Amino acid dipepetide frequency for bacterium 1XD42-54

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.91AlaAla: 7.91 ± 0.114
1.196AlaCys: 1.196 ± 0.036
4.619AlaAsp: 4.619 ± 0.076
6.06AlaGlu: 6.06 ± 0.1
3.144AlaPhe: 3.144 ± 0.062
6.79AlaGly: 6.79 ± 0.098
1.111AlaHis: 1.111 ± 0.035
4.65AlaIle: 4.65 ± 0.079
4.445AlaLys: 4.445 ± 0.072
7.476AlaLeu: 7.476 ± 0.102
2.341AlaMet: 2.341 ± 0.055
2.446AlaAsn: 2.446 ± 0.058
2.106AlaPro: 2.106 ± 0.05
2.896AlaGln: 2.896 ± 0.058
3.305AlaArg: 3.305 ± 0.061
4.143AlaSer: 4.143 ± 0.06
3.146AlaThr: 3.146 ± 0.063
6.755AlaVal: 6.755 ± 0.1
0.657AlaTrp: 0.657 ± 0.025
3.046AlaTyr: 3.046 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.152CysAla: 1.152 ± 0.037
0.344CysCys: 0.344 ± 0.02
0.833CysAsp: 0.833 ± 0.027
1.005CysGlu: 1.005 ± 0.031
0.722CysPhe: 0.722 ± 0.027
1.508CysGly: 1.508 ± 0.048
0.29CysHis: 0.29 ± 0.018
1.108CysIle: 1.108 ± 0.031
0.708CysLys: 0.708 ± 0.024
1.188CysLeu: 1.188 ± 0.034
0.491CysMet: 0.491 ± 0.02
0.557CysAsn: 0.557 ± 0.023
0.626CysPro: 0.626 ± 0.025
0.458CysGln: 0.458 ± 0.022
0.837CysArg: 0.837 ± 0.031
0.912CysSer: 0.912 ± 0.033
0.771CysThr: 0.771 ± 0.03
1.077CysVal: 1.077 ± 0.033
0.129CysTrp: 0.129 ± 0.012
0.615CysTyr: 0.615 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.36AspAla: 4.36 ± 0.076
0.845AspCys: 0.845 ± 0.027
2.553AspAsp: 2.553 ± 0.065
4.423AspGlu: 4.423 ± 0.07
2.538AspPhe: 2.538 ± 0.05
4.676AspGly: 4.676 ± 0.13
0.849AspHis: 0.849 ± 0.027
4.023AspIle: 4.023 ± 0.071
2.778AspLys: 2.778 ± 0.052
4.542AspLeu: 4.542 ± 0.068
1.701AspMet: 1.701 ± 0.041
1.863AspAsn: 1.863 ± 0.048
1.726AspPro: 1.726 ± 0.044
1.516AspGln: 1.516 ± 0.037
2.501AspArg: 2.501 ± 0.05
2.864AspSer: 2.864 ± 0.068
3.192AspThr: 3.192 ± 0.06
3.706AspVal: 3.706 ± 0.063
0.644AspTrp: 0.644 ± 0.025
2.762AspTyr: 2.762 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.342GluAla: 6.342 ± 0.098
0.794GluCys: 0.794 ± 0.026
3.992GluAsp: 3.992 ± 0.067
7.391GluGlu: 7.391 ± 0.102
2.58GluPhe: 2.58 ± 0.052
4.546GluGly: 4.546 ± 0.087
1.569GluHis: 1.569 ± 0.039
5.699GluIle: 5.699 ± 0.086
6.472GluLys: 6.472 ± 0.1
7.346GluLeu: 7.346 ± 0.106
2.492GluMet: 2.492 ± 0.047
4.054GluAsn: 4.054 ± 0.076
2.139GluPro: 2.139 ± 0.056
3.435GluGln: 3.435 ± 0.065
3.873GluArg: 3.873 ± 0.067
3.362GluSer: 3.362 ± 0.071
4.504GluThr: 4.504 ± 0.139
4.6GluVal: 4.6 ± 0.079
0.673GluTrp: 0.673 ± 0.028
3.092GluTyr: 3.092 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.072PheAla: 3.072 ± 0.055
0.781PheCys: 0.781 ± 0.03
2.422PheAsp: 2.422 ± 0.049
2.734PheGlu: 2.734 ± 0.058
1.836PhePhe: 1.836 ± 0.054
3.095PheGly: 3.095 ± 0.063
0.867PheHis: 0.867 ± 0.031
2.343PheIle: 2.343 ± 0.048
1.606PheLys: 1.606 ± 0.041
4.188PheLeu: 4.188 ± 0.086
1.096PheMet: 1.096 ± 0.032
1.274PheAsn: 1.274 ± 0.038
1.38PhePro: 1.38 ± 0.038
1.446PheGln: 1.446 ± 0.041
1.955PheArg: 1.955 ± 0.045
2.99PheSer: 2.99 ± 0.053
2.315PheThr: 2.315 ± 0.053
2.885PheVal: 2.885 ± 0.057
0.439PheTrp: 0.439 ± 0.02
1.735PheTyr: 1.735 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.379GlyAla: 5.379 ± 0.092
1.222GlyCys: 1.222 ± 0.038
3.504GlyAsp: 3.504 ± 0.07
5.002GlyGlu: 5.002 ± 0.09
3.045GlyPhe: 3.045 ± 0.059
5.04GlyGly: 5.04 ± 0.143
1.25GlyHis: 1.25 ± 0.036
6.281GlyIle: 6.281 ± 0.09
5.321GlyLys: 5.321 ± 0.074
5.957GlyLeu: 5.957 ± 0.098
2.626GlyMet: 2.626 ± 0.053
3.198GlyAsn: 3.198 ± 0.075
1.27GlyPro: 1.27 ± 0.038
2.369GlyGln: 2.369 ± 0.062
3.525GlyArg: 3.525 ± 0.057
4.303GlySer: 4.303 ± 0.074
4.572GlyThr: 4.572 ± 0.101
5.065GlyVal: 5.065 ± 0.063
0.792GlyTrp: 0.792 ± 0.032
3.317GlyTyr: 3.317 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.236HisAla: 1.236 ± 0.027
0.314HisCys: 0.314 ± 0.018
0.898HisAsp: 0.898 ± 0.035
1.143HisGlu: 1.143 ± 0.029
0.87HisPhe: 0.87 ± 0.03
1.292HisGly: 1.292 ± 0.037
0.373HisHis: 0.373 ± 0.024
1.258HisIle: 1.258 ± 0.036
0.81HisLys: 0.81 ± 0.031
1.482HisLeu: 1.482 ± 0.042
0.528HisMet: 0.528 ± 0.022
0.59HisAsn: 0.59 ± 0.022
0.847HisPro: 0.847 ± 0.032
0.594HisGln: 0.594 ± 0.024
0.864HisArg: 0.864 ± 0.033
0.937HisSer: 0.937 ± 0.032
1.026HisThr: 1.026 ± 0.031
1.188HisVal: 1.188 ± 0.034
0.178HisTrp: 0.178 ± 0.015
0.757HisTyr: 0.757 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.396IleAla: 5.396 ± 0.082
1.326IleCys: 1.326 ± 0.04
3.682IleAsp: 3.682 ± 0.056
4.53IleGlu: 4.53 ± 0.07
2.756IlePhe: 2.756 ± 0.049
5.009IleGly: 5.009 ± 0.094
1.304IleHis: 1.304 ± 0.034
4.021IleIle: 4.021 ± 0.08
3.237IleLys: 3.237 ± 0.061
6.881IleLeu: 6.881 ± 0.107
1.748IleMet: 1.748 ± 0.044
2.424IleAsn: 2.424 ± 0.047
2.906IlePro: 2.906 ± 0.054
2.379IleGln: 2.379 ± 0.047
4.022IleArg: 4.022 ± 0.074
4.711IleSer: 4.711 ± 0.075
3.92IleThr: 3.92 ± 0.075
4.687IleVal: 4.687 ± 0.069
0.681IleTrp: 0.681 ± 0.026
2.592IleTyr: 2.592 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.713LysAla: 4.713 ± 0.082
0.684LysCys: 0.684 ± 0.027
3.197LysAsp: 3.197 ± 0.072
5.977LysGlu: 5.977 ± 0.085
1.63LysPhe: 1.63 ± 0.041
3.846LysGly: 3.846 ± 0.065
0.903LysHis: 0.903 ± 0.028
4.326LysIle: 4.326 ± 0.066
5.585LysLys: 5.585 ± 0.09
4.958LysLeu: 4.958 ± 0.074
1.953LysMet: 1.953 ± 0.043
3.163LysAsn: 3.163 ± 0.049
1.772LysPro: 1.772 ± 0.05
2.306LysGln: 2.306 ± 0.055
3.197LysArg: 3.197 ± 0.06
3.224LysSer: 3.224 ± 0.06
3.583LysThr: 3.583 ± 0.066
3.623LysVal: 3.623 ± 0.068
0.535LysTrp: 0.535 ± 0.022
2.58LysTyr: 2.58 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.288LeuAla: 7.288 ± 0.089
1.669LeuCys: 1.669 ± 0.045
5.011LeuAsp: 5.011 ± 0.066
6.713LeuGlu: 6.713 ± 0.097
3.907LeuPhe: 3.907 ± 0.085
5.972LeuGly: 5.972 ± 0.079
1.677LeuHis: 1.677 ± 0.043
5.745LeuIle: 5.745 ± 0.091
5.511LeuLys: 5.511 ± 0.079
9.409LeuLeu: 9.409 ± 0.14
2.641LeuMet: 2.641 ± 0.051
3.617LeuAsn: 3.617 ± 0.062
3.669LeuPro: 3.669 ± 0.066
3.3LeuGln: 3.3 ± 0.061
4.194LeuArg: 4.194 ± 0.083
6.275LeuSer: 6.275 ± 0.099
5.136LeuThr: 5.136 ± 0.065
5.682LeuVal: 5.682 ± 0.081
0.79LeuTrp: 0.79 ± 0.028
3.463LeuTyr: 3.463 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.447MetAla: 2.447 ± 0.052
0.34MetCys: 0.34 ± 0.018
1.763MetAsp: 1.763 ± 0.038
2.705MetGlu: 2.705 ± 0.068
1.007MetPhe: 1.007 ± 0.036
1.935MetGly: 1.935 ± 0.047
0.44MetHis: 0.44 ± 0.022
2.091MetIle: 2.091 ± 0.047
2.421MetLys: 2.421 ± 0.046
2.793MetLeu: 2.793 ± 0.061
0.932MetMet: 0.932 ± 0.033
1.444MetAsn: 1.444 ± 0.039
1.088MetPro: 1.088 ± 0.03
1.322MetGln: 1.322 ± 0.039
1.493MetArg: 1.493 ± 0.04
1.6MetSer: 1.6 ± 0.039
1.724MetThr: 1.724 ± 0.041
1.942MetVal: 1.942 ± 0.044
0.219MetTrp: 0.219 ± 0.013
0.945MetTyr: 0.945 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.048AsnAla: 3.048 ± 0.062
0.606AsnCys: 0.606 ± 0.025
1.906AsnAsp: 1.906 ± 0.05
2.658AsnGlu: 2.658 ± 0.054
1.504AsnPhe: 1.504 ± 0.037
3.542AsnGly: 3.542 ± 0.077
0.74AsnHis: 0.74 ± 0.027
2.952AsnIle: 2.952 ± 0.063
2.088AsnLys: 2.088 ± 0.051
3.559AsnLeu: 3.559 ± 0.057
1.235AsnMet: 1.235 ± 0.036
1.528AsnAsn: 1.528 ± 0.05
1.931AsnPro: 1.931 ± 0.044
1.469AsnGln: 1.469 ± 0.04
2.063AsnArg: 2.063 ± 0.043
2.156AsnSer: 2.156 ± 0.054
2.373AsnThr: 2.373 ± 0.066
2.541AsnVal: 2.541 ± 0.053
0.413AsnTrp: 0.413 ± 0.019
1.773AsnTyr: 1.773 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.45ProAla: 2.45 ± 0.051
0.438ProCys: 0.438 ± 0.02
2.467ProAsp: 2.467 ± 0.05
3.69ProGlu: 3.69 ± 0.072
1.475ProPhe: 1.475 ± 0.043
2.467ProGly: 2.467 ± 0.052
0.591ProHis: 0.591 ± 0.024
1.849ProIle: 1.849 ± 0.042
1.714ProLys: 1.714 ± 0.043
2.639ProLeu: 2.639 ± 0.055
0.826ProMet: 0.826 ± 0.024
1.133ProAsn: 1.133 ± 0.038
0.738ProPro: 0.738 ± 0.03
1.225ProGln: 1.225 ± 0.039
0.983ProArg: 0.983 ± 0.029
1.753ProSer: 1.753 ± 0.04
1.444ProThr: 1.444 ± 0.04
3.055ProVal: 3.055 ± 0.059
0.311ProTrp: 0.311 ± 0.016
1.496ProTyr: 1.496 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.77GlnAla: 2.77 ± 0.052
0.372GlnCys: 0.372 ± 0.02
1.758GlnAsp: 1.758 ± 0.047
3.468GlnGlu: 3.468 ± 0.069
1.24GlnPhe: 1.24 ± 0.034
2.186GlnGly: 2.186 ± 0.051
0.512GlnHis: 0.512 ± 0.024
2.774GlnIle: 2.774 ± 0.048
3.088GlnLys: 3.088 ± 0.052
2.892GlnLeu: 2.892 ± 0.061
1.37GlnMet: 1.37 ± 0.035
1.854GlnAsn: 1.854 ± 0.044
1.05GlnPro: 1.05 ± 0.03
1.381GlnGln: 1.381 ± 0.043
1.683GlnArg: 1.683 ± 0.046
1.855GlnSer: 1.855 ± 0.04
1.978GlnThr: 1.978 ± 0.045
2.222GlnVal: 2.222 ± 0.049
0.293GlnTrp: 0.293 ± 0.018
1.445GlnTyr: 1.445 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.166ArgAla: 3.166 ± 0.057
0.695ArgCys: 0.695 ± 0.031
2.369ArgAsp: 2.369 ± 0.046
4.172ArgGlu: 4.172 ± 0.081
1.959ArgPhe: 1.959 ± 0.044
2.718ArgGly: 2.718 ± 0.053
0.765ArgHis: 0.765 ± 0.029
3.895ArgIle: 3.895 ± 0.065
3.624ArgLys: 3.624 ± 0.067
4.417ArgLeu: 4.417 ± 0.083
1.801ArgMet: 1.801 ± 0.045
2.103ArgAsn: 2.103 ± 0.044
1.384ArgPro: 1.384 ± 0.039
1.988ArgGln: 1.988 ± 0.048
2.782ArgArg: 2.782 ± 0.058
2.418ArgSer: 2.418 ± 0.049
2.505ArgThr: 2.505 ± 0.046
2.97ArgVal: 2.97 ± 0.055
0.414ArgTrp: 0.414 ± 0.02
2.009ArgTyr: 2.009 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.414SerAla: 4.414 ± 0.063
0.875SerCys: 0.875 ± 0.027
3.264SerAsp: 3.264 ± 0.064
4.219SerGlu: 4.219 ± 0.072
2.648SerPhe: 2.648 ± 0.051
5.558SerGly: 5.558 ± 0.096
0.993SerHis: 0.993 ± 0.03
3.69SerIle: 3.69 ± 0.057
2.837SerLys: 2.837 ± 0.061
4.938SerLeu: 4.938 ± 0.077
1.843SerMet: 1.843 ± 0.036
2.045SerAsn: 2.045 ± 0.048
1.65SerPro: 1.65 ± 0.039
1.835SerGln: 1.835 ± 0.048
2.786SerArg: 2.786 ± 0.05
3.535SerSer: 3.535 ± 0.082
2.713SerThr: 2.713 ± 0.059
4.665SerVal: 4.665 ± 0.072
0.665SerTrp: 0.665 ± 0.025
2.512SerTyr: 2.512 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.727ThrAla: 4.727 ± 0.074
0.687ThrCys: 0.687 ± 0.029
3.284ThrAsp: 3.284 ± 0.073
4.644ThrGlu: 4.644 ± 0.168
2.226ThrPhe: 2.226 ± 0.054
4.903ThrGly: 4.903 ± 0.091
0.801ThrHis: 0.801 ± 0.028
3.517ThrIle: 3.517 ± 0.063
2.794ThrLys: 2.794 ± 0.064
4.928ThrLeu: 4.928 ± 0.073
1.467ThrMet: 1.467 ± 0.034
1.877ThrAsn: 1.877 ± 0.048
2.068ThrPro: 2.068 ± 0.046
1.757ThrGln: 1.757 ± 0.045
1.996ThrArg: 1.996 ± 0.044
2.895ThrSer: 2.895 ± 0.067
2.73ThrThr: 2.73 ± 0.076
4.866ThrVal: 4.866 ± 0.104
0.571ThrTrp: 0.571 ± 0.031
2.155ThrTyr: 2.155 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.912ValAla: 4.912 ± 0.079
1.31ValCys: 1.31 ± 0.041
3.546ValAsp: 3.546 ± 0.063
4.581ValGlu: 4.581 ± 0.078
3.116ValPhe: 3.116 ± 0.054
4.165ValGly: 4.165 ± 0.066
1.103ValHis: 1.103 ± 0.034
4.857ValIle: 4.857 ± 0.068
4.021ValLys: 4.021 ± 0.067
7.086ValLeu: 7.086 ± 0.098
2.094ValMet: 2.094 ± 0.047
2.75ValAsn: 2.75 ± 0.053
2.675ValPro: 2.675 ± 0.051
2.401ValGln: 2.401 ± 0.049
3.37ValArg: 3.37 ± 0.06
4.87ValSer: 4.87 ± 0.07
4.345ValThr: 4.345 ± 0.104
4.74ValVal: 4.74 ± 0.074
0.686ValTrp: 0.686 ± 0.026
2.881ValTyr: 2.881 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.523TrpAla: 0.523 ± 0.023
0.154TrpCys: 0.154 ± 0.011
0.529TrpAsp: 0.529 ± 0.02
0.704TrpGlu: 0.704 ± 0.025
0.411TrpPhe: 0.411 ± 0.021
0.686TrpGly: 0.686 ± 0.024
0.18TrpHis: 0.18 ± 0.012
0.615TrpIle: 0.615 ± 0.024
0.787TrpLys: 0.787 ± 0.028
0.917TrpLeu: 0.917 ± 0.029
0.365TrpMet: 0.365 ± 0.017
0.555TrpAsn: 0.555 ± 0.02
0.235TrpPro: 0.235 ± 0.015
0.414TrpGln: 0.414 ± 0.021
0.44TrpArg: 0.44 ± 0.018
0.533TrpSer: 0.533 ± 0.024
0.475TrpThr: 0.475 ± 0.028
0.496TrpVal: 0.496 ± 0.025
0.11TrpTrp: 0.11 ± 0.01
0.437TrpTyr: 0.437 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.939TyrAla: 2.939 ± 0.052
0.679TyrCys: 0.679 ± 0.027
2.467TyrAsp: 2.467 ± 0.07
3.138TyrGlu: 3.138 ± 0.061
1.845TyrPhe: 1.845 ± 0.04
3.106TyrGly: 3.106 ± 0.059
0.87TyrHis: 0.87 ± 0.029
2.518TyrIle: 2.518 ± 0.052
1.909TyrLys: 1.909 ± 0.04
4.072TyrLeu: 4.072 ± 0.076
1.099TyrMet: 1.099 ± 0.028
1.611TyrAsn: 1.611 ± 0.039
1.481TyrPro: 1.481 ± 0.043
1.699TyrGln: 1.699 ± 0.04
2.285TyrArg: 2.285 ± 0.052
2.349TyrSer: 2.349 ± 0.05
2.437TyrThr: 2.437 ± 0.074
2.742TyrVal: 2.742 ± 0.061
0.365TyrTrp: 0.365 ± 0.023
1.99TyrTyr: 1.99 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3209 proteins (1081669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski