Amino acid dipepetide frequency for Idiomarina tyrosinivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.235AlaAla: 10.235 ± 0.143
0.923AlaCys: 0.923 ± 0.045
5.79AlaAsp: 5.79 ± 0.096
7.217AlaGlu: 7.217 ± 0.112
3.395AlaPhe: 3.395 ± 0.069
6.574AlaGly: 6.574 ± 0.107
1.746AlaHis: 1.746 ± 0.054
6.189AlaIle: 6.189 ± 0.118
4.868AlaLys: 4.868 ± 0.093
11.203AlaLeu: 11.203 ± 0.129
2.768AlaMet: 2.768 ± 0.072
3.501AlaAsn: 3.501 ± 0.075
3.32AlaPro: 3.32 ± 0.075
5.003AlaGln: 5.003 ± 0.103
4.68AlaArg: 4.68 ± 0.087
5.542AlaSer: 5.542 ± 0.088
4.966AlaThr: 4.966 ± 0.087
7.12AlaVal: 7.12 ± 0.109
1.185AlaTrp: 1.185 ± 0.045
2.368AlaTyr: 2.368 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.749CysAla: 0.749 ± 0.037
0.149CysCys: 0.149 ± 0.014
0.517CysAsp: 0.517 ± 0.029
0.556CysGlu: 0.556 ± 0.032
0.363CysPhe: 0.363 ± 0.023
0.801CysGly: 0.801 ± 0.037
0.281CysHis: 0.281 ± 0.021
0.419CysIle: 0.419 ± 0.026
0.281CysLys: 0.281 ± 0.021
0.851CysLeu: 0.851 ± 0.038
0.176CysMet: 0.176 ± 0.015
0.256CysAsn: 0.256 ± 0.02
0.421CysPro: 0.421 ± 0.028
0.533CysGln: 0.533 ± 0.028
0.519CysArg: 0.519 ± 0.027
0.586CysSer: 0.586 ± 0.031
0.342CysThr: 0.342 ± 0.021
0.571CysVal: 0.571 ± 0.026
0.15CysTrp: 0.15 ± 0.013
0.304CysTyr: 0.304 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.281AspAla: 5.281 ± 0.087
0.496AspCys: 0.496 ± 0.029
3.693AspAsp: 3.693 ± 0.089
4.063AspGlu: 4.063 ± 0.084
2.341AspPhe: 2.341 ± 0.06
4.06AspGly: 4.06 ± 0.104
1.14AspHis: 1.14 ± 0.037
3.808AspIle: 3.808 ± 0.088
2.704AspLys: 2.704 ± 0.074
4.841AspLeu: 4.841 ± 0.075
1.357AspMet: 1.357 ± 0.045
2.323AspAsn: 2.323 ± 0.064
2.325AspPro: 2.325 ± 0.058
2.313AspGln: 2.313 ± 0.057
2.57AspArg: 2.57 ± 0.066
3.255AspSer: 3.255 ± 0.071
2.636AspThr: 2.636 ± 0.064
4.224AspVal: 4.224 ± 0.084
1.004AspTrp: 1.004 ± 0.043
2.232AspTyr: 2.232 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.557GluAla: 5.557 ± 0.105
0.422GluCys: 0.422 ± 0.025
2.884GluAsp: 2.884 ± 0.072
3.302GluGlu: 3.302 ± 0.093
2.196GluPhe: 2.196 ± 0.052
3.501GluGly: 3.501 ± 0.072
1.72GluHis: 1.72 ± 0.051
3.292GluIle: 3.292 ± 0.076
3.205GluLys: 3.205 ± 0.074
6.674GluLeu: 6.674 ± 0.105
1.581GluMet: 1.581 ± 0.048
2.319GluAsn: 2.319 ± 0.057
2.311GluPro: 2.311 ± 0.062
5.357GluGln: 5.357 ± 0.107
4.368GluArg: 4.368 ± 0.089
3.115GluSer: 3.115 ± 0.065
2.917GluThr: 2.917 ± 0.07
4.086GluVal: 4.086 ± 0.083
0.801GluTrp: 0.801 ± 0.03
1.637GluTyr: 1.637 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.926PheAla: 3.926 ± 0.069
0.425PheCys: 0.425 ± 0.024
2.488PheAsp: 2.488 ± 0.067
2.168PheGlu: 2.168 ± 0.061
1.58PhePhe: 1.58 ± 0.055
2.933PheGly: 2.933 ± 0.073
0.84PheHis: 0.84 ± 0.035
2.223PheIle: 2.223 ± 0.062
1.312PheLys: 1.312 ± 0.039
3.007PheLeu: 3.007 ± 0.074
0.821PheMet: 0.821 ± 0.038
1.591PheAsn: 1.591 ± 0.044
1.422PhePro: 1.422 ± 0.043
1.404PheGln: 1.404 ± 0.045
1.867PheArg: 1.867 ± 0.052
2.916PheSer: 2.916 ± 0.065
2.196PheThr: 2.196 ± 0.052
2.574PheVal: 2.574 ± 0.071
0.563PheTrp: 0.563 ± 0.028
1.313PheTyr: 1.313 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.6GlyAla: 5.6 ± 0.097
0.742GlyCys: 0.742 ± 0.031
3.862GlyAsp: 3.862 ± 0.084
4.621GlyGlu: 4.621 ± 0.078
3.216GlyPhe: 3.216 ± 0.075
4.942GlyGly: 4.942 ± 0.107
1.637GlyHis: 1.637 ± 0.051
4.282GlyIle: 4.282 ± 0.073
3.603GlyLys: 3.603 ± 0.085
6.992GlyLeu: 6.992 ± 0.12
1.915GlyMet: 1.915 ± 0.061
2.443GlyAsn: 2.443 ± 0.075
1.848GlyPro: 1.848 ± 0.052
3.231GlyGln: 3.231 ± 0.068
3.484GlyArg: 3.484 ± 0.072
4.019GlySer: 4.019 ± 0.079
3.33GlyThr: 3.33 ± 0.086
5.329GlyVal: 5.329 ± 0.091
1.056GlyTrp: 1.056 ± 0.041
2.483GlyTyr: 2.483 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.905HisAla: 1.905 ± 0.055
0.364HisCys: 0.364 ± 0.025
1.235HisAsp: 1.235 ± 0.045
1.148HisGlu: 1.148 ± 0.038
0.989HisPhe: 0.989 ± 0.038
1.691HisGly: 1.691 ± 0.048
0.705HisHis: 0.705 ± 0.036
1.266HisIle: 1.266 ± 0.044
0.848HisLys: 0.848 ± 0.036
2.169HisLeu: 2.169 ± 0.063
0.469HisMet: 0.469 ± 0.024
0.77HisAsn: 0.77 ± 0.031
1.34HisPro: 1.34 ± 0.053
1.444HisGln: 1.444 ± 0.046
1.273HisArg: 1.273 ± 0.044
1.348HisSer: 1.348 ± 0.043
0.896HisThr: 0.896 ± 0.036
1.288HisVal: 1.288 ± 0.05
0.507HisTrp: 0.507 ± 0.029
0.927HisTyr: 0.927 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.589IleAla: 6.589 ± 0.102
0.489IleCys: 0.489 ± 0.026
4.118IleAsp: 4.118 ± 0.078
3.997IleGlu: 3.997 ± 0.09
1.775IlePhe: 1.775 ± 0.056
4.245IleGly: 4.245 ± 0.094
1.16IleHis: 1.16 ± 0.045
3.138IleIle: 3.138 ± 0.072
2.354IleLys: 2.354 ± 0.055
4.368IleLeu: 4.368 ± 0.098
1.047IleMet: 1.047 ± 0.036
2.289IleAsn: 2.289 ± 0.065
2.491IlePro: 2.491 ± 0.057
2.015IleGln: 2.015 ± 0.05
3.001IleArg: 3.001 ± 0.07
3.642IleSer: 3.642 ± 0.073
3.103IleThr: 3.103 ± 0.064
3.871IleVal: 3.871 ± 0.08
0.599IleTrp: 0.599 ± 0.029
1.493IleTyr: 1.493 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.761LysAla: 4.761 ± 0.105
0.232LysCys: 0.232 ± 0.019
2.27LysAsp: 2.27 ± 0.067
2.279LysGlu: 2.279 ± 0.063
1.233LysPhe: 1.233 ± 0.046
2.799LysGly: 2.799 ± 0.08
1.042LysHis: 1.042 ± 0.04
2.135LysIle: 2.135 ± 0.058
2.169LysLys: 2.169 ± 0.074
4.427LysLeu: 4.427 ± 0.082
1.022LysMet: 1.022 ± 0.042
1.503LysAsn: 1.503 ± 0.052
2.263LysPro: 2.263 ± 0.052
2.987LysGln: 2.987 ± 0.064
3.012LysArg: 3.012 ± 0.062
2.443LysSer: 2.443 ± 0.066
2.338LysThr: 2.338 ± 0.059
3.276LysVal: 3.276 ± 0.084
0.415LysTrp: 0.415 ± 0.024
1.067LysTyr: 1.067 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
11.905LeuAla: 11.905 ± 0.144
0.887LeuCys: 0.887 ± 0.036
5.506LeuAsp: 5.506 ± 0.091
5.676LeuGlu: 5.676 ± 0.101
3.776LeuPhe: 3.776 ± 0.101
7.095LeuGly: 7.095 ± 0.102
2.207LeuHis: 2.207 ± 0.058
5.153LeuIle: 5.153 ± 0.097
4.445LeuLys: 4.445 ± 0.082
11.838LeuLeu: 11.838 ± 0.213
2.553LeuMet: 2.553 ± 0.067
3.886LeuAsn: 3.886 ± 0.067
4.967LeuPro: 4.967 ± 0.091
5.786LeuGln: 5.786 ± 0.114
5.793LeuArg: 5.793 ± 0.098
7.021LeuSer: 7.021 ± 0.115
6.322LeuThr: 6.322 ± 0.1
6.918LeuVal: 6.918 ± 0.11
1.261LeuTrp: 1.261 ± 0.051
2.559LeuTyr: 2.559 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.677MetAla: 2.677 ± 0.059
0.129MetCys: 0.129 ± 0.012
1.127MetAsp: 1.127 ± 0.041
1.1MetGlu: 1.1 ± 0.042
0.73MetPhe: 0.73 ± 0.034
1.603MetGly: 1.603 ± 0.055
0.431MetHis: 0.431 ± 0.026
1.115MetIle: 1.115 ± 0.04
1.252MetLys: 1.252 ± 0.044
2.589MetLeu: 2.589 ± 0.059
0.653MetMet: 0.653 ± 0.028
0.954MetAsn: 0.954 ± 0.034
1.229MetPro: 1.229 ± 0.039
1.304MetGln: 1.304 ± 0.041
1.363MetArg: 1.363 ± 0.038
1.777MetSer: 1.777 ± 0.053
1.511MetThr: 1.511 ± 0.045
1.753MetVal: 1.753 ± 0.048
0.225MetTrp: 0.225 ± 0.019
0.445MetTyr: 0.445 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.578AsnAla: 3.578 ± 0.07
0.289AsnCys: 0.289 ± 0.019
2.388AsnAsp: 2.388 ± 0.06
2.049AsnGlu: 2.049 ± 0.056
1.261AsnPhe: 1.261 ± 0.042
2.89AsnGly: 2.89 ± 0.064
0.77AsnHis: 0.77 ± 0.032
2.109AsnIle: 2.109 ± 0.058
1.494AsnLys: 1.494 ± 0.047
3.283AsnLeu: 3.283 ± 0.07
0.769AsnMet: 0.769 ± 0.037
1.51AsnAsn: 1.51 ± 0.059
1.936AsnPro: 1.936 ± 0.052
1.98AsnGln: 1.98 ± 0.058
2.019AsnArg: 2.019 ± 0.054
2.055AsnSer: 2.055 ± 0.063
1.917AsnThr: 1.917 ± 0.06
2.453AsnVal: 2.453 ± 0.058
0.567AsnTrp: 0.567 ± 0.028
1.135AsnTyr: 1.135 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.737ProAla: 3.737 ± 0.074
0.265ProCys: 0.265 ± 0.019
2.448ProAsp: 2.448 ± 0.054
3.371ProGlu: 3.371 ± 0.07
1.574ProPhe: 1.574 ± 0.049
2.6ProGly: 2.6 ± 0.056
0.859ProHis: 0.859 ± 0.032
2.164ProIle: 2.164 ± 0.053
1.892ProLys: 1.892 ± 0.057
4.522ProLeu: 4.522 ± 0.086
1.032ProMet: 1.032 ± 0.035
1.678ProAsn: 1.678 ± 0.047
1.292ProPro: 1.292 ± 0.045
2.468ProGln: 2.468 ± 0.061
1.804ProArg: 1.804 ± 0.053
2.527ProSer: 2.527 ± 0.055
2.062ProThr: 2.062 ± 0.052
3.161ProVal: 3.161 ± 0.072
0.611ProTrp: 0.611 ± 0.03
1.27ProTyr: 1.27 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
5.699GlnAla: 5.699 ± 0.118
0.43GlnCys: 0.43 ± 0.026
2.017GlnAsp: 2.017 ± 0.052
2.277GlnGlu: 2.277 ± 0.063
2.03GlnPhe: 2.03 ± 0.052
3.458GlnGly: 3.458 ± 0.059
1.762GlnHis: 1.762 ± 0.056
2.325GlnIle: 2.325 ± 0.059
2.01GlnLys: 2.01 ± 0.057
7.411GlnLeu: 7.411 ± 0.134
1.156GlnMet: 1.156 ± 0.038
1.49GlnAsn: 1.49 ± 0.052
2.771GlnPro: 2.771 ± 0.064
7.489GlnGln: 7.489 ± 0.214
4.504GlnArg: 4.504 ± 0.092
2.957GlnSer: 2.957 ± 0.073
2.563GlnThr: 2.563 ± 0.058
3.533GlnVal: 3.533 ± 0.065
1.201GlnTrp: 1.201 ± 0.053
1.457GlnTyr: 1.457 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
4.553ArgAla: 4.553 ± 0.072
0.505ArgCys: 0.505 ± 0.028
3.008ArgAsp: 3.008 ± 0.064
3.84ArgGlu: 3.84 ± 0.077
2.445ArgPhe: 2.445 ± 0.058
3.204ArgGly: 3.204 ± 0.055
1.419ArgHis: 1.419 ± 0.051
3.33ArgIle: 3.33 ± 0.059
2.421ArgLys: 2.421 ± 0.057
6.421ArgLeu: 6.421 ± 0.114
1.392ArgMet: 1.392 ± 0.045
1.944ArgAsn: 1.944 ± 0.052
2.042ArgPro: 2.042 ± 0.058
3.533ArgGln: 3.533 ± 0.08
3.485ArgArg: 3.485 ± 0.077
3.075ArgSer: 3.075 ± 0.074
2.203ArgThr: 2.203 ± 0.06
3.86ArgVal: 3.86 ± 0.064
1.118ArgTrp: 1.118 ± 0.049
2.172ArgTyr: 2.172 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
6.004SerAla: 6.004 ± 0.095
0.539SerCys: 0.539 ± 0.029
3.566SerAsp: 3.566 ± 0.073
3.713SerGlu: 3.713 ± 0.073
2.325SerPhe: 2.325 ± 0.057
4.836SerGly: 4.836 ± 0.097
1.407SerHis: 1.407 ± 0.049
3.16SerIle: 3.16 ± 0.076
2.345SerLys: 2.345 ± 0.062
6.339SerLeu: 6.339 ± 0.113
1.482SerMet: 1.482 ± 0.042
2.145SerAsn: 2.145 ± 0.061
2.202SerPro: 2.202 ± 0.053
3.14SerGln: 3.14 ± 0.074
3.208SerArg: 3.208 ± 0.064
3.645SerSer: 3.645 ± 0.08
2.776SerThr: 2.776 ± 0.063
4.467SerVal: 4.467 ± 0.085
0.821SerTrp: 0.821 ± 0.038
1.751SerTyr: 1.751 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.08ThrAla: 5.08 ± 0.095
0.39ThrCys: 0.39 ± 0.021
3.081ThrAsp: 3.081 ± 0.077
3.216ThrGlu: 3.216 ± 0.068
1.88ThrPhe: 1.88 ± 0.053
3.68ThrGly: 3.68 ± 0.081
1.036ThrHis: 1.036 ± 0.038
3.099ThrIle: 3.099 ± 0.066
1.726ThrLys: 1.726 ± 0.052
6.13ThrLeu: 6.13 ± 0.092
1.022ThrMet: 1.022 ± 0.038
1.591ThrAsn: 1.591 ± 0.066
2.53ThrPro: 2.53 ± 0.067
2.254ThrGln: 2.254 ± 0.065
2.455ThrArg: 2.455 ± 0.063
2.735ThrSer: 2.735 ± 0.061
2.652ThrThr: 2.652 ± 0.063
4.092ThrVal: 4.092 ± 0.078
0.541ThrTrp: 0.541 ± 0.032
1.27ThrTyr: 1.27 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
7.486ValAla: 7.486 ± 0.115
0.647ValCys: 0.647 ± 0.033
4.388ValAsp: 4.388 ± 0.078
4.652ValGlu: 4.652 ± 0.08
2.549ValPhe: 2.549 ± 0.066
4.822ValGly: 4.822 ± 0.1
1.194ValHis: 1.194 ± 0.036
4.601ValIle: 4.601 ± 0.097
3.362ValLys: 3.362 ± 0.077
6.976ValLeu: 6.976 ± 0.096
1.871ValMet: 1.871 ± 0.048
2.929ValAsn: 2.929 ± 0.063
2.687ValPro: 2.687 ± 0.06
2.541ValGln: 2.541 ± 0.059
3.472ValArg: 3.472 ± 0.067
4.731ValSer: 4.731 ± 0.084
4.002ValThr: 4.002 ± 0.079
5.687ValVal: 5.687 ± 0.112
0.779ValTrp: 0.779 ± 0.032
1.725ValTyr: 1.725 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.855TrpAla: 0.855 ± 0.035
0.159TrpCys: 0.159 ± 0.015
0.592TrpAsp: 0.592 ± 0.031
0.527TrpGlu: 0.527 ± 0.027
0.678TrpPhe: 0.678 ± 0.032
0.77TrpGly: 0.77 ± 0.036
0.429TrpHis: 0.429 ± 0.027
0.687TrpIle: 0.687 ± 0.033
0.394TrpLys: 0.394 ± 0.023
2.291TrpLeu: 2.291 ± 0.074
0.389TrpMet: 0.389 ± 0.026
0.427TrpAsn: 0.427 ± 0.023
0.572TrpPro: 0.572 ± 0.028
1.489TrpGln: 1.489 ± 0.059
1.045TrpArg: 1.045 ± 0.044
0.71TrpSer: 0.71 ± 0.036
0.456TrpThr: 0.456 ± 0.023
1.049TrpVal: 1.049 ± 0.038
0.271TrpTrp: 0.271 ± 0.023
0.406TrpTyr: 0.406 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.419TyrAla: 2.419 ± 0.058
0.342TyrCys: 0.342 ± 0.022
1.688TyrAsp: 1.688 ± 0.054
1.475TyrGlu: 1.475 ± 0.049
1.231TyrPhe: 1.231 ± 0.046
2.129TyrGly: 2.129 ± 0.059
0.797TyrHis: 0.797 ± 0.029
1.288TyrIle: 1.288 ± 0.044
0.989TyrLys: 0.989 ± 0.036
3.221TyrLeu: 3.221 ± 0.074
0.489TyrMet: 0.489 ± 0.029
0.904TyrAsn: 0.904 ± 0.043
1.369TyrPro: 1.369 ± 0.038
2.269TyrGln: 2.269 ± 0.062
2.051TyrArg: 2.051 ± 0.06
1.771TyrSer: 1.771 ± 0.059
1.269TyrThr: 1.269 ± 0.045
1.787TyrVal: 1.787 ± 0.052
0.524TyrTrp: 0.524 ± 0.03
0.958TyrTyr: 0.958 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2274 proteins (746298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski