Amino acid dipepetide frequency for Weissella viridescens (Lactobacillus viridescens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.973AlaAla: 7.973 ± 0.173
0.192AlaCys: 0.192 ± 0.021
6.164AlaAsp: 6.164 ± 0.128
5.77AlaGlu: 5.77 ± 0.134
3.543AlaPhe: 3.543 ± 0.095
6.362AlaGly: 6.362 ± 0.145
1.721AlaHis: 1.721 ± 0.058
6.006AlaIle: 6.006 ± 0.134
5.282AlaLys: 5.282 ± 0.148
8.661AlaLeu: 8.661 ± 0.194
2.692AlaMet: 2.692 ± 0.083
4.013AlaAsn: 4.013 ± 0.096
2.779AlaPro: 2.779 ± 0.089
4.75AlaGln: 4.75 ± 0.163
3.225AlaArg: 3.225 ± 0.083
4.971AlaSer: 4.971 ± 0.45
5.525AlaThr: 5.525 ± 0.146
6.278AlaVal: 6.278 ± 0.122
0.862AlaTrp: 0.862 ± 0.047
2.793AlaTyr: 2.793 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
0.167CysAla: 0.167 ± 0.02
0.027CysCys: 0.027 ± 0.008
0.091CysAsp: 0.091 ± 0.014
0.091CysGlu: 0.091 ± 0.015
0.143CysPhe: 0.143 ± 0.019
0.196CysGly: 0.196 ± 0.023
0.076CysHis: 0.076 ± 0.014
0.163CysIle: 0.163 ± 0.021
0.06CysLys: 0.06 ± 0.011
0.314CysLeu: 0.314 ± 0.033
0.045CysMet: 0.045 ± 0.011
0.069CysAsn: 0.069 ± 0.012
0.129CysPro: 0.129 ± 0.02
0.114CysGln: 0.114 ± 0.017
0.073CysArg: 0.073 ± 0.013
0.114CysSer: 0.114 ± 0.017
0.125CysThr: 0.125 ± 0.018
0.14CysVal: 0.14 ± 0.018
0.024CysTrp: 0.024 ± 0.008
0.094CysTyr: 0.094 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.182AspAla: 6.182 ± 0.196
0.127AspCys: 0.127 ± 0.019
4.414AspAsp: 4.414 ± 0.128
4.817AspGlu: 4.817 ± 0.126
2.808AspPhe: 2.808 ± 0.083
4.162AspGly: 4.162 ± 0.108
1.243AspHis: 1.243 ± 0.056
3.904AspIle: 3.904 ± 0.106
3.238AspLys: 3.238 ± 0.089
5.979AspLeu: 5.979 ± 0.127
1.922AspMet: 1.922 ± 0.076
2.349AspAsn: 2.349 ± 0.077
2.341AspPro: 2.341 ± 0.069
3.095AspGln: 3.095 ± 0.105
2.499AspArg: 2.499 ± 0.079
2.975AspSer: 2.975 ± 0.198
3.24AspThr: 3.24 ± 0.084
5.015AspVal: 5.015 ± 0.127
0.753AspTrp: 0.753 ± 0.042
2.619AspTyr: 2.619 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
5.49GluAla: 5.49 ± 0.137
0.105GluCys: 0.105 ± 0.02
3.173GluAsp: 3.173 ± 0.098
3.327GluGlu: 3.327 ± 0.122
2.234GluPhe: 2.234 ± 0.073
2.819GluGly: 2.819 ± 0.094
1.47GluHis: 1.47 ± 0.063
4.024GluIle: 4.024 ± 0.106
3.83GluLys: 3.83 ± 0.104
5.922GluLeu: 5.922 ± 0.126
1.94GluMet: 1.94 ± 0.066
3.169GluAsn: 3.169 ± 0.084
2.118GluPro: 2.118 ± 0.071
3.43GluGln: 3.43 ± 0.102
2.977GluArg: 2.977 ± 0.093
3.053GluSer: 3.053 ± 0.151
3.804GluThr: 3.804 ± 0.113
4.225GluVal: 4.225 ± 0.106
0.517GluTrp: 0.517 ± 0.032
1.728GluTyr: 1.728 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
3.443PheAla: 3.443 ± 0.109
0.107PheCys: 0.107 ± 0.015
3.0PheAsp: 3.0 ± 0.094
2.472PheGlu: 2.472 ± 0.094
1.79PhePhe: 1.79 ± 0.085
3.456PheGly: 3.456 ± 0.103
0.604PheHis: 0.604 ± 0.032
2.768PheIle: 2.768 ± 0.094
2.347PheLys: 2.347 ± 0.073
3.378PheLeu: 3.378 ± 0.102
1.316PheMet: 1.316 ± 0.055
2.113PheAsn: 2.113 ± 0.072
1.383PhePro: 1.383 ± 0.052
1.401PheGln: 1.401 ± 0.056
1.162PheArg: 1.162 ± 0.052
2.581PheSer: 2.581 ± 0.084
2.385PheThr: 2.385 ± 0.077
3.071PheVal: 3.071 ± 0.094
0.514PheTrp: 0.514 ± 0.04
1.519PheTyr: 1.519 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
5.458GlyAla: 5.458 ± 0.129
0.145GlyCys: 0.145 ± 0.02
3.773GlyAsp: 3.773 ± 0.112
3.639GlyGlu: 3.639 ± 0.084
3.098GlyPhe: 3.098 ± 0.113
4.487GlyGly: 4.487 ± 0.146
1.468GlyHis: 1.468 ± 0.059
4.884GlyIle: 4.884 ± 0.119
3.931GlyLys: 3.931 ± 0.117
7.028GlyLeu: 7.028 ± 0.172
2.194GlyMet: 2.194 ± 0.082
2.646GlyAsn: 2.646 ± 0.082
1.782GlyPro: 1.782 ± 0.075
3.062GlyGln: 3.062 ± 0.099
2.797GlyArg: 2.797 ± 0.093
3.984GlySer: 3.984 ± 0.11
4.369GlyThr: 4.369 ± 0.102
5.294GlyVal: 5.294 ± 0.123
0.779GlyTrp: 0.779 ± 0.048
2.684GlyTyr: 2.684 ± 0.073
0.002GlyXaa: 0.002 ± 0.002
His
1.824HisAla: 1.824 ± 0.07
0.04HisCys: 0.04 ± 0.009
1.367HisAsp: 1.367 ± 0.064
1.247HisGlu: 1.247 ± 0.057
1.009HisPhe: 1.009 ± 0.054
1.378HisGly: 1.378 ± 0.061
0.483HisHis: 0.483 ± 0.033
1.2HisIle: 1.2 ± 0.059
0.793HisLys: 0.793 ± 0.034
2.04HisLeu: 2.04 ± 0.065
0.541HisMet: 0.541 ± 0.031
0.862HisAsn: 0.862 ± 0.044
1.029HisPro: 1.029 ± 0.05
1.062HisGln: 1.062 ± 0.053
0.904HisArg: 0.904 ± 0.046
0.946HisSer: 0.946 ± 0.048
1.138HisThr: 1.138 ± 0.057
1.577HisVal: 1.577 ± 0.061
0.234HisTrp: 0.234 ± 0.023
0.851HisTyr: 0.851 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.037IleAla: 6.037 ± 0.112
0.218IleCys: 0.218 ± 0.026
4.561IleAsp: 4.561 ± 0.105
3.868IleGlu: 3.868 ± 0.103
2.908IlePhe: 2.908 ± 0.094
5.069IleGly: 5.069 ± 0.134
1.156IleHis: 1.156 ± 0.055
4.182IleIle: 4.182 ± 0.128
3.532IleLys: 3.532 ± 0.109
6.109IleLeu: 6.109 ± 0.13
1.755IleMet: 1.755 ± 0.065
3.211IleAsn: 3.211 ± 0.089
2.479IlePro: 2.479 ± 0.073
2.701IleGln: 2.701 ± 0.079
2.276IleArg: 2.276 ± 0.076
3.971IleSer: 3.971 ± 0.116
3.948IleThr: 3.948 ± 0.103
5.051IleVal: 5.051 ± 0.112
0.637IleTrp: 0.637 ± 0.038
2.064IleTyr: 2.064 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
4.839LysAla: 4.839 ± 0.123
0.073LysCys: 0.073 ± 0.014
2.917LysAsp: 2.917 ± 0.112
3.091LysGlu: 3.091 ± 0.116
1.726LysPhe: 1.726 ± 0.066
2.786LysGly: 2.786 ± 0.087
1.236LysHis: 1.236 ± 0.057
3.438LysIle: 3.438 ± 0.095
3.764LysLys: 3.764 ± 0.134
4.897LysLeu: 4.897 ± 0.1
2.011LysMet: 2.011 ± 0.068
2.819LysAsn: 2.819 ± 0.093
2.185LysPro: 2.185 ± 0.062
3.505LysGln: 3.505 ± 0.131
2.73LysArg: 2.73 ± 0.071
3.285LysSer: 3.285 ± 0.178
3.837LysThr: 3.837 ± 0.098
3.808LysVal: 3.808 ± 0.107
0.57LysTrp: 0.57 ± 0.041
2.007LysTyr: 2.007 ± 0.059
0.002LysXaa: 0.002 ± 0.002
Leu
9.173LeuAla: 9.173 ± 0.185
0.252LeuCys: 0.252 ± 0.023
6.086LeuAsp: 6.086 ± 0.122
4.995LeuGlu: 4.995 ± 0.122
3.612LeuPhe: 3.612 ± 0.113
6.578LeuGly: 6.578 ± 0.139
1.715LeuHis: 1.715 ± 0.064
6.293LeuIle: 6.293 ± 0.154
5.245LeuLys: 5.245 ± 0.133
8.251LeuLeu: 8.251 ± 0.208
2.735LeuMet: 2.735 ± 0.098
4.766LeuAsn: 4.766 ± 0.097
4.387LeuPro: 4.387 ± 0.118
4.053LeuGln: 4.053 ± 0.102
3.452LeuArg: 3.452 ± 0.093
6.135LeuSer: 6.135 ± 0.188
6.625LeuThr: 6.625 ± 0.145
7.011LeuVal: 7.011 ± 0.15
0.828LeuTrp: 0.828 ± 0.045
2.463LeuTyr: 2.463 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
2.92MetAla: 2.92 ± 0.09
0.06MetCys: 0.06 ± 0.012
1.704MetAsp: 1.704 ± 0.072
1.26MetGlu: 1.26 ± 0.055
1.067MetPhe: 1.067 ± 0.05
1.962MetGly: 1.962 ± 0.07
0.624MetHis: 0.624 ± 0.041
1.917MetIle: 1.917 ± 0.076
1.376MetLys: 1.376 ± 0.063
2.784MetLeu: 2.784 ± 0.091
1.031MetMet: 1.031 ± 0.053
1.403MetAsn: 1.403 ± 0.053
1.356MetPro: 1.356 ± 0.056
1.664MetGln: 1.664 ± 0.058
1.276MetArg: 1.276 ± 0.055
1.788MetSer: 1.788 ± 0.06
2.185MetThr: 2.185 ± 0.067
2.122MetVal: 2.122 ± 0.085
0.229MetTrp: 0.229 ± 0.023
0.742MetTyr: 0.742 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.96AsnAla: 3.96 ± 0.111
0.091AsnCys: 0.091 ± 0.016
2.877AsnAsp: 2.877 ± 0.069
2.793AsnGlu: 2.793 ± 0.093
1.724AsnPhe: 1.724 ± 0.06
3.574AsnGly: 3.574 ± 0.112
1.125AsnHis: 1.125 ± 0.052
2.704AsnIle: 2.704 ± 0.075
2.405AsnLys: 2.405 ± 0.084
4.046AsnLeu: 4.046 ± 0.107
1.423AsnMet: 1.423 ± 0.06
1.828AsnAsn: 1.828 ± 0.072
2.247AsnPro: 2.247 ± 0.083
2.717AsnGln: 2.717 ± 0.103
1.911AsnArg: 1.911 ± 0.065
1.926AsnSer: 1.926 ± 0.085
2.296AsnThr: 2.296 ± 0.075
3.258AsnVal: 3.258 ± 0.103
0.583AsnTrp: 0.583 ± 0.043
1.724AsnTyr: 1.724 ± 0.066
0.002AsnXaa: 0.002 ± 0.002
Pro
3.294ProAla: 3.294 ± 0.087
0.062ProCys: 0.062 ± 0.011
2.706ProAsp: 2.706 ± 0.079
3.456ProGlu: 3.456 ± 0.123
1.635ProPhe: 1.635 ± 0.064
2.327ProGly: 2.327 ± 0.078
0.664ProHis: 0.664 ± 0.04
2.608ProIle: 2.608 ± 0.08
2.39ProLys: 2.39 ± 0.088
3.122ProLeu: 3.122 ± 0.085
1.007ProMet: 1.007 ± 0.051
1.888ProAsn: 1.888 ± 0.073
0.53ProPro: 0.53 ± 0.035
1.561ProGln: 1.561 ± 0.068
1.229ProArg: 1.229 ± 0.058
1.964ProSer: 1.964 ± 0.067
2.565ProThr: 2.565 ± 0.076
3.102ProVal: 3.102 ± 0.089
0.37ProTrp: 0.37 ± 0.033
1.296ProTyr: 1.296 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
5.343GlnAla: 5.343 ± 0.177
0.091GlnCys: 0.091 ± 0.015
2.496GlnAsp: 2.496 ± 0.1
2.26GlnGlu: 2.26 ± 0.08
1.755GlnPhe: 1.755 ± 0.065
2.655GlnGly: 2.655 ± 0.088
1.069GlnHis: 1.069 ± 0.044
3.024GlnIle: 3.024 ± 0.091
2.913GlnLys: 2.913 ± 0.095
5.017GlnLeu: 5.017 ± 0.125
1.423GlnMet: 1.423 ± 0.066
2.283GlnAsn: 2.283 ± 0.078
2.009GlnPro: 2.009 ± 0.097
2.875GlnGln: 2.875 ± 0.141
2.307GlnArg: 2.307 ± 0.083
2.768GlnSer: 2.768 ± 0.179
3.523GlnThr: 3.523 ± 0.103
3.623GlnVal: 3.623 ± 0.103
0.454GlnTrp: 0.454 ± 0.029
1.615GlnTyr: 1.615 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.951ArgAla: 2.951 ± 0.077
0.08ArgCys: 0.08 ± 0.014
2.499ArgAsp: 2.499 ± 0.092
2.795ArgGlu: 2.795 ± 0.085
1.819ArgPhe: 1.819 ± 0.072
2.456ArgGly: 2.456 ± 0.072
0.964ArgHis: 0.964 ± 0.056
2.579ArgIle: 2.579 ± 0.078
2.174ArgLys: 2.174 ± 0.068
4.046ArgLeu: 4.046 ± 0.101
1.189ArgMet: 1.189 ± 0.047
1.639ArgAsn: 1.639 ± 0.062
1.483ArgPro: 1.483 ± 0.064
2.174ArgGln: 2.174 ± 0.074
2.024ArgArg: 2.024 ± 0.069
2.073ArgSer: 2.073 ± 0.065
2.104ArgThr: 2.104 ± 0.07
3.018ArgVal: 3.018 ± 0.082
0.392ArgTrp: 0.392 ± 0.029
1.579ArgTyr: 1.579 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.066SerAla: 5.066 ± 0.377
0.114SerCys: 0.114 ± 0.018
3.897SerAsp: 3.897 ± 0.142
3.378SerGlu: 3.378 ± 0.166
2.3SerPhe: 2.3 ± 0.074
4.467SerGly: 4.467 ± 0.112
1.147SerHis: 1.147 ± 0.046
3.953SerIle: 3.953 ± 0.176
3.138SerLys: 3.138 ± 0.217
5.144SerLeu: 5.144 ± 0.222
1.432SerMet: 1.432 ± 0.07
2.414SerAsn: 2.414 ± 0.082
1.65SerPro: 1.65 ± 0.062
2.67SerGln: 2.67 ± 0.172
2.127SerArg: 2.127 ± 0.071
3.158SerSer: 3.158 ± 0.16
3.601SerThr: 3.601 ± 0.314
4.363SerVal: 4.363 ± 0.236
0.568SerTrp: 0.568 ± 0.04
1.755SerTyr: 1.755 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
5.015ThrAla: 5.015 ± 0.121
0.136ThrCys: 0.136 ± 0.019
4.32ThrAsp: 4.32 ± 0.095
3.623ThrGlu: 3.623 ± 0.098
2.655ThrPhe: 2.655 ± 0.067
4.666ThrGly: 4.666 ± 0.116
1.327ThrHis: 1.327 ± 0.054
4.358ThrIle: 4.358 ± 0.095
3.32ThrLys: 3.32 ± 0.089
6.169ThrLeu: 6.169 ± 0.127
1.541ThrMet: 1.541 ± 0.057
2.677ThrAsn: 2.677 ± 0.083
3.127ThrPro: 3.127 ± 0.103
2.819ThrGln: 2.819 ± 0.102
2.087ThrArg: 2.087 ± 0.064
3.677ThrSer: 3.677 ± 0.332
4.066ThrThr: 4.066 ± 0.119
4.868ThrVal: 4.868 ± 0.133
0.579ThrTrp: 0.579 ± 0.035
2.076ThrTyr: 2.076 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
6.933ValAla: 6.933 ± 0.157
0.189ValCys: 0.189 ± 0.021
4.966ValAsp: 4.966 ± 0.134
4.187ValGlu: 4.187 ± 0.104
2.779ValPhe: 2.779 ± 0.084
5.189ValGly: 5.189 ± 0.105
1.267ValHis: 1.267 ± 0.056
5.102ValIle: 5.102 ± 0.104
3.964ValLys: 3.964 ± 0.08
6.944ValLeu: 6.944 ± 0.166
2.076ValMet: 2.076 ± 0.079
3.26ValAsn: 3.26 ± 0.099
3.153ValPro: 3.153 ± 0.087
3.118ValGln: 3.118 ± 0.102
2.706ValArg: 2.706 ± 0.082
4.764ValSer: 4.764 ± 0.227
5.296ValThr: 5.296 ± 0.104
6.022ValVal: 6.022 ± 0.134
0.708ValTrp: 0.708 ± 0.047
2.225ValTyr: 2.225 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.722TrpAla: 0.722 ± 0.044
0.042TrpCys: 0.042 ± 0.009
0.472TrpAsp: 0.472 ± 0.035
0.392TrpGlu: 0.392 ± 0.027
0.492TrpPhe: 0.492 ± 0.035
0.601TrpGly: 0.601 ± 0.037
0.35TrpHis: 0.35 ± 0.028
0.717TrpIle: 0.717 ± 0.04
0.343TrpLys: 0.343 ± 0.032
1.298TrpLeu: 1.298 ± 0.067
0.336TrpMet: 0.336 ± 0.028
0.436TrpAsn: 0.436 ± 0.031
0.314TrpPro: 0.314 ± 0.027
0.802TrpGln: 0.802 ± 0.044
0.537TrpArg: 0.537 ± 0.038
0.595TrpSer: 0.595 ± 0.042
0.557TrpThr: 0.557 ± 0.041
0.659TrpVal: 0.659 ± 0.039
0.178TrpTrp: 0.178 ± 0.023
0.318TrpTyr: 0.318 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 0.083
0.102TyrCys: 0.102 ± 0.018
2.198TyrAsp: 2.198 ± 0.066
1.891TyrGlu: 1.891 ± 0.068
1.715TyrPhe: 1.715 ± 0.062
2.307TyrGly: 2.307 ± 0.073
0.817TyrHis: 0.817 ± 0.046
1.909TyrIle: 1.909 ± 0.068
1.481TyrLys: 1.481 ± 0.068
3.505TyrLeu: 3.505 ± 0.103
0.86TyrMet: 0.86 ± 0.046
1.367TyrAsn: 1.367 ± 0.067
1.296TyrPro: 1.296 ± 0.056
1.933TyrGln: 1.933 ± 0.07
1.739TyrArg: 1.739 ± 0.063
1.615TyrSer: 1.615 ± 0.062
1.915TyrThr: 1.915 ± 0.074
2.343TyrVal: 2.343 ± 0.077
0.381TyrTrp: 0.381 ± 0.032
1.307TyrTyr: 1.307 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.002XaaHis: 0.002 ± 0.002
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.47XaaXaa: 0.47 ± 0.306
Statistics based on 1462 proteins (449040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski