Amino acid dipepetide frequency for Trichobilharzia regenti (Nasal bird schistosome)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.09AlaAla: 4.09 ± 0.046	1.069AlaCys: 1.069 ± 0.016	2.493AlaAsp: 2.493 ± 0.024	2.851AlaGlu: 2.851 ± 0.028	1.958AlaPhe: 1.958 ± 0.022	2.439AlaGly: 2.439 ± 0.028	1.11AlaHis: 1.11 ± 0.017	2.742AlaIle: 2.742 ± 0.026	2.614AlaLys: 2.614 ± 0.027	4.501AlaLeu: 4.501 ± 0.033	1.081AlaMet: 1.081 ± 0.013	2.829AlaAsn: 2.829 ± 0.028	1.917AlaPro: 1.917 ± 0.023	1.763AlaGln: 1.763 ± 0.021	2.256AlaArg: 2.256 ± 0.025	5.008AlaSer: 5.008 ± 0.033	3.217AlaThr: 3.217 ± 0.036	3.286AlaVal: 3.286 ± 0.028	0.462AlaTrp: 0.462 ± 0.01	1.772AlaTyr: 1.772 ± 0.019	0.026AlaXaa: 0.026 ± 0.003
Cys	0.887CysAla: 0.887 ± 0.013	0.629CysCys: 0.629 ± 0.014	1.124CysAsp: 1.124 ± 0.017	1.112CysGlu: 1.112 ± 0.018	0.947CysPhe: 0.947 ± 0.015	1.044CysGly: 1.044 ± 0.016	0.629CysHis: 0.629 ± 0.012	1.445CysIle: 1.445 ± 0.019	1.089CysLys: 1.089 ± 0.017	2.427CysLeu: 2.427 ± 0.023	0.5CysMet: 0.5 ± 0.01	1.12CysAsn: 1.12 ± 0.017	1.003CysPro: 1.003 ± 0.017	0.945CysGln: 0.945 ± 0.014	1.13CysArg: 1.13 ± 0.017	2.041CysSer: 2.041 ± 0.023	1.187CysThr: 1.187 ± 0.016	1.228CysVal: 1.228 ± 0.019	0.204CysTrp: 0.204 ± 0.006	0.685CysTyr: 0.685 ± 0.013	0.008CysXaa: 0.008 ± 0.001
Asp	2.509AspAla: 2.509 ± 0.024	1.065AspCys: 1.065 ± 0.016	4.148AspAsp: 4.148 ± 0.052	3.781AspGlu: 3.781 ± 0.034	1.912AspPhe: 1.912 ± 0.021	2.672AspGly: 2.672 ± 0.034	1.262AspHis: 1.262 ± 0.018	3.216AspIle: 3.216 ± 0.025	2.785AspLys: 2.785 ± 0.024	4.397AspLeu: 4.397 ± 0.029	1.113AspMet: 1.113 ± 0.017	3.591AspAsn: 3.591 ± 0.029	2.105AspPro: 2.105 ± 0.02	1.895AspGln: 1.895 ± 0.022	2.29AspArg: 2.29 ± 0.026	4.877AspSer: 4.877 ± 0.036	2.774AspThr: 2.774 ± 0.022	2.956AspVal: 2.956 ± 0.029	0.553AspTrp: 0.553 ± 0.011	1.845AspTyr: 1.845 ± 0.018	0.022AspXaa: 0.022 ± 0.002
Glu	3.135GluAla: 3.135 ± 0.029	1.092GluCys: 1.092 ± 0.016	3.09GluAsp: 3.09 ± 0.03	4.328GluGlu: 4.328 ± 0.047	2.073GluPhe: 2.073 ± 0.024	1.973GluGly: 1.973 ± 0.021	1.306GluHis: 1.306 ± 0.017	3.357GluIle: 3.357 ± 0.025	3.64GluLys: 3.64 ± 0.035	5.224GluLeu: 5.224 ± 0.034	1.4GluMet: 1.4 ± 0.017	3.683GluAsn: 3.683 ± 0.029	1.713GluPro: 1.713 ± 0.021	2.408GluGln: 2.408 ± 0.027	2.715GluArg: 2.715 ± 0.025	4.622GluSer: 4.622 ± 0.031	3.114GluThr: 3.114 ± 0.028	3.165GluVal: 3.165 ± 0.024	0.493GluTrp: 0.493 ± 0.012	1.794GluTyr: 1.794 ± 0.022	0.018GluXaa: 0.018 ± 0.002
Phe	1.637PheAla: 1.637 ± 0.017	0.952PheCys: 0.952 ± 0.015	1.956PheAsp: 1.956 ± 0.019	1.845PheGlu: 1.845 ± 0.023	1.648PhePhe: 1.648 ± 0.022	1.796PheGly: 1.796 ± 0.023	1.128PheHis: 1.128 ± 0.014	2.698PheIle: 2.698 ± 0.026	1.811PheLys: 1.811 ± 0.02	3.655PheLeu: 3.655 ± 0.034	0.953PheMet: 0.953 ± 0.014	2.232PheAsn: 2.232 ± 0.022	1.743PhePro: 1.743 ± 0.021	1.47PheGln: 1.47 ± 0.02	1.804PheArg: 1.804 ± 0.019	3.683PheSer: 3.683 ± 0.03	2.451PheThr: 2.451 ± 0.024	2.136PheVal: 2.136 ± 0.021	0.386PheTrp: 0.386 ± 0.01	1.406PheTyr: 1.406 ± 0.018	0.016PheXaa: 0.016 ± 0.002
Gly	2.087GlyAla: 2.087 ± 0.026	0.965GlyCys: 0.965 ± 0.013	2.586GlyAsp: 2.586 ± 0.03	2.465GlyGlu: 2.465 ± 0.032	1.743GlyPhe: 1.743 ± 0.02	3.614GlyGly: 3.614 ± 0.048	1.126GlyHis: 1.126 ± 0.017	2.844GlyIle: 2.844 ± 0.024	2.608GlyLys: 2.608 ± 0.025	4.093GlyLeu: 4.093 ± 0.038	1.053GlyMet: 1.053 ± 0.014	2.647GlyAsn: 2.647 ± 0.025	1.695GlyPro: 1.695 ± 0.041	1.756GlyGln: 1.756 ± 0.02	2.412GlyArg: 2.412 ± 0.027	4.22GlySer: 4.22 ± 0.033	2.428GlyThr: 2.428 ± 0.024	2.841GlyVal: 2.841 ± 0.026	0.485GlyTrp: 0.485 ± 0.01	1.6GlyTyr: 1.6 ± 0.02	0.025GlyXaa: 0.025 ± 0.002
His	1.103HisAla: 1.103 ± 0.015	0.623HisCys: 0.623 ± 0.012	1.207HisAsp: 1.207 ± 0.017	1.345HisGlu: 1.345 ± 0.017	1.181HisPhe: 1.181 ± 0.015	1.146HisGly: 1.146 ± 0.016	1.703HisHis: 1.703 ± 0.027	1.597HisIle: 1.597 ± 0.019	1.324HisLys: 1.324 ± 0.016	2.978HisLeu: 2.978 ± 0.022	0.572HisMet: 0.572 ± 0.011	1.674HisAsn: 1.674 ± 0.02	1.486HisPro: 1.486 ± 0.02	1.64HisGln: 1.64 ± 0.023	1.593HisArg: 1.593 ± 0.02	2.894HisSer: 2.894 ± 0.026	1.564HisThr: 1.564 ± 0.018	1.328HisVal: 1.328 ± 0.018	0.292HisTrp: 0.292 ± 0.008	0.994HisTyr: 0.994 ± 0.016	0.011HisXaa: 0.011 ± 0.001
Ile	2.728IleAla: 2.728 ± 0.026	1.368IleCys: 1.368 ± 0.02	3.305IleAsp: 3.305 ± 0.03	3.066IleGlu: 3.066 ± 0.027	2.317IlePhe: 2.317 ± 0.026	2.596IleGly: 2.596 ± 0.025	1.867IleHis: 1.867 ± 0.019	3.805IleIle: 3.805 ± 0.036	3.158IleLys: 3.158 ± 0.032	5.384IleLeu: 5.384 ± 0.033	1.287IleMet: 1.287 ± 0.017	3.913IleAsn: 3.913 ± 0.03	3.25IlePro: 3.25 ± 0.029	2.655IleGln: 2.655 ± 0.025	2.922IleArg: 2.922 ± 0.02	5.875IleSer: 5.875 ± 0.037	3.81IleThr: 3.81 ± 0.029	3.042IleVal: 3.042 ± 0.026	0.588IleTrp: 0.588 ± 0.011	2.01IleTyr: 2.01 ± 0.022	0.024IleXaa: 0.024 ± 0.002
Lys	2.699LysAla: 2.699 ± 0.027	1.242LysCys: 1.242 ± 0.018	2.507LysAsp: 2.507 ± 0.025	3.212LysGlu: 3.212 ± 0.028	1.928LysPhe: 1.928 ± 0.021	1.919LysGly: 1.919 ± 0.032	1.627LysHis: 1.627 ± 0.021	2.943LysIle: 2.943 ± 0.025	3.377LysLys: 3.377 ± 0.039	5.567LysLeu: 5.567 ± 0.039	1.382LysMet: 1.382 ± 0.017	2.888LysAsn: 2.888 ± 0.026	2.638LysPro: 2.638 ± 0.026	2.719LysGln: 2.719 ± 0.028	3.294LysArg: 3.294 ± 0.027	5.743LysSer: 5.743 ± 0.041	3.138LysThr: 3.138 ± 0.029	2.878LysVal: 2.878 ± 0.026	0.551LysTrp: 0.551 ± 0.009	1.877LysTyr: 1.877 ± 0.022	0.019LysXaa: 0.019 ± 0.002
Leu	4.845LeuAla: 4.845 ± 0.037	2.113LeuCys: 2.113 ± 0.025	4.446LeuAsp: 4.446 ± 0.032	4.684LeuGlu: 4.684 ± 0.042	3.942LeuPhe: 3.942 ± 0.029	3.657LeuGly: 3.657 ± 0.033	2.648LeuHis: 2.648 ± 0.026	5.756LeuIle: 5.756 ± 0.039	5.404LeuLys: 5.404 ± 0.042	9.622LeuLeu: 9.622 ± 0.063	2.119LeuMet: 2.119 ± 0.021	5.784LeuAsn: 5.784 ± 0.036	5.108LeuPro: 5.108 ± 0.033	4.001LeuGln: 4.001 ± 0.031	4.778LeuArg: 4.778 ± 0.037	9.505LeuSer: 9.505 ± 0.042	5.684LeuThr: 5.684 ± 0.035	4.718LeuVal: 4.718 ± 0.036	0.904LeuTrp: 0.904 ± 0.013	2.737LeuTyr: 2.737 ± 0.026	0.039LeuXaa: 0.039 ± 0.003
Met	1.12MetAla: 1.12 ± 0.017	0.464MetCys: 0.464 ± 0.01	1.231MetAsp: 1.231 ± 0.014	1.225MetGlu: 1.225 ± 0.015	0.796MetPhe: 0.796 ± 0.013	0.862MetGly: 0.862 ± 0.013	0.705MetHis: 0.705 ± 0.011	1.286MetIle: 1.286 ± 0.016	1.605MetLys: 1.605 ± 0.017	2.029MetLeu: 2.029 ± 0.022	0.655MetMet: 0.655 ± 0.014	1.988MetAsn: 1.988 ± 0.02	1.096MetPro: 1.096 ± 0.014	0.808MetGln: 0.808 ± 0.012	1.038MetArg: 1.038 ± 0.016	2.057MetSer: 2.057 ± 0.019	1.408MetThr: 1.408 ± 0.017	1.07MetVal: 1.07 ± 0.016	0.168MetTrp: 0.168 ± 0.006	0.687MetTyr: 0.687 ± 0.013	0.008MetXaa: 0.008 ± 0.001
