Amino acid dipepetide frequency for Lachnospiraceae bacterium A10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.076AlaAla: 6.076 ± 0.135
0.99AlaCys: 0.99 ± 0.038
4.398AlaAsp: 4.398 ± 0.085
5.444AlaGlu: 5.444 ± 0.101
3.012AlaPhe: 3.012 ± 0.062
5.358AlaGly: 5.358 ± 0.094
1.084AlaHis: 1.084 ± 0.036
5.679AlaIle: 5.679 ± 0.086
5.154AlaLys: 5.154 ± 0.096
6.674AlaLeu: 6.674 ± 0.105
2.632AlaMet: 2.632 ± 0.063
2.939AlaAsn: 2.939 ± 0.076
1.81AlaPro: 1.81 ± 0.051
1.936AlaGln: 1.936 ± 0.061
2.741AlaArg: 2.741 ± 0.07
4.221AlaSer: 4.221 ± 0.088
3.822AlaThr: 3.822 ± 0.096
5.54AlaVal: 5.54 ± 0.104
0.536AlaTrp: 0.536 ± 0.025
2.86AlaTyr: 2.86 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.032
0.185CysCys: 0.185 ± 0.015
0.842CysAsp: 0.842 ± 0.038
0.838CysGlu: 0.838 ± 0.042
0.602CysPhe: 0.602 ± 0.034
1.214CysGly: 1.214 ± 0.044
0.271CysHis: 0.271 ± 0.016
1.074CysIle: 1.074 ± 0.038
0.819CysLys: 0.819 ± 0.033
1.008CysLeu: 1.008 ± 0.038
0.408CysMet: 0.408 ± 0.023
0.568CysAsn: 0.568 ± 0.029
0.536CysPro: 0.536 ± 0.029
0.315CysGln: 0.315 ± 0.02
0.527CysArg: 0.527 ± 0.027
0.799CysSer: 0.799 ± 0.037
0.616CysThr: 0.616 ± 0.029
0.882CysVal: 0.882 ± 0.033
0.1CysTrp: 0.1 ± 0.011
0.514CysTyr: 0.514 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.998AspAla: 4.998 ± 0.096
0.762AspCys: 0.762 ± 0.033
3.504AspAsp: 3.504 ± 0.079
5.178AspGlu: 5.178 ± 0.086
3.005AspPhe: 3.005 ± 0.072
4.721AspGly: 4.721 ± 0.119
1.051AspHis: 1.051 ± 0.044
4.697AspIle: 4.697 ± 0.081
3.536AspLys: 3.536 ± 0.07
5.274AspLeu: 5.274 ± 0.086
1.865AspMet: 1.865 ± 0.047
2.202AspAsn: 2.202 ± 0.057
1.882AspPro: 1.882 ± 0.049
1.861AspGln: 1.861 ± 0.052
2.508AspArg: 2.508 ± 0.059
3.472AspSer: 3.472 ± 0.079
3.212AspThr: 3.212 ± 0.07
4.485AspVal: 4.485 ± 0.077
0.542AspTrp: 0.542 ± 0.032
3.205AspTyr: 3.205 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.68GluAla: 5.68 ± 0.104
0.767GluCys: 0.767 ± 0.035
5.218GluAsp: 5.218 ± 0.098
8.112GluGlu: 8.112 ± 0.149
2.647GluPhe: 2.647 ± 0.057
4.237GluGly: 4.237 ± 0.081
1.569GluHis: 1.569 ± 0.048
6.021GluIle: 6.021 ± 0.097
6.224GluLys: 6.224 ± 0.112
6.638GluLeu: 6.638 ± 0.099
3.112GluMet: 3.112 ± 0.064
4.155GluAsn: 4.155 ± 0.08
1.685GluPro: 1.685 ± 0.062
2.707GluGln: 2.707 ± 0.063
3.396GluArg: 3.396 ± 0.072
3.844GluSer: 3.844 ± 0.07
3.8GluThr: 3.8 ± 0.082
5.113GluVal: 5.113 ± 0.102
0.606GluTrp: 0.606 ± 0.034
3.227GluTyr: 3.227 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
2.987PheAla: 2.987 ± 0.059
0.604PheCys: 0.604 ± 0.03
2.665PheAsp: 2.665 ± 0.068
2.707PheGlu: 2.707 ± 0.065
2.033PhePhe: 2.033 ± 0.067
2.968PheGly: 2.968 ± 0.075
0.976PheHis: 0.976 ± 0.033
2.916PheIle: 2.916 ± 0.07
1.982PheLys: 1.982 ± 0.049
4.094PheLeu: 4.094 ± 0.094
1.279PheMet: 1.279 ± 0.046
1.497PheAsn: 1.497 ± 0.046
1.274PhePro: 1.274 ± 0.039
1.522PheGln: 1.522 ± 0.044
1.679PheArg: 1.679 ± 0.045
2.661PheSer: 2.661 ± 0.063
2.293PheThr: 2.293 ± 0.055
3.107PheVal: 3.107 ± 0.072
0.384PheTrp: 0.384 ± 0.021
1.846PheTyr: 1.846 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.917GlyAla: 4.917 ± 0.091
1.063GlyCys: 1.063 ± 0.042
3.743GlyAsp: 3.743 ± 0.072
4.574GlyGlu: 4.574 ± 0.095
3.143GlyPhe: 3.143 ± 0.068
4.326GlyGly: 4.326 ± 0.102
1.261GlyHis: 1.261 ± 0.047
5.707GlyIle: 5.707 ± 0.092
4.623GlyLys: 4.623 ± 0.081
5.588GlyLeu: 5.588 ± 0.09
2.409GlyMet: 2.409 ± 0.066
3.233GlyAsn: 3.233 ± 0.064
1.277GlyPro: 1.277 ± 0.044
1.981GlyGln: 1.981 ± 0.057
2.775GlyArg: 2.775 ± 0.066
3.807GlySer: 3.807 ± 0.085
4.012GlyThr: 4.012 ± 0.096
5.109GlyVal: 5.109 ± 0.097
0.603GlyTrp: 0.603 ± 0.031
3.256GlyTyr: 3.256 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.258HisAla: 1.258 ± 0.038
0.296HisCys: 0.296 ± 0.02
1.019HisAsp: 1.019 ± 0.041
1.229HisGlu: 1.229 ± 0.045
1.007HisPhe: 1.007 ± 0.042
1.317HisGly: 1.317 ± 0.043
0.514HisHis: 0.514 ± 0.031
1.434HisIle: 1.434 ± 0.053
0.966HisLys: 0.966 ± 0.038
1.586HisLeu: 1.586 ± 0.046
0.627HisMet: 0.627 ± 0.027
0.756HisAsn: 0.756 ± 0.037
0.927HisPro: 0.927 ± 0.039
0.52HisGln: 0.52 ± 0.026
0.815HisArg: 0.815 ± 0.034
0.964HisSer: 0.964 ± 0.031
1.003HisThr: 1.003 ± 0.039
1.314HisVal: 1.314 ± 0.044
0.167HisTrp: 0.167 ± 0.016
0.779HisTyr: 0.779 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.921IleAla: 5.921 ± 0.099
1.266IleCys: 1.266 ± 0.039
4.577IleAsp: 4.577 ± 0.082
5.262IleGlu: 5.262 ± 0.093
2.989IlePhe: 2.989 ± 0.076
5.168IleGly: 5.168 ± 0.08
1.483IleHis: 1.483 ± 0.046
5.24IleIle: 5.24 ± 0.109
4.004IleLys: 4.004 ± 0.071
6.927IleLeu: 6.927 ± 0.143
2.017IleMet: 2.017 ± 0.052
2.967IleAsn: 2.967 ± 0.066
2.939IlePro: 2.939 ± 0.063
2.413IleGln: 2.413 ± 0.053
3.412IleArg: 3.412 ± 0.059
5.29IleSer: 5.29 ± 0.095
4.318IleThr: 4.318 ± 0.095
5.233IleVal: 5.233 ± 0.094
0.606IleTrp: 0.606 ± 0.032
2.979IleTyr: 2.979 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.534LysAla: 4.534 ± 0.089
0.638LysCys: 0.638 ± 0.036
3.99LysAsp: 3.99 ± 0.085
6.219LysGlu: 6.219 ± 0.093
1.985LysPhe: 1.985 ± 0.056
3.488LysGly: 3.488 ± 0.082
1.197LysHis: 1.197 ± 0.041
4.659LysIle: 4.659 ± 0.075
6.104LysLys: 6.104 ± 0.122
5.472LysLeu: 5.472 ± 0.083
2.362LysMet: 2.362 ± 0.058
3.562LysAsn: 3.562 ± 0.077
1.826LysPro: 1.826 ± 0.054
2.205LysGln: 2.205 ± 0.054
3.216LysArg: 3.216 ± 0.061
3.478LysSer: 3.478 ± 0.07
3.555LysThr: 3.555 ± 0.072
4.114LysVal: 4.114 ± 0.085
0.519LysTrp: 0.519 ± 0.028
2.963LysTyr: 2.963 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
6.144LeuAla: 6.144 ± 0.097
1.33LeuCys: 1.33 ± 0.042
5.45LeuAsp: 5.45 ± 0.091
6.563LeuGlu: 6.563 ± 0.118
3.635LeuPhe: 3.635 ± 0.096
5.651LeuGly: 5.651 ± 0.085
1.71LeuHis: 1.71 ± 0.048
5.867LeuIle: 5.867 ± 0.106
5.653LeuLys: 5.653 ± 0.097
8.282LeuLeu: 8.282 ± 0.139
2.693LeuMet: 2.693 ± 0.06
3.843LeuAsn: 3.843 ± 0.08
2.995LeuPro: 2.995 ± 0.061
3.032LeuGln: 3.032 ± 0.073
3.702LeuArg: 3.702 ± 0.091
6.171LeuSer: 6.171 ± 0.094
4.793LeuThr: 4.793 ± 0.102
5.816LeuVal: 5.816 ± 0.091
0.686LeuTrp: 0.686 ± 0.035
3.38LeuTyr: 3.38 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.45MetAla: 2.45 ± 0.063
0.355MetCys: 0.355 ± 0.023
2.249MetAsp: 2.249 ± 0.048
2.624MetGlu: 2.624 ± 0.062
1.09MetPhe: 1.09 ± 0.041
2.208MetGly: 2.208 ± 0.055
0.556MetHis: 0.556 ± 0.028
2.533MetIle: 2.533 ± 0.059
2.635MetLys: 2.635 ± 0.057
2.819MetLeu: 2.819 ± 0.07
1.162MetMet: 1.162 ± 0.043
1.746MetAsn: 1.746 ± 0.044
1.122MetPro: 1.122 ± 0.04
1.165MetGln: 1.165 ± 0.038
1.397MetArg: 1.397 ± 0.045
1.942MetSer: 1.942 ± 0.049
1.856MetThr: 1.856 ± 0.051
2.113MetVal: 2.113 ± 0.049
0.191MetTrp: 0.191 ± 0.017
1.023MetTyr: 1.023 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.315AsnAla: 3.315 ± 0.071
0.542AsnCys: 0.542 ± 0.032
2.485AsnAsp: 2.485 ± 0.058
2.931AsnGlu: 2.931 ± 0.065
1.606AsnPhe: 1.606 ± 0.045
3.415AsnGly: 3.415 ± 0.078
1.004AsnHis: 1.004 ± 0.031
3.343AsnIle: 3.343 ± 0.074
2.621AsnLys: 2.621 ± 0.066
3.882AsnLeu: 3.882 ± 0.071
1.498AsnMet: 1.498 ± 0.041
1.9AsnAsn: 1.9 ± 0.059
2.076AsnPro: 2.076 ± 0.063
1.714AsnGln: 1.714 ± 0.055
2.161AsnArg: 2.161 ± 0.066
2.39AsnSer: 2.39 ± 0.064
2.502AsnThr: 2.502 ± 0.063
3.199AsnVal: 3.199 ± 0.06
0.398AsnTrp: 0.398 ± 0.022
1.969AsnTyr: 1.969 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.998ProAla: 1.998 ± 0.056
0.363ProCys: 0.363 ± 0.023
2.049ProAsp: 2.049 ± 0.055
3.128ProGlu: 3.128 ± 0.075
1.365ProPhe: 1.365 ± 0.043
2.012ProGly: 2.012 ± 0.049
0.459ProHis: 0.459 ± 0.026
2.17ProIle: 2.17 ± 0.046
1.897ProLys: 1.897 ± 0.045
2.446ProLeu: 2.446 ± 0.057
0.916ProMet: 0.916 ± 0.036
1.303ProAsn: 1.303 ± 0.043
0.544ProPro: 0.544 ± 0.026
0.899ProGln: 0.899 ± 0.034
0.938ProArg: 0.938 ± 0.039
1.682ProSer: 1.682 ± 0.046
1.637ProThr: 1.637 ± 0.046
2.537ProVal: 2.537 ± 0.056
0.303ProTrp: 0.303 ± 0.024
1.385ProTyr: 1.385 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.288GlnAla: 2.288 ± 0.061
0.327GlnCys: 0.327 ± 0.023
1.815GlnAsp: 1.815 ± 0.049
2.677GlnGlu: 2.677 ± 0.067
1.177GlnPhe: 1.177 ± 0.04
1.88GlnGly: 1.88 ± 0.044
0.53GlnHis: 0.53 ± 0.025
2.485GlnIle: 2.485 ± 0.066
2.53GlnLys: 2.53 ± 0.067
2.615GlnLeu: 2.615 ± 0.065
1.298GlnMet: 1.298 ± 0.042
1.703GlnAsn: 1.703 ± 0.06
0.766GlnPro: 0.766 ± 0.032
1.082GlnGln: 1.082 ± 0.042
1.379GlnArg: 1.379 ± 0.05
1.806GlnSer: 1.806 ± 0.054
1.615GlnThr: 1.615 ± 0.054
2.113GlnVal: 2.113 ± 0.057
0.28GlnTrp: 0.28 ± 0.024
1.298GlnTyr: 1.298 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.772ArgAla: 2.772 ± 0.06
0.482ArgCys: 0.482 ± 0.033
2.532ArgAsp: 2.532 ± 0.062
3.824ArgGlu: 3.824 ± 0.086
1.868ArgPhe: 1.868 ± 0.057
2.388ArgGly: 2.388 ± 0.06
0.71ArgHis: 0.71 ± 0.034
3.514ArgIle: 3.514 ± 0.08
3.199ArgLys: 3.199 ± 0.066
3.388ArgLeu: 3.388 ± 0.081
1.513ArgMet: 1.513 ± 0.046
2.244ArgAsn: 2.244 ± 0.059
1.165ArgPro: 1.165 ± 0.039
1.337ArgGln: 1.337 ± 0.044
2.126ArgArg: 2.126 ± 0.065
2.018ArgSer: 2.018 ± 0.055
2.046ArgThr: 2.046 ± 0.05
2.749ArgVal: 2.749 ± 0.055
0.335ArgTrp: 0.335 ± 0.023
1.773ArgTyr: 1.773 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.257SerAla: 4.257 ± 0.098
0.595SerCys: 0.595 ± 0.028
3.886SerAsp: 3.886 ± 0.089
4.349SerGlu: 4.349 ± 0.081
2.683SerPhe: 2.683 ± 0.056
4.695SerGly: 4.695 ± 0.088
1.074SerHis: 1.074 ± 0.041
4.375SerIle: 4.375 ± 0.08
3.674SerLys: 3.674 ± 0.058
5.038SerLeu: 5.038 ± 0.092
2.108SerMet: 2.108 ± 0.057
2.648SerAsn: 2.648 ± 0.07
1.426SerPro: 1.426 ± 0.05
1.661SerGln: 1.661 ± 0.056
2.252SerArg: 2.252 ± 0.054
3.844SerSer: 3.844 ± 0.101
3.196SerThr: 3.196 ± 0.091
4.463SerVal: 4.463 ± 0.087
0.494SerTrp: 0.494 ± 0.023
2.669SerTyr: 2.669 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
4.049ThrAla: 4.049 ± 0.097
0.636ThrCys: 0.636 ± 0.032
3.45ThrAsp: 3.45 ± 0.085
4.063ThrGlu: 4.063 ± 0.082
2.262ThrPhe: 2.262 ± 0.059
4.355ThrGly: 4.355 ± 0.101
0.79ThrHis: 0.79 ± 0.033
4.287ThrIle: 4.287 ± 0.094
3.189ThrLys: 3.189 ± 0.073
4.609ThrLeu: 4.609 ± 0.088
1.591ThrMet: 1.591 ± 0.045
2.349ThrAsn: 2.349 ± 0.062
1.849ThrPro: 1.849 ± 0.056
1.342ThrGln: 1.342 ± 0.048
1.841ThrArg: 1.841 ± 0.05
3.394ThrSer: 3.394 ± 0.094
3.243ThrThr: 3.243 ± 0.097
4.331ThrVal: 4.331 ± 0.093
0.459ThrTrp: 0.459 ± 0.022
2.373ThrTyr: 2.373 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
5.128ValAla: 5.128 ± 0.096
1.113ValCys: 1.113 ± 0.038
4.591ValAsp: 4.591 ± 0.086
5.208ValGlu: 5.208 ± 0.101
3.061ValPhe: 3.061 ± 0.073
4.467ValGly: 4.467 ± 0.087
1.174ValHis: 1.174 ± 0.045
5.388ValIle: 5.388 ± 0.093
4.365ValLys: 4.365 ± 0.084
6.574ValLeu: 6.574 ± 0.105
2.204ValMet: 2.204 ± 0.055
2.985ValAsn: 2.985 ± 0.063
2.344ValPro: 2.344 ± 0.061
2.038ValGln: 2.038 ± 0.047
2.765ValArg: 2.765 ± 0.065
4.675ValSer: 4.675 ± 0.089
4.218ValThr: 4.218 ± 0.091
5.409ValVal: 5.409 ± 0.111
0.556ValTrp: 0.556 ± 0.027
2.812ValTyr: 2.812 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.466TrpAla: 0.466 ± 0.024
0.112TrpCys: 0.112 ± 0.013
0.575TrpAsp: 0.575 ± 0.031
0.559TrpGlu: 0.559 ± 0.028
0.39TrpPhe: 0.39 ± 0.022
0.567TrpGly: 0.567 ± 0.03
0.132TrpHis: 0.132 ± 0.014
0.65TrpIle: 0.65 ± 0.03
0.604TrpLys: 0.604 ± 0.03
0.698TrpLeu: 0.698 ± 0.032
0.332TrpMet: 0.332 ± 0.022
0.53TrpAsn: 0.53 ± 0.027
0.204TrpPro: 0.204 ± 0.02
0.251TrpGln: 0.251 ± 0.017
0.329TrpArg: 0.329 ± 0.023
0.444TrpSer: 0.444 ± 0.025
0.408TrpThr: 0.408 ± 0.023
0.495TrpVal: 0.495 ± 0.026
0.108TrpTrp: 0.108 ± 0.013
0.331TrpTyr: 0.331 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.808TyrAla: 2.808 ± 0.064
0.554TyrCys: 0.554 ± 0.031
2.923TyrAsp: 2.923 ± 0.072
3.269TyrGlu: 3.269 ± 0.065
1.917TyrPhe: 1.917 ± 0.058
2.973TyrGly: 2.973 ± 0.063
0.954TyrHis: 0.954 ± 0.038
2.973TyrIle: 2.973 ± 0.066
2.304TyrLys: 2.304 ± 0.061
3.786TyrLeu: 3.786 ± 0.077
1.206TyrMet: 1.206 ± 0.04
1.819TyrAsn: 1.819 ± 0.05
1.386TyrPro: 1.386 ± 0.047
1.685TyrGln: 1.685 ± 0.052
2.021TyrArg: 2.021 ± 0.056
2.481TyrSer: 2.481 ± 0.061
2.316TyrThr: 2.316 ± 0.082
2.953TyrVal: 2.953 ± 0.071
0.313TyrTrp: 0.313 ± 0.021
1.922TyrTyr: 1.922 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2244 proteins (749661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski