Amino acid dipepetide frequency for Chiqui virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.76AlaAla: 2.76 ± 0.4
0.627AlaCys: 0.627 ± 0.227
3.262AlaAsp: 3.262 ± 0.501
2.76AlaGlu: 2.76 ± 0.606
2.635AlaPhe: 2.635 ± 0.576
2.384AlaGly: 2.384 ± 0.501
1.255AlaHis: 1.255 ± 0.437
5.019AlaIle: 5.019 ± 1.209
4.015AlaLys: 4.015 ± 0.41
4.768AlaLeu: 4.768 ± 0.666
0.753AlaMet: 0.753 ± 0.44
4.015AlaAsn: 4.015 ± 0.317
2.509AlaPro: 2.509 ± 0.608
1.631AlaGln: 1.631 ± 0.404
3.011AlaArg: 3.011 ± 0.494
3.388AlaSer: 3.388 ± 0.554
3.388AlaThr: 3.388 ± 0.651
2.384AlaVal: 2.384 ± 0.572
0.251AlaTrp: 0.251 ± 0.165
2.384AlaTyr: 2.384 ± 0.655
0.0AlaXaa: 0.0 ± 0.0
Cys
0.753CysAla: 0.753 ± 0.301
0.376CysCys: 0.376 ± 0.161
1.004CysAsp: 1.004 ± 0.333
0.627CysGlu: 0.627 ± 0.223
0.502CysPhe: 0.502 ± 0.253
0.627CysGly: 0.627 ± 0.332
0.0CysHis: 0.0 ± 0.0
0.627CysIle: 0.627 ± 0.19
0.502CysLys: 0.502 ± 0.325
0.627CysLeu: 0.627 ± 0.239
0.125CysMet: 0.125 ± 0.11
0.125CysAsn: 0.125 ± 0.119
0.376CysPro: 0.376 ± 0.236
0.502CysGln: 0.502 ± 0.321
1.004CysArg: 1.004 ± 0.385
0.878CysSer: 0.878 ± 0.329
0.753CysThr: 0.753 ± 0.233
0.878CysVal: 0.878 ± 0.327
0.376CysTrp: 0.376 ± 0.15
0.376CysTyr: 0.376 ± 0.229
0.0CysXaa: 0.0 ± 0.0
Asp
4.893AspAla: 4.893 ± 0.804
0.0AspCys: 0.0 ± 0.0
4.768AspAsp: 4.768 ± 0.261
5.019AspGlu: 5.019 ± 0.648
1.757AspPhe: 1.757 ± 0.287
3.011AspGly: 3.011 ± 0.579
1.255AspHis: 1.255 ± 0.332
4.015AspIle: 4.015 ± 0.447
4.642AspLys: 4.642 ± 0.865
4.768AspLeu: 4.768 ± 0.658
1.882AspMet: 1.882 ± 0.501
3.639AspAsn: 3.639 ± 0.814
2.008AspPro: 2.008 ± 0.462
2.384AspGln: 2.384 ± 0.615
2.509AspArg: 2.509 ± 0.518
4.015AspSer: 4.015 ± 0.557
3.764AspThr: 3.764 ± 0.414
4.768AspVal: 4.768 ± 0.674
0.502AspTrp: 0.502 ± 0.263
2.384AspTyr: 2.384 ± 0.41
0.0AspXaa: 0.0 ± 0.0
Glu
2.384GluAla: 2.384 ± 0.693
0.627GluCys: 0.627 ± 0.287
2.886GluAsp: 2.886 ± 0.299
3.513GluGlu: 3.513 ± 0.543
2.886GluPhe: 2.886 ± 0.547
2.509GluGly: 2.509 ± 0.803
1.506GluHis: 1.506 ± 0.297
5.019GluIle: 5.019 ± 0.464
3.639GluLys: 3.639 ± 0.704
6.524GluLeu: 6.524 ± 0.597
1.631GluMet: 1.631 ± 0.357
3.639GluAsn: 3.639 ± 0.343
3.137GluPro: 3.137 ± 0.788
3.011GluGln: 3.011 ± 0.652
3.011GluArg: 3.011 ± 0.567
3.764GluSer: 3.764 ± 0.46
4.517GluThr: 4.517 ± 0.798
3.513GluVal: 3.513 ± 0.532
1.506GluTrp: 1.506 ± 0.422
2.008GluTyr: 2.008 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
2.509PheAla: 2.509 ± 0.579
0.502PheCys: 0.502 ± 0.237
2.76PheAsp: 2.76 ± 0.754
3.639PheGlu: 3.639 ± 0.556
1.38PhePhe: 1.38 ± 0.554
2.509PheGly: 2.509 ± 0.5
0.627PheHis: 0.627 ± 0.231
2.635PheIle: 2.635 ± 0.501
3.262PheLys: 3.262 ± 0.593
2.76PheLeu: 2.76 ± 0.535
1.129PheMet: 1.129 ± 0.206
2.76PheAsn: 2.76 ± 0.67
1.631PhePro: 1.631 ± 0.409
1.506PheGln: 1.506 ± 0.496
2.886PheArg: 2.886 ± 0.647
3.513PheSer: 3.513 ± 0.823
2.384PheThr: 2.384 ± 0.603
1.757PheVal: 1.757 ± 0.346
0.502PheTrp: 0.502 ± 0.333
1.506PheTyr: 1.506 ± 0.452
0.0PheXaa: 0.0 ± 0.0
Gly
2.76GlyAla: 2.76 ± 0.521
0.627GlyCys: 0.627 ± 0.279
2.76GlyAsp: 2.76 ± 0.649
2.886GlyGlu: 2.886 ± 0.425
2.133GlyPhe: 2.133 ± 0.399
2.133GlyGly: 2.133 ± 1.039
0.627GlyHis: 0.627 ± 0.243
5.019GlyIle: 5.019 ± 0.768
3.89GlyLys: 3.89 ± 0.745
3.89GlyLeu: 3.89 ± 0.58
2.008GlyMet: 2.008 ± 0.386
2.384GlyAsn: 2.384 ± 0.462
1.129GlyPro: 1.129 ± 0.4
1.882GlyGln: 1.882 ± 0.546
2.76GlyArg: 2.76 ± 0.465
3.388GlySer: 3.388 ± 0.736
4.015GlyThr: 4.015 ± 0.411
2.635GlyVal: 2.635 ± 0.639
0.502GlyTrp: 0.502 ± 0.213
2.76GlyTyr: 2.76 ± 0.607
0.0GlyXaa: 0.0 ± 0.0
His
1.004HisAla: 1.004 ± 0.306
0.125HisCys: 0.125 ± 0.11
1.004HisAsp: 1.004 ± 0.259
1.255HisGlu: 1.255 ± 0.509
0.627HisPhe: 0.627 ± 0.232
0.753HisGly: 0.753 ± 0.301
0.627HisHis: 0.627 ± 0.352
1.38HisIle: 1.38 ± 0.262
0.878HisLys: 0.878 ± 0.265
1.882HisLeu: 1.882 ± 0.467
0.125HisMet: 0.125 ± 0.143
1.255HisAsn: 1.255 ± 0.299
1.757HisPro: 1.757 ± 0.456
1.38HisGln: 1.38 ± 0.351
1.129HisArg: 1.129 ± 0.442
0.627HisSer: 0.627 ± 0.184
1.38HisThr: 1.38 ± 0.656
1.004HisVal: 1.004 ± 0.247
0.125HisTrp: 0.125 ± 0.112
0.502HisTyr: 0.502 ± 0.31
0.0HisXaa: 0.0 ± 0.0
Ile
4.642IleAla: 4.642 ± 0.592
0.753IleCys: 0.753 ± 0.475
4.517IleAsp: 4.517 ± 0.92
4.642IleGlu: 4.642 ± 0.506
3.011IlePhe: 3.011 ± 0.756
3.764IleGly: 3.764 ± 0.678
1.506IleHis: 1.506 ± 0.408
5.646IleIle: 5.646 ± 1.026
3.764IleLys: 3.764 ± 0.583
6.023IleLeu: 6.023 ± 0.646
1.631IleMet: 1.631 ± 0.657
4.015IleAsn: 4.015 ± 0.339
5.019IlePro: 5.019 ± 0.56
3.513IleGln: 3.513 ± 0.685
4.642IleArg: 4.642 ± 0.908
7.654IleSer: 7.654 ± 0.446
5.395IleThr: 5.395 ± 0.729
4.391IleVal: 4.391 ± 0.672
1.506IleTrp: 1.506 ± 0.306
3.137IleTyr: 3.137 ± 0.482
0.0IleXaa: 0.0 ± 0.0
Lys
3.262LysAla: 3.262 ± 0.502
0.376LysCys: 0.376 ± 0.277
3.513LysAsp: 3.513 ± 0.646
2.133LysGlu: 2.133 ± 0.43
2.258LysPhe: 2.258 ± 0.428
3.513LysGly: 3.513 ± 0.363
1.129LysHis: 1.129 ± 0.276
6.148LysIle: 6.148 ± 1.016
1.38LysLys: 1.38 ± 0.471
5.521LysLeu: 5.521 ± 0.896
2.008LysMet: 2.008 ± 0.692
3.011LysAsn: 3.011 ± 0.346
2.384LysPro: 2.384 ± 0.607
2.509LysGln: 2.509 ± 0.577
2.384LysArg: 2.384 ± 0.543
3.513LysSer: 3.513 ± 0.534
4.141LysThr: 4.141 ± 0.414
3.89LysVal: 3.89 ± 0.817
1.129LysTrp: 1.129 ± 0.475
3.011LysTyr: 3.011 ± 0.606
0.0LysXaa: 0.0 ± 0.0
Leu
4.517LeuAla: 4.517 ± 0.617
1.255LeuCys: 1.255 ± 0.354
4.893LeuAsp: 4.893 ± 0.595
4.893LeuGlu: 4.893 ± 0.906
4.015LeuPhe: 4.015 ± 0.882
4.517LeuGly: 4.517 ± 1.452
1.129LeuHis: 1.129 ± 0.329
6.274LeuIle: 6.274 ± 1.393
2.886LeuLys: 2.886 ± 0.565
7.779LeuLeu: 7.779 ± 0.827
2.635LeuMet: 2.635 ± 0.299
3.639LeuAsn: 3.639 ± 0.51
5.144LeuPro: 5.144 ± 0.65
3.639LeuGln: 3.639 ± 0.739
5.772LeuArg: 5.772 ± 1.06
9.034LeuSer: 9.034 ± 1.347
6.399LeuThr: 6.399 ± 0.614
5.144LeuVal: 5.144 ± 0.777
0.502LeuTrp: 0.502 ± 0.23
3.388LeuTyr: 3.388 ± 0.549
0.0LeuXaa: 0.0 ± 0.0
Met
1.255MetAla: 1.255 ± 0.379
0.376MetCys: 0.376 ± 0.174
1.882MetAsp: 1.882 ± 0.47
1.506MetGlu: 1.506 ± 0.32
0.878MetPhe: 0.878 ± 0.273
1.506MetGly: 1.506 ± 0.301
0.502MetHis: 0.502 ± 0.189
1.38MetIle: 1.38 ± 0.44
1.255MetLys: 1.255 ± 0.392
3.011MetLeu: 3.011 ± 0.939
1.129MetMet: 1.129 ± 0.234
0.878MetAsn: 0.878 ± 0.325
1.882MetPro: 1.882 ± 0.599
1.004MetGln: 1.004 ± 0.424
1.631MetArg: 1.631 ± 0.411
2.384MetSer: 2.384 ± 0.542
2.008MetThr: 2.008 ± 0.43
1.129MetVal: 1.129 ± 0.324
0.627MetTrp: 0.627 ± 0.253
1.631MetTyr: 1.631 ± 0.497
0.0MetXaa: 0.0 ± 0.0
Asn
2.509AsnAla: 2.509 ± 0.426
0.627AsnCys: 0.627 ± 0.325
4.266AsnAsp: 4.266 ± 0.896
4.266AsnGlu: 4.266 ± 0.733
2.886AsnPhe: 2.886 ± 0.755
3.764AsnGly: 3.764 ± 0.475
0.878AsnHis: 0.878 ± 0.548
3.262AsnIle: 3.262 ± 0.559
3.764AsnLys: 3.764 ± 0.856
4.642AsnLeu: 4.642 ± 0.808
1.004AsnMet: 1.004 ± 0.372
2.635AsnAsn: 2.635 ± 0.779
2.258AsnPro: 2.258 ± 0.45
2.384AsnGln: 2.384 ± 0.372
2.258AsnArg: 2.258 ± 0.516
4.266AsnSer: 4.266 ± 0.459
3.388AsnThr: 3.388 ± 0.794
3.262AsnVal: 3.262 ± 0.618
1.506AsnTrp: 1.506 ± 0.385
1.506AsnTyr: 1.506 ± 0.305
0.0AsnXaa: 0.0 ± 0.0
Pro
1.882ProAla: 1.882 ± 0.67
0.251ProCys: 0.251 ± 0.219
2.635ProAsp: 2.635 ± 0.493
3.262ProGlu: 3.262 ± 0.566
2.008ProPhe: 2.008 ± 0.417
1.38ProGly: 1.38 ± 0.283
0.753ProHis: 0.753 ± 0.235
2.886ProIle: 2.886 ± 0.546
2.76ProLys: 2.76 ± 0.477
2.635ProLeu: 2.635 ± 0.364
1.631ProMet: 1.631 ± 0.524
2.886ProAsn: 2.886 ± 0.578
0.753ProPro: 0.753 ± 0.461
1.882ProGln: 1.882 ± 0.665
2.509ProArg: 2.509 ± 0.467
4.266ProSer: 4.266 ± 0.662
4.642ProThr: 4.642 ± 0.811
2.635ProVal: 2.635 ± 0.703
0.376ProTrp: 0.376 ± 0.232
1.882ProTyr: 1.882 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
1.631GlnAla: 1.631 ± 0.515
0.753GlnCys: 0.753 ± 0.317
1.38GlnAsp: 1.38 ± 0.424
1.882GlnGlu: 1.882 ± 0.41
1.882GlnPhe: 1.882 ± 0.606
1.631GlnGly: 1.631 ± 0.341
0.753GlnHis: 0.753 ± 0.309
4.391GlnIle: 4.391 ± 0.703
2.886GlnLys: 2.886 ± 0.728
5.646GlnLeu: 5.646 ± 0.4
2.008GlnMet: 2.008 ± 0.388
2.509GlnAsn: 2.509 ± 0.296
1.757GlnPro: 1.757 ± 0.355
2.133GlnGln: 2.133 ± 0.697
2.258GlnArg: 2.258 ± 0.508
2.886GlnSer: 2.886 ± 0.531
3.262GlnThr: 3.262 ± 0.503
1.506GlnVal: 1.506 ± 0.32
0.502GlnTrp: 0.502 ± 0.307
1.38GlnTyr: 1.38 ± 0.32
0.0GlnXaa: 0.0 ± 0.0
Arg
3.513ArgAla: 3.513 ± 0.597
0.502ArgCys: 0.502 ± 0.261
2.635ArgAsp: 2.635 ± 0.43
2.133ArgGlu: 2.133 ± 0.636
2.509ArgPhe: 2.509 ± 0.535
1.506ArgGly: 1.506 ± 0.427
1.255ArgHis: 1.255 ± 0.156
5.019ArgIle: 5.019 ± 0.974
2.76ArgLys: 2.76 ± 0.599
6.65ArgLeu: 6.65 ± 1.241
1.255ArgMet: 1.255 ± 0.321
3.639ArgAsn: 3.639 ± 0.534
1.506ArgPro: 1.506 ± 0.646
1.882ArgGln: 1.882 ± 0.666
1.882ArgArg: 1.882 ± 0.355
3.011ArgSer: 3.011 ± 0.602
3.639ArgThr: 3.639 ± 0.304
2.886ArgVal: 2.886 ± 0.642
0.627ArgTrp: 0.627 ± 0.371
2.509ArgTyr: 2.509 ± 0.776
0.0ArgXaa: 0.0 ± 0.0
Ser
3.639SerAla: 3.639 ± 0.619
0.878SerCys: 0.878 ± 0.403
5.395SerAsp: 5.395 ± 0.831
5.521SerGlu: 5.521 ± 1.181
2.886SerPhe: 2.886 ± 0.713
3.89SerGly: 3.89 ± 0.506
1.506SerHis: 1.506 ± 0.674
5.897SerIle: 5.897 ± 0.745
5.019SerLys: 5.019 ± 1.067
6.399SerLeu: 6.399 ± 1.193
1.882SerMet: 1.882 ± 0.466
3.89SerAsn: 3.89 ± 0.593
2.008SerPro: 2.008 ± 0.4
3.137SerGln: 3.137 ± 0.519
3.89SerArg: 3.89 ± 0.799
5.019SerSer: 5.019 ± 0.725
5.27SerThr: 5.27 ± 0.76
4.015SerVal: 4.015 ± 0.625
0.502SerTrp: 0.502 ± 0.154
3.137SerTyr: 3.137 ± 0.662
0.0SerXaa: 0.0 ± 0.0
Thr
2.635ThrAla: 2.635 ± 0.686
0.627ThrCys: 0.627 ± 0.256
4.266ThrAsp: 4.266 ± 0.714
5.019ThrGlu: 5.019 ± 0.759
3.388ThrPhe: 3.388 ± 0.358
4.642ThrGly: 4.642 ± 0.717
1.506ThrHis: 1.506 ± 0.32
7.403ThrIle: 7.403 ± 1.002
3.89ThrLys: 3.89 ± 0.454
6.524ThrLeu: 6.524 ± 0.694
1.882ThrMet: 1.882 ± 0.364
3.137ThrAsn: 3.137 ± 0.645
3.262ThrPro: 3.262 ± 0.534
3.513ThrGln: 3.513 ± 0.801
2.886ThrArg: 2.886 ± 0.573
4.391ThrSer: 4.391 ± 0.684
6.023ThrThr: 6.023 ± 1.05
4.517ThrVal: 4.517 ± 0.841
0.753ThrTrp: 0.753 ± 0.222
3.011ThrTyr: 3.011 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
2.509ValAla: 2.509 ± 0.431
0.878ValCys: 0.878 ± 0.288
4.642ValAsp: 4.642 ± 0.644
2.886ValGlu: 2.886 ± 0.547
2.133ValPhe: 2.133 ± 0.391
3.137ValGly: 3.137 ± 0.941
1.129ValHis: 1.129 ± 0.483
4.015ValIle: 4.015 ± 0.488
2.886ValLys: 2.886 ± 0.624
3.89ValLeu: 3.89 ± 0.27
1.38ValMet: 1.38 ± 0.333
3.764ValAsn: 3.764 ± 0.497
3.513ValPro: 3.513 ± 0.607
2.886ValGln: 2.886 ± 0.741
2.635ValArg: 2.635 ± 0.728
4.642ValSer: 4.642 ± 0.628
4.141ValThr: 4.141 ± 0.882
3.388ValVal: 3.388 ± 0.637
0.251ValTrp: 0.251 ± 0.152
1.631ValTyr: 1.631 ± 0.542
0.0ValXaa: 0.0 ± 0.0
Trp
0.627TrpAla: 0.627 ± 0.202
0.125TrpCys: 0.125 ± 0.112
0.753TrpAsp: 0.753 ± 0.207
0.627TrpGlu: 0.627 ± 0.288
0.502TrpPhe: 0.502 ± 0.29
0.376TrpGly: 0.376 ± 0.264
0.125TrpHis: 0.125 ± 0.143
1.004TrpIle: 1.004 ± 0.341
1.255TrpLys: 1.255 ± 0.29
0.753TrpLeu: 0.753 ± 0.281
0.627TrpMet: 0.627 ± 0.283
1.004TrpAsn: 1.004 ± 0.222
0.376TrpPro: 0.376 ± 0.187
0.878TrpGln: 0.878 ± 0.6
0.502TrpArg: 0.502 ± 0.156
0.878TrpSer: 0.878 ± 0.212
1.004TrpThr: 1.004 ± 0.362
0.502TrpVal: 0.502 ± 0.259
0.502TrpTrp: 0.502 ± 0.223
0.376TrpTyr: 0.376 ± 0.228
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.513TyrAla: 3.513 ± 0.906
0.753TyrCys: 0.753 ± 0.293
2.76TyrAsp: 2.76 ± 0.475
2.76TyrGlu: 2.76 ± 0.614
1.882TyrPhe: 1.882 ± 0.504
2.635TyrGly: 2.635 ± 0.541
0.753TyrHis: 0.753 ± 0.266
2.133TyrIle: 2.133 ± 0.373
1.882TyrLys: 1.882 ± 0.386
2.76TyrLeu: 2.76 ± 0.75
1.004TyrMet: 1.004 ± 0.198
2.635TyrAsn: 2.635 ± 0.417
1.506TyrPro: 1.506 ± 0.673
1.38TyrGln: 1.38 ± 0.356
1.757TyrArg: 1.757 ± 0.46
2.258TyrSer: 2.258 ± 0.479
3.764TyrThr: 3.764 ± 0.72
2.133TyrVal: 2.133 ± 1.149
0.251TyrTrp: 0.251 ± 0.174
1.38TyrTyr: 1.38 ± 0.352
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (7971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski