Amino acid dipepetide frequency for Hyunsoonleella jejuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.157AlaAla: 4.157 ± 0.08	0.598AlaCys: 0.598 ± 0.032	3.377AlaAsp: 3.377 ± 0.066	4.029AlaGlu: 4.029 ± 0.082	3.362AlaPhe: 3.362 ± 0.063	3.925AlaGly: 3.925 ± 0.082	1.19AlaHis: 1.19 ± 0.035	5.629AlaIle: 5.629 ± 0.098	4.744AlaLys: 4.744 ± 0.096	6.404AlaLeu: 6.404 ± 0.094	1.468AlaMet: 1.468 ± 0.037	3.592AlaAsn: 3.592 ± 0.071	2.041AlaPro: 2.041 ± 0.048	2.303AlaGln: 2.303 ± 0.048	2.02AlaArg: 2.02 ± 0.049	4.39AlaSer: 4.39 ± 0.079	3.806AlaThr: 3.806 ± 0.084	3.997AlaVal: 3.997 ± 0.073	0.61AlaTrp: 0.61 ± 0.024	2.563AlaTyr: 2.563 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.5CysAla: 0.5 ± 0.022	0.096CysCys: 0.096 ± 0.009	0.534CysAsp: 0.534 ± 0.037	0.562CysGlu: 0.562 ± 0.035	0.47CysPhe: 0.47 ± 0.022	0.672CysGly: 0.672 ± 0.042	0.207CysHis: 0.207 ± 0.019	0.633CysIle: 0.633 ± 0.026	0.534CysLys: 0.534 ± 0.022	0.675CysLeu: 0.675 ± 0.026	0.15CysMet: 0.15 ± 0.011	0.452CysAsn: 0.452 ± 0.024	0.341CysPro: 0.341 ± 0.019	0.193CysGln: 0.193 ± 0.014	0.19CysArg: 0.19 ± 0.013	0.548CysSer: 0.548 ± 0.026	0.438CysThr: 0.438 ± 0.026	0.457CysVal: 0.457 ± 0.019	0.07CysTrp: 0.07 ± 0.009	0.323CysTyr: 0.323 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.182AspAla: 4.182 ± 0.082	0.482AspCys: 0.482 ± 0.035	3.456AspAsp: 3.456 ± 0.08	3.79AspGlu: 3.79 ± 0.073	3.674AspPhe: 3.674 ± 0.065	3.864AspGly: 3.864 ± 0.091	0.831AspHis: 0.831 ± 0.029	5.036AspIle: 5.036 ± 0.079	4.155AspLys: 4.155 ± 0.081	5.22AspLeu: 5.22 ± 0.073	1.186AspMet: 1.186 ± 0.035	3.591AspAsn: 3.591 ± 0.078	1.559AspPro: 1.559 ± 0.045	1.197AspGln: 1.197 ± 0.037	1.826AspArg: 1.826 ± 0.04	3.081AspSer: 3.081 ± 0.063	3.116AspThr: 3.116 ± 0.063	4.103AspVal: 4.103 ± 0.068	0.781AspTrp: 0.781 ± 0.031	2.96AspTyr: 2.96 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.694GluAla: 4.694 ± 0.092	0.382GluCys: 0.382 ± 0.026	4.047GluAsp: 4.047 ± 0.079	4.428GluGlu: 4.428 ± 0.085	2.984GluPhe: 2.984 ± 0.06	3.692GluGly: 3.692 ± 0.073	1.244GluHis: 1.244 ± 0.036	5.153GluIle: 5.153 ± 0.072	5.33GluLys: 5.33 ± 0.094	6.015GluLeu: 6.015 ± 0.086	1.415GluMet: 1.415 ± 0.043	4.573GluAsn: 4.573 ± 0.076	1.633GluPro: 1.633 ± 0.041	2.256GluGln: 2.256 ± 0.049	2.573GluArg: 2.573 ± 0.051	3.316GluSer: 3.316 ± 0.062	3.946GluThr: 3.946 ± 0.056	4.298GluVal: 4.298 ± 0.07	0.619GluTrp: 0.619 ± 0.026	2.314GluTyr: 2.314 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.844PheAla: 2.844 ± 0.054	0.457PheCys: 0.457 ± 0.021	3.342PheAsp: 3.342 ± 0.063	3.543PheGlu: 3.543 ± 0.065	2.642PhePhe: 2.642 ± 0.058	3.678PheGly: 3.678 ± 0.074	0.807PheHis: 0.807 ± 0.025	3.796PheIle: 3.796 ± 0.075	4.126PheLys: 4.126 ± 0.076	4.576PheLeu: 4.576 ± 0.08	1.1PheMet: 1.1 ± 0.031	3.669PheAsn: 3.669 ± 0.07	1.71PhePro: 1.71 ± 0.047	1.555PheGln: 1.555 ± 0.034	1.624PheArg: 1.624 ± 0.038	3.976PheSer: 3.976 ± 0.065	3.11PheThr: 3.11 ± 0.061	3.053PheVal: 3.053 ± 0.056	0.553PheTrp: 0.553 ± 0.023	2.081PheTyr: 2.081 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.258GlyAla: 4.258 ± 0.075	0.645GlyCys: 0.645 ± 0.032	3.672GlyAsp: 3.672 ± 0.082	3.686GlyGlu: 3.686 ± 0.057	3.721GlyPhe: 3.721 ± 0.072	4.567GlyGly: 4.567 ± 0.089	1.131GlyHis: 1.131 ± 0.036	5.201GlyIle: 5.201 ± 0.072	4.891GlyLys: 4.891 ± 0.082	5.619GlyLeu: 5.619 ± 0.08	1.527GlyMet: 1.527 ± 0.039	3.801GlyAsn: 3.801 ± 0.08	1.388GlyPro: 1.388 ± 0.038	1.816GlyGln: 1.816 ± 0.049	2.141GlyArg: 2.141 ± 0.045	3.871GlySer: 3.871 ± 0.078	3.942GlyThr: 3.942 ± 0.097	4.633GlyVal: 4.633 ± 0.082	0.814GlyTrp: 0.814 ± 0.035	2.856GlyTyr: 2.856 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.002HisAla: 1.002 ± 0.03	0.189HisCys: 0.189 ± 0.015	0.9HisAsp: 0.9 ± 0.025	0.977HisGlu: 0.977 ± 0.025	1.115HisPhe: 1.115 ± 0.035	1.131HisGly: 1.131 ± 0.035	0.48HisHis: 0.48 ± 0.024	1.562HisIle: 1.562 ± 0.044	1.296HisLys: 1.296 ± 0.041	1.807HisLeu: 1.807 ± 0.045	0.332HisMet: 0.332 ± 0.019	1.076HisAsn: 1.076 ± 0.032	0.886HisPro: 0.886 ± 0.031	0.69HisGln: 0.69 ± 0.024	0.662HisArg: 0.662 ± 0.025	1.005HisSer: 1.005 ± 0.028	0.94HisThr: 0.94 ± 0.029	1.008HisVal: 1.008 ± 0.034	0.242HisTrp: 0.242 ± 0.015	0.871HisTyr: 0.871 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.546IleAla: 5.546 ± 0.086	0.676IleCys: 0.676 ± 0.026	5.147IleAsp: 5.147 ± 0.082	5.605IleGlu: 5.605 ± 0.091	3.506IlePhe: 3.506 ± 0.063	5.052IleGly: 5.052 ± 0.084	1.316IleHis: 1.316 ± 0.038	6.035IleIle: 6.035 ± 0.097	6.017IleLys: 6.017 ± 0.086	6.855IleLeu: 6.855 ± 0.111	1.415IleMet: 1.415 ± 0.035	4.864IleAsn: 4.864 ± 0.078	3.19IlePro: 3.19 ± 0.063	2.424IleGln: 2.424 ± 0.045	2.378IleArg: 2.378 ± 0.051	5.588IleSer: 5.588 ± 0.083	4.942IleThr: 4.942 ± 0.079	4.821IleVal: 4.821 ± 0.076	0.706IleTrp: 0.706 ± 0.033	2.849IleTyr: 2.849 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.251LysAla: 5.251 ± 0.1	0.387LysCys: 0.387 ± 0.023	4.64LysAsp: 4.64 ± 0.072	5.474LysGlu: 5.474 ± 0.103	2.997LysPhe: 2.997 ± 0.059	4.568LysGly: 4.568 ± 0.063	1.717LysHis: 1.717 ± 0.045	5.724LysIle: 5.724 ± 0.083	6.409LysLys: 6.409 ± 0.109	6.76LysLeu: 6.76 ± 0.101	1.773LysMet: 1.773 ± 0.046	4.994LysAsn: 4.994 ± 0.077	2.711LysPro: 2.711 ± 0.056	2.883LysGln: 2.883 ± 0.057	3.199LysArg: 3.199 ± 0.068	4.693LysSer: 4.693 ± 0.082	4.98LysThr: 4.98 ± 0.089	4.7LysVal: 4.7 ± 0.072	0.801LysTrp: 0.801 ± 0.028	2.994LysTyr: 2.994 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.402LeuAla: 5.402 ± 0.086	0.703LeuCys: 0.703 ± 0.027	5.157LeuAsp: 5.157 ± 0.094	6.14LeuGlu: 6.14 ± 0.082	4.644LeuPhe: 4.644 ± 0.086	5.82LeuGly: 5.82 ± 0.082	1.537LeuHis: 1.537 ± 0.044	6.756LeuIle: 6.756 ± 0.096	8.05LeuLys: 8.05 ± 0.121	8.098LeuLeu: 8.098 ± 0.119	1.943LeuMet: 1.943 ± 0.046	6.053LeuAsn: 6.053 ± 0.072	3.441LeuPro: 3.441 ± 0.057	2.998LeuGln: 2.998 ± 0.054	3.191LeuArg: 3.191 ± 0.059	6.48LeuSer: 6.48 ± 0.087	4.855LeuThr: 4.855 ± 0.079	5.634LeuVal: 5.634 ± 0.091	0.841LeuTrp: 0.841 ± 0.028	3.168LeuTyr: 3.168 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.617MetAla: 1.617 ± 0.048	0.167MetCys: 0.167 ± 0.014	1.058MetAsp: 1.058 ± 0.033	1.244MetGlu: 1.244 ± 0.034	0.882MetPhe: 0.882 ± 0.031	1.31MetGly: 1.31 ± 0.035	0.442MetHis: 0.442 ± 0.021	1.431MetIle: 1.431 ± 0.04	2.028MetLys: 2.028 ± 0.043	1.983MetLeu: 1.983 ± 0.051	0.539MetMet: 0.539 ± 0.022	1.199MetAsn: 1.199 ± 0.035	0.837MetPro: 0.837 ± 0.032	0.825MetGln: 0.825 ± 0.027	0.888MetArg: 0.888 ± 0.033	1.339MetSer: 1.339 ± 0.037	1.056MetThr: 1.056 ± 0.032	1.356MetVal: 1.356 ± 0.04	0.174MetTrp: 0.174 ± 0.014	0.712MetTyr: 0.712 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.127AsnAla: 4.127 ± 0.063	0.547AsnCys: 0.547 ± 0.027	3.601AsnAsp: 3.601 ± 0.088	3.758AsnGlu: 3.758 ± 0.061	3.1AsnPhe: 3.1 ± 0.071	4.234AsnGly: 4.234 ± 0.085	1.089AsnHis: 1.089 ± 0.033	5.158AsnIle: 5.158 ± 0.075	4.319AsnLys: 4.319 ± 0.076	5.442AsnLeu: 5.442 ± 0.088	1.294AsnMet: 1.294 ± 0.03	4.292AsnAsn: 4.292 ± 0.103	2.929AsnPro: 2.929 ± 0.066	2.024AsnGln: 2.024 ± 0.046	2.33AsnArg: 2.33 ± 0.046	3.845AsnSer: 3.845 ± 0.07	4.145AsnThr: 4.145 ± 0.072	3.792AsnVal: 3.792 ± 0.067	0.801AsnTrp: 0.801 ± 0.03	2.849AsnTyr: 2.849 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.778ProAla: 1.778 ± 0.051	0.219ProCys: 0.219 ± 0.014	2.076ProAsp: 2.076 ± 0.049	2.994ProGlu: 2.994 ± 0.05	1.887ProPhe: 1.887 ± 0.039	1.847ProGly: 1.847 ± 0.051	0.641ProHis: 0.641 ± 0.03	2.739ProIle: 2.739 ± 0.059	2.765ProLys: 2.765 ± 0.053	3.005ProLeu: 3.005 ± 0.06	0.695ProMet: 0.695 ± 0.03	2.427ProAsn: 2.427 ± 0.05	0.839ProPro: 0.839 ± 0.035	1.13ProGln: 1.13 ± 0.035	0.987ProArg: 0.987 ± 0.028	2.157ProSer: 2.157 ± 0.049	1.916ProThr: 1.916 ± 0.053	2.307ProVal: 2.307 ± 0.052	0.381ProTrp: 0.381 ± 0.019	1.416ProTyr: 1.416 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.817GlnAla: 1.817 ± 0.046	0.189GlnCys: 0.189 ± 0.014	1.735GlnAsp: 1.735 ± 0.043	2.042GlnGlu: 2.042 ± 0.041	1.666GlnPhe: 1.666 ± 0.044	1.769GlnGly: 1.769 ± 0.043	0.632GlnHis: 0.632 ± 0.025	2.571GlnIle: 2.571 ± 0.051	2.564GlnLys: 2.564 ± 0.063	3.292GlnLeu: 3.292 ± 0.062	0.73GlnMet: 0.73 ± 0.033	2.192GlnAsn: 2.192 ± 0.053	1.166GlnPro: 1.166 ± 0.04	1.297GlnGln: 1.297 ± 0.04	1.203GlnArg: 1.203 ± 0.035	1.81GlnSer: 1.81 ± 0.048	1.851GlnThr: 1.851 ± 0.039	1.815GlnVal: 1.815 ± 0.046	0.362GlnTrp: 0.362 ± 0.02	1.235GlnTyr: 1.235 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.153ArgAla: 2.153 ± 0.052	0.204ArgCys: 0.204 ± 0.015	1.888ArgAsp: 1.888 ± 0.043	2.122ArgGlu: 2.122 ± 0.045	1.996ArgPhe: 1.996 ± 0.044	2.093ArgGly: 2.093 ± 0.051	0.667ArgHis: 0.667 ± 0.024	2.905ArgIle: 2.905 ± 0.054	2.677ArgLys: 2.677 ± 0.061	3.334ArgLeu: 3.334 ± 0.053	0.832ArgMet: 0.832 ± 0.031	2.07ArgAsn: 2.07 ± 0.048	1.131ArgPro: 1.131 ± 0.038	1.111ArgGln: 1.111 ± 0.037	1.425ArgArg: 1.425 ± 0.047	1.877ArgSer: 1.877 ± 0.044	1.91ArgThr: 1.91 ± 0.042	2.206ArgVal: 2.206 ± 0.049	0.404ArgTrp: 0.404 ± 0.019	1.565ArgTyr: 1.565 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.783SerAla: 3.783 ± 0.054	0.664SerCys: 0.664 ± 0.028	3.432SerAsp: 3.432 ± 0.059	4.183SerGlu: 4.183 ± 0.056	3.723SerPhe: 3.723 ± 0.066	4.63SerGly: 4.63 ± 0.086	1.08SerHis: 1.08 ± 0.032	5.172SerIle: 5.172 ± 0.08	5.048SerLys: 5.048 ± 0.084	5.566SerLeu: 5.566 ± 0.094	1.261SerMet: 1.261 ± 0.038	4.065SerAsn: 4.065 ± 0.087	2.045SerPro: 2.045 ± 0.045	1.936SerGln: 1.936 ± 0.048	2.169SerArg: 2.169 ± 0.043	4.094SerSer: 4.094 ± 0.079	3.523SerThr: 3.523 ± 0.073	3.964SerVal: 3.964 ± 0.072	0.734SerTrp: 0.734 ± 0.038	2.674SerTyr: 2.674 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.707ThrAla: 3.707 ± 0.074	0.425ThrCys: 0.425 ± 0.019	3.277ThrAsp: 3.277 ± 0.068	3.445ThrGlu: 3.445 ± 0.049	3.206ThrPhe: 3.206 ± 0.067	4.012ThrGly: 4.012 ± 0.084	1.027ThrHis: 1.027 ± 0.031	4.997ThrIle: 4.997 ± 0.067	4.039ThrLys: 4.039 ± 0.067	5.444ThrLeu: 5.444 ± 0.069	0.969ThrMet: 0.969 ± 0.031	3.471ThrAsn: 3.471 ± 0.077	2.487ThrPro: 2.487 ± 0.051	1.786ThrGln: 1.786 ± 0.041	1.722ThrArg: 1.722 ± 0.049	4.014ThrSer: 4.014 ± 0.078	3.506ThrThr: 3.506 ± 0.085	3.874ThrVal: 3.874 ± 0.085	0.658ThrTrp: 0.658 ± 0.027	2.555ThrTyr: 2.555 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.253ValAla: 4.253 ± 0.079	0.543ValCys: 0.543 ± 0.027	3.737ValAsp: 3.737 ± 0.066	4.009ValGlu: 4.009 ± 0.072	3.573ValPhe: 3.573 ± 0.071	3.955ValGly: 3.955 ± 0.07	1.036ValHis: 1.036 ± 0.034	4.874ValIle: 4.874 ± 0.07	4.651ValLys: 4.651 ± 0.076	6.157ValLeu: 6.157 ± 0.086	1.386ValMet: 1.386 ± 0.039	3.753ValAsn: 3.753 ± 0.073	2.167ValPro: 2.167 ± 0.039	1.633ValGln: 1.633 ± 0.04	1.992ValArg: 1.992 ± 0.049	4.499ValSer: 4.499 ± 0.077	3.664ValThr: 3.664 ± 0.08	4.363ValVal: 4.363 ± 0.079	0.598ValTrp: 0.598 ± 0.024	2.414ValTyr: 2.414 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.603TrpAla: 0.603 ± 0.026	0.108TrpCys: 0.108 ± 0.011	0.672TrpAsp: 0.672 ± 0.033	0.643TrpGlu: 0.643 ± 0.026	0.583TrpPhe: 0.583 ± 0.025	0.704TrpGly: 0.704 ± 0.026	0.25TrpHis: 0.25 ± 0.016	0.728TrpIle: 0.728 ± 0.028	0.796TrpLys: 0.796 ± 0.032	1.015TrpLeu: 1.015 ± 0.032	0.316TrpMet: 0.316 ± 0.019	0.749TrpAsn: 0.749 ± 0.029	0.243TrpPro: 0.243 ± 0.017	0.434TrpGln: 0.434 ± 0.021	0.429TrpArg: 0.429 ± 0.025	0.637TrpSer: 0.637 ± 0.026	0.609TrpThr: 0.609 ± 0.028	0.623TrpVal: 0.623 ± 0.026	0.159TrpTrp: 0.159 ± 0.014	0.495TrpTyr: 0.495 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.049	0.361TyrCys: 0.361 ± 0.018	2.344TyrAsp: 2.344 ± 0.053	2.24TyrGlu: 2.24 ± 0.047	2.51TyrPhe: 2.51 ± 0.052	2.656TyrGly: 2.656 ± 0.05	0.848TyrHis: 0.848 ± 0.029	2.831TyrIle: 2.831 ± 0.057	3.217TyrLys: 3.217 ± 0.065	3.645TyrLeu: 3.645 ± 0.061	0.751TyrMet: 0.751 ± 0.028	2.794TyrAsn: 2.794 ± 0.063	1.464TyrPro: 1.464 ± 0.034	1.448TyrGln: 1.448 ± 0.039	1.621TyrArg: 1.621 ± 0.041	2.528TyrSer: 2.528 ± 0.053	2.366TyrThr: 2.366 ± 0.048	2.253TyrVal: 2.253 ± 0.046	0.485TyrTrp: 0.485 ± 0.023	1.86TyrTyr: 1.86 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2939 proteins (1056956 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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