Amino acid dipepetide frequency for Klebsiella phage YMC16/01/N133_KPN_BP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.078AlaAla: 13.078 ± 2.008
0.8AlaCys: 0.8 ± 0.258
6.739AlaAsp: 6.739 ± 0.693
6.967AlaGlu: 6.967 ± 0.709
3.883AlaPhe: 3.883 ± 0.425
8.509AlaGly: 8.509 ± 1.156
1.142AlaHis: 1.142 ± 0.221
5.254AlaIle: 5.254 ± 0.553
5.14AlaLys: 5.14 ± 1.08
10.109AlaLeu: 10.109 ± 1.001
2.399AlaMet: 2.399 ± 0.313
3.712AlaAsn: 3.712 ± 0.439
3.712AlaPro: 3.712 ± 0.563
4.397AlaGln: 4.397 ± 0.803
5.768AlaArg: 5.768 ± 0.603
5.825AlaSer: 5.825 ± 0.911
5.083AlaThr: 5.083 ± 0.72
6.625AlaVal: 6.625 ± 0.92
1.485AlaTrp: 1.485 ± 0.257
2.97AlaTyr: 2.97 ± 0.523
0.0AlaXaa: 0.0 ± 0.0
Cys
1.314CysAla: 1.314 ± 0.316
0.343CysCys: 0.343 ± 0.215
0.457CysAsp: 0.457 ± 0.165
0.685CysGlu: 0.685 ± 0.209
0.228CysPhe: 0.228 ± 0.097
0.742CysGly: 0.742 ± 0.27
0.457CysHis: 0.457 ± 0.155
0.457CysIle: 0.457 ± 0.154
0.457CysLys: 0.457 ± 0.177
0.857CysLeu: 0.857 ± 0.22
0.057CysMet: 0.057 ± 0.063
0.343CysAsn: 0.343 ± 0.145
0.8CysPro: 0.8 ± 0.241
0.228CysGln: 0.228 ± 0.116
0.628CysArg: 0.628 ± 0.218
0.343CysSer: 0.343 ± 0.143
0.4CysThr: 0.4 ± 0.119
0.685CysVal: 0.685 ± 0.175
0.343CysTrp: 0.343 ± 0.143
0.4CysTyr: 0.4 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
6.396AspAla: 6.396 ± 0.599
0.457AspCys: 0.457 ± 0.176
5.254AspAsp: 5.254 ± 1.136
4.683AspGlu: 4.683 ± 0.802
1.77AspPhe: 1.77 ± 0.341
4.969AspGly: 4.969 ± 0.441
1.142AspHis: 1.142 ± 0.302
3.769AspIle: 3.769 ± 0.456
2.856AspLys: 2.856 ± 0.423
6.625AspLeu: 6.625 ± 0.621
1.371AspMet: 1.371 ± 0.256
2.284AspAsn: 2.284 ± 0.303
4.226AspPro: 4.226 ± 0.498
2.227AspGln: 2.227 ± 0.323
3.541AspArg: 3.541 ± 0.507
3.769AspSer: 3.769 ± 0.601
3.998AspThr: 3.998 ± 0.406
4.34AspVal: 4.34 ± 0.371
2.056AspTrp: 2.056 ± 0.453
2.627AspTyr: 2.627 ± 0.334
0.0AspXaa: 0.0 ± 0.0
Glu
6.054GluAla: 6.054 ± 0.606
0.857GluCys: 0.857 ± 0.196
3.826GluAsp: 3.826 ± 0.548
3.427GluGlu: 3.427 ± 0.63
2.113GluPhe: 2.113 ± 0.301
4.226GluGly: 4.226 ± 0.538
0.742GluHis: 0.742 ± 0.17
3.084GluIle: 3.084 ± 0.391
3.484GluLys: 3.484 ± 0.661
5.768GluLeu: 5.768 ± 0.647
1.542GluMet: 1.542 ± 0.258
2.342GluAsn: 2.342 ± 0.538
1.314GluPro: 1.314 ± 0.249
2.57GluGln: 2.57 ± 0.484
4.283GluArg: 4.283 ± 0.535
2.856GluSer: 2.856 ± 0.305
2.57GluThr: 2.57 ± 0.368
4.455GluVal: 4.455 ± 0.6
1.314GluTrp: 1.314 ± 0.289
1.314GluTyr: 1.314 ± 0.324
0.0GluXaa: 0.0 ± 0.0
Phe
3.255PheAla: 3.255 ± 0.558
0.171PheCys: 0.171 ± 0.101
1.885PheAsp: 1.885 ± 0.287
1.656PheGlu: 1.656 ± 0.246
0.8PhePhe: 0.8 ± 0.217
2.856PheGly: 2.856 ± 0.476
0.457PheHis: 0.457 ± 0.153
1.656PheIle: 1.656 ± 0.308
2.113PheLys: 2.113 ± 0.283
1.77PheLeu: 1.77 ± 0.352
0.628PheMet: 0.628 ± 0.155
1.256PheAsn: 1.256 ± 0.218
1.371PhePro: 1.371 ± 0.298
0.685PheGln: 0.685 ± 0.184
1.713PheArg: 1.713 ± 0.298
2.456PheSer: 2.456 ± 0.351
1.942PheThr: 1.942 ± 0.347
2.17PheVal: 2.17 ± 0.481
0.857PheTrp: 0.857 ± 0.25
0.857PheTyr: 0.857 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
6.625GlyAla: 6.625 ± 0.656
0.914GlyCys: 0.914 ± 0.258
5.54GlyAsp: 5.54 ± 0.388
4.112GlyGlu: 4.112 ± 0.499
2.227GlyPhe: 2.227 ± 0.413
6.339GlyGly: 6.339 ± 0.602
0.742GlyHis: 0.742 ± 0.218
3.541GlyIle: 3.541 ± 0.405
4.626GlyLys: 4.626 ± 0.554
6.739GlyLeu: 6.739 ± 0.753
1.77GlyMet: 1.77 ± 0.326
2.342GlyAsn: 2.342 ± 0.409
2.913GlyPro: 2.913 ± 0.531
2.57GlyGln: 2.57 ± 0.479
4.969GlyArg: 4.969 ± 0.621
4.797GlySer: 4.797 ± 0.508
6.111GlyThr: 6.111 ± 0.745
5.083GlyVal: 5.083 ± 0.456
1.77GlyTrp: 1.77 ± 0.34
2.456GlyTyr: 2.456 ± 0.5
0.0GlyXaa: 0.0 ± 0.0
His
1.256HisAla: 1.256 ± 0.288
0.4HisCys: 0.4 ± 0.156
1.371HisAsp: 1.371 ± 0.349
0.685HisGlu: 0.685 ± 0.179
0.286HisPhe: 0.286 ± 0.112
1.199HisGly: 1.199 ± 0.196
0.343HisHis: 0.343 ± 0.124
0.628HisIle: 0.628 ± 0.181
0.571HisLys: 0.571 ± 0.184
1.371HisLeu: 1.371 ± 0.284
0.457HisMet: 0.457 ± 0.173
0.4HisAsn: 0.4 ± 0.145
1.085HisPro: 1.085 ± 0.255
0.514HisGln: 0.514 ± 0.152
1.428HisArg: 1.428 ± 0.299
0.742HisSer: 0.742 ± 0.251
1.256HisThr: 1.256 ± 0.276
0.628HisVal: 0.628 ± 0.216
0.286HisTrp: 0.286 ± 0.12
0.628HisTyr: 0.628 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
4.112IleAla: 4.112 ± 0.586
0.514IleCys: 0.514 ± 0.144
3.541IleAsp: 3.541 ± 0.333
3.427IleGlu: 3.427 ± 0.559
1.656IlePhe: 1.656 ± 0.308
3.598IleGly: 3.598 ± 0.488
1.314IleHis: 1.314 ± 0.311
3.027IleIle: 3.027 ± 0.461
1.828IleLys: 1.828 ± 0.425
3.769IleLeu: 3.769 ± 0.513
1.713IleMet: 1.713 ± 0.33
1.77IleAsn: 1.77 ± 0.369
2.513IlePro: 2.513 ± 0.369
1.885IleGln: 1.885 ± 0.335
2.513IleArg: 2.513 ± 0.364
2.684IleSer: 2.684 ± 0.341
3.655IleThr: 3.655 ± 0.47
3.255IleVal: 3.255 ± 0.461
0.8IleTrp: 0.8 ± 0.214
1.428IleTyr: 1.428 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
6.568LysAla: 6.568 ± 1.237
0.514LysCys: 0.514 ± 0.193
3.541LysAsp: 3.541 ± 0.442
2.456LysGlu: 2.456 ± 0.583
1.142LysPhe: 1.142 ± 0.254
3.084LysGly: 3.084 ± 0.357
1.028LysHis: 1.028 ± 0.233
2.056LysIle: 2.056 ± 0.282
3.141LysLys: 3.141 ± 0.535
4.911LysLeu: 4.911 ± 0.666
1.085LysMet: 1.085 ± 0.233
2.684LysAsn: 2.684 ± 0.384
2.741LysPro: 2.741 ± 0.322
1.828LysGln: 1.828 ± 0.315
3.598LysArg: 3.598 ± 0.578
2.97LysSer: 2.97 ± 0.415
2.284LysThr: 2.284 ± 0.32
2.513LysVal: 2.513 ± 0.388
0.857LysTrp: 0.857 ± 0.264
1.828LysTyr: 1.828 ± 0.308
0.0LysXaa: 0.0 ± 0.0
Leu
10.794LeuAla: 10.794 ± 1.168
0.8LeuCys: 0.8 ± 0.195
6.111LeuAsp: 6.111 ± 0.528
4.74LeuGlu: 4.74 ± 0.727
1.828LeuPhe: 1.828 ± 0.26
5.14LeuGly: 5.14 ± 0.516
1.085LeuHis: 1.085 ± 0.281
4.569LeuIle: 4.569 ± 0.657
4.969LeuLys: 4.969 ± 0.598
6.853LeuLeu: 6.853 ± 0.797
2.342LeuMet: 2.342 ± 0.34
3.484LeuAsn: 3.484 ± 0.378
4.626LeuPro: 4.626 ± 0.584
3.484LeuGln: 3.484 ± 0.585
5.768LeuArg: 5.768 ± 0.812
6.282LeuSer: 6.282 ± 0.611
5.825LeuThr: 5.825 ± 0.549
6.225LeuVal: 6.225 ± 0.488
1.085LeuTrp: 1.085 ± 0.252
2.741LeuTyr: 2.741 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
3.427MetAla: 3.427 ± 0.462
0.057MetCys: 0.057 ± 0.054
1.656MetAsp: 1.656 ± 0.363
1.199MetGlu: 1.199 ± 0.2
0.685MetPhe: 0.685 ± 0.194
1.428MetGly: 1.428 ± 0.314
0.171MetHis: 0.171 ± 0.114
1.428MetIle: 1.428 ± 0.323
1.314MetLys: 1.314 ± 0.275
2.056MetLeu: 2.056 ± 0.296
0.971MetMet: 0.971 ± 0.207
1.028MetAsn: 1.028 ± 0.26
1.314MetPro: 1.314 ± 0.257
0.914MetGln: 0.914 ± 0.273
1.142MetArg: 1.142 ± 0.228
1.599MetSer: 1.599 ± 0.259
1.885MetThr: 1.885 ± 0.323
1.371MetVal: 1.371 ± 0.249
0.628MetTrp: 0.628 ± 0.178
0.4MetTyr: 0.4 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
4.055AsnAla: 4.055 ± 0.551
0.228AsnCys: 0.228 ± 0.118
2.17AsnAsp: 2.17 ± 0.359
2.113AsnGlu: 2.113 ± 0.405
1.028AsnPhe: 1.028 ± 0.251
4.226AsnGly: 4.226 ± 0.483
0.457AsnHis: 0.457 ± 0.197
2.627AsnIle: 2.627 ± 0.399
1.828AsnLys: 1.828 ± 0.317
2.913AsnLeu: 2.913 ± 0.357
0.8AsnMet: 0.8 ± 0.212
1.999AsnAsn: 1.999 ± 0.317
2.113AsnPro: 2.113 ± 0.412
0.742AsnGln: 0.742 ± 0.237
2.113AsnArg: 2.113 ± 0.364
1.828AsnSer: 1.828 ± 0.349
2.227AsnThr: 2.227 ± 0.337
2.856AsnVal: 2.856 ± 0.569
0.971AsnTrp: 0.971 ± 0.221
1.371AsnTyr: 1.371 ± 0.323
0.0AsnXaa: 0.0 ± 0.0
Pro
5.026ProAla: 5.026 ± 0.694
0.514ProCys: 0.514 ± 0.168
4.683ProAsp: 4.683 ± 0.618
2.913ProGlu: 2.913 ± 0.434
1.656ProPhe: 1.656 ± 0.374
4.283ProGly: 4.283 ± 0.482
0.685ProHis: 0.685 ± 0.244
1.828ProIle: 1.828 ± 0.295
2.798ProLys: 2.798 ± 0.422
3.198ProLeu: 3.198 ± 0.484
1.142ProMet: 1.142 ± 0.316
1.656ProAsn: 1.656 ± 0.35
1.656ProPro: 1.656 ± 0.454
1.028ProGln: 1.028 ± 0.282
2.684ProArg: 2.684 ± 0.467
2.17ProSer: 2.17 ± 0.323
2.399ProThr: 2.399 ± 0.355
4.226ProVal: 4.226 ± 0.513
0.742ProTrp: 0.742 ± 0.153
1.599ProTyr: 1.599 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
4.34GlnAla: 4.34 ± 1.022
0.4GlnCys: 0.4 ± 0.155
1.942GlnAsp: 1.942 ± 0.406
1.828GlnGlu: 1.828 ± 0.292
1.428GlnPhe: 1.428 ± 0.335
1.713GlnGly: 1.713 ± 0.329
0.571GlnHis: 0.571 ± 0.229
2.399GlnIle: 2.399 ± 0.37
1.942GlnLys: 1.942 ± 0.478
3.598GlnLeu: 3.598 ± 0.652
0.914GlnMet: 0.914 ± 0.221
1.713GlnAsn: 1.713 ± 0.285
1.142GlnPro: 1.142 ± 0.227
1.656GlnGln: 1.656 ± 0.539
1.999GlnArg: 1.999 ± 0.33
2.113GlnSer: 2.113 ± 0.478
2.456GlnThr: 2.456 ± 0.393
2.399GlnVal: 2.399 ± 0.301
0.8GlnTrp: 0.8 ± 0.178
0.971GlnTyr: 0.971 ± 0.425
0.0GlnXaa: 0.0 ± 0.0
Arg
5.597ArgAla: 5.597 ± 0.632
0.628ArgCys: 0.628 ± 0.179
4.112ArgAsp: 4.112 ± 0.513
3.141ArgGlu: 3.141 ± 0.427
1.542ArgPhe: 1.542 ± 0.405
4.569ArgGly: 4.569 ± 0.374
1.542ArgHis: 1.542 ± 0.34
2.913ArgIle: 2.913 ± 0.404
3.312ArgLys: 3.312 ± 0.613
6.739ArgLeu: 6.739 ± 0.809
1.485ArgMet: 1.485 ± 0.278
2.57ArgAsn: 2.57 ± 0.361
3.484ArgPro: 3.484 ± 0.573
2.456ArgGln: 2.456 ± 0.345
3.769ArgArg: 3.769 ± 0.552
3.255ArgSer: 3.255 ± 0.364
2.57ArgThr: 2.57 ± 0.416
4.169ArgVal: 4.169 ± 0.455
1.256ArgTrp: 1.256 ± 0.291
2.227ArgTyr: 2.227 ± 0.45
0.0ArgXaa: 0.0 ± 0.0
Ser
5.425SerAla: 5.425 ± 0.952
0.457SerCys: 0.457 ± 0.147
3.655SerAsp: 3.655 ± 0.518
3.941SerGlu: 3.941 ± 0.373
2.798SerPhe: 2.798 ± 0.322
5.54SerGly: 5.54 ± 0.621
0.685SerHis: 0.685 ± 0.201
2.684SerIle: 2.684 ± 0.389
2.227SerLys: 2.227 ± 0.433
5.254SerLeu: 5.254 ± 0.744
1.656SerMet: 1.656 ± 0.278
2.456SerAsn: 2.456 ± 0.335
2.684SerPro: 2.684 ± 0.455
1.77SerGln: 1.77 ± 0.306
3.198SerArg: 3.198 ± 0.428
3.941SerSer: 3.941 ± 0.741
3.883SerThr: 3.883 ± 0.416
4.226SerVal: 4.226 ± 0.466
1.77SerTrp: 1.77 ± 0.284
1.542SerTyr: 1.542 ± 0.284
0.0SerXaa: 0.0 ± 0.0
Thr
5.54ThrAla: 5.54 ± 0.708
0.628ThrCys: 0.628 ± 0.179
4.112ThrAsp: 4.112 ± 0.469
3.255ThrGlu: 3.255 ± 0.412
2.056ThrPhe: 2.056 ± 0.231
5.654ThrGly: 5.654 ± 0.618
0.685ThrHis: 0.685 ± 0.225
2.399ThrIle: 2.399 ± 0.514
2.57ThrLys: 2.57 ± 0.418
6.396ThrLeu: 6.396 ± 0.825
0.914ThrMet: 0.914 ± 0.257
1.599ThrAsn: 1.599 ± 0.338
3.655ThrPro: 3.655 ± 0.52
2.17ThrGln: 2.17 ± 0.348
3.027ThrArg: 3.027 ± 0.49
3.826ThrSer: 3.826 ± 0.603
4.683ThrThr: 4.683 ± 0.541
5.197ThrVal: 5.197 ± 0.525
0.971ThrTrp: 0.971 ± 0.26
1.542ThrTyr: 1.542 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
6.225ValAla: 6.225 ± 0.443
1.028ValCys: 1.028 ± 0.245
4.34ValAsp: 4.34 ± 0.463
3.998ValGlu: 3.998 ± 0.47
2.056ValPhe: 2.056 ± 0.337
4.512ValGly: 4.512 ± 0.527
1.428ValHis: 1.428 ± 0.323
2.856ValIle: 2.856 ± 0.342
3.312ValLys: 3.312 ± 0.476
5.311ValLeu: 5.311 ± 0.636
2.17ValMet: 2.17 ± 0.424
3.141ValAsn: 3.141 ± 0.495
2.856ValPro: 2.856 ± 0.374
2.856ValGln: 2.856 ± 0.361
5.083ValArg: 5.083 ± 0.514
5.026ValSer: 5.026 ± 0.479
5.311ValThr: 5.311 ± 0.66
5.026ValVal: 5.026 ± 0.507
1.028ValTrp: 1.028 ± 0.185
1.828ValTyr: 1.828 ± 0.315
0.0ValXaa: 0.0 ± 0.0
Trp
1.599TrpAla: 1.599 ± 0.263
0.228TrpCys: 0.228 ± 0.121
1.485TrpAsp: 1.485 ± 0.34
1.085TrpGlu: 1.085 ± 0.222
0.457TrpPhe: 0.457 ± 0.145
0.742TrpGly: 0.742 ± 0.184
0.4TrpHis: 0.4 ± 0.166
0.857TrpIle: 0.857 ± 0.214
0.971TrpLys: 0.971 ± 0.231
2.513TrpLeu: 2.513 ± 0.428
0.571TrpMet: 0.571 ± 0.214
0.514TrpAsn: 0.514 ± 0.127
1.371TrpPro: 1.371 ± 0.291
0.971TrpGln: 0.971 ± 0.219
1.77TrpArg: 1.77 ± 0.247
1.085TrpSer: 1.085 ± 0.198
0.971TrpThr: 0.971 ± 0.249
1.428TrpVal: 1.428 ± 0.312
0.571TrpTrp: 0.571 ± 0.208
0.742TrpTyr: 0.742 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.913TyrAla: 2.913 ± 0.333
0.286TyrCys: 0.286 ± 0.156
1.942TyrAsp: 1.942 ± 0.338
1.828TyrGlu: 1.828 ± 0.381
0.914TyrPhe: 0.914 ± 0.257
2.856TyrGly: 2.856 ± 0.527
0.457TyrHis: 0.457 ± 0.152
1.028TyrIle: 1.028 ± 0.235
1.371TyrLys: 1.371 ± 0.262
1.999TyrLeu: 1.999 ± 0.39
0.628TyrMet: 0.628 ± 0.183
1.371TyrAsn: 1.371 ± 0.327
1.314TyrPro: 1.314 ± 0.288
1.371TyrGln: 1.371 ± 0.292
2.342TyrArg: 2.342 ± 0.49
2.227TyrSer: 2.227 ± 0.376
1.371TyrThr: 1.371 ± 0.339
2.513TyrVal: 2.513 ± 0.447
0.742TyrTrp: 0.742 ± 0.24
1.085TyrTyr: 1.085 ± 0.247
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (17511 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski