Amino acid dipepetide frequency for spirochete symbiont of Stewartia floridana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.648AlaAla: 11.648 ± 0.306
1.13AlaCys: 1.13 ± 0.072
5.452AlaAsp: 5.452 ± 0.162
6.019AlaGlu: 6.019 ± 0.177
3.391AlaPhe: 3.391 ± 0.135
8.093AlaGly: 8.093 ± 0.189
1.598AlaHis: 1.598 ± 0.077
5.478AlaIle: 5.478 ± 0.167
3.611AlaLys: 3.611 ± 0.118
10.167AlaLeu: 10.167 ± 0.227
2.728AlaMet: 2.728 ± 0.113
2.23AlaAsn: 2.23 ± 0.097
3.109AlaPro: 3.109 ± 0.141
2.542AlaGln: 2.542 ± 0.087
5.521AlaArg: 5.521 ± 0.159
4.789AlaSer: 4.789 ± 0.169
2.789AlaThr: 2.789 ± 0.12
7.976AlaVal: 7.976 ± 0.21
1.247AlaTrp: 1.247 ± 0.079
2.23AlaTyr: 2.23 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
1.018CysAla: 1.018 ± 0.059
0.152CysCys: 0.152 ± 0.027
0.58CysAsp: 0.58 ± 0.053
0.58CysGlu: 0.58 ± 0.052
0.381CysPhe: 0.381 ± 0.039
1.165CysGly: 1.165 ± 0.077
0.312CysHis: 0.312 ± 0.038
0.624CysIle: 0.624 ± 0.054
0.364CysLys: 0.364 ± 0.042
1.13CysLeu: 1.13 ± 0.071
0.242CysMet: 0.242 ± 0.032
0.294CysAsn: 0.294 ± 0.034
0.693CysPro: 0.693 ± 0.054
0.29CysGln: 0.29 ± 0.04
1.104CysArg: 1.104 ± 0.067
0.697CysSer: 0.697 ± 0.064
0.511CysThr: 0.511 ± 0.048
0.602CysVal: 0.602 ± 0.055
0.169CysTrp: 0.169 ± 0.03
0.303CysTyr: 0.303 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
5.11AspAla: 5.11 ± 0.151
0.654AspCys: 0.654 ± 0.052
2.988AspAsp: 2.988 ± 0.142
4.222AspGlu: 4.222 ± 0.146
2.308AspPhe: 2.308 ± 0.101
4.811AspGly: 4.811 ± 0.17
0.948AspHis: 0.948 ± 0.06
4.135AspIle: 4.135 ± 0.143
2.377AspLys: 2.377 ± 0.103
4.46AspLeu: 4.46 ± 0.142
1.524AspMet: 1.524 ± 0.089
1.736AspAsn: 1.736 ± 0.089
2.377AspPro: 2.377 ± 0.117
1.26AspGln: 1.26 ± 0.083
3.447AspArg: 3.447 ± 0.142
3.776AspSer: 3.776 ± 0.14
2.689AspThr: 2.689 ± 0.102
3.295AspVal: 3.295 ± 0.132
0.909AspTrp: 0.909 ± 0.059
1.892AspTyr: 1.892 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
5.79GluAla: 5.79 ± 0.17
0.576GluCys: 0.576 ± 0.045
3.36GluAsp: 3.36 ± 0.132
4.768GluGlu: 4.768 ± 0.163
2.499GluPhe: 2.499 ± 0.099
4.763GluGly: 4.763 ± 0.147
1.195GluHis: 1.195 ± 0.082
4.82GluIle: 4.82 ± 0.142
3.62GluLys: 3.62 ± 0.154
5.928GluLeu: 5.928 ± 0.161
1.897GluMet: 1.897 ± 0.093
2.858GluAsn: 2.858 ± 0.1
2.053GluPro: 2.053 ± 0.092
1.979GluGln: 1.979 ± 0.101
4.127GluArg: 4.127 ± 0.156
4.161GluSer: 4.161 ± 0.148
3.36GluThr: 3.36 ± 0.11
3.928GluVal: 3.928 ± 0.137
0.862GluTrp: 0.862 ± 0.071
1.832GluTyr: 1.832 ± 0.1
0.0GluXaa: 0.0 ± 0.0
Phe
3.049PheAla: 3.049 ± 0.135
0.446PheCys: 0.446 ± 0.044
2.325PheAsp: 2.325 ± 0.094
2.13PheGlu: 2.13 ± 0.089
1.754PhePhe: 1.754 ± 0.099
3.269PheGly: 3.269 ± 0.145
1.039PheHis: 1.039 ± 0.063
2.819PheIle: 2.819 ± 0.135
1.503PheLys: 1.503 ± 0.081
4.317PheLeu: 4.317 ± 0.165
0.797PheMet: 0.797 ± 0.057
1.36PheAsn: 1.36 ± 0.084
2.092PhePro: 2.092 ± 0.094
1.273PheGln: 1.273 ± 0.075
2.52PheArg: 2.52 ± 0.12
3.04PheSer: 3.04 ± 0.114
2.135PheThr: 2.135 ± 0.092
2.36PheVal: 2.36 ± 0.105
0.424PheTrp: 0.424 ± 0.045
1.126PheTyr: 1.126 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
6.863GlyAla: 6.863 ± 0.185
1.109GlyCys: 1.109 ± 0.07
4.062GlyAsp: 4.062 ± 0.142
4.984GlyGlu: 4.984 ± 0.179
3.598GlyPhe: 3.598 ± 0.121
6.604GlyGly: 6.604 ± 0.181
1.84GlyHis: 1.84 ± 0.096
6.643GlyIle: 6.643 ± 0.219
4.014GlyLys: 4.014 ± 0.141
8.067GlyLeu: 8.067 ± 0.185
2.784GlyMet: 2.784 ± 0.089
2.784GlyAsn: 2.784 ± 0.112
2.538GlyPro: 2.538 ± 0.114
2.473GlyGln: 2.473 ± 0.097
5.872GlyArg: 5.872 ± 0.156
4.988GlySer: 4.988 ± 0.155
3.954GlyThr: 3.954 ± 0.146
5.188GlyVal: 5.188 ± 0.153
1.026GlyTrp: 1.026 ± 0.069
2.884GlyTyr: 2.884 ± 0.113
0.0GlyXaa: 0.0 ± 0.0
His
1.749HisAla: 1.749 ± 0.085
0.281HisCys: 0.281 ± 0.04
1.035HisAsp: 1.035 ± 0.073
1.234HisGlu: 1.234 ± 0.068
0.844HisPhe: 0.844 ± 0.056
2.035HisGly: 2.035 ± 0.099
0.58HisHis: 0.58 ± 0.052
1.49HisIle: 1.49 ± 0.076
0.714HisLys: 0.714 ± 0.053
2.122HisLeu: 2.122 ± 0.096
0.32HisMet: 0.32 ± 0.034
0.637HisAsn: 0.637 ± 0.063
1.394HisPro: 1.394 ± 0.077
0.576HisGln: 0.576 ± 0.044
1.732HisArg: 1.732 ± 0.081
1.433HisSer: 1.433 ± 0.075
0.953HisThr: 0.953 ± 0.074
1.256HisVal: 1.256 ± 0.06
0.294HisTrp: 0.294 ± 0.031
0.632HisTyr: 0.632 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
6.747IleAla: 6.747 ± 0.207
0.801IleCys: 0.801 ± 0.067
4.274IleAsp: 4.274 ± 0.134
4.153IleGlu: 4.153 ± 0.128
2.377IlePhe: 2.377 ± 0.12
5.53IleGly: 5.53 ± 0.177
1.55IleHis: 1.55 ± 0.077
4.534IleIle: 4.534 ± 0.173
2.754IleLys: 2.754 ± 0.111
7.383IleLeu: 7.383 ± 0.201
1.55IleMet: 1.55 ± 0.096
2.269IleAsn: 2.269 ± 0.109
3.936IlePro: 3.936 ± 0.135
1.988IleGln: 1.988 ± 0.08
4.443IleArg: 4.443 ± 0.14
4.755IleSer: 4.755 ± 0.17
3.594IleThr: 3.594 ± 0.151
4.161IleVal: 4.161 ± 0.14
0.689IleTrp: 0.689 ± 0.055
1.607IleTyr: 1.607 ± 0.093
0.0IleXaa: 0.0 ± 0.0
Lys
4.287LysAla: 4.287 ± 0.138
0.32LysCys: 0.32 ± 0.039
2.447LysAsp: 2.447 ± 0.118
3.308LysGlu: 3.308 ± 0.119
1.156LysPhe: 1.156 ± 0.077
3.564LysGly: 3.564 ± 0.13
0.957LysHis: 0.957 ± 0.062
2.75LysIle: 2.75 ± 0.121
2.875LysLys: 2.875 ± 0.134
3.698LysLeu: 3.698 ± 0.133
1.031LysMet: 1.031 ± 0.071
2.061LysAsn: 2.061 ± 0.093
2.035LysPro: 2.035 ± 0.098
1.364LysGln: 1.364 ± 0.086
2.789LysArg: 2.789 ± 0.117
2.906LysSer: 2.906 ± 0.113
3.079LysThr: 3.079 ± 0.11
2.906LysVal: 2.906 ± 0.118
0.576LysTrp: 0.576 ± 0.051
1.165LysTyr: 1.165 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
9.457LeuAla: 9.457 ± 0.226
1.104LeuCys: 1.104 ± 0.072
5.725LeuAsp: 5.725 ± 0.157
6.214LeuGlu: 6.214 ± 0.186
4.031LeuPhe: 4.031 ± 0.189
7.487LeuGly: 7.487 ± 0.218
2.001LeuHis: 2.001 ± 0.085
7.123LeuIle: 7.123 ± 0.186
5.279LeuLys: 5.279 ± 0.178
9.877LeuLeu: 9.877 ± 0.295
2.507LeuMet: 2.507 ± 0.11
3.585LeuAsn: 3.585 ± 0.122
5.309LeuPro: 5.309 ± 0.179
2.737LeuGln: 2.737 ± 0.111
6.058LeuArg: 6.058 ± 0.167
7.565LeuSer: 7.565 ± 0.194
5.014LeuThr: 5.014 ± 0.138
5.803LeuVal: 5.803 ± 0.19
1.117LeuTrp: 1.117 ± 0.073
2.494LeuTyr: 2.494 ± 0.102
0.0LeuXaa: 0.0 ± 0.0
Met
3.187MetAla: 3.187 ± 0.112
0.139MetCys: 0.139 ± 0.027
1.49MetAsp: 1.49 ± 0.087
1.957MetGlu: 1.957 ± 0.098
0.645MetPhe: 0.645 ± 0.053
2.152MetGly: 2.152 ± 0.092
0.433MetHis: 0.433 ± 0.04
1.793MetIle: 1.793 ± 0.092
1.806MetLys: 1.806 ± 0.086
2.464MetLeu: 2.464 ± 0.109
0.857MetMet: 0.857 ± 0.066
1.243MetAsn: 1.243 ± 0.074
1.42MetPro: 1.42 ± 0.08
0.645MetGln: 0.645 ± 0.051
1.736MetArg: 1.736 ± 0.093
1.65MetSer: 1.65 ± 0.086
1.42MetThr: 1.42 ± 0.077
1.689MetVal: 1.689 ± 0.09
0.104MetTrp: 0.104 ± 0.022
0.407MetTyr: 0.407 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.07AsnAla: 3.07 ± 0.11
0.381AsnCys: 0.381 ± 0.038
1.62AsnAsp: 1.62 ± 0.092
1.936AsnGlu: 1.936 ± 0.095
1.321AsnPhe: 1.321 ± 0.079
2.607AsnGly: 2.607 ± 0.105
0.684AsnHis: 0.684 ± 0.053
2.373AsnIle: 2.373 ± 0.095
1.338AsnLys: 1.338 ± 0.084
3.889AsnLeu: 3.889 ± 0.141
0.81AsnMet: 0.81 ± 0.064
0.953AsnAsn: 0.953 ± 0.07
2.611AsnPro: 2.611 ± 0.09
1.061AsnGln: 1.061 ± 0.069
2.538AsnArg: 2.538 ± 0.108
2.312AsnSer: 2.312 ± 0.103
1.62AsnThr: 1.62 ± 0.09
1.793AsnVal: 1.793 ± 0.099
0.489AsnTrp: 0.489 ± 0.051
0.918AsnTyr: 0.918 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
4.079ProAla: 4.079 ± 0.151
0.481ProCys: 0.481 ± 0.049
3.023ProAsp: 3.023 ± 0.122
3.585ProGlu: 3.585 ± 0.126
1.979ProPhe: 1.979 ± 0.092
4.33ProGly: 4.33 ± 0.142
1.005ProHis: 1.005 ± 0.061
2.59ProIle: 2.59 ± 0.118
1.628ProLys: 1.628 ± 0.072
4.499ProLeu: 4.499 ± 0.148
1.165ProMet: 1.165 ± 0.069
1.286ProAsn: 1.286 ± 0.087
2.351ProPro: 2.351 ± 0.109
1.472ProGln: 1.472 ± 0.086
2.412ProArg: 2.412 ± 0.095
3.079ProSer: 3.079 ± 0.103
1.671ProThr: 1.671 ± 0.094
3.611ProVal: 3.611 ± 0.147
0.702ProTrp: 0.702 ± 0.053
1.451ProTyr: 1.451 ± 0.089
0.0ProXaa: 0.0 ± 0.0
Gln
2.815GlnAla: 2.815 ± 0.114
0.286GlnCys: 0.286 ± 0.033
1.589GlnAsp: 1.589 ± 0.08
2.053GlnGlu: 2.053 ± 0.104
1.251GlnPhe: 1.251 ± 0.07
2.399GlnGly: 2.399 ± 0.097
0.55GlnHis: 0.55 ± 0.053
1.897GlnIle: 1.897 ± 0.093
1.247GlnLys: 1.247 ± 0.073
2.334GlnLeu: 2.334 ± 0.112
0.905GlnMet: 0.905 ± 0.073
1.13GlnAsn: 1.13 ± 0.069
1.139GlnPro: 1.139 ± 0.087
0.857GlnGln: 0.857 ± 0.065
1.78GlnArg: 1.78 ± 0.093
1.927GlnSer: 1.927 ± 0.089
1.477GlnThr: 1.477 ± 0.086
1.858GlnVal: 1.858 ± 0.079
0.524GlnTrp: 0.524 ± 0.052
0.996GlnTyr: 0.996 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
4.395ArgAla: 4.395 ± 0.143
0.805ArgCys: 0.805 ± 0.056
3.356ArgAsp: 3.356 ± 0.122
4.343ArgGlu: 4.343 ± 0.15
2.767ArgPhe: 2.767 ± 0.125
4.469ArgGly: 4.469 ± 0.125
1.923ArgHis: 1.923 ± 0.094
5.058ArgIle: 5.058 ± 0.151
3.096ArgLys: 3.096 ± 0.1
7.457ArgLeu: 7.457 ± 0.169
1.944ArgMet: 1.944 ± 0.092
2.468ArgAsn: 2.468 ± 0.109
2.516ArgPro: 2.516 ± 0.129
2.213ArgGln: 2.213 ± 0.108
5.153ArgArg: 5.153 ± 0.171
3.447ArgSer: 3.447 ± 0.12
2.81ArgThr: 2.81 ± 0.118
4.2ArgVal: 4.2 ± 0.138
0.849ArgTrp: 0.849 ± 0.065
2.105ArgTyr: 2.105 ± 0.097
0.0ArgXaa: 0.0 ± 0.0
Ser
5.755SerAla: 5.755 ± 0.164
0.753SerCys: 0.753 ± 0.062
3.126SerAsp: 3.126 ± 0.112
3.585SerGlu: 3.585 ± 0.128
2.858SerPhe: 2.858 ± 0.111
6.409SerGly: 6.409 ± 0.173
1.472SerHis: 1.472 ± 0.085
4.439SerIle: 4.439 ± 0.134
2.46SerLys: 2.46 ± 0.105
6.946SerLeu: 6.946 ± 0.185
1.936SerMet: 1.936 ± 0.093
1.849SerAsn: 1.849 ± 0.101
3.239SerPro: 3.239 ± 0.12
1.871SerGln: 1.871 ± 0.092
4.551SerArg: 4.551 ± 0.132
4.283SerSer: 4.283 ± 0.139
2.685SerThr: 2.685 ± 0.126
3.984SerVal: 3.984 ± 0.145
0.931SerTrp: 0.931 ± 0.065
1.654SerTyr: 1.654 ± 0.088
0.0SerXaa: 0.0 ± 0.0
Thr
5.075ThrAla: 5.075 ± 0.165
0.463ThrCys: 0.463 ± 0.041
2.724ThrAsp: 2.724 ± 0.107
2.568ThrGlu: 2.568 ± 0.098
1.568ThrPhe: 1.568 ± 0.085
5.062ThrGly: 5.062 ± 0.178
0.948ThrHis: 0.948 ± 0.058
3.07ThrIle: 3.07 ± 0.136
1.589ThrLys: 1.589 ± 0.08
4.85ThrLeu: 4.85 ± 0.138
1.269ThrMet: 1.269 ± 0.08
1.355ThrAsn: 1.355 ± 0.085
2.438ThrPro: 2.438 ± 0.101
1.251ThrGln: 1.251 ± 0.075
2.598ThrArg: 2.598 ± 0.103
2.59ThrSer: 2.59 ± 0.13
1.914ThrThr: 1.914 ± 0.106
3.78ThrVal: 3.78 ± 0.121
0.689ThrTrp: 0.689 ± 0.058
1.139ThrTyr: 1.139 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.382ValAla: 4.382 ± 0.154
0.81ValCys: 0.81 ± 0.058
3.521ValAsp: 3.521 ± 0.118
4.252ValGlu: 4.252 ± 0.126
3.347ValPhe: 3.347 ± 0.137
4.222ValGly: 4.222 ± 0.14
1.364ValHis: 1.364 ± 0.088
4.893ValIle: 4.893 ± 0.156
3.2ValLys: 3.2 ± 0.122
6.786ValLeu: 6.786 ± 0.171
1.91ValMet: 1.91 ± 0.095
2.711ValAsn: 2.711 ± 0.116
3.07ValPro: 3.07 ± 0.134
1.806ValGln: 1.806 ± 0.079
3.897ValArg: 3.897 ± 0.125
4.763ValSer: 4.763 ± 0.129
3.053ValThr: 3.053 ± 0.13
3.993ValVal: 3.993 ± 0.133
0.68ValTrp: 0.68 ± 0.058
1.957ValTyr: 1.957 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.068
0.16TrpCys: 0.16 ± 0.029
0.702TrpAsp: 0.702 ± 0.061
0.788TrpGlu: 0.788 ± 0.059
0.528TrpPhe: 0.528 ± 0.052
0.862TrpGly: 0.862 ± 0.068
0.251TrpHis: 0.251 ± 0.032
0.797TrpIle: 0.797 ± 0.06
0.641TrpLys: 0.641 ± 0.058
1.368TrpLeu: 1.368 ± 0.081
0.385TrpMet: 0.385 ± 0.037
0.554TrpAsn: 0.554 ± 0.051
0.598TrpPro: 0.598 ± 0.056
0.507TrpGln: 0.507 ± 0.047
1.0TrpArg: 1.0 ± 0.071
0.771TrpSer: 0.771 ± 0.056
0.645TrpThr: 0.645 ± 0.057
0.753TrpVal: 0.753 ± 0.064
0.23TrpTrp: 0.23 ± 0.035
0.39TrpTyr: 0.39 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.334TyrAla: 2.334 ± 0.11
0.359TyrCys: 0.359 ± 0.039
1.524TyrAsp: 1.524 ± 0.07
1.693TyrGlu: 1.693 ± 0.101
1.174TyrPhe: 1.174 ± 0.075
2.442TyrGly: 2.442 ± 0.097
0.663TyrHis: 0.663 ± 0.056
1.771TyrIle: 1.771 ± 0.085
1.156TyrLys: 1.156 ± 0.07
2.745TyrLeu: 2.745 ± 0.11
0.676TyrMet: 0.676 ± 0.052
0.957TyrAsn: 0.957 ± 0.063
1.477TyrPro: 1.477 ± 0.09
0.849TyrGln: 0.849 ± 0.066
2.096TyrArg: 2.096 ± 0.102
1.858TyrSer: 1.858 ± 0.092
1.568TyrThr: 1.568 ± 0.084
1.481TyrVal: 1.481 ± 0.081
0.359TyrTrp: 0.359 ± 0.042
0.784TyrTyr: 0.784 ± 0.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 817 proteins (230933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski