Amino acid dipepetide frequency for Desulfuromonas sp. DDH964

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.006AlaAla: 15.006 ± 0.205	1.336AlaCys: 1.336 ± 0.043	5.49AlaAsp: 5.49 ± 0.067	7.374AlaGlu: 7.374 ± 0.098	3.746AlaPhe: 3.746 ± 0.055	10.411AlaGly: 10.411 ± 0.121	1.7AlaHis: 1.7 ± 0.042	5.443AlaIle: 5.443 ± 0.078	3.363AlaLys: 3.363 ± 0.063	12.473AlaLeu: 12.473 ± 0.134	2.441AlaMet: 2.441 ± 0.054	2.614AlaAsn: 2.614 ± 0.061	4.87AlaPro: 4.87 ± 0.09	3.157AlaGln: 3.157 ± 0.054	7.616AlaArg: 7.616 ± 0.108	5.019AlaSer: 5.019 ± 0.069	5.827AlaThr: 5.827 ± 0.102	7.6AlaVal: 7.6 ± 0.095	1.262AlaTrp: 1.262 ± 0.038	2.241AlaTyr: 2.241 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.118CysAla: 1.118 ± 0.039	0.238CysCys: 0.238 ± 0.016	0.622CysAsp: 0.622 ± 0.023	0.554CysGlu: 0.554 ± 0.02	0.465CysPhe: 0.465 ± 0.018	1.366CysGly: 1.366 ± 0.038	0.656CysHis: 0.656 ± 0.077	0.478CysIle: 0.478 ± 0.02	0.318CysLys: 0.318 ± 0.018	1.084CysLeu: 1.084 ± 0.031	0.178CysMet: 0.178 ± 0.013	0.37CysAsn: 0.37 ± 0.02	0.786CysPro: 0.786 ± 0.032	0.45CysGln: 0.45 ± 0.018	1.103CysArg: 1.103 ± 0.031	0.747CysSer: 0.747 ± 0.031	0.492CysThr: 0.492 ± 0.021	0.585CysVal: 0.585 ± 0.023	0.141CysTrp: 0.141 ± 0.011	0.326CysTyr: 0.326 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.762AspAla: 4.762 ± 0.068	0.693AspCys: 0.693 ± 0.031	2.448AspAsp: 2.448 ± 0.043	2.999AspGlu: 2.999 ± 0.058	2.441AspPhe: 2.441 ± 0.041	4.331AspGly: 4.331 ± 0.072	1.167AspHis: 1.167 ± 0.033	2.671AspIle: 2.671 ± 0.05	1.634AspLys: 1.634 ± 0.048	6.866AspLeu: 6.866 ± 0.077	0.85AspMet: 0.85 ± 0.029	1.3AspAsn: 1.3 ± 0.039	3.298AspPro: 3.298 ± 0.06	1.97AspGln: 1.97 ± 0.045	3.804AspArg: 3.804 ± 0.062	2.461AspSer: 2.461 ± 0.05	1.9AspThr: 1.9 ± 0.049	2.901AspVal: 2.901 ± 0.053	0.73AspTrp: 0.73 ± 0.028	1.774AspTyr: 1.774 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.557GluAla: 6.557 ± 0.083	0.522GluCys: 0.522 ± 0.022	2.542GluAsp: 2.542 ± 0.05	5.079GluGlu: 5.079 ± 0.085	2.306GluPhe: 2.306 ± 0.049	4.523GluGly: 4.523 ± 0.078	1.128GluHis: 1.128 ± 0.028	4.078GluIle: 4.078 ± 0.077	3.33GluLys: 3.33 ± 0.07	7.782GluLeu: 7.782 ± 0.112	1.544GluMet: 1.544 ± 0.039	1.858GluAsn: 1.858 ± 0.043	2.371GluPro: 2.371 ± 0.056	2.717GluGln: 2.717 ± 0.049	5.026GluArg: 5.026 ± 0.076	2.817GluSer: 2.817 ± 0.048	3.337GluThr: 3.337 ± 0.059	4.934GluVal: 4.934 ± 0.074	0.567GluTrp: 0.567 ± 0.025	1.237GluTyr: 1.237 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.262PheAla: 4.262 ± 0.072	0.561PheCys: 0.561 ± 0.021	2.456PheAsp: 2.456 ± 0.051	2.074PheGlu: 2.074 ± 0.043	1.896PhePhe: 1.896 ± 0.045	3.505PheGly: 3.505 ± 0.063	0.794PheHis: 0.794 ± 0.028	1.852PheIle: 1.852 ± 0.04	1.216PheLys: 1.216 ± 0.035	4.456PheLeu: 4.456 ± 0.078	0.708PheMet: 0.708 ± 0.029	1.245PheAsn: 1.245 ± 0.035	1.865PhePro: 1.865 ± 0.048	1.165PheGln: 1.165 ± 0.037	2.572PheArg: 2.572 ± 0.055	2.71PheSer: 2.71 ± 0.055	2.093PheThr: 2.093 ± 0.041	2.611PheVal: 2.611 ± 0.051	0.536PheTrp: 0.536 ± 0.022	1.078PheTyr: 1.078 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.893GlyAla: 7.893 ± 0.103	1.311GlyCys: 1.311 ± 0.043	4.121GlyAsp: 4.121 ± 0.061	5.752GlyGlu: 5.752 ± 0.081	3.213GlyPhe: 3.213 ± 0.06	6.955GlyGly: 6.955 ± 0.09	1.798GlyHis: 1.798 ± 0.046	4.804GlyIle: 4.804 ± 0.064	3.812GlyLys: 3.812 ± 0.07	9.254GlyLeu: 9.254 ± 0.102	2.18GlyMet: 2.18 ± 0.052	2.443GlyAsn: 2.443 ± 0.051	2.904GlyPro: 2.904 ± 0.055	2.893GlyGln: 2.893 ± 0.056	5.981GlyArg: 5.981 ± 0.077	4.703GlySer: 4.703 ± 0.075	4.424GlyThr: 4.424 ± 0.093	6.004GlyVal: 6.004 ± 0.08	1.095GlyTrp: 1.095 ± 0.035	2.556GlyTyr: 2.556 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.671HisAla: 1.671 ± 0.037	0.334HisCys: 0.334 ± 0.016	1.085HisAsp: 1.085 ± 0.035	0.981HisGlu: 0.981 ± 0.033	1.007HisPhe: 1.007 ± 0.029	1.759HisGly: 1.759 ± 0.045	0.587HisHis: 0.587 ± 0.025	0.9HisIle: 0.9 ± 0.029	0.553HisLys: 0.553 ± 0.023	2.464HisLeu: 2.464 ± 0.049	0.379HisMet: 0.379 ± 0.017	0.592HisAsn: 0.592 ± 0.032	1.521HisPro: 1.521 ± 0.037	0.861HisGln: 0.861 ± 0.027	1.473HisArg: 1.473 ± 0.036	1.08HisSer: 1.08 ± 0.035	0.796HisThr: 0.796 ± 0.024	0.994HisVal: 0.994 ± 0.032	0.267HisTrp: 0.267 ± 0.015	0.638HisTyr: 0.638 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.586IleAla: 5.586 ± 0.072	0.605IleCys: 0.605 ± 0.023	3.397IleAsp: 3.397 ± 0.051	3.459IleGlu: 3.459 ± 0.061	2.219IlePhe: 2.219 ± 0.048	4.428IleGly: 4.428 ± 0.063	1.096IleHis: 1.096 ± 0.035	2.404IleIle: 2.404 ± 0.06	1.691IleLys: 1.691 ± 0.043	5.715IleLeu: 5.715 ± 0.077	0.866IleMet: 0.866 ± 0.029	1.599IleAsn: 1.599 ± 0.04	2.758IlePro: 2.758 ± 0.053	1.429IleGln: 1.429 ± 0.04	3.306IleArg: 3.306 ± 0.054	2.811IleSer: 2.811 ± 0.049	2.485IleThr: 2.485 ± 0.051	3.453IleVal: 3.453 ± 0.06	0.442IleTrp: 0.442 ± 0.019	1.322IleTyr: 1.322 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.559LysAla: 3.559 ± 0.059	0.322LysCys: 0.322 ± 0.019	1.756LysAsp: 1.756 ± 0.055	2.68LysGlu: 2.68 ± 0.053	1.1LysPhe: 1.1 ± 0.034	2.978LysGly: 2.978 ± 0.055	0.582LysHis: 0.582 ± 0.024	2.159LysIle: 2.159 ± 0.05	1.966LysLys: 1.966 ± 0.056	3.521LysLeu: 3.521 ± 0.059	0.869LysMet: 0.869 ± 0.03	1.21LysAsn: 1.21 ± 0.038	1.677LysPro: 1.677 ± 0.043	1.292LysGln: 1.292 ± 0.036	2.278LysArg: 2.278 ± 0.055	1.947LysSer: 1.947 ± 0.052	1.87LysThr: 1.87 ± 0.046	3.004LysVal: 3.004 ± 0.061	0.296LysTrp: 0.296 ± 0.019	0.863LysTyr: 0.863 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	15.071LeuAla: 15.071 ± 0.174	1.319LeuCys: 1.319 ± 0.033	6.205LeuAsp: 6.205 ± 0.081	7.174LeuGlu: 7.174 ± 0.096	4.708LeuPhe: 4.708 ± 0.08	9.169LeuGly: 9.169 ± 0.099	2.219LeuHis: 2.219 ± 0.042	5.13LeuIle: 5.13 ± 0.074	4.249LeuLys: 4.249 ± 0.069	15.121LeuLeu: 15.121 ± 0.19	1.93LeuMet: 1.93 ± 0.043	2.796LeuAsn: 2.796 ± 0.06	6.552LeuPro: 6.552 ± 0.094	4.553LeuGln: 4.553 ± 0.067	8.017LeuArg: 8.017 ± 0.1	5.823LeuSer: 5.823 ± 0.076	5.962LeuThr: 5.962 ± 0.074	8.765LeuVal: 8.765 ± 0.107	1.115LeuTrp: 1.115 ± 0.035	2.562LeuTyr: 2.562 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.448MetAla: 2.448 ± 0.045	0.141MetCys: 0.141 ± 0.012	0.937MetAsp: 0.937 ± 0.031	1.296MetGlu: 1.296 ± 0.035	0.552MetPhe: 0.552 ± 0.021	1.5MetGly: 1.5 ± 0.041	0.32MetHis: 0.32 ± 0.017	1.085MetIle: 1.085 ± 0.036	1.111MetLys: 1.111 ± 0.03	2.024MetLeu: 2.024 ± 0.039	0.448MetMet: 0.448 ± 0.021	0.736MetAsn: 0.736 ± 0.026	1.086MetPro: 1.086 ± 0.032	0.742MetGln: 0.742 ± 0.026	1.17MetArg: 1.17 ± 0.028	1.115MetSer: 1.115 ± 0.034	1.457MetThr: 1.457 ± 0.037	1.603MetVal: 1.603 ± 0.039	0.114MetTrp: 0.114 ± 0.01	0.332MetTyr: 0.332 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.502AsnAla: 2.502 ± 0.057	0.397AsnCys: 0.397 ± 0.02	1.336AsnAsp: 1.336 ± 0.039	1.259AsnGlu: 1.259 ± 0.031	1.164AsnPhe: 1.164 ± 0.034	2.146AsnGly: 2.146 ± 0.053	0.625AsnHis: 0.625 ± 0.026	1.585AsnIle: 1.585 ± 0.04	0.841AsnLys: 0.841 ± 0.029	3.648AsnLeu: 3.648 ± 0.058	0.547AsnMet: 0.547 ± 0.02	0.828AsnAsn: 0.828 ± 0.042	1.968AsnPro: 1.968 ± 0.047	1.025AsnGln: 1.025 ± 0.031	2.166AsnArg: 2.166 ± 0.043	1.383AsnSer: 1.383 ± 0.039	1.188AsnThr: 1.188 ± 0.044	1.652AsnVal: 1.652 ± 0.044	0.402AsnTrp: 0.402 ± 0.022	0.889AsnTyr: 0.889 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.191ProAla: 6.191 ± 0.104	0.467ProCys: 0.467 ± 0.021	2.763ProAsp: 2.763 ± 0.058	4.015ProGlu: 4.015 ± 0.059	2.043ProPhe: 2.043 ± 0.047	4.966ProGly: 4.966 ± 0.075	0.917ProHis: 0.917 ± 0.032	1.97ProIle: 1.97 ± 0.045	1.384ProLys: 1.384 ± 0.036	5.908ProLeu: 5.908 ± 0.097	0.878ProMet: 0.878 ± 0.026	1.121ProAsn: 1.121 ± 0.036	2.795ProPro: 2.795 ± 0.072	1.922ProGln: 1.922 ± 0.05	2.904ProArg: 2.904 ± 0.057	2.102ProSer: 2.102 ± 0.042	2.257ProThr: 2.257 ± 0.05	4.152ProVal: 4.152 ± 0.06	0.65ProTrp: 0.65 ± 0.026	1.127ProTyr: 1.127 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.121GlnAla: 4.121 ± 0.067	0.28GlnCys: 0.28 ± 0.017	1.465GlnAsp: 1.465 ± 0.039	2.498GlnGlu: 2.498 ± 0.054	1.169GlnPhe: 1.169 ± 0.031	2.946GlnGly: 2.946 ± 0.054	0.642GlnHis: 0.642 ± 0.024	1.847GlnIle: 1.847 ± 0.041	1.423GlnLys: 1.423 ± 0.035	4.43GlnLeu: 4.43 ± 0.072	0.767GlnMet: 0.767 ± 0.029	0.898GlnAsn: 0.898 ± 0.028	1.687GlnPro: 1.687 ± 0.041	1.967GlnGln: 1.967 ± 0.057	2.907GlnArg: 2.907 ± 0.055	1.575GlnSer: 1.575 ± 0.037	1.696GlnThr: 1.696 ± 0.038	3.204GlnVal: 3.204 ± 0.057	0.366GlnTrp: 0.366 ± 0.018	0.642GlnTyr: 0.642 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	5.822ArgAla: 5.822 ± 0.081	0.799ArgCys: 0.799 ± 0.03	3.589ArgAsp: 3.589 ± 0.059	5.427ArgGlu: 5.427 ± 0.079	3.061ArgPhe: 3.061 ± 0.053	4.708ArgGly: 4.708 ± 0.062	1.64ArgHis: 1.64 ± 0.044	4.016ArgIle: 4.016 ± 0.063	2.664ArgLys: 2.664 ± 0.063	8.76ArgLeu: 8.76 ± 0.103	1.538ArgMet: 1.538 ± 0.037	1.986ArgAsn: 1.986 ± 0.047	3.27ArgPro: 3.27 ± 0.065	3.608ArgGln: 3.608 ± 0.069	5.724ArgArg: 5.724 ± 0.085	3.719ArgSer: 3.719 ± 0.061	2.954ArgThr: 2.954 ± 0.047	4.706ArgVal: 4.706 ± 0.071	0.887ArgTrp: 0.887 ± 0.029	2.034ArgTyr: 2.034 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.252SerAla: 5.252 ± 0.076	0.774SerCys: 0.774 ± 0.036	2.606SerAsp: 2.606 ± 0.052	2.737SerGlu: 2.737 ± 0.058	2.284SerPhe: 2.284 ± 0.045	5.341SerGly: 5.341 ± 0.083	1.077SerHis: 1.077 ± 0.031	2.48SerIle: 2.48 ± 0.051	1.508SerLys: 1.508 ± 0.047	5.953SerLeu: 5.953 ± 0.077	1.083SerMet: 1.083 ± 0.032	1.441SerAsn: 1.441 ± 0.039	2.691SerPro: 2.691 ± 0.047	1.649SerGln: 1.649 ± 0.034	3.708SerArg: 3.708 ± 0.055	2.888SerSer: 2.888 ± 0.064	2.347SerThr: 2.347 ± 0.059	3.188SerVal: 3.188 ± 0.062	0.737SerTrp: 0.737 ± 0.027	1.468SerTyr: 1.468 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.449ThrAla: 5.449 ± 0.098	0.603ThrCys: 0.603 ± 0.033	2.354ThrAsp: 2.354 ± 0.054	2.472ThrGlu: 2.472 ± 0.054	2.011ThrPhe: 2.011 ± 0.047	4.813ThrGly: 4.813 ± 0.073	0.826ThrHis: 0.826 ± 0.028	2.792ThrIle: 2.792 ± 0.048	1.227ThrLys: 1.227 ± 0.039	6.563ThrLeu: 6.563 ± 0.094	0.924ThrMet: 0.924 ± 0.026	1.225ThrAsn: 1.225 ± 0.041	3.158ThrPro: 3.158 ± 0.062	1.129ThrGln: 1.129 ± 0.03	3.076ThrArg: 3.076 ± 0.055	2.626ThrSer: 2.626 ± 0.061	2.872ThrThr: 2.872 ± 0.077	4.032ThrVal: 4.032 ± 0.076	0.517ThrTrp: 0.517 ± 0.021	1.217ThrTyr: 1.217 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	8.558ValAla: 8.558 ± 0.106	0.863ValCys: 0.863 ± 0.026	3.984ValAsp: 3.984 ± 0.059	4.719ValGlu: 4.719 ± 0.075	2.61ValPhe: 2.61 ± 0.048	5.374ValGly: 5.374 ± 0.075	1.283ValHis: 1.283 ± 0.035	3.907ValIle: 3.907 ± 0.071	2.524ValLys: 2.524 ± 0.052	7.565ValLeu: 7.565 ± 0.09	1.486ValMet: 1.486 ± 0.042	2.206ValAsn: 2.206 ± 0.051	3.373ValPro: 3.373 ± 0.057	2.122ValGln: 2.122 ± 0.046	4.781ValArg: 4.781 ± 0.066	3.677ValSer: 3.677 ± 0.068	4.244ValThr: 4.244 ± 0.071	5.834ValVal: 5.834 ± 0.093	0.679ValTrp: 0.679 ± 0.025	1.602ValTyr: 1.602 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.029	0.137TrpCys: 0.137 ± 0.013	0.549TrpAsp: 0.549 ± 0.022	0.647TrpGlu: 0.647 ± 0.026	0.482TrpPhe: 0.482 ± 0.021	0.826TrpGly: 0.826 ± 0.028	0.263TrpHis: 0.263 ± 0.015	0.493TrpIle: 0.493 ± 0.023	0.398TrpLys: 0.398 ± 0.02	1.508TrpLeu: 1.508 ± 0.043	0.224TrpMet: 0.224 ± 0.014	0.348TrpAsn: 0.348 ± 0.02	0.566TrpPro: 0.566 ± 0.025	0.671TrpGln: 0.671 ± 0.026	0.942TrpArg: 0.942 ± 0.029	0.67TrpSer: 0.67 ± 0.028	0.522TrpThr: 0.522 ± 0.024	0.714TrpVal: 0.714 ± 0.025	0.191TrpTrp: 0.191 ± 0.012	0.31TrpTyr: 0.31 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.276TyrAla: 2.276 ± 0.048	0.375TyrCys: 0.375 ± 0.017	1.3TyrAsp: 1.3 ± 0.035	1.059TyrGlu: 1.059 ± 0.027	1.174TyrPhe: 1.174 ± 0.033	2.052TyrGly: 2.052 ± 0.043	0.623TyrHis: 0.623 ± 0.023	0.976TyrIle: 0.976 ± 0.028	0.713TyrLys: 0.713 ± 0.029	3.344TyrLeu: 3.344 ± 0.055	0.377TyrMet: 0.377 ± 0.016	0.735TyrAsn: 0.735 ± 0.027	1.34TyrPro: 1.34 ± 0.031	1.208TyrGln: 1.208 ± 0.032	2.36TyrArg: 2.36 ± 0.05	1.337TyrSer: 1.337 ± 0.041	1.161TyrThr: 1.161 ± 0.039	1.453TyrVal: 1.453 ± 0.037	0.352TyrTrp: 0.352 ± 0.018	0.751TyrTyr: 0.751 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3483 proteins (1134986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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