Asn	2.918AsnAla: 2.918 ± 0.025	1.262AsnCys: 1.262 ± 0.017	3.787AsnAsp: 3.787 ± 0.031	3.715AsnGlu: 3.715 ± 0.034	2.101AsnPhe: 2.101 ± 0.023	2.831AsnGly: 2.831 ± 0.032	1.967AsnHis: 1.967 ± 0.023	3.748AsnIle: 3.748 ± 0.03	3.508AsnLys: 3.508 ± 0.034	5.352AsnLeu: 5.352 ± 0.036	1.3AsnMet: 1.3 ± 0.016	8.267AsnAsn: 8.267 ± 0.11	2.835AsnPro: 2.835 ± 0.026	2.828AsnGln: 2.828 ± 0.025	2.853AsnArg: 2.853 ± 0.025	7.405AsnSer: 7.405 ± 0.056	4.476AsnThr: 4.476 ± 0.037	3.017AsnVal: 3.017 ± 0.027	0.531AsnTrp: 0.531 ± 0.011	2.122AsnTyr: 2.122 ± 0.022	0.027AsnXaa: 0.027 ± 0.002
Pro	2.245ProAla: 2.245 ± 0.02	0.854ProCys: 0.854 ± 0.014	2.247ProAsp: 2.247 ± 0.022	2.499ProGlu: 2.499 ± 0.023	1.639ProPhe: 1.639 ± 0.017	2.347ProGly: 2.347 ± 0.045	1.193ProHis: 1.193 ± 0.015	2.832ProIle: 2.832 ± 0.027	2.36ProLys: 2.36 ± 0.025	4.062ProLeu: 4.062 ± 0.031	0.966ProMet: 0.966 ± 0.016	2.803ProAsn: 2.803 ± 0.026	3.688ProPro: 3.688 ± 0.046	1.816ProGln: 1.816 ± 0.022	2.014ProArg: 2.014 ± 0.022	5.434ProSer: 5.434 ± 0.042	3.522ProThr: 3.522 ± 0.035	3.302ProVal: 3.302 ± 0.026	0.395ProTrp: 0.395 ± 0.009	1.471ProTyr: 1.471 ± 0.019	0.026ProXaa: 0.026 ± 0.002
Gln	1.962GlnAla: 1.962 ± 0.022	0.904GlnCys: 0.904 ± 0.013	1.457GlnAsp: 1.457 ± 0.019	1.984GlnGlu: 1.984 ± 0.024	1.522GlnPhe: 1.522 ± 0.019	1.344GlnGly: 1.344 ± 0.018	1.478GlnHis: 1.478 ± 0.021	2.552GlnIle: 2.552 ± 0.026	2.274GlnLys: 2.274 ± 0.026	4.685GlnLeu: 4.685 ± 0.035	1.05GlnMet: 1.05 ± 0.016	2.558GlnAsn: 2.558 ± 0.027	2.214GlnPro: 2.214 ± 0.028	3.75GlnGln: 3.75 ± 0.064	2.256GlnArg: 2.256 ± 0.023	4.4GlnSer: 4.4 ± 0.033	2.646GlnThr: 2.646 ± 0.025	2.163GlnVal: 2.163 ± 0.021	0.424GlnTrp: 0.424 ± 0.009	1.339GlnTyr: 1.339 ± 0.018	0.014GlnXaa: 0.014 ± 0.002
Arg	2.168ArgAla: 2.168 ± 0.023	1.038ArgCys: 1.038 ± 0.016	2.087ArgAsp: 2.087 ± 0.019	2.513ArgGlu: 2.513 ± 0.027	1.945ArgPhe: 1.945 ± 0.02	2.113ArgGly: 2.113 ± 0.031	1.506ArgHis: 1.506 ± 0.018	3.144ArgIle: 3.144 ± 0.025	3.102ArgLys: 3.102 ± 0.029	5.558ArgLeu: 5.558 ± 0.042	1.216ArgMet: 1.216 ± 0.016	2.726ArgAsn: 2.726 ± 0.025	2.169ArgPro: 2.169 ± 0.024	2.463ArgGln: 2.463 ± 0.022	3.831ArgArg: 3.831 ± 0.037	4.413ArgSer: 4.413 ± 0.039	2.409ArgThr: 2.409 ± 0.021	2.607ArgVal: 2.607 ± 0.027	0.517ArgTrp: 0.517 ± 0.01	1.623ArgTyr: 1.623 ± 0.021	0.017ArgXaa: 0.017 ± 0.002
Ser	4.828SerAla: 4.828 ± 0.035	1.993SerCys: 1.993 ± 0.021	5.263SerAsp: 5.263 ± 0.035	5.225SerGlu: 5.225 ± 0.034	3.574SerPhe: 3.574 ± 0.03	5.124SerGly: 5.124 ± 0.045	2.709SerHis: 2.709 ± 0.026	5.575SerIle: 5.575 ± 0.036	5.217SerLys: 5.217 ± 0.044	9.056SerLeu: 9.056 ± 0.048	2.178SerMet: 2.178 ± 0.022	7.265SerAsn: 7.265 ± 0.049	5.122SerPro: 5.122 ± 0.043	4.163SerGln: 4.163 ± 0.032	4.615SerArg: 4.615 ± 0.036	15.671SerSer: 15.671 ± 0.111	7.714SerThr: 7.714 ± 0.058	6.251SerVal: 6.251 ± 0.035	0.783SerTrp: 0.783 ± 0.014	2.697SerTyr: 2.697 ± 0.026	0.052SerXaa: 0.052 ± 0.003
Thr	3.646ThrAla: 3.646 ± 0.033	1.243ThrCys: 1.243 ± 0.017	3.417ThrAsp: 3.417 ± 0.027	3.336ThrGlu: 3.336 ± 0.029	2.031ThrPhe: 2.031 ± 0.02	3.29ThrGly: 3.29 ± 0.028	1.466ThrHis: 1.466 ± 0.016	3.439ThrIle: 3.439 ± 0.029	3.014ThrLys: 3.014 ± 0.03	4.976ThrLeu: 4.976 ± 0.031	1.282ThrMet: 1.282 ± 0.017	4.509ThrAsn: 4.509 ± 0.037	3.569ThrPro: 3.569 ± 0.032	2.079ThrGln: 2.079 ± 0.021	2.502ThrArg: 2.502 ± 0.024	7.431ThrSer: 7.431 ± 0.056	7.286ThrThr: 7.286 ± 0.091	3.873ThrVal: 3.873 ± 0.032	0.471ThrTrp: 0.471 ± 0.011	1.675ThrTyr: 1.675 ± 0.019	0.034ThrXaa: 0.034 ± 0.003
Val	2.764ValAla: 2.764 ± 0.028	1.475ValCys: 1.475 ± 0.019	3.241ValAsp: 3.241 ± 0.028	2.977ValGlu: 2.977 ± 0.027	2.138ValPhe: 2.138 ± 0.022	2.668ValGly: 2.668 ± 0.027	1.536ValHis: 1.536 ± 0.017	3.412ValIle: 3.412 ± 0.03	3.155ValLys: 3.155 ± 0.029	4.602ValLeu: 4.602 ± 0.033	1.199ValMet: 1.199 ± 0.015	3.97ValAsn: 3.97 ± 0.028	2.325ValPro: 2.325 ± 0.025	2.135ValGln: 2.135 ± 0.021	2.546ValArg: 2.546 ± 0.024	5.826ValSer: 5.826 ± 0.037	3.354ValThr: 3.354 ± 0.024	3.455ValVal: 3.455 ± 0.031	0.543ValTrp: 0.543 ± 0.011	1.957ValTyr: 1.957 ± 0.024	0.029ValXaa: 0.029 ± 0.002
Trp	0.399TrpAla: 0.399 ± 0.01	0.228TrpCys: 0.228 ± 0.007	0.479TrpAsp: 0.479 ± 0.009	0.442TrpGlu: 0.442 ± 0.008	0.431TrpPhe: 0.431 ± 0.01	0.344TrpGly: 0.344 ± 0.009	0.235TrpHis: 0.235 ± 0.007	0.71TrpIle: 0.71 ± 0.013	0.557TrpLys: 0.557 ± 0.01	1.091TrpLeu: 1.091 ± 0.015	0.245TrpMet: 0.245 ± 0.007	0.563TrpAsn: 0.563 ± 0.011	0.429TrpPro: 0.429 ± 0.01	0.329TrpGln: 0.329 ± 0.007	0.587TrpArg: 0.587 ± 0.011	0.879TrpSer: 0.879 ± 0.013	0.483TrpThr: 0.483 ± 0.011	0.377TrpVal: 0.377 ± 0.009	0.138TrpTrp: 0.138 ± 0.006	0.296TrpTyr: 0.296 ± 0.007	0.002TrpXaa: 0.002 ± 0.001
Tyr	1.693TyrAla: 1.693 ± 0.021	0.794TyrCys: 0.794 ± 0.012	1.674TyrAsp: 1.674 ± 0.024	1.717TyrGlu: 1.717 ± 0.02	1.564TyrPhe: 1.564 ± 0.021	1.498TyrGly: 1.498 ± 0.022	1.047TyrHis: 1.047 ± 0.015	1.84TyrIle: 1.84 ± 0.021	1.525TyrLys: 1.525 ± 0.02	3.192TyrLeu: 3.192 ± 0.029	0.738TyrMet: 0.738 ± 0.012	1.814TyrAsn: 1.814 ± 0.02	1.589TyrPro: 1.589 ± 0.017	1.338TyrGln: 1.338 ± 0.019	1.704TyrArg: 1.704 ± 0.018	3.044TyrSer: 3.044 ± 0.032	1.875TyrThr: 1.875 ± 0.021	1.592TyrVal: 1.592 ± 0.015	0.352TyrTrp: 0.352 ± 0.008	1.389TyrTyr: 1.389 ± 0.021	0.012TyrXaa: 0.012 ± 0.002
Xaa	0.023XaaAla: 0.023 ± 0.002	0.009XaaCys: 0.009 ± 0.001	0.022XaaAsp: 0.022 ± 0.002	0.02XaaGlu: 0.02 ± 0.002	0.014XaaPhe: 0.014 ± 0.002	0.017XaaGly: 0.017 ± 0.002	0.009XaaHis: 0.009 ± 0.001	0.029XaaIle: 0.029 ± 0.003	0.022XaaLys: 0.022 ± 0.002	0.043XaaLeu: 0.043 ± 0.003	0.018XaaMet: 0.018 ± 0.002	0.027XaaAsn: 0.027 ± 0.002	0.02XaaPro: 0.02 ± 0.002	0.016XaaGln: 0.016 ± 0.002	0.023XaaArg: 0.023 ± 0.002	0.045XaaSer: 0.045 ± 0.003	0.03XaaThr: 0.03 ± 0.003	0.021XaaVal: 0.021 ± 0.002	0.004XaaTrp: 0.004 ± 0.001	0.016XaaTyr: 0.016 ± 0.002	10.835XaaXaa: 10.835 ± 0.299

Statistics based on 22165 proteins (4891284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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