Amino acid dipepetide frequency for Homoserinimonas aerilata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.043AlaAla: 19.043 ± 0.232	0.628AlaCys: 0.628 ± 0.03	7.596AlaAsp: 7.596 ± 0.1	8.304AlaGlu: 8.304 ± 0.122	3.743AlaPhe: 3.743 ± 0.08	11.771AlaGly: 11.771 ± 0.152	2.255AlaHis: 2.255 ± 0.052	6.365AlaIle: 6.365 ± 0.099	3.031AlaLys: 3.031 ± 0.076	13.386AlaLeu: 13.386 ± 0.167	2.578AlaMet: 2.578 ± 0.053	2.529AlaAsn: 2.529 ± 0.054	5.974AlaPro: 5.974 ± 0.127	3.94AlaGln: 3.94 ± 0.072	8.204AlaArg: 8.204 ± 0.117	8.129AlaSer: 8.129 ± 0.109	7.439AlaThr: 7.439 ± 0.105	11.259AlaVal: 11.259 ± 0.135	1.62AlaTrp: 1.62 ± 0.044	2.188AlaTyr: 2.188 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.601CysAla: 0.601 ± 0.033	0.053CysCys: 0.053 ± 0.008	0.311CysAsp: 0.311 ± 0.02	0.242CysGlu: 0.242 ± 0.019	0.158CysPhe: 0.158 ± 0.014	0.543CysGly: 0.543 ± 0.026	0.115CysHis: 0.115 ± 0.011	0.239CysIle: 0.239 ± 0.016	0.06CysLys: 0.06 ± 0.009	0.447CysLeu: 0.447 ± 0.023	0.088CysMet: 0.088 ± 0.01	0.11CysAsn: 0.11 ± 0.011	0.23CysPro: 0.23 ± 0.014	0.103CysGln: 0.103 ± 0.011	0.311CysArg: 0.311 ± 0.018	0.306CysSer: 0.306 ± 0.02	0.302CysThr: 0.302 ± 0.022	0.392CysVal: 0.392 ± 0.019	0.047CysTrp: 0.047 ± 0.007	0.096CysTyr: 0.096 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.572AspAla: 8.572 ± 0.108	0.245AspCys: 0.245 ± 0.017	3.991AspAsp: 3.991 ± 0.089	4.2AspGlu: 4.2 ± 0.077	1.916AspPhe: 1.916 ± 0.051	5.914AspGly: 5.914 ± 0.091	1.108AspHis: 1.108 ± 0.036	2.511AspIle: 2.511 ± 0.058	1.117AspLys: 1.117 ± 0.035	5.278AspLeu: 5.278 ± 0.08	0.873AspMet: 0.873 ± 0.035	1.146AspAsn: 1.146 ± 0.038	3.481AspPro: 3.481 ± 0.061	1.336AspGln: 1.336 ± 0.037	3.885AspArg: 3.885 ± 0.075	3.236AspSer: 3.236 ± 0.067	2.959AspThr: 2.959 ± 0.052	5.119AspVal: 5.119 ± 0.071	0.913AspTrp: 0.913 ± 0.033	1.319AspTyr: 1.319 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.17GluAla: 7.17 ± 0.106	0.238GluCys: 0.238 ± 0.019	2.352GluAsp: 2.352 ± 0.051	3.047GluGlu: 3.047 ± 0.067	2.018GluPhe: 2.018 ± 0.05	4.283GluGly: 4.283 ± 0.08	1.566GluHis: 1.566 ± 0.051	2.833GluIle: 2.833 ± 0.064	1.701GluLys: 1.701 ± 0.054	7.42GluLeu: 7.42 ± 0.109	0.991GluMet: 0.991 ± 0.032	1.405GluAsn: 1.405 ± 0.039	2.934GluPro: 2.934 ± 0.07	2.615GluGln: 2.615 ± 0.058	4.845GluArg: 4.845 ± 0.091	3.161GluSer: 3.161 ± 0.065	3.115GluThr: 3.115 ± 0.058	4.411GluVal: 4.411 ± 0.076	0.887GluTrp: 0.887 ± 0.035	1.19GluTyr: 1.19 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.216PheAla: 4.216 ± 0.065	0.18PheCys: 0.18 ± 0.014	2.373PheAsp: 2.373 ± 0.061	1.988PheGlu: 1.988 ± 0.048	1.157PhePhe: 1.157 ± 0.043	3.64PheGly: 3.64 ± 0.068	0.508PheHis: 0.508 ± 0.027	1.507PheIle: 1.507 ± 0.051	0.515PheLys: 0.515 ± 0.023	2.754PheLeu: 2.754 ± 0.06	0.547PheMet: 0.547 ± 0.026	0.72PheAsn: 0.72 ± 0.028	1.292PhePro: 1.292 ± 0.041	0.708PheGln: 0.708 ± 0.03	1.728PheArg: 1.728 ± 0.05	2.121PheSer: 2.121 ± 0.047	2.245PheThr: 2.245 ± 0.054	2.919PheVal: 2.919 ± 0.065	0.512PheTrp: 0.512 ± 0.028	0.727PheTyr: 0.727 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.351GlyAla: 10.351 ± 0.132	0.553GlyCys: 0.553 ± 0.022	4.936GlyAsp: 4.936 ± 0.091	5.319GlyGlu: 5.319 ± 0.097	3.355GlyPhe: 3.355 ± 0.055	7.794GlyGly: 7.794 ± 0.135	1.95GlyHis: 1.95 ± 0.053	5.092GlyIle: 5.092 ± 0.085	2.202GlyLys: 2.202 ± 0.058	9.242GlyLeu: 9.242 ± 0.132	2.083GlyMet: 2.083 ± 0.055	1.851GlyAsn: 1.851 ± 0.056	3.551GlyPro: 3.551 ± 0.07	2.576GlyGln: 2.576 ± 0.057	6.01GlyArg: 6.01 ± 0.083	5.708GlySer: 5.708 ± 0.086	5.539GlyThr: 5.539 ± 0.101	8.059GlyVal: 8.059 ± 0.08	1.515GlyTrp: 1.515 ± 0.046	2.204GlyTyr: 2.204 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.09HisAla: 2.09 ± 0.052	0.107HisCys: 0.107 ± 0.012	1.338HisAsp: 1.338 ± 0.044	1.211HisGlu: 1.211 ± 0.042	0.574HisPhe: 0.574 ± 0.022	1.91HisGly: 1.91 ± 0.049	0.533HisHis: 0.533 ± 0.027	0.832HisIle: 0.832 ± 0.032	0.329HisLys: 0.329 ± 0.02	1.836HisLeu: 1.836 ± 0.046	0.303HisMet: 0.303 ± 0.017	0.425HisAsn: 0.425 ± 0.024	1.531HisPro: 1.531 ± 0.043	0.506HisGln: 0.506 ± 0.023	1.441HisArg: 1.441 ± 0.042	1.185HisSer: 1.185 ± 0.035	0.951HisThr: 0.951 ± 0.033	1.474HisVal: 1.474 ± 0.041	0.299HisTrp: 0.299 ± 0.019	0.438HisTyr: 0.438 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.243IleAla: 7.243 ± 0.092	0.224IleCys: 0.224 ± 0.017	3.779IleAsp: 3.779 ± 0.065	3.189IleGlu: 3.189 ± 0.06	1.286IlePhe: 1.286 ± 0.047	4.956IleGly: 4.956 ± 0.092	0.768IleHis: 0.768 ± 0.03	2.274IleIle: 2.274 ± 0.063	0.924IleLys: 0.924 ± 0.041	4.082IleLeu: 4.082 ± 0.076	0.805IleMet: 0.805 ± 0.032	1.072IleAsn: 1.072 ± 0.039	2.47IlePro: 2.47 ± 0.051	1.049IleGln: 1.049 ± 0.036	3.034IleArg: 3.034 ± 0.063	2.744IleSer: 2.744 ± 0.065	2.928IleThr: 2.928 ± 0.06	5.049IleVal: 5.049 ± 0.089	0.504IleTrp: 0.504 ± 0.026	0.799IleTyr: 0.799 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.919LysAla: 2.919 ± 0.077	0.073LysCys: 0.073 ± 0.008	1.205LysAsp: 1.205 ± 0.043	1.114LysGlu: 1.114 ± 0.039	0.566LysPhe: 0.566 ± 0.024	1.801LysGly: 1.801 ± 0.052	0.447LysHis: 0.447 ± 0.025	1.102LysIle: 1.102 ± 0.037	0.897LysLys: 0.897 ± 0.039	2.195LysLeu: 2.195 ± 0.059	0.441LysMet: 0.441 ± 0.024	0.619LysAsn: 0.619 ± 0.026	1.364LysPro: 1.364 ± 0.044	0.842LysGln: 0.842 ± 0.031	1.739LysArg: 1.739 ± 0.045	1.285LysSer: 1.285 ± 0.041	1.457LysThr: 1.457 ± 0.042	1.87LysVal: 1.87 ± 0.053	0.261LysTrp: 0.261 ± 0.019	0.494LysTyr: 0.494 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.415LeuAla: 14.415 ± 0.153	0.521LeuCys: 0.521 ± 0.026	6.542LeuAsp: 6.542 ± 0.099	5.357LeuGlu: 5.357 ± 0.088	3.144LeuPhe: 3.144 ± 0.07	9.717LeuGly: 9.717 ± 0.132	1.764LeuHis: 1.764 ± 0.042	4.745LeuIle: 4.745 ± 0.099	2.108LeuLys: 2.108 ± 0.055	10.957LeuLeu: 10.957 ± 0.175	1.806LeuMet: 1.806 ± 0.047	1.93LeuAsn: 1.93 ± 0.045	5.454LeuPro: 5.454 ± 0.091	2.632LeuGln: 2.632 ± 0.056	7.115LeuArg: 7.115 ± 0.102	6.528LeuSer: 6.528 ± 0.094	5.828LeuThr: 5.828 ± 0.089	9.486LeuVal: 9.486 ± 0.133	1.236LeuTrp: 1.236 ± 0.041	1.66LeuTyr: 1.66 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.345MetAla: 2.345 ± 0.057	0.081MetCys: 0.081 ± 0.01	0.769MetAsp: 0.769 ± 0.03	0.704MetGlu: 0.704 ± 0.028	0.559MetPhe: 0.559 ± 0.027	1.428MetGly: 1.428 ± 0.046	0.346MetHis: 0.346 ± 0.021	0.933MetIle: 0.933 ± 0.032	0.514MetLys: 0.514 ± 0.024	2.25MetLeu: 2.25 ± 0.049	0.351MetMet: 0.351 ± 0.02	0.538MetAsn: 0.538 ± 0.027	1.193MetPro: 1.193 ± 0.045	0.57MetGln: 0.57 ± 0.026	1.397MetArg: 1.397 ± 0.041	1.509MetSer: 1.509 ± 0.042	1.646MetThr: 1.646 ± 0.039	1.448MetVal: 1.448 ± 0.042	0.216MetTrp: 0.216 ± 0.016	0.264MetTyr: 0.264 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.494AsnAla: 2.494 ± 0.052	0.124AsnCys: 0.124 ± 0.014	1.27AsnAsp: 1.27 ± 0.038	1.184AsnGlu: 1.184 ± 0.036	0.723AsnPhe: 0.723 ± 0.034	2.075AsnGly: 2.075 ± 0.056	0.414AsnHis: 0.414 ± 0.022	0.972AsnIle: 0.972 ± 0.034	0.52AsnLys: 0.52 ± 0.027	2.047AsnLeu: 2.047 ± 0.047	0.39AsnMet: 0.39 ± 0.021	0.563AsnAsn: 0.563 ± 0.029	1.621AsnPro: 1.621 ± 0.043	0.648AsnGln: 0.648 ± 0.028	1.468AsnArg: 1.468 ± 0.039	1.305AsnSer: 1.305 ± 0.04	1.214AsnThr: 1.214 ± 0.044	1.761AsnVal: 1.761 ± 0.05	0.317AsnTrp: 0.317 ± 0.022	0.546AsnTyr: 0.546 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.714ProAla: 6.714 ± 0.11	0.183ProCys: 0.183 ± 0.016	3.512ProAsp: 3.512 ± 0.068	3.704ProGlu: 3.704 ± 0.07	1.676ProPhe: 1.676 ± 0.046	4.774ProGly: 4.774 ± 0.08	1.007ProHis: 1.007 ± 0.034	2.241ProIle: 2.241 ± 0.048	1.168ProLys: 1.168 ± 0.037	4.87ProLeu: 4.87 ± 0.082	0.84ProMet: 0.84 ± 0.038	1.066ProAsn: 1.066 ± 0.036	2.114ProPro: 2.114 ± 0.072	1.59ProGln: 1.59 ± 0.037	3.054ProArg: 3.054 ± 0.062	3.306ProSer: 3.306 ± 0.075	2.973ProThr: 2.973 ± 0.051	4.683ProVal: 4.683 ± 0.077	0.775ProTrp: 0.775 ± 0.027	0.928ProTyr: 0.928 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.568GlnAla: 3.568 ± 0.066	0.101GlnCys: 0.101 ± 0.011	1.221GlnAsp: 1.221 ± 0.035	1.425GlnGlu: 1.425 ± 0.045	0.92GlnPhe: 0.92 ± 0.033	2.089GlnGly: 2.089 ± 0.047	0.67GlnHis: 0.67 ± 0.029	1.475GlnIle: 1.475 ± 0.045	0.871GlnLys: 0.871 ± 0.033	3.747GlnLeu: 3.747 ± 0.066	0.561GlnMet: 0.561 ± 0.027	0.711GlnAsn: 0.711 ± 0.033	1.622GlnPro: 1.622 ± 0.049	1.45GlnGln: 1.45 ± 0.054	2.333GlnArg: 2.333 ± 0.054	1.59GlnSer: 1.59 ± 0.048	1.448GlnThr: 1.448 ± 0.038	2.374GlnVal: 2.374 ± 0.046	0.433GlnTrp: 0.433 ± 0.026	0.583GlnTyr: 0.583 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.824ArgAla: 7.824 ± 0.113	0.275ArgCys: 0.275 ± 0.019	3.815ArgAsp: 3.815 ± 0.071	4.13ArgGlu: 4.13 ± 0.083	2.448ArgPhe: 2.448 ± 0.053	5.224ArgGly: 5.224 ± 0.072	1.526ArgHis: 1.526 ± 0.046	3.621ArgIle: 3.621 ± 0.067	1.443ArgLys: 1.443 ± 0.044	7.086ArgLeu: 7.086 ± 0.108	1.892ArgMet: 1.892 ± 0.052	1.472ArgAsn: 1.472 ± 0.041	3.197ArgPro: 3.197 ± 0.076	2.089ArgGln: 2.089 ± 0.046	5.787ArgArg: 5.787 ± 0.104	4.221ArgSer: 4.221 ± 0.08	3.703ArgThr: 3.703 ± 0.072	5.453ArgVal: 5.453 ± 0.083	1.074ArgTrp: 1.074 ± 0.041	1.484ArgTyr: 1.484 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.579SerAla: 7.579 ± 0.097	0.298SerCys: 0.298 ± 0.02	3.477SerAsp: 3.477 ± 0.068	3.254SerGlu: 3.254 ± 0.066	2.065SerPhe: 2.065 ± 0.052	6.364SerGly: 6.364 ± 0.099	1.103SerHis: 1.103 ± 0.034	3.081SerIle: 3.081 ± 0.057	1.358SerLys: 1.358 ± 0.047	5.872SerLeu: 5.872 ± 0.086	1.282SerMet: 1.282 ± 0.033	1.335SerAsn: 1.335 ± 0.045	3.155SerPro: 3.155 ± 0.061	1.639SerGln: 1.639 ± 0.044	3.988SerArg: 3.988 ± 0.083	4.027SerSer: 4.027 ± 0.072	3.934SerThr: 3.934 ± 0.079	5.328SerVal: 5.328 ± 0.085	0.961SerTrp: 0.961 ± 0.037	1.38SerTyr: 1.38 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.713ThrAla: 7.713 ± 0.091	0.215ThrCys: 0.215 ± 0.016	3.148ThrAsp: 3.148 ± 0.055	3.12ThrGlu: 3.12 ± 0.06	1.77ThrPhe: 1.77 ± 0.055	5.646ThrGly: 5.646 ± 0.083	1.09ThrHis: 1.09 ± 0.038	3.23ThrIle: 3.23 ± 0.061	1.323ThrLys: 1.323 ± 0.044	6.109ThrLeu: 6.109 ± 0.09	1.034ThrMet: 1.034 ± 0.035	1.229ThrAsn: 1.229 ± 0.037	3.867ThrPro: 3.867 ± 0.081	1.545ThrGln: 1.545 ± 0.042	3.499ThrArg: 3.499 ± 0.064	3.511ThrSer: 3.511 ± 0.077	3.822ThrThr: 3.822 ± 0.077	5.939ThrVal: 5.939 ± 0.113	0.707ThrTrp: 0.707 ± 0.029	0.955ThrTyr: 0.955 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	11.343ValAla: 11.343 ± 0.139	0.446ValCys: 0.446 ± 0.027	5.537ValAsp: 5.537 ± 0.091	4.844ValGlu: 4.844 ± 0.085	3.011ValPhe: 3.011 ± 0.062	7.126ValGly: 7.126 ± 0.099	1.559ValHis: 1.559 ± 0.044	4.724ValIle: 4.724 ± 0.079	1.859ValLys: 1.859 ± 0.04	9.424ValLeu: 9.424 ± 0.151	1.568ValMet: 1.568 ± 0.05	1.998ValAsn: 1.998 ± 0.054	4.5ValPro: 4.5 ± 0.077	2.174ValGln: 2.174 ± 0.049	5.341ValArg: 5.341 ± 0.086	5.507ValSer: 5.507 ± 0.069	6.213ValThr: 6.213 ± 0.097	8.614ValVal: 8.614 ± 0.13	1.073ValTrp: 1.073 ± 0.04	1.488ValTyr: 1.488 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.602TrpAla: 1.602 ± 0.044	0.087TrpCys: 0.087 ± 0.01	0.639TrpAsp: 0.639 ± 0.027	0.603TrpGlu: 0.603 ± 0.029	0.552TrpPhe: 0.552 ± 0.026	1.021TrpGly: 1.021 ± 0.037	0.309TrpHis: 0.309 ± 0.02	0.595TrpIle: 0.595 ± 0.028	0.333TrpLys: 0.333 ± 0.022	1.792TrpLeu: 1.792 ± 0.049	0.339TrpMet: 0.339 ± 0.021	0.414TrpAsn: 0.414 ± 0.025	0.682TrpPro: 0.682 ± 0.031	0.581TrpGln: 0.581 ± 0.026	1.085TrpArg: 1.085 ± 0.043	0.896TrpSer: 0.896 ± 0.035	0.693TrpThr: 0.693 ± 0.03	1.169TrpVal: 1.169 ± 0.036	0.333TrpTrp: 0.333 ± 0.02	0.277TrpTyr: 0.277 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.181TyrAla: 2.181 ± 0.052	0.124TyrCys: 0.124 ± 0.013	1.309TyrAsp: 1.309 ± 0.041	1.243TyrGlu: 1.243 ± 0.044	0.716TyrPhe: 0.716 ± 0.032	1.812TyrGly: 1.812 ± 0.049	0.275TyrHis: 0.275 ± 0.016	0.806TyrIle: 0.806 ± 0.032	0.418TyrLys: 0.418 ± 0.024	2.151TyrLeu: 2.151 ± 0.054	0.288TyrMet: 0.288 ± 0.02	0.526TyrAsn: 0.526 ± 0.027	0.946TyrPro: 0.946 ± 0.04	0.602TyrGln: 0.602 ± 0.028	1.499TyrArg: 1.499 ± 0.046	1.203TyrSer: 1.203 ± 0.039	1.063TyrThr: 1.063 ± 0.036	1.54TyrVal: 1.54 ± 0.045	0.319TyrTrp: 0.319 ± 0.02	0.41TyrTyr: 0.41 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2633 proteins (851979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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