Amino acid dipepetide frequency for Pueribacillus theae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.973AlaAla: 5.973 ± 0.087	0.639AlaCys: 0.639 ± 0.025	3.179AlaAsp: 3.179 ± 0.056	4.943AlaGlu: 4.943 ± 0.073	3.426AlaPhe: 3.426 ± 0.055	5.194AlaGly: 5.194 ± 0.079	1.199AlaHis: 1.199 ± 0.032	6.192AlaIle: 6.192 ± 0.093	5.023AlaLys: 5.023 ± 0.076	7.102AlaLeu: 7.102 ± 0.092	2.041AlaMet: 2.041 ± 0.046	2.895AlaAsn: 2.895 ± 0.057	1.995AlaPro: 1.995 ± 0.052	2.023AlaGln: 2.023 ± 0.045	2.723AlaArg: 2.723 ± 0.054	4.14AlaSer: 4.14 ± 0.073	3.45AlaThr: 3.45 ± 0.059	5.444AlaVal: 5.444 ± 0.086	0.616AlaTrp: 0.616 ± 0.024	2.383AlaTyr: 2.383 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.415CysAla: 0.415 ± 0.021	0.105CysCys: 0.105 ± 0.011	0.398CysAsp: 0.398 ± 0.022	0.491CysGlu: 0.491 ± 0.022	0.376CysPhe: 0.376 ± 0.02	0.71CysGly: 0.71 ± 0.027	0.199CysHis: 0.199 ± 0.013	0.541CysIle: 0.541 ± 0.023	0.402CysLys: 0.402 ± 0.016	0.648CysLeu: 0.648 ± 0.024	0.178CysMet: 0.178 ± 0.013	0.297CysAsn: 0.297 ± 0.018	0.38CysPro: 0.38 ± 0.02	0.218CysGln: 0.218 ± 0.015	0.306CysArg: 0.306 ± 0.018	0.477CysSer: 0.477 ± 0.022	0.382CysThr: 0.382 ± 0.02	0.417CysVal: 0.417 ± 0.021	0.079CysTrp: 0.079 ± 0.009	0.269CysTyr: 0.269 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.191AspAla: 3.191 ± 0.066	0.392AspCys: 0.392 ± 0.018	2.519AspAsp: 2.519 ± 0.058	4.689AspGlu: 4.689 ± 0.076	2.421AspPhe: 2.421 ± 0.043	3.396AspGly: 3.396 ± 0.061	1.041AspHis: 1.041 ± 0.03	3.834AspIle: 3.834 ± 0.064	3.345AspLys: 3.345 ± 0.067	4.934AspLeu: 4.934 ± 0.066	1.313AspMet: 1.313 ± 0.04	1.807AspAsn: 1.807 ± 0.048	1.991AspPro: 1.991 ± 0.05	1.492AspGln: 1.492 ± 0.032	2.308AspArg: 2.308 ± 0.05	2.472AspSer: 2.472 ± 0.05	2.173AspThr: 2.173 ± 0.054	3.704AspVal: 3.704 ± 0.064	0.625AspTrp: 0.625 ± 0.025	2.036AspTyr: 2.036 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.771GluAla: 5.771 ± 0.082	0.437GluCys: 0.437 ± 0.021	3.614GluAsp: 3.614 ± 0.069	7.378GluGlu: 7.378 ± 0.106	2.5GluPhe: 2.5 ± 0.053	4.482GluGly: 4.482 ± 0.068	1.523GluHis: 1.523 ± 0.036	5.954GluIle: 5.954 ± 0.08	7.608GluLys: 7.608 ± 0.11	7.223GluLeu: 7.223 ± 0.082	2.448GluMet: 2.448 ± 0.05	4.05GluAsn: 4.05 ± 0.064	2.225GluPro: 2.225 ± 0.046	3.42GluGln: 3.42 ± 0.064	4.071GluArg: 4.071 ± 0.074	3.609GluSer: 3.609 ± 0.062	4.053GluThr: 4.053 ± 0.063	4.908GluVal: 4.908 ± 0.08	0.852GluTrp: 0.852 ± 0.028	2.171GluTyr: 2.171 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.969PheAla: 2.969 ± 0.057	0.383PheCys: 0.383 ± 0.02	2.301PheAsp: 2.301 ± 0.043	2.995PheGlu: 2.995 ± 0.059	2.508PhePhe: 2.508 ± 0.073	3.356PheGly: 3.356 ± 0.055	1.062PheHis: 1.062 ± 0.032	3.983PheIle: 3.983 ± 0.075	2.456PheLys: 2.456 ± 0.047	4.82PheLeu: 4.82 ± 0.08	1.121PheMet: 1.121 ± 0.035	1.868PheAsn: 1.868 ± 0.042	1.785PhePro: 1.785 ± 0.048	1.614PheGln: 1.614 ± 0.038	1.66PheArg: 1.66 ± 0.039	3.331PheSer: 3.331 ± 0.069	2.43PheThr: 2.43 ± 0.052	3.084PheVal: 3.084 ± 0.062	0.476PheTrp: 0.476 ± 0.023	1.706PheTyr: 1.706 ± 0.036	0.001PheXaa: 0.001 ± 0.001
Gly	4.856GlyAla: 4.856 ± 0.073	0.631GlyCys: 0.631 ± 0.028	3.134GlyAsp: 3.134 ± 0.059	4.737GlyGlu: 4.737 ± 0.068	3.398GlyPhe: 3.398 ± 0.069	4.996GlyGly: 4.996 ± 0.084	1.342GlyHis: 1.342 ± 0.04	5.982GlyIle: 5.982 ± 0.091	5.422GlyLys: 5.422 ± 0.074	6.682GlyLeu: 6.682 ± 0.078	2.093GlyMet: 2.093 ± 0.045	2.773GlyAsn: 2.773 ± 0.056	1.787GlyPro: 1.787 ± 0.045	2.142GlyGln: 2.142 ± 0.047	2.713GlyArg: 2.713 ± 0.049	4.037GlySer: 4.037 ± 0.065	3.884GlyThr: 3.884 ± 0.066	4.865GlyVal: 4.865 ± 0.078	0.78GlyTrp: 0.78 ± 0.026	2.73GlyTyr: 2.73 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.302HisAla: 1.302 ± 0.037	0.209HisCys: 0.209 ± 0.013	1.043HisAsp: 1.043 ± 0.03	1.361HisGlu: 1.361 ± 0.041	1.073HisPhe: 1.073 ± 0.032	1.35HisGly: 1.35 ± 0.038	0.653HisHis: 0.653 ± 0.027	1.455HisIle: 1.455 ± 0.039	1.063HisLys: 1.063 ± 0.031	2.117HisLeu: 2.117 ± 0.046	0.493HisMet: 0.493 ± 0.021	0.774HisAsn: 0.774 ± 0.027	1.181HisPro: 1.181 ± 0.034	0.802HisGln: 0.802 ± 0.028	0.902HisArg: 0.902 ± 0.03	1.219HisSer: 1.219 ± 0.042	1.029HisThr: 1.029 ± 0.032	1.413HisVal: 1.413 ± 0.042	0.253HisTrp: 0.253 ± 0.017	0.889HisTyr: 0.889 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.308IleAla: 6.308 ± 0.082	0.621IleCys: 0.621 ± 0.024	4.501IleAsp: 4.501 ± 0.076	6.243IleGlu: 6.243 ± 0.088	3.388IlePhe: 3.388 ± 0.067	6.098IleGly: 6.098 ± 0.077	1.665IleHis: 1.665 ± 0.041	5.872IleIle: 5.872 ± 0.081	4.663IleLys: 4.663 ± 0.072	7.085IleLeu: 7.085 ± 0.104	1.732IleMet: 1.732 ± 0.042	3.281IleAsn: 3.281 ± 0.06	3.482IlePro: 3.482 ± 0.063	2.881IleGln: 2.881 ± 0.054	3.29IleArg: 3.29 ± 0.056	4.953IleSer: 4.953 ± 0.079	4.24IleThr: 4.24 ± 0.078	5.854IleVal: 5.854 ± 0.085	0.68IleTrp: 0.68 ± 0.025	2.414IleTyr: 2.414 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.926LysAla: 4.926 ± 0.067	0.322LysCys: 0.322 ± 0.02	3.772LysAsp: 3.772 ± 0.063	7.656LysGlu: 7.656 ± 0.099	2.041LysPhe: 2.041 ± 0.043	4.618LysGly: 4.618 ± 0.068	1.373LysHis: 1.373 ± 0.042	5.06LysIle: 5.06 ± 0.076	6.664LysLys: 6.664 ± 0.097	6.18LysLeu: 6.18 ± 0.08	2.273LysMet: 2.273 ± 0.045	3.765LysAsn: 3.765 ± 0.061	2.532LysPro: 2.532 ± 0.051	3.298LysGln: 3.298 ± 0.061	3.568LysArg: 3.568 ± 0.057	3.573LysSer: 3.573 ± 0.064	3.81LysThr: 3.81 ± 0.063	4.527LysVal: 4.527 ± 0.074	0.815LysTrp: 0.815 ± 0.029	2.166LysTyr: 2.166 ± 0.05	0.001LysXaa: 0.001 ± 0.001
Leu	7.281LeuAla: 7.281 ± 0.095	0.672LeuCys: 0.672 ± 0.026	4.684LeuAsp: 4.684 ± 0.082	6.78LeuGlu: 6.78 ± 0.084	4.918LeuPhe: 4.918 ± 0.077	6.37LeuGly: 6.37 ± 0.088	2.046LeuHis: 2.046 ± 0.043	7.491LeuIle: 7.491 ± 0.101	7.071LeuLys: 7.071 ± 0.089	10.072LeuLeu: 10.072 ± 0.15	2.389LeuMet: 2.389 ± 0.047	4.502LeuAsn: 4.502 ± 0.071	4.068LeuPro: 4.068 ± 0.063	3.374LeuGln: 3.374 ± 0.052	3.742LeuArg: 3.742 ± 0.069	6.725LeuSer: 6.725 ± 0.08	5.319LeuThr: 5.319 ± 0.075	5.885LeuVal: 5.885 ± 0.082	0.743LeuTrp: 0.743 ± 0.034	2.993LeuTyr: 2.993 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.13MetAla: 2.13 ± 0.044	0.144MetCys: 0.144 ± 0.012	1.36MetAsp: 1.36 ± 0.036	2.059MetGlu: 2.059 ± 0.047	1.084MetPhe: 1.084 ± 0.034	1.815MetGly: 1.815 ± 0.044	0.414MetHis: 0.414 ± 0.02	2.207MetIle: 2.207 ± 0.04	2.493MetLys: 2.493 ± 0.047	2.597MetLeu: 2.597 ± 0.056	0.905MetMet: 0.905 ± 0.034	1.483MetAsn: 1.483 ± 0.037	1.132MetPro: 1.132 ± 0.034	0.89MetGln: 0.89 ± 0.029	1.105MetArg: 1.105 ± 0.034	1.575MetSer: 1.575 ± 0.037	1.544MetThr: 1.544 ± 0.039	1.594MetVal: 1.594 ± 0.037	0.191MetTrp: 0.191 ± 0.016	0.687MetTyr: 0.687 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.825AsnAla: 2.825 ± 0.059	0.332AsnCys: 0.332 ± 0.019	2.419AsnAsp: 2.419 ± 0.052	4.083AsnGlu: 4.083 ± 0.062	1.692AsnPhe: 1.692 ± 0.037	3.387AsnGly: 3.387 ± 0.064	1.113AsnHis: 1.113 ± 0.034	3.356AsnIle: 3.356 ± 0.063	3.045AsnLys: 3.045 ± 0.058	3.858AsnLeu: 3.858 ± 0.063	1.225AsnMet: 1.225 ± 0.034	2.013AsnAsn: 2.013 ± 0.049	2.139AsnPro: 2.139 ± 0.049	1.869AsnGln: 1.869 ± 0.047	2.242AsnArg: 2.242 ± 0.051	2.112AsnSer: 2.112 ± 0.046	1.988AsnThr: 1.988 ± 0.044	3.141AsnVal: 3.141 ± 0.047	0.529AsnTrp: 0.529 ± 0.022	1.464AsnTyr: 1.464 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.22ProAla: 2.22 ± 0.055	0.218ProCys: 0.218 ± 0.014	2.101ProAsp: 2.101 ± 0.042	3.19ProGlu: 3.19 ± 0.065	2.085ProPhe: 2.085 ± 0.046	2.443ProGly: 2.443 ± 0.054	0.827ProHis: 0.827 ± 0.03	3.09ProIle: 3.09 ± 0.059	2.556ProLys: 2.556 ± 0.052	3.606ProLeu: 3.606 ± 0.059	0.89ProMet: 0.89 ± 0.027	1.816ProAsn: 1.816 ± 0.047	1.145ProPro: 1.145 ± 0.037	1.095ProGln: 1.095 ± 0.032	1.226ProArg: 1.226 ± 0.038	2.343ProSer: 2.343 ± 0.052	1.889ProThr: 1.889 ± 0.043	2.834ProVal: 2.834 ± 0.052	0.361ProTrp: 0.361 ± 0.019	1.373ProTyr: 1.373 ± 0.033	0.001ProXaa: 0.001 ± 0.001
Gln	2.725GlnAla: 2.725 ± 0.05	0.203GlnCys: 0.203 ± 0.016	1.444GlnAsp: 1.444 ± 0.036	2.63GlnGlu: 2.63 ± 0.056	1.694GlnPhe: 1.694 ± 0.043	1.941GlnGly: 1.941 ± 0.049	0.713GlnHis: 0.713 ± 0.03	2.702GlnIle: 2.702 ± 0.047	2.677GlnLys: 2.677 ± 0.054	4.023GlnLeu: 4.023 ± 0.066	1.177GlnMet: 1.177 ± 0.032	1.53GlnAsn: 1.53 ± 0.039	1.182GlnPro: 1.182 ± 0.034	1.597GlnGln: 1.597 ± 0.051	1.497GlnArg: 1.497 ± 0.036	2.067GlnSer: 2.067 ± 0.047	1.815GlnThr: 1.815 ± 0.049	2.164GlnVal: 2.164 ± 0.046	0.371GlnTrp: 0.371 ± 0.02	1.081GlnTyr: 1.081 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.54ArgAla: 2.54 ± 0.056	0.266ArgCys: 0.266 ± 0.016	2.072ArgAsp: 2.072 ± 0.047	3.381ArgGlu: 3.381 ± 0.06	2.119ArgPhe: 2.119 ± 0.043	2.426ArgGly: 2.426 ± 0.053	0.862ArgHis: 0.862 ± 0.029	3.236ArgIle: 3.236 ± 0.059	3.532ArgLys: 3.532 ± 0.059	4.306ArgLeu: 4.306 ± 0.073	1.348ArgMet: 1.348 ± 0.037	2.032ArgAsn: 2.032 ± 0.046	1.457ArgPro: 1.457 ± 0.035	1.595ArgGln: 1.595 ± 0.045	2.034ArgArg: 2.034 ± 0.05	2.331ArgSer: 2.331 ± 0.041	2.127ArgThr: 2.127 ± 0.048	2.613ArgVal: 2.613 ± 0.05	0.476ArgTrp: 0.476 ± 0.021	1.576ArgTyr: 1.576 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	3.606SerAla: 3.606 ± 0.065	0.377SerCys: 0.377 ± 0.018	2.846SerAsp: 2.846 ± 0.052	4.025SerGlu: 4.025 ± 0.065	3.175SerPhe: 3.175 ± 0.06	4.484SerGly: 4.484 ± 0.067	1.223SerHis: 1.223 ± 0.039	4.926SerIle: 4.926 ± 0.074	3.944SerLys: 3.944 ± 0.071	6.054SerLeu: 6.054 ± 0.088	1.608SerMet: 1.608 ± 0.038	2.493SerAsn: 2.493 ± 0.055	2.224SerPro: 2.224 ± 0.048	1.844SerGln: 1.844 ± 0.039	2.411SerArg: 2.411 ± 0.05	3.757SerSer: 3.757 ± 0.068	2.887SerThr: 2.887 ± 0.054	4.065SerVal: 4.065 ± 0.05	0.592SerTrp: 0.592 ± 0.029	2.026SerTyr: 2.026 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.856ThrAla: 3.856 ± 0.056	0.373ThrCys: 0.373 ± 0.018	2.5ThrAsp: 2.5 ± 0.058	3.492ThrGlu: 3.492 ± 0.059	2.613ThrPhe: 2.613 ± 0.056	4.181ThrGly: 4.181 ± 0.062	0.984ThrHis: 0.984 ± 0.035	4.541ThrIle: 4.541 ± 0.075	3.401ThrLys: 3.401 ± 0.06	5.069ThrLeu: 5.069 ± 0.063	1.257ThrMet: 1.257 ± 0.037	2.293ThrAsn: 2.293 ± 0.047	2.231ThrPro: 2.231 ± 0.049	1.263ThrGln: 1.263 ± 0.033	1.83ThrArg: 1.83 ± 0.036	3.018ThrSer: 3.018 ± 0.062	2.68ThrThr: 2.68 ± 0.056	4.044ThrVal: 4.044 ± 0.064	0.507ThrTrp: 0.507 ± 0.021	1.809ThrTyr: 1.809 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.908ValAla: 4.908 ± 0.078	0.582ValCys: 0.582 ± 0.021	3.393ValAsp: 3.393 ± 0.063	4.811ValGlu: 4.811 ± 0.075	3.122ValPhe: 3.122 ± 0.059	4.576ValGly: 4.576 ± 0.077	1.313ValHis: 1.313 ± 0.036	5.724ValIle: 5.724 ± 0.082	4.721ValLys: 4.721 ± 0.077	6.356ValLeu: 6.356 ± 0.081	1.787ValMet: 1.787 ± 0.044	3.287ValAsn: 3.287 ± 0.056	2.698ValPro: 2.698 ± 0.052	2.212ValGln: 2.212 ± 0.041	2.626ValArg: 2.626 ± 0.049	4.302ValSer: 4.302 ± 0.067	4.022ValThr: 4.022 ± 0.065	4.768ValVal: 4.768 ± 0.073	0.652ValTrp: 0.652 ± 0.026	2.188ValTyr: 2.188 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.645TrpAla: 0.645 ± 0.027	0.078TrpCys: 0.078 ± 0.008	0.504TrpAsp: 0.504 ± 0.023	0.67TrpGlu: 0.67 ± 0.03	0.504TrpPhe: 0.504 ± 0.022	0.685TrpGly: 0.685 ± 0.032	0.211TrpHis: 0.211 ± 0.016	0.836TrpIle: 0.836 ± 0.031	0.812TrpLys: 0.812 ± 0.03	1.183TrpLeu: 1.183 ± 0.039	0.359TrpMet: 0.359 ± 0.021	0.532TrpAsn: 0.532 ± 0.022	0.281TrpPro: 0.281 ± 0.016	0.379TrpGln: 0.379 ± 0.018	0.417TrpArg: 0.417 ± 0.019	0.539TrpSer: 0.539 ± 0.022	0.484TrpThr: 0.484 ± 0.021	0.605TrpVal: 0.605 ± 0.028	0.143TrpTrp: 0.143 ± 0.013	0.283TrpTyr: 0.283 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.134TyrAla: 2.134 ± 0.044	0.304TyrCys: 0.304 ± 0.017	1.9TyrAsp: 1.9 ± 0.045	2.684TyrGlu: 2.684 ± 0.056	1.774TyrPhe: 1.774 ± 0.045	2.475TyrGly: 2.475 ± 0.045	0.821TyrHis: 0.821 ± 0.025	2.269TyrIle: 2.269 ± 0.045	2.043TyrLys: 2.043 ± 0.049	3.209TyrLeu: 3.209 ± 0.053	0.768TyrMet: 0.768 ± 0.021	1.338TyrAsn: 1.338 ± 0.04	1.396TyrPro: 1.396 ± 0.034	1.226TyrGln: 1.226 ± 0.037	1.656TyrArg: 1.656 ± 0.038	1.989TyrSer: 1.989 ± 0.044	1.734TyrThr: 1.734 ± 0.043	2.12TyrVal: 2.12 ± 0.045	0.407TyrTrp: 0.407 ± 0.022	1.29TyrTyr: 1.29 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3627 proteins (1053953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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