Amino acid dipepetide frequency for Legionella londiniensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.524AlaAla: 7.524 ± 0.164	1.182AlaCys: 1.182 ± 0.047	3.655AlaAsp: 3.655 ± 0.066	5.156AlaGlu: 5.156 ± 0.084	3.551AlaPhe: 3.551 ± 0.07	5.676AlaGly: 5.676 ± 0.108	1.87AlaHis: 1.87 ± 0.05	6.331AlaIle: 6.331 ± 0.105	5.125AlaLys: 5.125 ± 0.077	10.14AlaLeu: 10.14 ± 0.139	2.37AlaMet: 2.37 ± 0.064	3.421AlaAsn: 3.421 ± 0.057	2.477AlaPro: 2.477 ± 0.064	3.308AlaGln: 3.308 ± 0.078	4.223AlaArg: 4.223 ± 0.09	5.044AlaSer: 5.044 ± 0.08	3.525AlaThr: 3.525 ± 0.074	5.484AlaVal: 5.484 ± 0.11	0.889AlaTrp: 0.889 ± 0.034	2.765AlaTyr: 2.765 ± 0.065	0.003AlaXaa: 0.003 ± 0.002
Cys	0.864CysAla: 0.864 ± 0.031	0.205CysCys: 0.205 ± 0.016	0.562CysAsp: 0.562 ± 0.03	0.648CysGlu: 0.648 ± 0.032	0.623CysPhe: 0.623 ± 0.028	0.941CysGly: 0.941 ± 0.037	0.382CysHis: 0.382 ± 0.025	0.743CysIle: 0.743 ± 0.034	0.612CysLys: 0.612 ± 0.03	1.365CysLeu: 1.365 ± 0.044	0.259CysMet: 0.259 ± 0.019	0.417CysAsn: 0.417 ± 0.026	0.498CysPro: 0.498 ± 0.024	0.562CysGln: 0.562 ± 0.029	0.612CysArg: 0.612 ± 0.032	0.732CysSer: 0.732 ± 0.036	0.527CysThr: 0.527 ± 0.029	0.678CysVal: 0.678 ± 0.032	0.158CysTrp: 0.158 ± 0.013	0.491CysTyr: 0.491 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	3.913AspAla: 3.913 ± 0.075	0.591AspCys: 0.591 ± 0.029	2.209AspAsp: 2.209 ± 0.05	3.733AspGlu: 3.733 ± 0.089	2.298AspPhe: 2.298 ± 0.06	2.525AspGly: 2.525 ± 0.073	0.908AspHis: 0.908 ± 0.036	3.749AspIle: 3.749 ± 0.08	3.484AspLys: 3.484 ± 0.102	5.12AspLeu: 5.12 ± 0.109	1.206AspMet: 1.206 ± 0.034	2.058AspAsn: 2.058 ± 0.055	1.852AspPro: 1.852 ± 0.052	1.356AspGln: 1.356 ± 0.044	1.821AspArg: 1.821 ± 0.052	2.601AspSer: 2.601 ± 0.061	2.014AspThr: 2.014 ± 0.057	2.779AspVal: 2.779 ± 0.062	0.711AspTrp: 0.711 ± 0.033	2.076AspTyr: 2.076 ± 0.052	0.001AspXaa: 0.001 ± 0.001
Glu	5.295GluAla: 5.295 ± 0.096	0.523GluCys: 0.523 ± 0.028	2.738GluAsp: 2.738 ± 0.067	4.706GluGlu: 4.706 ± 0.099	2.489GluPhe: 2.489 ± 0.059	3.369GluGly: 3.369 ± 0.069	1.65GluHis: 1.65 ± 0.049	4.691GluIle: 4.691 ± 0.084	4.941GluLys: 4.941 ± 0.104	7.02GluLeu: 7.02 ± 0.109	1.56GluMet: 1.56 ± 0.047	2.93GluAsn: 2.93 ± 0.065	2.179GluPro: 2.179 ± 0.067	3.413GluGln: 3.413 ± 0.085	3.276GluArg: 3.276 ± 0.076	3.522GluSer: 3.522 ± 0.082	3.048GluThr: 3.048 ± 0.071	3.491GluVal: 3.491 ± 0.074	0.613GluTrp: 0.613 ± 0.034	1.904GluTyr: 1.904 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.787PheAla: 3.787 ± 0.071	0.681PheCys: 0.681 ± 0.034	2.25PheAsp: 2.25 ± 0.056	2.191PheGlu: 2.191 ± 0.054	2.531PhePhe: 2.531 ± 0.072	2.779PheGly: 2.779 ± 0.087	1.015PheHis: 1.015 ± 0.044	3.56PheIle: 3.56 ± 0.086	2.414PheLys: 2.414 ± 0.062	4.915PheLeu: 4.915 ± 0.102	0.988PheMet: 0.988 ± 0.034	2.213PheAsn: 2.213 ± 0.06	1.752PhePro: 1.752 ± 0.046	1.574PheGln: 1.574 ± 0.052	1.662PheArg: 1.662 ± 0.048	3.385PheSer: 3.385 ± 0.071	2.295PheThr: 2.295 ± 0.059	2.386PheVal: 2.386 ± 0.061	0.573PheTrp: 0.573 ± 0.03	1.759PheTyr: 1.759 ± 0.052	0.003PheXaa: 0.003 ± 0.002
Gly	4.484GlyAla: 4.484 ± 0.089	0.826GlyCys: 0.826 ± 0.039	2.801GlyAsp: 2.801 ± 0.068	3.668GlyGlu: 3.668 ± 0.075	3.351GlyPhe: 3.351 ± 0.091	4.136GlyGly: 4.136 ± 0.097	1.657GlyHis: 1.657 ± 0.049	5.181GlyIle: 5.181 ± 0.103	4.019GlyLys: 4.019 ± 0.083	6.825GlyLeu: 6.825 ± 0.116	1.767GlyMet: 1.767 ± 0.056	2.465GlyAsn: 2.465 ± 0.068	1.575GlyPro: 1.575 ± 0.049	2.49GlyGln: 2.49 ± 0.063	2.974GlyArg: 2.974 ± 0.071	3.671GlySer: 3.671 ± 0.078	2.909GlyThr: 2.909 ± 0.061	4.019GlyVal: 4.019 ± 0.086	0.819GlyTrp: 0.819 ± 0.042	2.443GlyTyr: 2.443 ± 0.06	0.003GlyXaa: 0.003 ± 0.002
His	2.144HisAla: 2.144 ± 0.054	0.376HisCys: 0.376 ± 0.024	1.261HisAsp: 1.261 ± 0.044	1.715HisGlu: 1.715 ± 0.054	1.199HisPhe: 1.199 ± 0.045	1.779HisGly: 1.779 ± 0.049	0.974HisHis: 0.974 ± 0.039	1.648HisIle: 1.648 ± 0.046	1.19HisLys: 1.19 ± 0.047	2.814HisLeu: 2.814 ± 0.065	0.534HisMet: 0.534 ± 0.025	0.911HisAsn: 0.911 ± 0.035	1.376HisPro: 1.376 ± 0.045	1.337HisGln: 1.337 ± 0.048	1.286HisArg: 1.286 ± 0.039	1.421HisSer: 1.421 ± 0.035	1.033HisThr: 1.033 ± 0.036	1.365HisVal: 1.365 ± 0.045	0.443HisTrp: 0.443 ± 0.025	1.149HisTyr: 1.149 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	6.837IleAla: 6.837 ± 0.117	0.844IleCys: 0.844 ± 0.038	4.046IleAsp: 4.046 ± 0.092	4.776IleGlu: 4.776 ± 0.098	2.862IlePhe: 2.862 ± 0.069	4.585IleGly: 4.585 ± 0.084	1.976IleHis: 1.976 ± 0.05	5.032IleIle: 5.032 ± 0.097	4.57IleLys: 4.57 ± 0.086	7.298IleLeu: 7.298 ± 0.117	1.365IleMet: 1.365 ± 0.041	3.388IleAsn: 3.388 ± 0.077	3.403IlePro: 3.403 ± 0.063	2.819IleGln: 2.819 ± 0.066	3.384IleArg: 3.384 ± 0.082	4.893IleSer: 4.893 ± 0.092	3.734IleThr: 3.734 ± 0.075	3.867IleVal: 3.867 ± 0.077	0.671IleTrp: 0.671 ± 0.034	2.184IleTyr: 2.184 ± 0.064	0.003IleXaa: 0.003 ± 0.002
Lys	5.163LysAla: 5.163 ± 0.093	0.372LysCys: 0.372 ± 0.025	2.817LysAsp: 2.817 ± 0.074	4.713LysGlu: 4.713 ± 0.1	1.668LysPhe: 1.668 ± 0.053	3.064LysGly: 3.064 ± 0.066	1.567LysHis: 1.567 ± 0.049	4.53LysIle: 4.53 ± 0.085	5.129LysLys: 5.129 ± 0.099	6.31LysLeu: 6.31 ± 0.114	1.449LysMet: 1.449 ± 0.045	3.399LysAsn: 3.399 ± 0.077	3.02LysPro: 3.02 ± 0.063	3.347LysGln: 3.347 ± 0.084	3.228LysArg: 3.228 ± 0.075	3.481LysSer: 3.481 ± 0.073	3.666LysThr: 3.666 ± 0.073	2.88LysVal: 2.88 ± 0.072	0.556LysTrp: 0.556 ± 0.028	1.535LysTyr: 1.535 ± 0.049	0.001LysXaa: 0.001 ± 0.002
Leu	10.314LeuAla: 10.314 ± 0.14	1.401LeuCys: 1.401 ± 0.048	5.03LeuAsp: 5.03 ± 0.099	6.076LeuGlu: 6.076 ± 0.109	5.142LeuPhe: 5.142 ± 0.114	6.873LeuGly: 6.873 ± 0.11	2.703LeuHis: 2.703 ± 0.056	7.878LeuIle: 7.878 ± 0.125	7.056LeuLys: 7.056 ± 0.112	12.83LeuLeu: 12.83 ± 0.207	2.561LeuMet: 2.561 ± 0.07	5.257LeuAsn: 5.257 ± 0.106	5.326LeuPro: 5.326 ± 0.095	5.221LeuGln: 5.221 ± 0.096	5.147LeuArg: 5.147 ± 0.108	7.843LeuSer: 7.843 ± 0.11	5.676LeuThr: 5.676 ± 0.095	5.915LeuVal: 5.915 ± 0.102	1.081LeuTrp: 1.081 ± 0.044	3.334LeuTyr: 3.334 ± 0.072	0.001LeuXaa: 0.001 ± 0.001
Met	2.192MetAla: 2.192 ± 0.057	0.188MetCys: 0.188 ± 0.016	1.139MetAsp: 1.139 ± 0.04	1.248MetGlu: 1.248 ± 0.047	0.695MetPhe: 0.695 ± 0.031	1.482MetGly: 1.482 ± 0.042	0.653MetHis: 0.653 ± 0.029	1.65MetIle: 1.65 ± 0.052	1.421MetLys: 1.421 ± 0.044	2.605MetLeu: 2.605 ± 0.062	0.71MetMet: 0.71 ± 0.035	1.168MetAsn: 1.168 ± 0.04	1.279MetPro: 1.279 ± 0.041	1.236MetGln: 1.236 ± 0.044	1.309MetArg: 1.309 ± 0.043	1.421MetSer: 1.421 ± 0.047	1.361MetThr: 1.361 ± 0.042	1.522MetVal: 1.522 ± 0.054	0.19MetTrp: 0.19 ± 0.019	0.491MetTyr: 0.491 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.432AsnAla: 3.432 ± 0.072	0.495AsnCys: 0.495 ± 0.026	1.985AsnAsp: 1.985 ± 0.061	2.704AsnGlu: 2.704 ± 0.065	1.611AsnPhe: 1.611 ± 0.054	2.365AsnGly: 2.365 ± 0.071	1.468AsnHis: 1.468 ± 0.048	3.223AsnIle: 3.223 ± 0.074	2.627AsnLys: 2.627 ± 0.075	4.767AsnLeu: 4.767 ± 0.094	0.943AsnMet: 0.943 ± 0.032	2.037AsnAsn: 2.037 ± 0.07	2.559AsnPro: 2.559 ± 0.061	2.664AsnGln: 2.664 ± 0.069	2.231AsnArg: 2.231 ± 0.058	2.374AsnSer: 2.374 ± 0.063	2.039AsnThr: 2.039 ± 0.051	1.992AsnVal: 1.992 ± 0.058	0.576AsnTrp: 0.576 ± 0.026	1.63AsnTyr: 1.63 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.211ProAla: 3.211 ± 0.064	0.495ProCys: 0.495 ± 0.027	2.299ProAsp: 2.299 ± 0.054	3.534ProGlu: 3.534 ± 0.074	1.925ProPhe: 1.925 ± 0.047	2.918ProGly: 2.918 ± 0.073	0.973ProHis: 0.973 ± 0.036	2.458ProIle: 2.458 ± 0.055	2.4ProLys: 2.4 ± 0.06	4.652ProLeu: 4.652 ± 0.083	0.883ProMet: 0.883 ± 0.033	1.575ProAsn: 1.575 ± 0.054	1.553ProPro: 1.553 ± 0.053	1.641ProGln: 1.641 ± 0.051	1.679ProArg: 1.679 ± 0.051	2.295ProSer: 2.295 ± 0.054	1.619ProThr: 1.619 ± 0.053	3.334ProVal: 3.334 ± 0.077	0.498ProTrp: 0.498 ± 0.031	1.43ProTyr: 1.43 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.119GlnAla: 4.119 ± 0.088	0.501GlnCys: 0.501 ± 0.03	2.037GlnAsp: 2.037 ± 0.061	3.122GlnGlu: 3.122 ± 0.092	2.174GlnPhe: 2.174 ± 0.055	2.83GlnGly: 2.83 ± 0.061	1.14GlnHis: 1.14 ± 0.043	2.927GlnIle: 2.927 ± 0.057	3.211GlnLys: 3.211 ± 0.073	4.733GlnLeu: 4.733 ± 0.089	1.044GlnMet: 1.044 ± 0.042	2.093GlnAsn: 2.093 ± 0.053	1.496GlnPro: 1.496 ± 0.047	2.686GlnGln: 2.686 ± 0.079	2.104GlnArg: 2.104 ± 0.056	2.727GlnSer: 2.727 ± 0.059	2.109GlnThr: 2.109 ± 0.052	2.603GlnVal: 2.603 ± 0.065	0.594GlnTrp: 0.594 ± 0.031	1.677GlnTyr: 1.677 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	3.463ArgAla: 3.463 ± 0.075	0.545ArgCys: 0.545 ± 0.036	2.372ArgAsp: 2.372 ± 0.053	3.462ArgGlu: 3.462 ± 0.075	2.522ArgPhe: 2.522 ± 0.058	2.644ArgGly: 2.644 ± 0.073	1.428ArgHis: 1.428 ± 0.048	3.586ArgIle: 3.586 ± 0.078	2.685ArgLys: 2.685 ± 0.068	5.868ArgLeu: 5.868 ± 0.102	1.179ArgMet: 1.179 ± 0.046	1.956ArgAsn: 1.956 ± 0.053	1.561ArgPro: 1.561 ± 0.048	2.638ArgGln: 2.638 ± 0.065	2.436ArgArg: 2.436 ± 0.065	2.375ArgSer: 2.375 ± 0.058	1.992ArgThr: 1.992 ± 0.056	2.709ArgVal: 2.709 ± 0.069	0.583ArgTrp: 0.583 ± 0.028	1.935ArgTyr: 1.935 ± 0.053	0.001ArgXaa: 0.001 ± 0.001
Ser	4.709SerAla: 4.709 ± 0.086	0.771SerCys: 0.771 ± 0.041	2.664SerAsp: 2.664 ± 0.062	3.56SerGlu: 3.56 ± 0.087	2.985SerPhe: 2.985 ± 0.057	4.389SerGly: 4.389 ± 0.086	1.545SerHis: 1.545 ± 0.049	4.339SerIle: 4.339 ± 0.087	3.327SerLys: 3.327 ± 0.067	7.557SerLeu: 7.557 ± 0.11	1.619SerMet: 1.619 ± 0.048	2.278SerAsn: 2.278 ± 0.063	2.692SerPro: 2.692 ± 0.069	2.659SerGln: 2.659 ± 0.06	3.006SerArg: 3.006 ± 0.055	3.913SerSer: 3.913 ± 0.084	2.649SerThr: 2.649 ± 0.06	3.363SerVal: 3.363 ± 0.07	0.811SerTrp: 0.811 ± 0.037	1.974SerTyr: 1.974 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.206ThrAla: 4.206 ± 0.091	0.537ThrCys: 0.537 ± 0.029	2.094ThrAsp: 2.094 ± 0.055	2.577ThrGlu: 2.577 ± 0.07	1.871ThrPhe: 1.871 ± 0.053	3.597ThrGly: 3.597 ± 0.081	1.279ThrHis: 1.279 ± 0.044	3.576ThrIle: 3.576 ± 0.074	2.127ThrLys: 2.127 ± 0.05	5.769ThrLeu: 5.769 ± 0.086	1.023ThrMet: 1.023 ± 0.037	1.767ThrAsn: 1.767 ± 0.057	2.353ThrPro: 2.353 ± 0.059	1.882ThrGln: 1.882 ± 0.058	2.321ThrArg: 2.321 ± 0.056	2.632ThrSer: 2.632 ± 0.07	2.245ThrThr: 2.245 ± 0.065	3.295ThrVal: 3.295 ± 0.066	0.458ThrTrp: 0.458 ± 0.024	1.539ThrTyr: 1.539 ± 0.056	0.001ThrXaa: 0.001 ± 0.001
Val	4.695ValAla: 4.695 ± 0.09	0.713ValCys: 0.713 ± 0.032	2.976ValAsp: 2.976 ± 0.066	3.302ValGlu: 3.302 ± 0.066	2.848ValPhe: 2.848 ± 0.062	3.414ValGly: 3.414 ± 0.076	1.329ValHis: 1.329 ± 0.048	4.68ValIle: 4.68 ± 0.091	3.474ValLys: 3.474 ± 0.079	6.31ValLeu: 6.31 ± 0.104	1.542ValMet: 1.542 ± 0.049	2.711ValAsn: 2.711 ± 0.061	2.285ValPro: 2.285 ± 0.051	1.972ValGln: 1.972 ± 0.056	2.614ValArg: 2.614 ± 0.06	3.951ValSer: 3.951 ± 0.083	2.866ValThr: 2.866 ± 0.07	3.759ValVal: 3.759 ± 0.094	0.538ValTrp: 0.538 ± 0.024	1.886ValTyr: 1.886 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.707TrpAla: 0.707 ± 0.032	0.122TrpCys: 0.122 ± 0.013	0.472TrpAsp: 0.472 ± 0.027	0.587TrpGlu: 0.587 ± 0.027	0.597TrpPhe: 0.597 ± 0.029	0.651TrpGly: 0.651 ± 0.034	0.396TrpHis: 0.396 ± 0.022	0.772TrpIle: 0.772 ± 0.03	0.48TrpLys: 0.48 ± 0.025	1.672TrpLeu: 1.672 ± 0.059	0.31TrpMet: 0.31 ± 0.021	0.447TrpAsn: 0.447 ± 0.027	0.489TrpPro: 0.489 ± 0.026	0.862TrpGln: 0.862 ± 0.039	0.675TrpArg: 0.675 ± 0.031	0.566TrpSer: 0.566 ± 0.031	0.368TrpThr: 0.368 ± 0.027	0.736TrpVal: 0.736 ± 0.032	0.152TrpTrp: 0.152 ± 0.014	0.37TrpTyr: 0.37 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.657TyrAla: 2.657 ± 0.062	0.507TyrCys: 0.507 ± 0.027	1.597TyrAsp: 1.597 ± 0.044	1.881TyrGlu: 1.881 ± 0.056	1.77TyrPhe: 1.77 ± 0.046	2.065TyrGly: 2.065 ± 0.058	1.041TyrHis: 1.041 ± 0.037	1.985TyrIle: 1.985 ± 0.049	1.597TyrLys: 1.597 ± 0.054	4.095TyrLeu: 4.095 ± 0.084	0.651TyrMet: 0.651 ± 0.033	1.232TyrAsn: 1.232 ± 0.042	1.647TyrPro: 1.647 ± 0.048	2.262TyrGln: 2.262 ± 0.062	1.949TyrArg: 1.949 ± 0.052	1.963TyrSer: 1.963 ± 0.057	1.475TyrThr: 1.475 ± 0.047	1.686TyrVal: 1.686 ± 0.057	0.516TyrTrp: 0.516 ± 0.031	1.358TyrTyr: 1.358 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.004XaaLys: 0.004 ± 0.003	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.002	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.053XaaXaa: 0.053 ± 0.014

Statistics based on 2172 proteins (722513 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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