Amino acid dipepetide frequency for Microbacterium protaetiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.053AlaAla: 22.053 ± 0.2	0.688AlaCys: 0.688 ± 0.026	8.816AlaAsp: 8.816 ± 0.099	7.488AlaGlu: 7.488 ± 0.104	3.896AlaPhe: 3.896 ± 0.062	12.359AlaGly: 12.359 ± 0.124	2.921AlaHis: 2.921 ± 0.051	5.622AlaIle: 5.622 ± 0.08	2.694AlaLys: 2.694 ± 0.051	14.082AlaLeu: 14.082 ± 0.134	2.681AlaMet: 2.681 ± 0.057	2.131AlaAsn: 2.131 ± 0.046	6.441AlaPro: 6.441 ± 0.098	4.641AlaGln: 4.641 ± 0.078	9.859AlaArg: 9.859 ± 0.13	7.479AlaSer: 7.479 ± 0.09	7.656AlaThr: 7.656 ± 0.107	12.027AlaVal: 12.027 ± 0.135	2.009AlaTrp: 2.009 ± 0.052	2.435AlaTyr: 2.435 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.749CysAla: 0.749 ± 0.025	0.045CysCys: 0.045 ± 0.006	0.356CysAsp: 0.356 ± 0.019	0.28CysGlu: 0.28 ± 0.017	0.157CysPhe: 0.157 ± 0.011	0.541CysGly: 0.541 ± 0.025	0.136CysHis: 0.136 ± 0.011	0.2CysIle: 0.2 ± 0.014	0.066CysLys: 0.066 ± 0.007	0.44CysLeu: 0.44 ± 0.02	0.087CysMet: 0.087 ± 0.01	0.089CysAsn: 0.089 ± 0.01	0.291CysPro: 0.291 ± 0.017	0.112CysGln: 0.112 ± 0.012	0.383CysArg: 0.383 ± 0.019	0.325CysSer: 0.325 ± 0.018	0.374CysThr: 0.374 ± 0.02	0.443CysVal: 0.443 ± 0.02	0.08CysTrp: 0.08 ± 0.009	0.102CysTyr: 0.102 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	10.151AspAla: 10.151 ± 0.127	0.244AspCys: 0.244 ± 0.016	4.991AspAsp: 4.991 ± 0.083	4.579AspGlu: 4.579 ± 0.078	1.737AspPhe: 1.737 ± 0.039	6.049AspGly: 6.049 ± 0.097	1.206AspHis: 1.206 ± 0.031	2.687AspIle: 2.687 ± 0.048	1.165AspLys: 1.165 ± 0.04	5.891AspLeu: 5.891 ± 0.071	0.87AspMet: 0.87 ± 0.029	0.909AspAsn: 0.909 ± 0.031	4.115AspPro: 4.115 ± 0.061	1.671AspGln: 1.671 ± 0.042	4.423AspArg: 4.423 ± 0.073	2.494AspSer: 2.494 ± 0.054	3.047AspThr: 3.047 ± 0.06	5.741AspVal: 5.741 ± 0.074	0.958AspTrp: 0.958 ± 0.028	1.32AspTyr: 1.32 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.569GluAla: 6.569 ± 0.087	0.218GluCys: 0.218 ± 0.014	2.382GluAsp: 2.382 ± 0.05	2.302GluGlu: 2.302 ± 0.057	1.609GluPhe: 1.609 ± 0.043	3.674GluGly: 3.674 ± 0.059	1.491GluHis: 1.491 ± 0.038	2.608GluIle: 2.608 ± 0.054	1.437GluLys: 1.437 ± 0.037	6.267GluLeu: 6.267 ± 0.087	0.863GluMet: 0.863 ± 0.032	1.232GluAsn: 1.232 ± 0.032	2.88GluPro: 2.88 ± 0.06	2.309GluGln: 2.309 ± 0.052	4.96GluArg: 4.96 ± 0.082	2.473GluSer: 2.473 ± 0.049	2.676GluThr: 2.676 ± 0.051	4.414GluVal: 4.414 ± 0.07	0.832GluTrp: 0.832 ± 0.032	1.132GluTyr: 1.132 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.37PheAla: 4.37 ± 0.068	0.174PheCys: 0.174 ± 0.012	2.446PheAsp: 2.446 ± 0.053	1.658PheGlu: 1.658 ± 0.046	1.077PhePhe: 1.077 ± 0.039	3.341PheGly: 3.341 ± 0.069	0.58PheHis: 0.58 ± 0.021	1.218PheIle: 1.218 ± 0.038	0.421PheLys: 0.421 ± 0.019	2.772PheLeu: 2.772 ± 0.057	0.409PheMet: 0.409 ± 0.019	0.655PheAsn: 0.655 ± 0.026	1.356PhePro: 1.356 ± 0.038	0.747PheGln: 0.747 ± 0.026	1.779PheArg: 1.779 ± 0.04	1.734PheSer: 1.734 ± 0.038	2.212PheThr: 2.212 ± 0.043	2.769PheVal: 2.769 ± 0.055	0.529PheTrp: 0.529 ± 0.026	0.666PheTyr: 0.666 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.744GlyAla: 10.744 ± 0.12	0.582GlyCys: 0.582 ± 0.023	5.131GlyAsp: 5.131 ± 0.083	4.655GlyGlu: 4.655 ± 0.063	3.093GlyPhe: 3.093 ± 0.047	7.472GlyGly: 7.472 ± 0.122	1.881GlyHis: 1.881 ± 0.041	4.83GlyIle: 4.83 ± 0.07	2.177GlyLys: 2.177 ± 0.046	8.362GlyLeu: 8.362 ± 0.098	2.147GlyMet: 2.147 ± 0.045	1.631GlyAsn: 1.631 ± 0.041	3.65GlyPro: 3.65 ± 0.064	2.638GlyGln: 2.638 ± 0.05	6.324GlyArg: 6.324 ± 0.082	4.95GlySer: 4.95 ± 0.072	5.607GlyThr: 5.607 ± 0.091	7.872GlyVal: 7.872 ± 0.092	1.703GlyTrp: 1.703 ± 0.048	2.226GlyTyr: 2.226 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.673HisAla: 2.673 ± 0.052	0.106HisCys: 0.106 ± 0.011	1.58HisAsp: 1.58 ± 0.042	1.267HisGlu: 1.267 ± 0.038	0.614HisPhe: 0.614 ± 0.025	2.061HisGly: 2.061 ± 0.042	0.606HisHis: 0.606 ± 0.025	0.813HisIle: 0.813 ± 0.028	0.303HisLys: 0.303 ± 0.014	2.033HisLeu: 2.033 ± 0.04	0.362HisMet: 0.362 ± 0.018	0.356HisAsn: 0.356 ± 0.017	1.671HisPro: 1.671 ± 0.042	0.494HisGln: 0.494 ± 0.024	1.711HisArg: 1.711 ± 0.041	1.01HisSer: 1.01 ± 0.03	1.159HisThr: 1.159 ± 0.04	1.729HisVal: 1.729 ± 0.04	0.298HisTrp: 0.298 ± 0.017	0.426HisTyr: 0.426 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.055IleAla: 7.055 ± 0.09	0.254IleCys: 0.254 ± 0.016	3.57IleAsp: 3.57 ± 0.06	2.715IleGlu: 2.715 ± 0.049	1.186IlePhe: 1.186 ± 0.04	4.667IleGly: 4.667 ± 0.072	0.808IleHis: 0.808 ± 0.032	1.945IleIle: 1.945 ± 0.054	0.719IleLys: 0.719 ± 0.028	3.667IleLeu: 3.667 ± 0.063	0.663IleMet: 0.663 ± 0.026	0.857IleAsn: 0.857 ± 0.03	2.459IlePro: 2.459 ± 0.049	0.979IleGln: 0.979 ± 0.03	2.748IleArg: 2.748 ± 0.058	2.307IleSer: 2.307 ± 0.052	2.95IleThr: 2.95 ± 0.053	4.889IleVal: 4.889 ± 0.071	0.533IleTrp: 0.533 ± 0.024	0.723IleTyr: 0.723 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.511LysAla: 2.511 ± 0.055	0.071LysCys: 0.071 ± 0.009	1.193LysAsp: 1.193 ± 0.034	0.849LysGlu: 0.849 ± 0.032	0.476LysPhe: 0.476 ± 0.02	1.525LysGly: 1.525 ± 0.043	0.438LysHis: 0.438 ± 0.02	1.057LysIle: 1.057 ± 0.036	0.828LysLys: 0.828 ± 0.04	1.89LysLeu: 1.89 ± 0.045	0.412LysMet: 0.412 ± 0.016	0.547LysAsn: 0.547 ± 0.025	1.179LysPro: 1.179 ± 0.035	0.707LysGln: 0.707 ± 0.027	1.446LysArg: 1.446 ± 0.04	1.101LysSer: 1.101 ± 0.036	1.427LysThr: 1.427 ± 0.036	1.788LysVal: 1.788 ± 0.053	0.267LysTrp: 0.267 ± 0.015	0.449LysTyr: 0.449 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.238LeuAla: 14.238 ± 0.136	0.579LeuCys: 0.579 ± 0.021	6.539LeuAsp: 6.539 ± 0.089	4.805LeuGlu: 4.805 ± 0.075	2.874LeuPhe: 2.874 ± 0.061	8.71LeuGly: 8.71 ± 0.103	1.991LeuHis: 1.991 ± 0.046	4.471LeuIle: 4.471 ± 0.082	1.789LeuLys: 1.789 ± 0.043	9.587LeuLeu: 9.587 ± 0.118	1.637LeuMet: 1.637 ± 0.038	1.833LeuAsn: 1.833 ± 0.041	5.359LeuPro: 5.359 ± 0.069	2.683LeuGln: 2.683 ± 0.055	7.613LeuArg: 7.613 ± 0.083	5.766LeuSer: 5.766 ± 0.072	6.304LeuThr: 6.304 ± 0.08	9.25LeuVal: 9.25 ± 0.123	1.289LeuTrp: 1.289 ± 0.037	1.64LeuTyr: 1.64 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.155MetAla: 2.155 ± 0.047	0.107MetCys: 0.107 ± 0.009	0.902MetAsp: 0.902 ± 0.028	0.562MetGlu: 0.562 ± 0.022	0.591MetPhe: 0.591 ± 0.025	1.311MetGly: 1.311 ± 0.038	0.345MetHis: 0.345 ± 0.017	0.857MetIle: 0.857 ± 0.029	0.429MetLys: 0.429 ± 0.019	2.011MetLeu: 2.011 ± 0.045	0.365MetMet: 0.365 ± 0.023	0.472MetAsn: 0.472 ± 0.019	1.268MetPro: 1.268 ± 0.038	0.533MetGln: 0.533 ± 0.019	1.476MetArg: 1.476 ± 0.04	1.497MetSer: 1.497 ± 0.038	1.728MetThr: 1.728 ± 0.037	1.292MetVal: 1.292 ± 0.036	0.235MetTrp: 0.235 ± 0.013	0.296MetTyr: 0.296 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.538AsnAla: 2.538 ± 0.05	0.091AsnCys: 0.091 ± 0.01	1.204AsnAsp: 1.204 ± 0.035	0.903AsnGlu: 0.903 ± 0.03	0.582AsnPhe: 0.582 ± 0.023	1.866AsnGly: 1.866 ± 0.045	0.335AsnHis: 0.335 ± 0.019	0.877AsnIle: 0.877 ± 0.027	0.379AsnLys: 0.379 ± 0.021	1.777AsnLeu: 1.777 ± 0.039	0.319AsnMet: 0.319 ± 0.018	0.439AsnAsn: 0.439 ± 0.02	1.498AsnPro: 1.498 ± 0.039	0.569AsnGln: 0.569 ± 0.026	1.244AsnArg: 1.244 ± 0.037	0.894AsnSer: 0.894 ± 0.029	1.18AsnThr: 1.18 ± 0.041	1.545AsnVal: 1.545 ± 0.039	0.304AsnTrp: 0.304 ± 0.019	0.456AsnTyr: 0.456 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.33ProAla: 7.33 ± 0.106	0.192ProCys: 0.192 ± 0.014	4.192ProAsp: 4.192 ± 0.071	3.376ProGlu: 3.376 ± 0.057	1.658ProPhe: 1.658 ± 0.038	4.823ProGly: 4.823 ± 0.082	1.215ProHis: 1.215 ± 0.033	2.086ProIle: 2.086 ± 0.043	1.017ProLys: 1.017 ± 0.031	4.938ProLeu: 4.938 ± 0.07	0.897ProMet: 0.897 ± 0.027	0.965ProAsn: 0.965 ± 0.03	2.291ProPro: 2.291 ± 0.061	1.619ProGln: 1.619 ± 0.041	3.46ProArg: 3.46 ± 0.056	3.013ProSer: 3.013 ± 0.047	3.369ProThr: 3.369 ± 0.06	4.845ProVal: 4.845 ± 0.069	0.874ProTrp: 0.874 ± 0.029	1.072ProTyr: 1.072 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.865GlnAla: 3.865 ± 0.065	0.145GlnCys: 0.145 ± 0.013	1.306GlnAsp: 1.306 ± 0.035	1.276GlnGlu: 1.276 ± 0.036	0.903GlnPhe: 0.903 ± 0.025	2.104GlnGly: 2.104 ± 0.049	0.69GlnHis: 0.69 ± 0.025	1.556GlnIle: 1.556 ± 0.031	0.779GlnLys: 0.779 ± 0.028	3.441GlnLeu: 3.441 ± 0.052	0.583GlnMet: 0.583 ± 0.024	0.701GlnAsn: 0.701 ± 0.027	1.549GlnPro: 1.549 ± 0.037	1.298GlnGln: 1.298 ± 0.039	2.691GlnArg: 2.691 ± 0.057	1.568GlnSer: 1.568 ± 0.038	1.794GlnThr: 1.794 ± 0.04	2.559GlnVal: 2.559 ± 0.049	0.529GlnTrp: 0.529 ± 0.026	0.603GlnTyr: 0.603 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.553ArgAla: 9.553 ± 0.123	0.337ArgCys: 0.337 ± 0.02	4.517ArgAsp: 4.517 ± 0.071	4.336ArgGlu: 4.336 ± 0.071	2.385ArgPhe: 2.385 ± 0.05	5.562ArgGly: 5.562 ± 0.073	1.728ArgHis: 1.728 ± 0.039	3.564ArgIle: 3.564 ± 0.054	1.386ArgLys: 1.386 ± 0.037	7.438ArgLeu: 7.438 ± 0.1	1.833ArgMet: 1.833 ± 0.047	1.375ArgAsn: 1.375 ± 0.039	3.575ArgPro: 3.575 ± 0.064	2.174ArgGln: 2.174 ± 0.044	7.043ArgArg: 7.043 ± 0.11	4.035ArgSer: 4.035 ± 0.065	4.384ArgThr: 4.384 ± 0.062	6.272ArgVal: 6.272 ± 0.078	1.212ArgTrp: 1.212 ± 0.032	1.623ArgTyr: 1.623 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.159SerAla: 7.159 ± 0.097	0.29SerCys: 0.29 ± 0.018	3.235SerAsp: 3.235 ± 0.063	2.416SerGlu: 2.416 ± 0.05	1.861SerPhe: 1.861 ± 0.042	5.677SerGly: 5.677 ± 0.078	1.027SerHis: 1.027 ± 0.031	2.416SerIle: 2.416 ± 0.053	1.018SerLys: 1.018 ± 0.035	5.219SerLeu: 5.219 ± 0.076	1.167SerMet: 1.167 ± 0.031	0.999SerAsn: 0.999 ± 0.032	3.001SerPro: 3.001 ± 0.052	1.466SerGln: 1.466 ± 0.034	3.7SerArg: 3.7 ± 0.062	3.246SerSer: 3.246 ± 0.063	3.689SerThr: 3.689 ± 0.062	4.515SerVal: 4.515 ± 0.068	0.905SerTrp: 0.905 ± 0.031	1.137SerTyr: 1.137 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.166ThrAla: 8.166 ± 0.104	0.326ThrCys: 0.326 ± 0.02	3.756ThrAsp: 3.756 ± 0.066	2.783ThrGlu: 2.783 ± 0.058	1.93ThrPhe: 1.93 ± 0.046	5.986ThrGly: 5.986 ± 0.082	1.252ThrHis: 1.252 ± 0.034	2.902ThrIle: 2.902 ± 0.051	1.22ThrLys: 1.22 ± 0.037	6.112ThrLeu: 6.112 ± 0.085	1.021ThrMet: 1.021 ± 0.031	1.164ThrAsn: 1.164 ± 0.038	3.987ThrPro: 3.987 ± 0.058	1.676ThrGln: 1.676 ± 0.039	3.935ThrArg: 3.935 ± 0.066	3.41ThrSer: 3.41 ± 0.061	4.098ThrThr: 4.098 ± 0.083	5.957ThrVal: 5.957 ± 0.088	0.925ThrTrp: 0.925 ± 0.03	1.178ThrTyr: 1.178 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	11.971ValAla: 11.971 ± 0.137	0.589ValCys: 0.589 ± 0.024	5.905ValAsp: 5.905 ± 0.074	4.386ValGlu: 4.386 ± 0.073	3.04ValPhe: 3.04 ± 0.05	6.922ValGly: 6.922 ± 0.095	1.917ValHis: 1.917 ± 0.045	4.484ValIle: 4.484 ± 0.07	1.614ValLys: 1.614 ± 0.041	9.149ValLeu: 9.149 ± 0.109	1.421ValMet: 1.421 ± 0.037	1.764ValAsn: 1.764 ± 0.046	4.805ValPro: 4.805 ± 0.066	2.446ValGln: 2.446 ± 0.046	6.502ValArg: 6.502 ± 0.075	4.956ValSer: 4.956 ± 0.073	6.002ValThr: 6.002 ± 0.091	8.791ValVal: 8.791 ± 0.115	1.204ValTrp: 1.204 ± 0.038	1.578ValTyr: 1.578 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.713TrpAla: 1.713 ± 0.044	0.102TrpCys: 0.102 ± 0.009	0.859TrpAsp: 0.859 ± 0.028	0.639TrpGlu: 0.639 ± 0.026	0.578TrpPhe: 0.578 ± 0.026	1.085TrpGly: 1.085 ± 0.031	0.396TrpHis: 0.396 ± 0.019	0.742TrpIle: 0.742 ± 0.028	0.33TrpLys: 0.33 ± 0.019	1.737TrpLeu: 1.737 ± 0.046	0.41TrpMet: 0.41 ± 0.021	0.451TrpAsn: 0.451 ± 0.02	0.776TrpPro: 0.776 ± 0.03	0.594TrpGln: 0.594 ± 0.024	1.335TrpArg: 1.335 ± 0.041	0.885TrpSer: 0.885 ± 0.029	0.891TrpThr: 0.891 ± 0.034	1.185TrpVal: 1.185 ± 0.036	0.38TrpTrp: 0.38 ± 0.021	0.298TrpTyr: 0.298 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.414TyrAla: 2.414 ± 0.051	0.114TyrCys: 0.114 ± 0.009	1.368TyrAsp: 1.368 ± 0.034	1.053TyrGlu: 1.053 ± 0.031	0.668TyrPhe: 0.668 ± 0.026	1.939TyrGly: 1.939 ± 0.049	0.309TyrHis: 0.309 ± 0.017	0.76TyrIle: 0.76 ± 0.027	0.389TyrLys: 0.389 ± 0.021	2.142TyrLeu: 2.142 ± 0.046	0.281TyrMet: 0.281 ± 0.016	0.431TyrAsn: 0.431 ± 0.023	1.08TyrPro: 1.08 ± 0.034	0.587TyrGln: 0.587 ± 0.023	1.702TyrArg: 1.702 ± 0.046	1.002TyrSer: 1.002 ± 0.032	1.239TyrThr: 1.239 ± 0.046	1.559TyrVal: 1.559 ± 0.037	0.323TyrTrp: 0.323 ± 0.016	0.455TyrTyr: 0.455 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3400 proteins (1112479 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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