Amino acid dipepetide frequency for Nocardioides anomalus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.68AlaAla: 20.68 ± 0.2	0.995AlaCys: 0.995 ± 0.026	8.697AlaAsp: 8.697 ± 0.076	8.234AlaGlu: 8.234 ± 0.121	3.607AlaPhe: 3.607 ± 0.053	12.857AlaGly: 12.857 ± 0.116	2.716AlaHis: 2.716 ± 0.05	3.484AlaIle: 3.484 ± 0.05	2.297AlaLys: 2.297 ± 0.044	14.693AlaLeu: 14.693 ± 0.125	2.569AlaMet: 2.569 ± 0.045	1.811AlaAsn: 1.811 ± 0.04	6.625AlaPro: 6.625 ± 0.077	3.872AlaGln: 3.872 ± 0.058	9.699AlaArg: 9.699 ± 0.104	6.414AlaSer: 6.414 ± 0.078	7.901AlaThr: 7.901 ± 0.093	12.64AlaVal: 12.64 ± 0.116	2.099AlaTrp: 2.099 ± 0.043	2.89AlaTyr: 2.89 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.925CysAla: 0.925 ± 0.022	0.081CysCys: 0.081 ± 0.008	0.466CysAsp: 0.466 ± 0.016	0.338CysGlu: 0.338 ± 0.015	0.221CysPhe: 0.221 ± 0.013	0.839CysGly: 0.839 ± 0.024	0.164CysHis: 0.164 ± 0.009	0.15CysIle: 0.15 ± 0.01	0.1CysLys: 0.1 ± 0.008	0.681CysLeu: 0.681 ± 0.021	0.089CysMet: 0.089 ± 0.007	0.122CysAsn: 0.122 ± 0.009	0.43CysPro: 0.43 ± 0.019	0.185CysGln: 0.185 ± 0.009	0.54CysArg: 0.54 ± 0.027	0.402CysSer: 0.402 ± 0.016	0.476CysThr: 0.476 ± 0.017	0.617CysVal: 0.617 ± 0.022	0.125CysTrp: 0.125 ± 0.009	0.152CysTyr: 0.152 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.335AspAla: 8.335 ± 0.078	0.377AspCys: 0.377 ± 0.016	4.789AspAsp: 4.789 ± 0.062	4.479AspGlu: 4.479 ± 0.063	1.595AspPhe: 1.595 ± 0.038	6.922AspGly: 6.922 ± 0.085	1.586AspHis: 1.586 ± 0.037	1.543AspIle: 1.543 ± 0.034	1.018AspLys: 1.018 ± 0.031	7.3AspLeu: 7.3 ± 0.073	0.759AspMet: 0.759 ± 0.023	0.86AspAsn: 0.86 ± 0.025	4.871AspPro: 4.871 ± 0.059	2.036AspGln: 2.036 ± 0.037	5.025AspArg: 5.025 ± 0.054	2.449AspSer: 2.449 ± 0.042	2.966AspThr: 2.966 ± 0.046	6.526AspVal: 6.526 ± 0.064	1.015AspTrp: 1.015 ± 0.03	1.145AspTyr: 1.145 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.392GluAla: 7.392 ± 0.115	0.313GluCys: 0.313 ± 0.015	3.209GluAsp: 3.209 ± 0.052	3.455GluGlu: 3.455 ± 0.059	1.266GluPhe: 1.266 ± 0.03	4.237GluGly: 4.237 ± 0.059	1.72GluHis: 1.72 ± 0.04	1.863GluIle: 1.863 ± 0.041	1.069GluLys: 1.069 ± 0.032	6.953GluLeu: 6.953 ± 0.081	0.872GluMet: 0.872 ± 0.023	0.755GluAsn: 0.755 ± 0.022	3.443GluPro: 3.443 ± 0.052	2.407GluGln: 2.407 ± 0.043	5.46GluArg: 5.46 ± 0.067	2.404GluSer: 2.404 ± 0.041	2.795GluThr: 2.795 ± 0.042	5.597GluVal: 5.597 ± 0.061	0.803GluTrp: 0.803 ± 0.025	0.936GluTyr: 0.936 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.649PheAla: 3.649 ± 0.051	0.255PheCys: 0.255 ± 0.013	2.054PheAsp: 2.054 ± 0.042	1.482PheGlu: 1.482 ± 0.033	0.902PhePhe: 0.902 ± 0.027	2.973PheGly: 2.973 ± 0.048	0.565PheHis: 0.565 ± 0.02	0.693PheIle: 0.693 ± 0.024	0.44PheLys: 0.44 ± 0.018	2.648PheLeu: 2.648 ± 0.045	0.389PheMet: 0.389 ± 0.018	0.534PheAsn: 0.534 ± 0.022	1.323PhePro: 1.323 ± 0.03	0.667PheGln: 0.667 ± 0.021	1.793PheArg: 1.793 ± 0.038	1.448PheSer: 1.448 ± 0.032	1.863PheThr: 1.863 ± 0.04	2.579PheVal: 2.579 ± 0.043	0.442PheTrp: 0.442 ± 0.018	0.588PheTyr: 0.588 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.019GlyAla: 11.019 ± 0.101	0.78GlyCys: 0.78 ± 0.021	5.672GlyAsp: 5.672 ± 0.071	4.918GlyGlu: 4.918 ± 0.059	2.948GlyPhe: 2.948 ± 0.042	8.711GlyGly: 8.711 ± 0.085	2.166GlyHis: 2.166 ± 0.038	3.137GlyIle: 3.137 ± 0.052	1.942GlyLys: 1.942 ± 0.049	9.892GlyLeu: 9.892 ± 0.075	1.822GlyMet: 1.822 ± 0.035	1.521GlyAsn: 1.521 ± 0.035	4.928GlyPro: 4.928 ± 0.064	2.846GlyGln: 2.846 ± 0.046	7.296GlyArg: 7.296 ± 0.076	5.477GlySer: 5.477 ± 0.066	6.12GlyThr: 6.12 ± 0.077	8.573GlyVal: 8.573 ± 0.086	1.783GlyTrp: 1.783 ± 0.036	2.197GlyTyr: 2.197 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.721HisAla: 2.721 ± 0.051	0.185HisCys: 0.185 ± 0.011	1.624HisAsp: 1.624 ± 0.034	1.368HisGlu: 1.368 ± 0.037	0.58HisPhe: 0.58 ± 0.017	2.23HisGly: 2.23 ± 0.039	0.725HisHis: 0.725 ± 0.024	0.403HisIle: 0.403 ± 0.017	0.263HisLys: 0.263 ± 0.015	2.557HisLeu: 2.557 ± 0.049	0.26HisMet: 0.26 ± 0.013	0.291HisAsn: 0.291 ± 0.012	1.622HisPro: 1.622 ± 0.033	0.676HisGln: 0.676 ± 0.022	1.869HisArg: 1.869 ± 0.038	0.793HisSer: 0.793 ± 0.022	1.118HisThr: 1.118 ± 0.027	2.124HisVal: 2.124 ± 0.037	0.344HisTrp: 0.344 ± 0.015	0.423HisTyr: 0.423 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.217IleAla: 4.217 ± 0.057	0.223IleCys: 0.223 ± 0.014	2.091IleAsp: 2.091 ± 0.043	1.831IleGlu: 1.831 ± 0.044	0.659IlePhe: 0.659 ± 0.024	3.269IleGly: 3.269 ± 0.05	0.519IleHis: 0.519 ± 0.018	0.802IleIle: 0.802 ± 0.029	0.639IleLys: 0.639 ± 0.027	2.057IleLeu: 2.057 ± 0.042	0.349IleMet: 0.349 ± 0.017	0.609IleAsn: 0.609 ± 0.02	1.467IlePro: 1.467 ± 0.031	0.675IleGln: 0.675 ± 0.022	1.892IleArg: 1.892 ± 0.04	1.528IleSer: 1.528 ± 0.036	1.955IleThr: 1.955 ± 0.035	2.56IleVal: 2.56 ± 0.045	0.324IleTrp: 0.324 ± 0.015	0.496IleTyr: 0.496 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.355LysAla: 2.355 ± 0.047	0.093LysCys: 0.093 ± 0.008	1.069LysAsp: 1.069 ± 0.033	0.825LysGlu: 0.825 ± 0.027	0.392LysPhe: 0.392 ± 0.016	1.464LysGly: 1.464 ± 0.036	0.398LysHis: 0.398 ± 0.013	0.693LysIle: 0.693 ± 0.024	0.769LysLys: 0.769 ± 0.037	1.578LysLeu: 1.578 ± 0.035	0.322LysMet: 0.322 ± 0.016	0.396LysAsn: 0.396 ± 0.018	1.066LysPro: 1.066 ± 0.031	0.631LysGln: 0.631 ± 0.022	1.232LysArg: 1.232 ± 0.032	0.88LysSer: 0.88 ± 0.025	1.043LysThr: 1.043 ± 0.028	1.758LysVal: 1.758 ± 0.038	0.201LysTrp: 0.201 ± 0.012	0.395LysTyr: 0.395 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.733LeuAla: 15.733 ± 0.125	0.725LeuCys: 0.725 ± 0.024	7.469LeuAsp: 7.469 ± 0.082	5.726LeuGlu: 5.726 ± 0.067	2.563LeuPhe: 2.563 ± 0.046	9.965LeuGly: 9.965 ± 0.097	2.155LeuHis: 2.155 ± 0.039	2.517LeuIle: 2.517 ± 0.047	1.597LeuLys: 1.597 ± 0.041	11.358LeuLeu: 11.358 ± 0.125	1.525LeuMet: 1.525 ± 0.036	1.549LeuAsn: 1.549 ± 0.03	5.814LeuPro: 5.814 ± 0.063	2.503LeuGln: 2.503 ± 0.043	8.025LeuArg: 8.025 ± 0.086	5.5LeuSer: 5.5 ± 0.063	6.754LeuThr: 6.754 ± 0.069	11.318LeuVal: 11.318 ± 0.115	1.297LeuTrp: 1.297 ± 0.037	1.544LeuTyr: 1.544 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.156MetAla: 2.156 ± 0.037	0.119MetCys: 0.119 ± 0.01	0.832MetAsp: 0.832 ± 0.025	0.661MetGlu: 0.661 ± 0.02	0.413MetPhe: 0.413 ± 0.018	1.31MetGly: 1.31 ± 0.031	0.319MetHis: 0.319 ± 0.015	0.525MetIle: 0.525 ± 0.019	0.367MetLys: 0.367 ± 0.019	1.592MetLeu: 1.592 ± 0.03	0.266MetMet: 0.266 ± 0.013	0.323MetAsn: 0.323 ± 0.015	0.988MetPro: 0.988 ± 0.026	0.442MetGln: 0.442 ± 0.015	1.292MetArg: 1.292 ± 0.03	1.365MetSer: 1.365 ± 0.027	1.513MetThr: 1.513 ± 0.031	1.451MetVal: 1.451 ± 0.032	0.177MetTrp: 0.177 ± 0.009	0.266MetTyr: 0.266 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.004AsnAla: 2.004 ± 0.043	0.134AsnCys: 0.134 ± 0.009	0.919AsnAsp: 0.919 ± 0.029	0.687AsnGlu: 0.687 ± 0.02	0.431AsnPhe: 0.431 ± 0.017	1.575AsnGly: 1.575 ± 0.044	0.358AsnHis: 0.358 ± 0.015	0.538AsnIle: 0.538 ± 0.02	0.328AsnLys: 0.328 ± 0.017	1.597AsnLeu: 1.597 ± 0.037	0.25AsnMet: 0.25 ± 0.013	0.397AsnAsn: 0.397 ± 0.018	1.265AsnPro: 1.265 ± 0.033	0.521AsnGln: 0.521 ± 0.021	1.109AsnArg: 1.109 ± 0.029	0.71AsnSer: 0.71 ± 0.029	0.927AsnThr: 0.927 ± 0.03	1.357AsnVal: 1.357 ± 0.036	0.225AsnTrp: 0.225 ± 0.013	0.363AsnTyr: 0.363 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.733ProAla: 7.733 ± 0.086	0.32ProCys: 0.32 ± 0.021	4.747ProAsp: 4.747 ± 0.059	4.036ProGlu: 4.036 ± 0.061	1.55ProPhe: 1.55 ± 0.031	5.925ProGly: 5.925 ± 0.073	1.236ProHis: 1.236 ± 0.028	1.324ProIle: 1.324 ± 0.03	0.843ProLys: 0.843 ± 0.025	5.131ProLeu: 5.131 ± 0.068	0.911ProMet: 0.911 ± 0.027	0.77ProAsn: 0.77 ± 0.026	3.17ProPro: 3.17 ± 0.06	1.539ProGln: 1.539 ± 0.033	3.683ProArg: 3.683 ± 0.056	3.074ProSer: 3.074 ± 0.048	3.741ProThr: 3.741 ± 0.06	5.548ProVal: 5.548 ± 0.061	0.924ProTrp: 0.924 ± 0.027	1.193ProTyr: 1.193 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.811GlnAla: 3.811 ± 0.065	0.17GlnCys: 0.17 ± 0.01	1.542GlnAsp: 1.542 ± 0.036	1.4GlnGlu: 1.4 ± 0.032	0.691GlnPhe: 0.691 ± 0.021	2.261GlnGly: 2.261 ± 0.041	0.67GlnHis: 0.67 ± 0.021	0.968GlnIle: 0.968 ± 0.026	0.539GlnLys: 0.539 ± 0.021	3.246GlnLeu: 3.246 ± 0.054	0.464GlnMet: 0.464 ± 0.015	0.472GlnAsn: 0.472 ± 0.021	1.805GlnPro: 1.805 ± 0.039	1.201GlnGln: 1.201 ± 0.037	2.587GlnArg: 2.587 ± 0.047	1.263GlnSer: 1.263 ± 0.031	1.459GlnThr: 1.459 ± 0.035	2.977GlnVal: 2.977 ± 0.044	0.458GlnTrp: 0.458 ± 0.018	0.574GlnTyr: 0.574 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.6ArgAla: 9.6 ± 0.103	0.492ArgCys: 0.492 ± 0.019	4.527ArgAsp: 4.527 ± 0.058	4.653ArgGlu: 4.653 ± 0.06	2.221ArgPhe: 2.221 ± 0.039	5.945ArgGly: 5.945 ± 0.069	1.868ArgHis: 1.868 ± 0.032	2.654ArgIle: 2.654 ± 0.048	1.279ArgLys: 1.279 ± 0.033	8.548ArgLeu: 8.548 ± 0.08	1.664ArgMet: 1.664 ± 0.031	1.141ArgAsn: 1.141 ± 0.029	4.345ArgPro: 4.345 ± 0.066	2.129ArgGln: 2.129 ± 0.04	7.518ArgArg: 7.518 ± 0.08	4.074ArgSer: 4.074 ± 0.051	4.818ArgThr: 4.818 ± 0.06	6.48ArgVal: 6.48 ± 0.074	1.409ArgTrp: 1.409 ± 0.029	1.583ArgTyr: 1.583 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.62SerAla: 6.62 ± 0.078	0.358SerCys: 0.358 ± 0.015	2.988SerAsp: 2.988 ± 0.051	2.395SerGlu: 2.395 ± 0.044	1.672SerPhe: 1.672 ± 0.032	5.719SerGly: 5.719 ± 0.073	1.004SerHis: 1.004 ± 0.023	1.567SerIle: 1.567 ± 0.037	0.863SerLys: 0.863 ± 0.025	5.0SerLeu: 5.0 ± 0.054	1.082SerMet: 1.082 ± 0.022	0.877SerAsn: 0.877 ± 0.022	2.925SerPro: 2.925 ± 0.043	1.324SerGln: 1.324 ± 0.029	3.604SerArg: 3.604 ± 0.058	3.102SerSer: 3.102 ± 0.052	3.245SerThr: 3.245 ± 0.047	4.581SerVal: 4.581 ± 0.055	0.964SerTrp: 0.964 ± 0.028	1.296SerTyr: 1.296 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.838ThrAla: 7.838 ± 0.087	0.477ThrCys: 0.477 ± 0.02	3.632ThrAsp: 3.632 ± 0.052	3.035ThrGlu: 3.035 ± 0.046	1.897ThrPhe: 1.897 ± 0.037	6.296ThrGly: 6.296 ± 0.082	1.194ThrHis: 1.194 ± 0.027	1.92ThrIle: 1.92 ± 0.041	1.05ThrLys: 1.05 ± 0.029	5.914ThrLeu: 5.914 ± 0.068	0.94ThrMet: 0.94 ± 0.025	1.006ThrAsn: 1.006 ± 0.03	3.977ThrPro: 3.977 ± 0.062	1.547ThrGln: 1.547 ± 0.029	3.991ThrArg: 3.991 ± 0.053	3.482ThrSer: 3.482 ± 0.054	4.44ThrThr: 4.44 ± 0.07	6.186ThrVal: 6.186 ± 0.081	1.057ThrTrp: 1.057 ± 0.029	1.56ThrTyr: 1.56 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	13.365ValAla: 13.365 ± 0.124	0.699ValCys: 0.699 ± 0.021	6.627ValAsp: 6.627 ± 0.072	5.704ValGlu: 5.704 ± 0.063	2.504ValPhe: 2.504 ± 0.046	8.135ValGly: 8.135 ± 0.08	2.1ValHis: 2.1 ± 0.037	2.569ValIle: 2.569 ± 0.044	1.564ValLys: 1.564 ± 0.036	11.004ValLeu: 11.004 ± 0.104	1.378ValMet: 1.378 ± 0.031	1.629ValAsn: 1.629 ± 0.037	5.516ValPro: 5.516 ± 0.07	2.357ValGln: 2.357 ± 0.046	7.452ValArg: 7.452 ± 0.076	4.75ValSer: 4.75 ± 0.053	6.196ValThr: 6.196 ± 0.067	11.559ValVal: 11.559 ± 0.126	1.253ValTrp: 1.253 ± 0.031	1.532ValTyr: 1.532 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.702TrpAla: 1.702 ± 0.032	0.146TrpCys: 0.146 ± 0.01	0.891TrpAsp: 0.891 ± 0.024	0.719TrpGlu: 0.719 ± 0.023	0.544TrpPhe: 0.544 ± 0.018	1.128TrpGly: 1.128 ± 0.026	0.359TrpHis: 0.359 ± 0.016	0.462TrpIle: 0.462 ± 0.018	0.274TrpLys: 0.274 ± 0.015	1.889TrpLeu: 1.889 ± 0.041	0.275TrpMet: 0.275 ± 0.012	0.291TrpAsn: 0.291 ± 0.013	0.819TrpPro: 0.819 ± 0.022	0.497TrpGln: 0.497 ± 0.018	1.341TrpArg: 1.341 ± 0.034	1.093TrpSer: 1.093 ± 0.027	1.049TrpThr: 1.049 ± 0.027	1.388TrpVal: 1.388 ± 0.032	0.421TrpTrp: 0.421 ± 0.016	0.332TrpTyr: 0.332 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.923TyrAla: 2.923 ± 0.044	0.163TyrCys: 0.163 ± 0.01	1.753TyrAsp: 1.753 ± 0.034	1.003TyrGlu: 1.003 ± 0.026	0.631TyrPhe: 0.631 ± 0.021	1.986TyrGly: 1.986 ± 0.041	0.354TyrHis: 0.354 ± 0.015	0.349TyrIle: 0.349 ± 0.016	0.316TyrLys: 0.316 ± 0.015	2.001TyrLeu: 2.001 ± 0.031	0.188TyrMet: 0.188 ± 0.011	0.343TyrAsn: 0.343 ± 0.017	1.0TyrPro: 1.0 ± 0.027	0.502TyrGln: 0.502 ± 0.018	1.541TyrArg: 1.541 ± 0.036	0.977TyrSer: 0.977 ± 0.028	1.058TyrThr: 1.058 ± 0.032	2.076TyrVal: 2.076 ± 0.035	0.301TyrTrp: 0.301 ± 0.016	0.423TyrTyr: 0.423 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4914 proteins (1544052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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