Amino acid dipepetide frequency for Inquilinus limosus MP06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.599AlaAla: 20.599 ± 0.166
1.05AlaCys: 1.05 ± 0.022
7.405AlaAsp: 7.405 ± 0.069
8.401AlaGlu: 8.401 ± 0.1
4.534AlaPhe: 4.534 ± 0.055
12.773AlaGly: 12.773 ± 0.104
2.134AlaHis: 2.134 ± 0.037
6.32AlaIle: 6.32 ± 0.059
3.431AlaLys: 3.431 ± 0.054
14.76AlaLeu: 14.76 ± 0.108
3.572AlaMet: 3.572 ± 0.044
2.318AlaAsn: 2.318 ± 0.039
5.955AlaPro: 5.955 ± 0.071
3.931AlaGln: 3.931 ± 0.054
9.301AlaArg: 9.301 ± 0.089
5.354AlaSer: 5.354 ± 0.067
6.11AlaThr: 6.11 ± 0.065
10.487AlaVal: 10.487 ± 0.079
1.852AlaTrp: 1.852 ± 0.036
2.721AlaTyr: 2.721 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.91CysAla: 0.91 ± 0.022
0.096CysCys: 0.096 ± 0.007
0.522CysAsp: 0.522 ± 0.017
0.356CysGlu: 0.356 ± 0.012
0.28CysPhe: 0.28 ± 0.014
0.982CysGly: 0.982 ± 0.025
0.244CysHis: 0.244 ± 0.014
0.359CysIle: 0.359 ± 0.016
0.117CysLys: 0.117 ± 0.008
0.792CysLeu: 0.792 ± 0.02
0.138CysMet: 0.138 ± 0.01
0.171CysAsn: 0.171 ± 0.01
0.42CysPro: 0.42 ± 0.016
0.212CysGln: 0.212 ± 0.01
0.73CysArg: 0.73 ± 0.024
0.398CysSer: 0.398 ± 0.015
0.379CysThr: 0.379 ± 0.014
0.544CysVal: 0.544 ± 0.019
0.117CysTrp: 0.117 ± 0.009
0.192CysTyr: 0.192 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.087AspAla: 7.087 ± 0.069
0.461AspCys: 0.461 ± 0.017
3.09AspAsp: 3.09 ± 0.048
3.003AspGlu: 3.003 ± 0.042
2.064AspPhe: 2.064 ± 0.04
5.976AspGly: 5.976 ± 0.069
1.284AspHis: 1.284 ± 0.027
2.735AspIle: 2.735 ± 0.039
1.339AspLys: 1.339 ± 0.038
6.362AspLeu: 6.362 ± 0.067
1.058AspMet: 1.058 ± 0.024
1.07AspAsn: 1.07 ± 0.028
4.439AspPro: 4.439 ± 0.055
1.748AspGln: 1.748 ± 0.036
5.349AspArg: 5.349 ± 0.058
2.214AspSer: 2.214 ± 0.042
2.67AspThr: 2.67 ± 0.054
3.926AspVal: 3.926 ± 0.057
1.077AspTrp: 1.077 ± 0.027
1.448AspTyr: 1.448 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
8.131GluAla: 8.131 ± 0.081
0.268GluCys: 0.268 ± 0.012
2.555GluAsp: 2.555 ± 0.047
2.864GluGlu: 2.864 ± 0.043
1.627GluPhe: 1.627 ± 0.029
4.231GluGly: 4.231 ± 0.052
1.056GluHis: 1.056 ± 0.024
3.248GluIle: 3.248 ± 0.049
1.499GluLys: 1.499 ± 0.034
5.097GluLeu: 5.097 ± 0.056
1.279GluMet: 1.279 ± 0.03
1.132GluAsn: 1.132 ± 0.026
2.758GluPro: 2.758 ± 0.041
1.844GluGln: 1.844 ± 0.033
4.535GluArg: 4.535 ± 0.054
2.075GluSer: 2.075 ± 0.035
3.218GluThr: 3.218 ± 0.04
3.718GluVal: 3.718 ± 0.049
0.679GluTrp: 0.679 ± 0.02
0.868GluTyr: 0.868 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.599PheAla: 4.599 ± 0.055
0.357PheCys: 0.357 ± 0.012
2.599PheAsp: 2.599 ± 0.046
1.827PheGlu: 1.827 ± 0.033
1.26PhePhe: 1.26 ± 0.03
3.779PheGly: 3.779 ± 0.054
0.773PheHis: 0.773 ± 0.02
1.534PheIle: 1.534 ± 0.033
0.778PheLys: 0.778 ± 0.023
3.441PheLeu: 3.441 ± 0.049
0.641PheMet: 0.641 ± 0.016
0.909PheAsn: 0.909 ± 0.026
1.725PhePro: 1.725 ± 0.033
1.052PheGln: 1.052 ± 0.028
2.422PheArg: 2.422 ± 0.036
1.787PheSer: 1.787 ± 0.029
2.035PheThr: 2.035 ± 0.031
2.757PheVal: 2.757 ± 0.039
0.585PheTrp: 0.585 ± 0.018
0.856PheTyr: 0.856 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.132GlyAla: 10.132 ± 0.088
0.921GlyCys: 0.921 ± 0.026
4.859GlyAsp: 4.859 ± 0.083
4.452GlyGlu: 4.452 ± 0.059
3.858GlyPhe: 3.858 ± 0.049
8.335GlyGly: 8.335 ± 0.107
1.958GlyHis: 1.958 ± 0.034
4.778GlyIle: 4.778 ± 0.052
2.701GlyLys: 2.701 ± 0.047
10.312GlyLeu: 10.312 ± 0.083
2.407GlyMet: 2.407 ± 0.038
2.075GlyAsn: 2.075 ± 0.047
4.276GlyPro: 4.276 ± 0.047
2.977GlyGln: 2.977 ± 0.043
7.622GlyArg: 7.622 ± 0.075
4.473GlySer: 4.473 ± 0.06
5.215GlyThr: 5.215 ± 0.059
6.666GlyVal: 6.666 ± 0.062
1.71GlyTrp: 1.71 ± 0.034
2.349GlyTyr: 2.349 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.256HisAla: 2.256 ± 0.037
0.219HisCys: 0.219 ± 0.012
1.252HisAsp: 1.252 ± 0.029
0.904HisGlu: 0.904 ± 0.022
0.748HisPhe: 0.748 ± 0.019
2.048HisGly: 2.048 ± 0.041
0.556HisHis: 0.556 ± 0.024
0.814HisIle: 0.814 ± 0.023
0.391HisLys: 0.391 ± 0.016
2.131HisLeu: 2.131 ± 0.038
0.424HisMet: 0.424 ± 0.015
0.399HisAsn: 0.399 ± 0.015
1.49HisPro: 1.49 ± 0.031
0.529HisGln: 0.529 ± 0.02
1.656HisArg: 1.656 ± 0.032
0.838HisSer: 0.838 ± 0.024
0.716HisThr: 0.716 ± 0.021
1.441HisVal: 1.441 ± 0.031
0.36HisTrp: 0.36 ± 0.015
0.489HisTyr: 0.489 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.217IleAla: 7.217 ± 0.074
0.432IleCys: 0.432 ± 0.016
3.641IleAsp: 3.641 ± 0.045
2.98IleGlu: 2.98 ± 0.045
1.466IlePhe: 1.466 ± 0.03
5.282IleGly: 5.282 ± 0.058
0.901IleHis: 0.901 ± 0.022
1.808IleIle: 1.808 ± 0.038
1.076IleLys: 1.076 ± 0.032
4.609IleLeu: 4.609 ± 0.062
0.787IleMet: 0.787 ± 0.022
1.083IleAsn: 1.083 ± 0.025
2.395IlePro: 2.395 ± 0.038
1.173IleGln: 1.173 ± 0.026
3.633IleArg: 3.633 ± 0.047
2.242IleSer: 2.242 ± 0.038
2.445IleThr: 2.445 ± 0.039
3.969IleVal: 3.969 ± 0.045
0.619IleTrp: 0.619 ± 0.02
1.047IleTyr: 1.047 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
3.773LysAla: 3.773 ± 0.062
0.099LysCys: 0.099 ± 0.007
1.391LysAsp: 1.391 ± 0.033
1.095LysGlu: 1.095 ± 0.03
0.646LysPhe: 0.646 ± 0.022
2.166LysGly: 2.166 ± 0.04
0.438LysHis: 0.438 ± 0.016
1.289LysIle: 1.289 ± 0.029
0.724LysLys: 0.724 ± 0.028
2.659LysLeu: 2.659 ± 0.051
0.535LysMet: 0.535 ± 0.018
0.511LysAsn: 0.511 ± 0.019
1.776LysPro: 1.776 ± 0.037
0.864LysGln: 0.864 ± 0.025
1.857LysArg: 1.857 ± 0.034
1.256LysSer: 1.256 ± 0.03
1.539LysThr: 1.539 ± 0.03
2.077LysVal: 2.077 ± 0.038
0.297LysTrp: 0.297 ± 0.014
0.481LysTyr: 0.481 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.379LeuAla: 15.379 ± 0.119
0.902LeuCys: 0.902 ± 0.023
6.655LeuAsp: 6.655 ± 0.058
4.807LeuGlu: 4.807 ± 0.047
3.628LeuPhe: 3.628 ± 0.049
9.44LeuGly: 9.44 ± 0.08
1.932LeuHis: 1.932 ± 0.034
4.603LeuIle: 4.603 ± 0.064
2.972LeuLys: 2.972 ± 0.044
10.718LeuLeu: 10.718 ± 0.114
2.213LeuMet: 2.213 ± 0.039
2.272LeuAsn: 2.272 ± 0.038
6.297LeuPro: 6.297 ± 0.057
3.113LeuGln: 3.113 ± 0.043
7.701LeuArg: 7.701 ± 0.078
6.001LeuSer: 6.001 ± 0.062
5.661LeuThr: 5.661 ± 0.064
8.302LeuVal: 8.302 ± 0.081
1.304LeuTrp: 1.304 ± 0.028
2.193LeuTyr: 2.193 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.184MetAla: 3.184 ± 0.044
0.136MetCys: 0.136 ± 0.009
1.009MetAsp: 1.009 ± 0.022
0.925MetGlu: 0.925 ± 0.021
0.603MetPhe: 0.603 ± 0.02
1.651MetGly: 1.651 ± 0.03
0.363MetHis: 0.363 ± 0.016
1.167MetIle: 1.167 ± 0.028
0.723MetLys: 0.723 ± 0.021
2.39MetLeu: 2.39 ± 0.034
0.567MetMet: 0.567 ± 0.018
0.543MetAsn: 0.543 ± 0.017
1.456MetPro: 1.456 ± 0.027
0.727MetGln: 0.727 ± 0.019
1.722MetArg: 1.722 ± 0.036
1.306MetSer: 1.306 ± 0.027
1.809MetThr: 1.809 ± 0.034
1.783MetVal: 1.783 ± 0.037
0.188MetTrp: 0.188 ± 0.01
0.334MetTyr: 0.334 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.555AsnAla: 2.555 ± 0.042
0.203AsnCys: 0.203 ± 0.011
1.194AsnAsp: 1.194 ± 0.043
0.87AsnGlu: 0.87 ± 0.023
0.816AsnPhe: 0.816 ± 0.023
2.058AsnGly: 2.058 ± 0.04
0.443AsnHis: 0.443 ± 0.016
1.09AsnIle: 1.09 ± 0.024
0.47AsnLys: 0.47 ± 0.017
2.261AsnLeu: 2.261 ± 0.037
0.444AsnMet: 0.444 ± 0.015
0.533AsnAsn: 0.533 ± 0.021
1.719AsnPro: 1.719 ± 0.033
0.659AsnGln: 0.659 ± 0.022
1.53AsnArg: 1.53 ± 0.031
0.965AsnSer: 0.965 ± 0.027
1.077AsnThr: 1.077 ± 0.028
1.578AsnVal: 1.578 ± 0.034
0.362AsnTrp: 0.362 ± 0.014
0.572AsnTyr: 0.572 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.546ProAla: 7.546 ± 0.08
0.331ProCys: 0.331 ± 0.015
4.178ProAsp: 4.178 ± 0.05
4.047ProGlu: 4.047 ± 0.058
2.015ProPhe: 2.015 ± 0.031
5.537ProGly: 5.537 ± 0.061
1.094ProHis: 1.094 ± 0.027
2.321ProIle: 2.321 ± 0.035
1.574ProLys: 1.574 ± 0.032
5.204ProLeu: 5.204 ± 0.052
1.268ProMet: 1.268 ± 0.03
1.276ProAsn: 1.276 ± 0.03
3.021ProPro: 3.021 ± 0.051
1.693ProGln: 1.693 ± 0.034
3.256ProArg: 3.256 ± 0.046
2.667ProSer: 2.667 ± 0.042
2.57ProThr: 2.57 ± 0.039
4.791ProVal: 4.791 ± 0.055
0.837ProTrp: 0.837 ± 0.021
1.344ProTyr: 1.344 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.628GlnAla: 4.628 ± 0.058
0.172GlnCys: 0.172 ± 0.01
1.566GlnAsp: 1.566 ± 0.031
1.397GlnGlu: 1.397 ± 0.032
0.951GlnPhe: 0.951 ± 0.027
2.641GlnGly: 2.641 ± 0.044
0.578GlnHis: 0.578 ± 0.017
1.686GlnIle: 1.686 ± 0.031
0.849GlnLys: 0.849 ± 0.029
2.78GlnLeu: 2.78 ± 0.037
0.747GlnMet: 0.747 ± 0.019
0.638GlnAsn: 0.638 ± 0.02
1.837GlnPro: 1.837 ± 0.032
1.254GlnGln: 1.254 ± 0.032
2.527GlnArg: 2.527 ± 0.036
1.455GlnSer: 1.455 ± 0.031
1.436GlnThr: 1.436 ± 0.031
2.305GlnVal: 2.305 ± 0.041
0.394GlnTrp: 0.394 ± 0.016
0.634GlnTyr: 0.634 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.441ArgAla: 8.441 ± 0.075
0.615ArgCys: 0.615 ± 0.02
4.527ArgAsp: 4.527 ± 0.054
3.816ArgGlu: 3.816 ± 0.048
3.124ArgPhe: 3.124 ± 0.042
5.525ArgGly: 5.525 ± 0.061
1.907ArgHis: 1.907 ± 0.036
4.49ArgIle: 4.49 ± 0.047
1.778ArgLys: 1.778 ± 0.034
8.953ArgLeu: 8.953 ± 0.089
1.816ArgMet: 1.816 ± 0.034
1.586ArgAsn: 1.586 ± 0.027
4.401ArgPro: 4.401 ± 0.055
2.648ArgGln: 2.648 ± 0.039
7.086ArgArg: 7.086 ± 0.074
3.648ArgSer: 3.648 ± 0.048
3.437ArgThr: 3.437 ± 0.044
5.082ArgVal: 5.082 ± 0.064
1.243ArgTrp: 1.243 ± 0.028
1.753ArgTyr: 1.753 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.471SerAla: 5.471 ± 0.059
0.379SerCys: 0.379 ± 0.015
2.41SerAsp: 2.41 ± 0.043
1.946SerGlu: 1.946 ± 0.035
2.101SerPhe: 2.101 ± 0.037
5.172SerGly: 5.172 ± 0.061
0.914SerHis: 0.914 ± 0.022
2.453SerIle: 2.453 ± 0.041
1.102SerLys: 1.102 ± 0.026
5.105SerLeu: 5.105 ± 0.055
1.108SerMet: 1.108 ± 0.029
1.054SerAsn: 1.054 ± 0.024
2.779SerPro: 2.779 ± 0.043
1.349SerGln: 1.349 ± 0.032
3.351SerArg: 3.351 ± 0.046
2.233SerSer: 2.233 ± 0.039
2.397SerThr: 2.397 ± 0.036
3.673SerVal: 3.673 ± 0.046
0.872SerTrp: 0.872 ± 0.025
1.206SerTyr: 1.206 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
6.724ThrAla: 6.724 ± 0.071
0.377ThrCys: 0.377 ± 0.015
2.775ThrAsp: 2.775 ± 0.04
2.539ThrGlu: 2.539 ± 0.036
1.783ThrPhe: 1.783 ± 0.032
5.246ThrGly: 5.246 ± 0.066
0.943ThrHis: 0.943 ± 0.024
2.693ThrIle: 2.693 ± 0.047
1.123ThrLys: 1.123 ± 0.027
6.146ThrLeu: 6.146 ± 0.065
1.076ThrMet: 1.076 ± 0.026
1.048ThrAsn: 1.048 ± 0.028
3.342ThrPro: 3.342 ± 0.047
1.277ThrGln: 1.277 ± 0.029
3.366ThrArg: 3.366 ± 0.046
2.324ThrSer: 2.324 ± 0.038
2.638ThrThr: 2.638 ± 0.047
4.88ThrVal: 4.88 ± 0.049
0.687ThrTrp: 0.687 ± 0.022
1.176ThrTyr: 1.176 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
10.199ValAla: 10.199 ± 0.076
0.609ValCys: 0.609 ± 0.02
4.453ValAsp: 4.453 ± 0.055
4.738ValGlu: 4.738 ± 0.055
2.853ValPhe: 2.853 ± 0.044
5.936ValGly: 5.936 ± 0.056
1.331ValHis: 1.331 ± 0.03
3.854ValIle: 3.854 ± 0.051
1.954ValLys: 1.954 ± 0.034
8.278ValLeu: 8.278 ± 0.077
1.776ValMet: 1.776 ± 0.032
1.804ValAsn: 1.804 ± 0.031
4.464ValPro: 4.464 ± 0.05
2.117ValGln: 2.117 ± 0.036
5.073ValArg: 5.073 ± 0.058
3.891ValSer: 3.891 ± 0.053
4.782ValThr: 4.782 ± 0.052
6.569ValVal: 6.569 ± 0.067
0.958ValTrp: 0.958 ± 0.023
1.515ValTyr: 1.515 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.506TrpAla: 1.506 ± 0.027
0.127TrpCys: 0.127 ± 0.008
0.802TrpAsp: 0.802 ± 0.019
0.593TrpGlu: 0.593 ± 0.017
0.552TrpPhe: 0.552 ± 0.02
1.126TrpGly: 1.126 ± 0.027
0.355TrpHis: 0.355 ± 0.015
0.719TrpIle: 0.719 ± 0.021
0.37TrpLys: 0.37 ± 0.017
1.765TrpLeu: 1.765 ± 0.032
0.358TrpMet: 0.358 ± 0.014
0.433TrpAsn: 0.433 ± 0.017
0.82TrpPro: 0.82 ± 0.021
0.606TrpGln: 0.606 ± 0.019
1.324TrpArg: 1.324 ± 0.031
0.867TrpSer: 0.867 ± 0.022
0.916TrpThr: 0.916 ± 0.024
0.979TrpVal: 0.979 ± 0.024
0.265TrpTrp: 0.265 ± 0.012
0.292TrpTyr: 0.292 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.669TyrAla: 2.669 ± 0.042
0.204TyrCys: 0.204 ± 0.011
1.516TyrAsp: 1.516 ± 0.033
1.12TyrGlu: 1.12 ± 0.027
0.806TyrPhe: 0.806 ± 0.022
2.176TyrGly: 2.176 ± 0.036
0.457TyrHis: 0.457 ± 0.013
0.845TyrIle: 0.845 ± 0.021
0.5TyrLys: 0.5 ± 0.018
2.328TyrLeu: 2.328 ± 0.036
0.372TyrMet: 0.372 ± 0.014
0.543TyrAsn: 0.543 ± 0.02
1.203TyrPro: 1.203 ± 0.028
0.701TyrGln: 0.701 ± 0.022
1.834TyrArg: 1.834 ± 0.032
1.08TyrSer: 1.08 ± 0.024
1.116TyrThr: 1.116 ± 0.026
1.629TyrVal: 1.629 ± 0.03
0.372TyrTrp: 0.372 ± 0.016
0.585TyrTyr: 0.585 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6228 proteins (1722682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski