111PheGln: 1.111 ± 0.333
1.19PheArg: 1.19 ± 0.386
3.65PheSer: 3.65 ± 0.563
2.857PheThr: 2.857 ± 0.575
3.492PheVal: 3.492 ± 0.499
0.317PheTrp: 0.317 ± 0.197
1.111PheTyr: 1.111 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
3.174GlyAla: 3.174 ± 0.877
0.873GlyCys: 0.873 ± 0.297
3.333GlyAsp: 3.333 ± 0.482
3.73GlyGlu: 3.73 ± 0.579
2.381GlyPhe: 2.381 ± 0.427
3.174GlyGly: 3.174 ± 0.617
0.635GlyHis: 0.635 ± 0.276
3.888GlyIle: 3.888 ± 0.606
5.317GlyLys: 5.317 ± 0.611
4.999GlyLeu: 4.999 ± 0.924
1.19GlyMet: 1.19 ± 0.363
3.333GlyAsn: 3.333 ± 0.543
0.317GlyPro: 0.317 ± 0.13
1.349GlyGln: 1.349 ± 0.345
2.143GlyArg: 2.143 ± 0.471
4.047GlySer: 4.047 ± 0.824
3.968GlyThr: 3.968 ± 0.656
4.841GlyVal: 4.841 ± 0.659
0.238GlyTrp: 0.238 ± 0.129
2.777GlyTyr: 2.777 ± 0.49
0.0GlyXaa: 0.0 ± 0.0
His
1.111HisAla: 1.111 ± 0.315
0.079HisCys: 0.079 ± 0.074
0.873HisAsp: 0.873 ± 0.267
1.111HisGlu: 1.111 ± 0.337
0.397HisPhe: 0.397 ± 0.17
0.238HisGly: 0.238 ± 0.133
0.476HisHis: 0.476 ± 0.196
1.111HisIle: 1.111 ± 0.347
0.714HisLys: 0.714 ± 0.309
0.794HisLeu: 0.794 ± 0.287
0.079HisMet: 0.079 ± 0.08
1.111HisAsn: 1.111 ± 0.373
0.476HisPro: 0.476 ± 0.199
0.476HisGln: 0.476 ± 0.186
0.397HisArg: 0.397 ± 0.21
0.714HisSer: 0.714 ± 0.223
1.032HisThr: 1.032 ± 0.381
1.032HisVal: 1.032 ± 0.278
0.238HisTrp: 0.238 ± 0.145
0.476HisTyr: 0.476 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
5.555IleAla: 5.555 ± 0.815
0.873IleCys: 0.873 ± 0.299
5.396IleAsp: 5.396 ± 0.688
7.062IleGlu: 7.062 ± 0.916
3.253IlePhe: 3.253 ± 0.616
2.698IleGly: 2.698 ± 0.534
1.349IleHis: 1.349 ± 0.456
3.968IleIle: 3.968 ± 0.526
6.348IleLys: 6.348 ± 0.888
4.047IleLeu: 4.047 ± 0.563
1.428IleMet: 1.428 ± 0.39
4.523IleAsn: 4.523 ± 0.44
2.143IlePro: 2.143 ± 0.378
3.095IleGln: 3.095 ± 0.564
2.539IleArg: 2.539 ± 0.556
4.92IleSer: 4.92 ± 0.622
4.206IleThr: 4.206 ± 0.693
3.968IleVal: 3.968 ± 0.573
0.635IleTrp: 0.635 ± 0.19
2.698IleTyr: 2.698 ± 0.622
0.0IleXaa: 0.0 ± 0.0
Lys
7.459LysAla: 7.459 ± 1.537
0.476LysCys: 0.476 ± 0.193
4.682LysAsp: 4.682 ± 0.558
6.189LysGlu: 6.189 ± 0.701
2.698LysPhe: 2.698 ± 0.507
5.158LysGly: 5.158 ± 0.656
0.873LysHis: 0.873 ± 0.276
4.523LysIle: 4.523 ± 0.547
7.3LysLys: 7.3 ± 1.012
7.38LysLeu: 7.38 ± 0.79
3.015LysMet: 3.015 ± 0.487
6.428LysAsn: 6.428 ± 0.784
2.222LysPro: 2.222 ± 0.39
4.206LysGln: 4.206 ± 0.61
3.968LysArg: 3.968 ± 0.646
6.348LysSer: 6.348 ± 1.682
6.507LysThr: 6.507 ± 0.65
5.713LysVal: 5.713 ± 0.715
0.952LysTrp: 0.952 ± 0.25
3.809LysTyr: 3.809 ± 0.616
0.0LysXaa: 0.0 ± 0.0
Leu
6.666LeuAla: 6.666 ± 0.765
0.476LeuCys: 0.476 ± 0.227
5.317LeuAsp: 5.317 ± 0.633
6.428LeuGlu: 6.428 ± 0.814
3.253LeuPhe: 3.253 ± 0.638
4.444LeuGly: 4.444 ± 0.685
0.476LeuHis: 0.476 ± 0.171
5.713LeuIle: 5.713 ± 0.746
8.57LeuLys: 8.57 ± 0.95
5.396LeuLeu: 5.396 ± 0.783
2.381LeuMet: 2.381 ± 0.453
4.92LeuAsn: 4.92 ± 0.645
1.984LeuPro: 1.984 ± 0.249
2.46LeuGln: 2.46 ± 0.407
3.412LeuArg: 3.412 ± 0.58
5.475LeuSer: 5.475 ± 0.612
6.189LeuThr: 6.189 ± 0.643
4.364LeuVal: 4.364 ± 0.401
0.555LeuTrp: 0.555 ± 0.281
3.095LeuTyr: 3.095 ± 0.448
0.0LeuXaa: 0.0 ± 0.0
Met
1.428MetAla: 1.428 ± 0.262
0.238MetCys: 0.238 ± 0.178
1.032MetAsp: 1.032 ± 0.279
1.349MetGlu: 1.349 ± 0.289
0.952MetPhe: 0.952 ± 0.252
1.508MetGly: 1.508 ± 0.274
0.714MetHis: 0.714 ± 0.248
1.27MetIle: 1.27 ± 0.39
2.222MetLys: 2.222 ± 0.428
2.063MetLeu: 2.063 ± 0.338
0.317MetMet: 0.317 ± 0.175
1.587MetAsn: 1.587 ± 0.37
0.714MetPro: 0.714 ± 0.249
1.508MetGln: 1.508 ± 0.352
1.032MetArg: 1.032 ± 0.227
1.904MetSer: 1.904 ± 0.456
2.46MetThr: 2.46 ± 0.375
1.587MetVal: 1.587 ± 0.294
0.238MetTrp: 0.238 ± 0.138
1.27MetTyr: 1.27 ± 0.304
0.0MetXaa: 0.0 ± 0.0
Asn
4.92AsnAla: 4.92 ± 0.996
0.397AsnCys: 0.397 ± 0.168
3.015AsnAsp: 3.015 ± 0.75
5.951AsnGlu: 5.951 ± 0.826
1.904AsnPhe: 1.904 ± 0.368
4.841AsnGly: 4.841 ± 0.573
0.952AsnHis: 0.952 ± 0.323
4.444AsnIle: 4.444 ± 0.515
4.602AsnLys: 4.602 ± 0.635
5.158AsnLeu: 5.158 ± 0.474
1.349AsnMet: 1.349 ± 0.246
4.206AsnAsn: 4.206 ± 0.682
1.904AsnPro: 1.904 ± 0.458
2.936AsnGln: 2.936 ± 0.471
2.222AsnArg: 2.222 ± 0.35
3.412AsnSer: 3.412 ± 0.62
3.73AsnThr: 3.73 ± 0.773
3.571AsnVal: 3.571 ± 0.451
0.794AsnTrp: 0.794 ± 0.259
3.095AsnTyr: 3.095 ± 0.53
0.0AsnXaa: 0.0 ± 0.0
Pro
2.46ProAla: 2.46 ± 0.542
0.079ProCys: 0.079 ± 0.075
0.635ProAsp: 0.635 ± 0.205
2.46ProGlu: 2.46 ± 0.505
1.349ProPhe: 1.349 ± 0.369
0.952ProGly: 0.952 ± 0.265
0.0ProHis: 0.0 ± 0.0
1.508ProIle: 1.508 ± 0.34
1.508ProLys: 1.508 ± 0.359
2.381ProLeu: 2.381 ± 0.568
0.635ProMet: 0.635 ± 0.253
1.032ProAsn: 1.032 ± 0.327
1.111ProPro: 1.111 ± 0.334
0.476ProGln: 0.476 ± 0.174
0.794ProArg: 0.794 ± 0.261
1.904ProSer: 1.904 ± 0.354
1.666ProThr: 1.666 ± 0.388
2.301ProVal: 2.301 ± 0.366
0.159ProTrp: 0.159 ± 0.121
0.476ProTyr: 0.476 ± 0.202
0.0ProXaa: 0.0 ± 0.0
Gln
3.253GlnAla: 3.253 ± 0.741
0.238GlnCys: 0.238 ± 0.136
2.063GlnAsp: 2.063 ± 0.494
2.777GlnGlu: 2.777 ± 0.567
1.19GlnPhe: 1.19 ± 0.26
1.666GlnGly: 1.666 ± 0.389
0.317GlnHis: 0.317 ± 0.151
2.777GlnIle: 2.777 ± 0.321
3.571GlnLys: 3.571 ± 0.56
2.936GlnLeu: 2.936 ± 0.567
0.794GlnMet: 0.794 ± 0.227
2.619GlnAsn: 2.619 ± 0.478
0.635GlnPro: 0.635 ± 0.249
1.825GlnGln: 1.825 ± 0.358
1.587GlnArg: 1.587 ± 0.373
2.301GlnSer: 2.301 ± 0.466
1.746GlnThr: 1.746 ± 0.269
2.381GlnVal: 2.381 ± 0.559
0.397GlnTrp: 0.397 ± 0.193
1.111GlnTyr: 1.111 ± 0.329
0.0GlnXaa: 0.0 ± 0.0
Arg
1.984ArgAla: 1.984 ± 0.534
0.238ArgCys: 0.238 ± 0.131
1.587ArgAsp: 1.587 ± 0.44
3.333ArgGlu: 3.333 ± 0.706
1.508ArgPhe: 1.508 ± 0.304
1.587ArgGly: 1.587 ± 0.349
1.111ArgHis: 1.111 ± 0.352
2.381ArgIle: 2.381 ± 0.427
3.571ArgLys: 3.571 ± 0.783
3.174ArgLeu: 3.174 ± 0.487
0.952ArgMet: 0.952 ± 0.275
2.46ArgAsn: 2.46 ± 0.549
0.952ArgPro: 0.952 ± 0.226
0.794ArgGln: 0.794 ± 0.33
1.19ArgArg: 1.19 ± 0.363
1.746ArgSer: 1.746 ± 0.418
1.666ArgThr: 1.666 ± 0.421
2.381ArgVal: 2.381 ± 0.404
0.476ArgTrp: 0.476 ± 0.177
1.746ArgTyr: 1.746 ± 0.458
0.0ArgXaa: 0.0 ± 0.0
Ser
6.507SerAla: 6.507 ± 1.64
0.079SerCys: 0.079 ± 0.083
4.047SerAsp: 4.047 ± 0.511
5.158SerGlu: 5.158 ± 0.686
3.65SerPhe: 3.65 ± 0.577
4.761SerGly: 4.761 ± 0.827
0.317SerHis: 0.317 ± 0.13
5.396SerIle: 5.396 ± 0.745
4.523SerLys: 4.523 ± 0.499
5.713SerLeu: 5.713 ± 0.843
1.111SerMet: 1.111 ± 0.256
4.364SerAsn: 4.364 ± 0.63
1.587SerPro: 1.587 ± 0.348
2.698SerGln: 2.698 ± 0.42
1.508SerArg: 1.508 ± 0.418
4.206SerSer: 4.206 ± 0.55
3.412SerThr: 3.412 ± 0.709
4.523SerVal: 4.523 ± 0.633
0.555SerTrp: 0.555 ± 0.212
2.222SerTyr: 2.222 ± 0.371
0.0SerXaa: 0.0 ± 0.0
Thr
5.634ThrAla: 5.634 ± 1.12
0.555ThrCys: 0.555 ± 0.22
2.539ThrAsp: 2.539 ± 0.421
4.682ThrGlu: 4.682 ± 0.645
2.698ThrPhe: 2.698 ± 0.401
3.968ThrGly: 3.968 ± 0.724
1.19ThrHis: 1.19 ± 0.327
5.793ThrIle: 5.793 ± 0.624
5.634ThrLys: 5.634 ± 0.597
4.364ThrLeu: 4.364 ± 0.457
1.349ThrMet: 1.349 ± 0.269
3.73ThrAsn: 3.73 ± 0.58
1.904ThrPro: 1.904 ± 0.395
1.666ThrGln: 1.666 ± 0.453
1.587ThrArg: 1.587 ± 0.36
4.047ThrSer: 4.047 ± 0.558
4.364ThrThr: 4.364 ± 0.61
3.888ThrVal: 3.888 ± 0.478
0.555ThrTrp: 0.555 ± 0.214
2.222ThrTyr: 2.222 ± 0.594
0.0ThrXaa: 0.0 ± 0.0
Val
5.158ValAla: 5.158 ± 0.95
0.238ValCys: 0.238 ± 0.203
4.523ValAsp: 4.523 ± 0.604
5.634ValGlu: 5.634 ± 0.692
2.619ValPhe: 2.619 ± 0.446
3.174ValGly: 3.174 ± 0.447
0.873ValHis: 0.873 ± 0.3
4.92ValIle: 4.92 ± 0.599
5.079ValLys: 5.079 ± 0.692
5.158ValLeu: 5.158 ± 0.66
1.666ValMet: 1.666 ± 0.315
3.095ValAsn: 3.095 ± 0.501
1.587ValPro: 1.587 ± 0.308
2.381ValGln: 2.381 ± 0.399
2.619ValArg: 2.619 ± 0.55
4.602ValSer: 4.602 ± 0.557
3.888ValThr: 3.888 ± 0.576
4.364ValVal: 4.364 ± 0.578
0.317ValTrp: 0.317 ± 0.137
2.46ValTyr: 2.46 ± 0.549
0.0ValXaa: 0.0 ± 0.0
Trp
1.111TrpAla: 1.111 ± 0.281
0.0TrpCys: 0.0 ± 0.0
0.317TrpAsp: 0.317 ± 0.158
0.397TrpGlu: 0.397 ± 0.181
0.397TrpPhe: 0.397 ± 0.185
0.159TrpGly: 0.159 ± 0.129
0.317TrpHis: 0.317 ± 0.152
0.794TrpIle: 0.794 ± 0.281
0.714TrpLys: 0.714 ± 0.275
0.555TrpLeu: 0.555 ± 0.195
0.476TrpMet: 0.476 ± 0.144
0.794TrpAsn: 0.794 ± 0.278
0.159TrpPro: 0.159 ± 0.123
0.476TrpGln: 0.476 ± 0.165
0.317TrpArg: 0.317 ± 0.162
0.476TrpSer: 0.476 ± 0.175
0.476TrpThr: 0.476 ± 0.187
0.794TrpVal: 0.794 ± 0.259
0.159TrpTrp: 0.159 ± 0.116
0.635TrpTyr: 0.635 ± 0.445
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.539TyrAla: 2.539 ± 0.495
0.317TyrCys: 0.317 ± 0.18
2.063TyrAsp: 2.063 ± 0.503
3.015TyrGlu: 3.015 ± 0.676
2.063TyrPhe: 2.063 ± 0.453
2.222TyrGly: 2.222 ± 0.398
0.317TyrHis: 0.317 ± 0.149
2.539TyrIle: 2.539 ± 0.504
3.888TyrLys: 3.888 ± 0.749
3.174TyrLeu: 3.174 ± 0.701
1.27TyrMet: 1.27 ± 0.24
2.539TyrAsn: 2.539 ± 0.551
1.19TyrPro: 1.19 ± 0.324
1.904TyrGln: 1.904 ± 0.48
1.111TyrArg: 1.111 ± 0.347
2.619TyrSer: 2.619 ± 0.409
2.857TyrThr: 2.857 ± 0.446
2.222TyrVal: 2.222 ± 0.426
0.397TyrTrp: 0.397 ± 0.182
2.063TyrTyr: 2.063 ± 0.622
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (12603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski