Amino acid dipepetide frequency for Streptomyces sp. 844.5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.848AlaAla: 22.848 ± 0.15	1.107AlaCys: 1.107 ± 0.023	8.327AlaAsp: 8.327 ± 0.066	8.488AlaGlu: 8.488 ± 0.103	3.477AlaPhe: 3.477 ± 0.041	13.067AlaGly: 13.067 ± 0.085	2.774AlaHis: 2.774 ± 0.037	3.478AlaIle: 3.478 ± 0.046	2.505AlaLys: 2.505 ± 0.039	15.094AlaLeu: 15.094 ± 0.122	2.567AlaMet: 2.567 ± 0.03	2.237AlaAsn: 2.237 ± 0.035	7.603AlaPro: 7.603 ± 0.086	4.317AlaGln: 4.317 ± 0.044	9.338AlaArg: 9.338 ± 0.074	6.18AlaSer: 6.18 ± 0.056	7.719AlaThr: 7.719 ± 0.065	12.49AlaVal: 12.49 ± 0.086	1.813AlaTrp: 1.813 ± 0.027	2.434AlaTyr: 2.434 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.021	0.127CysCys: 0.127 ± 0.007	0.481CysAsp: 0.481 ± 0.014	0.396CysGlu: 0.396 ± 0.013	0.243CysPhe: 0.243 ± 0.011	0.959CysGly: 0.959 ± 0.018	0.207CysHis: 0.207 ± 0.008	0.181CysIle: 0.181 ± 0.01	0.092CysLys: 0.092 ± 0.006	0.853CysLeu: 0.853 ± 0.018	0.122CysMet: 0.122 ± 0.007	0.173CysAsn: 0.173 ± 0.009	0.523CysPro: 0.523 ± 0.015	0.199CysGln: 0.199 ± 0.009	0.608CysArg: 0.608 ± 0.017	0.559CysSer: 0.559 ± 0.017	0.588CysThr: 0.588 ± 0.018	0.637CysVal: 0.637 ± 0.017	0.155CysTrp: 0.155 ± 0.007	0.17CysTyr: 0.17 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.18AspAla: 7.18 ± 0.067	0.491AspCys: 0.491 ± 0.016	3.01AspAsp: 3.01 ± 0.037	3.113AspGlu: 3.113 ± 0.04	1.561AspPhe: 1.561 ± 0.025	5.844AspGly: 5.844 ± 0.056	1.384AspHis: 1.384 ± 0.02	1.733AspIle: 1.733 ± 0.03	0.849AspLys: 0.849 ± 0.019	6.361AspLeu: 6.361 ± 0.053	0.722AspMet: 0.722 ± 0.019	1.01AspAsn: 1.01 ± 0.022	4.716AspPro: 4.716 ± 0.046	1.813AspGln: 1.813 ± 0.028	4.722AspArg: 4.722 ± 0.044	2.857AspSer: 2.857 ± 0.036	3.118AspThr: 3.118 ± 0.033	4.007AspVal: 4.007 ± 0.044	1.001AspTrp: 1.001 ± 0.019	1.174AspTyr: 1.174 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.554GluAla: 6.554 ± 0.075	0.348GluCys: 0.348 ± 0.01	2.427GluAsp: 2.427 ± 0.034	2.726GluGlu: 2.726 ± 0.042	1.364GluPhe: 1.364 ± 0.026	3.554GluGly: 3.554 ± 0.048	1.419GluHis: 1.419 ± 0.024	2.035GluIle: 2.035 ± 0.032	0.923GluLys: 0.923 ± 0.017	6.713GluLeu: 6.713 ± 0.069	0.77GluMet: 0.77 ± 0.018	0.9GluAsn: 0.9 ± 0.018	3.126GluPro: 3.126 ± 0.041	2.632GluGln: 2.632 ± 0.036	4.567GluArg: 4.567 ± 0.058	2.466GluSer: 2.466 ± 0.034	2.458GluThr: 2.458 ± 0.031	3.97GluVal: 3.97 ± 0.049	0.663GluTrp: 0.663 ± 0.017	0.963GluTyr: 0.963 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.048	0.282PheCys: 0.282 ± 0.011	1.861PheAsp: 1.861 ± 0.027	1.313PheGlu: 1.313 ± 0.024	0.788PhePhe: 0.788 ± 0.019	3.02PheGly: 3.02 ± 0.041	0.628PheHis: 0.628 ± 0.018	0.716PheIle: 0.716 ± 0.016	0.435PheLys: 0.435 ± 0.016	2.541PheLeu: 2.541 ± 0.039	0.402PheMet: 0.402 ± 0.013	0.627PheAsn: 0.627 ± 0.017	1.448PhePro: 1.448 ± 0.023	0.784PheGln: 0.784 ± 0.018	1.744PheArg: 1.744 ± 0.027	1.525PheSer: 1.525 ± 0.025	2.051PheThr: 2.051 ± 0.028	2.059PheVal: 2.059 ± 0.027	0.408PheTrp: 0.408 ± 0.013	0.568PheTyr: 0.568 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.203GlyAla: 11.203 ± 0.083	0.919GlyCys: 0.919 ± 0.019	4.737GlyAsp: 4.737 ± 0.042	4.324GlyGlu: 4.324 ± 0.05	2.983GlyPhe: 2.983 ± 0.035	9.016GlyGly: 9.016 ± 0.102	2.255GlyHis: 2.255 ± 0.034	3.481GlyIle: 3.481 ± 0.036	1.996GlyLys: 1.996 ± 0.034	9.762GlyLeu: 9.762 ± 0.079	2.012GlyMet: 2.012 ± 0.027	1.995GlyAsn: 1.995 ± 0.038	5.434GlyPro: 5.434 ± 0.054	2.932GlyGln: 2.932 ± 0.038	7.32GlyArg: 7.32 ± 0.055	6.486GlySer: 6.486 ± 0.063	6.698GlyThr: 6.698 ± 0.071	7.386GlyVal: 7.386 ± 0.058	1.773GlyTrp: 1.773 ± 0.027	2.45GlyTyr: 2.45 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.645HisAla: 2.645 ± 0.037	0.232HisCys: 0.232 ± 0.008	1.274HisAsp: 1.274 ± 0.022	1.029HisGlu: 1.029 ± 0.019	0.63HisPhe: 0.63 ± 0.015	2.444HisGly: 2.444 ± 0.037	0.687HisHis: 0.687 ± 0.02	0.621HisIle: 0.621 ± 0.014	0.296HisLys: 0.296 ± 0.011	2.476HisLeu: 2.476 ± 0.035	0.332HisMet: 0.332 ± 0.011	0.409HisAsn: 0.409 ± 0.013	1.923HisPro: 1.923 ± 0.029	0.811HisGln: 0.811 ± 0.02	2.097HisArg: 2.097 ± 0.03	1.171HisSer: 1.171 ± 0.024	1.34HisThr: 1.34 ± 0.027	1.418HisVal: 1.418 ± 0.029	0.409HisTrp: 0.409 ± 0.013	0.514HisTyr: 0.514 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.792IleAla: 4.792 ± 0.048	0.305IleCys: 0.305 ± 0.01	2.13IleAsp: 2.13 ± 0.033	1.794IleGlu: 1.794 ± 0.028	0.712IlePhe: 0.712 ± 0.02	3.609IleGly: 3.609 ± 0.04	0.656IleHis: 0.656 ± 0.014	0.903IleIle: 0.903 ± 0.023	0.63IleLys: 0.63 ± 0.018	2.435IleLeu: 2.435 ± 0.038	0.456IleMet: 0.456 ± 0.014	0.74IleAsn: 0.74 ± 0.019	1.872IlePro: 1.872 ± 0.031	0.812IleGln: 0.812 ± 0.019	2.209IleArg: 2.209 ± 0.027	1.831IleSer: 1.831 ± 0.03	2.312IleThr: 2.312 ± 0.032	2.54IleVal: 2.54 ± 0.035	0.392IleTrp: 0.392 ± 0.015	0.543IleTyr: 0.543 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.405LysAla: 2.405 ± 0.037	0.106LysCys: 0.106 ± 0.008	0.982LysAsp: 0.982 ± 0.021	0.81LysGlu: 0.81 ± 0.02	0.386LysPhe: 0.386 ± 0.012	1.443LysGly: 1.443 ± 0.024	0.41LysHis: 0.41 ± 0.012	0.696LysIle: 0.696 ± 0.02	0.475LysLys: 0.475 ± 0.017	1.76LysLeu: 1.76 ± 0.025	0.293LysMet: 0.293 ± 0.011	0.413LysAsn: 0.413 ± 0.014	1.162LysPro: 1.162 ± 0.024	0.682LysGln: 0.682 ± 0.021	1.162LysArg: 1.162 ± 0.024	0.976LysSer: 0.976 ± 0.022	0.977LysThr: 0.977 ± 0.022	1.583LysVal: 1.583 ± 0.029	0.212LysTrp: 0.212 ± 0.01	0.375LysTyr: 0.375 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.757LeuAla: 15.757 ± 0.114	0.924LeuCys: 0.924 ± 0.022	6.723LeuAsp: 6.723 ± 0.056	4.468LeuGlu: 4.468 ± 0.047	2.612LeuPhe: 2.612 ± 0.035	9.798LeuGly: 9.798 ± 0.087	2.432LeuHis: 2.432 ± 0.034	3.37LeuIle: 3.37 ± 0.042	1.673LeuLys: 1.673 ± 0.029	12.467LeuLeu: 12.467 ± 0.112	1.67LeuMet: 1.67 ± 0.028	1.873LeuAsn: 1.873 ± 0.03	6.945LeuPro: 6.945 ± 0.057	2.746LeuGln: 2.746 ± 0.036	8.615LeuArg: 8.615 ± 0.078	5.771LeuSer: 5.771 ± 0.052	6.834LeuThr: 6.834 ± 0.054	9.168LeuVal: 9.168 ± 0.077	1.313LeuTrp: 1.313 ± 0.022	1.734LeuTyr: 1.734 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.197MetAla: 2.197 ± 0.029	0.128MetCys: 0.128 ± 0.007	0.884MetAsp: 0.884 ± 0.019	0.703MetGlu: 0.703 ± 0.016	0.439MetPhe: 0.439 ± 0.015	1.265MetGly: 1.265 ± 0.025	0.368MetHis: 0.368 ± 0.013	0.645MetIle: 0.645 ± 0.017	0.345MetLys: 0.345 ± 0.011	1.767MetLeu: 1.767 ± 0.027	0.298MetMet: 0.298 ± 0.013	0.47MetAsn: 0.47 ± 0.013	1.127MetPro: 1.127 ± 0.021	0.486MetGln: 0.486 ± 0.015	1.309MetArg: 1.309 ± 0.024	1.37MetSer: 1.37 ± 0.025	1.552MetThr: 1.552 ± 0.026	1.342MetVal: 1.342 ± 0.025	0.193MetTrp: 0.193 ± 0.009	0.311MetTyr: 0.311 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.359AsnAla: 2.359 ± 0.034	0.186AsnCys: 0.186 ± 0.008	1.011AsnAsp: 1.011 ± 0.022	0.788AsnGlu: 0.788 ± 0.019	0.514AsnPhe: 0.514 ± 0.016	2.233AsnGly: 2.233 ± 0.039	0.417AsnHis: 0.417 ± 0.013	0.671AsnIle: 0.671 ± 0.016	0.349AsnLys: 0.349 ± 0.014	1.865AsnLeu: 1.865 ± 0.031	0.317AsnMet: 0.317 ± 0.011	0.508AsnAsn: 0.508 ± 0.017	1.599AsnPro: 1.599 ± 0.031	0.664AsnGln: 0.664 ± 0.016	1.311AsnArg: 1.311 ± 0.021	1.175AsnSer: 1.175 ± 0.026	1.289AsnThr: 1.289 ± 0.031	1.382AsnVal: 1.382 ± 0.028	0.332AsnTrp: 0.332 ± 0.012	0.441AsnTyr: 0.441 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.153ProAla: 9.153 ± 0.088	0.357ProCys: 0.357 ± 0.013	4.34ProAsp: 4.34 ± 0.042	3.974ProGlu: 3.974 ± 0.05	1.525ProPhe: 1.525 ± 0.026	7.116ProGly: 7.116 ± 0.064	1.32ProHis: 1.32 ± 0.025	1.498ProIle: 1.498 ± 0.029	0.981ProLys: 0.981 ± 0.022	5.676ProLeu: 5.676 ± 0.054	1.054ProMet: 1.054 ± 0.017	1.054ProAsn: 1.054 ± 0.02	3.592ProPro: 3.592 ± 0.059	2.178ProGln: 2.178 ± 0.038	3.784ProArg: 3.784 ± 0.043	3.602ProSer: 3.602 ± 0.046	4.005ProThr: 4.005 ± 0.048	5.641ProVal: 5.641 ± 0.05	0.911ProTrp: 0.911 ± 0.021	1.33ProTyr: 1.33 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.322GlnAla: 4.322 ± 0.05	0.203GlnCys: 0.203 ± 0.01	1.562GlnAsp: 1.562 ± 0.026	1.406GlnGlu: 1.406 ± 0.026	0.782GlnPhe: 0.782 ± 0.018	2.617GlnGly: 2.617 ± 0.04	0.804GlnHis: 0.804 ± 0.018	1.208GlnIle: 1.208 ± 0.02	0.519GlnLys: 0.519 ± 0.016	3.704GlnLeu: 3.704 ± 0.039	0.511GlnMet: 0.511 ± 0.014	0.619GlnAsn: 0.619 ± 0.017	2.121GlnPro: 2.121 ± 0.036	1.907GlnGln: 1.907 ± 0.055	2.68GlnArg: 2.68 ± 0.037	1.664GlnSer: 1.664 ± 0.029	1.594GlnThr: 1.594 ± 0.026	2.858GlnVal: 2.858 ± 0.036	0.543GlnTrp: 0.543 ± 0.014	0.702GlnTyr: 0.702 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.216ArgAla: 9.216 ± 0.076	0.607ArgCys: 0.607 ± 0.018	3.763ArgAsp: 3.763 ± 0.046	3.991ArgGlu: 3.991 ± 0.051	2.237ArgPhe: 2.237 ± 0.031	5.244ArgGly: 5.244 ± 0.05	1.94ArgHis: 1.94 ± 0.033	3.304ArgIle: 3.304 ± 0.038	1.318ArgLys: 1.318 ± 0.027	8.484ArgLeu: 8.484 ± 0.079	1.748ArgMet: 1.748 ± 0.027	1.406ArgAsn: 1.406 ± 0.024	4.824ArgPro: 4.824 ± 0.052	2.433ArgGln: 2.433 ± 0.033	7.288ArgArg: 7.288 ± 0.071	4.496ArgSer: 4.496 ± 0.046	5.139ArgThr: 5.139 ± 0.05	5.277ArgVal: 5.277 ± 0.051	1.337ArgTrp: 1.337 ± 0.022	1.707ArgTyr: 1.707 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	7.891SerAla: 7.891 ± 0.063	0.495SerCys: 0.495 ± 0.015	2.765SerAsp: 2.765 ± 0.033	2.416SerGlu: 2.416 ± 0.031	1.609SerPhe: 1.609 ± 0.026	6.771SerGly: 6.771 ± 0.067	1.093SerHis: 1.093 ± 0.02	1.66SerIle: 1.66 ± 0.032	0.932SerLys: 0.932 ± 0.019	5.08SerLeu: 5.08 ± 0.04	1.098SerMet: 1.098 ± 0.02	1.141SerAsn: 1.141 ± 0.025	3.391SerPro: 3.391 ± 0.042	1.476SerGln: 1.476 ± 0.025	3.756SerArg: 3.756 ± 0.045	3.672SerSer: 3.672 ± 0.054	3.925SerThr: 3.925 ± 0.056	4.485SerVal: 4.485 ± 0.044	1.059SerTrp: 1.059 ± 0.022	1.391SerTyr: 1.391 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.855ThrAla: 9.855 ± 0.082	0.47ThrCys: 0.47 ± 0.014	3.508ThrAsp: 3.508 ± 0.041	2.944ThrGlu: 2.944 ± 0.037	1.589ThrPhe: 1.589 ± 0.027	7.212ThrGly: 7.212 ± 0.077	1.169ThrHis: 1.169 ± 0.022	1.686ThrIle: 1.686 ± 0.03	0.956ThrLys: 0.956 ± 0.022	6.024ThrLeu: 6.024 ± 0.049	0.964ThrMet: 0.964 ± 0.02	1.157ThrAsn: 1.157 ± 0.026	4.454ThrPro: 4.454 ± 0.052	1.501ThrGln: 1.501 ± 0.028	3.804ThrArg: 3.804 ± 0.037	3.489ThrSer: 3.489 ± 0.049	4.212ThrThr: 4.212 ± 0.062	6.537ThrVal: 6.537 ± 0.058	0.942ThrTrp: 0.942 ± 0.021	1.123ThrTyr: 1.123 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.483ValAla: 10.483 ± 0.08	0.718ValCys: 0.718 ± 0.016	4.848ValAsp: 4.848 ± 0.05	4.273ValGlu: 4.273 ± 0.049	2.326ValPhe: 2.326 ± 0.032	6.765ValGly: 6.765 ± 0.053	1.978ValHis: 1.978 ± 0.03	2.728ValIle: 2.728 ± 0.035	1.414ValLys: 1.414 ± 0.029	9.776ValLeu: 9.776 ± 0.073	1.32ValMet: 1.32 ± 0.022	1.766ValAsn: 1.766 ± 0.03	5.272ValPro: 5.272 ± 0.054	2.44ValGln: 2.44 ± 0.033	6.434ValArg: 6.434 ± 0.052	4.637ValSer: 4.637 ± 0.049	5.361ValThr: 5.361 ± 0.055	7.612ValVal: 7.612 ± 0.073	1.09ValTrp: 1.09 ± 0.021	1.528ValTyr: 1.528 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.026	0.157TrpCys: 0.157 ± 0.008	0.784TrpAsp: 0.784 ± 0.016	0.682TrpGlu: 0.682 ± 0.016	0.519TrpPhe: 0.519 ± 0.016	1.084TrpGly: 1.084 ± 0.022	0.392TrpHis: 0.392 ± 0.013	0.583TrpIle: 0.583 ± 0.014	0.313TrpLys: 0.313 ± 0.012	1.734TrpLeu: 1.734 ± 0.027	0.3TrpMet: 0.3 ± 0.011	0.446TrpAsn: 0.446 ± 0.015	0.769TrpPro: 0.769 ± 0.019	0.699TrpGln: 0.699 ± 0.017	1.215TrpArg: 1.215 ± 0.025	1.058TrpSer: 1.058 ± 0.024	1.153TrpThr: 1.153 ± 0.024	0.961TrpVal: 0.961 ± 0.02	0.338TrpTrp: 0.338 ± 0.011	0.375TrpTyr: 0.375 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.524TyrAla: 2.524 ± 0.034	0.201TyrCys: 0.201 ± 0.01	1.251TyrAsp: 1.251 ± 0.025	0.94TyrGlu: 0.94 ± 0.018	0.624TyrPhe: 0.624 ± 0.016	2.103TyrGly: 2.103 ± 0.035	0.424TyrHis: 0.424 ± 0.015	0.477TyrIle: 0.477 ± 0.014	0.308TyrLys: 0.308 ± 0.012	2.321TyrLeu: 2.321 ± 0.031	0.244TyrMet: 0.244 ± 0.01	0.464TyrAsn: 0.464 ± 0.018	1.191TyrPro: 1.191 ± 0.027	0.81TyrGln: 0.81 ± 0.021	1.796TyrArg: 1.796 ± 0.029	1.118TyrSer: 1.118 ± 0.025	1.27TyrThr: 1.27 ± 0.028	1.414TyrVal: 1.414 ± 0.027	0.352TyrTrp: 0.352 ± 0.012	0.498TyrTyr: 0.498 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7536 proteins (2536846 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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