Amino acid dipepetide frequency for Oxalobacteraceae bacterium CAVE-383

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.138AlaAla: 18.138 ± 0.179	1.155AlaCys: 1.155 ± 0.033	6.856AlaAsp: 6.856 ± 0.079	6.265AlaGlu: 6.265 ± 0.083	4.12AlaPhe: 4.12 ± 0.062	10.656AlaGly: 10.656 ± 0.114	2.427AlaHis: 2.427 ± 0.051	6.478AlaIle: 6.478 ± 0.075	4.344AlaLys: 4.344 ± 0.087	13.769AlaLeu: 13.769 ± 0.145	3.584AlaMet: 3.584 ± 0.057	3.412AlaAsn: 3.412 ± 0.069	5.899AlaPro: 5.899 ± 0.093	5.292AlaGln: 5.292 ± 0.081	7.373AlaArg: 7.373 ± 0.086	6.559AlaSer: 6.559 ± 0.085	5.324AlaThr: 5.324 ± 0.08	8.144AlaVal: 8.144 ± 0.07	1.377AlaTrp: 1.377 ± 0.036	2.717AlaTyr: 2.717 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.029	0.135CysCys: 0.135 ± 0.011	0.523CysAsp: 0.523 ± 0.021	0.462CysGlu: 0.462 ± 0.018	0.322CysPhe: 0.322 ± 0.017	0.971CysGly: 0.971 ± 0.031	0.256CysHis: 0.256 ± 0.015	0.477CysIle: 0.477 ± 0.02	0.252CysLys: 0.252 ± 0.014	0.841CysLeu: 0.841 ± 0.027	0.21CysMet: 0.21 ± 0.015	0.273CysAsn: 0.273 ± 0.014	0.408CysPro: 0.408 ± 0.019	0.228CysGln: 0.228 ± 0.014	0.533CysArg: 0.533 ± 0.021	0.472CysSer: 0.472 ± 0.018	0.435CysThr: 0.435 ± 0.021	0.658CysVal: 0.658 ± 0.023	0.108CysTrp: 0.108 ± 0.008	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.231AspAla: 7.231 ± 0.082	0.505AspCys: 0.505 ± 0.021	2.906AspAsp: 2.906 ± 0.054	2.946AspGlu: 2.946 ± 0.055	2.201AspPhe: 2.201 ± 0.043	4.652AspGly: 4.652 ± 0.082	1.074AspHis: 1.074 ± 0.036	3.411AspIle: 3.411 ± 0.055	2.057AspLys: 2.057 ± 0.046	5.431AspLeu: 5.431 ± 0.07	1.417AspMet: 1.417 ± 0.034	1.664AspAsn: 1.664 ± 0.055	2.806AspPro: 2.806 ± 0.047	1.815AspGln: 1.815 ± 0.042	3.215AspArg: 3.215 ± 0.052	2.62AspSer: 2.62 ± 0.047	2.646AspThr: 2.646 ± 0.072	3.871AspVal: 3.871 ± 0.061	0.878AspTrp: 0.878 ± 0.026	1.646AspTyr: 1.646 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.01GluAla: 6.01 ± 0.092	0.401GluCys: 0.401 ± 0.019	2.291GluAsp: 2.291 ± 0.043	2.669GluGlu: 2.669 ± 0.061	1.888GluPhe: 1.888 ± 0.039	3.294GluGly: 3.294 ± 0.059	1.214GluHis: 1.214 ± 0.033	3.393GluIle: 3.393 ± 0.065	2.562GluLys: 2.562 ± 0.055	5.222GluLeu: 5.222 ± 0.08	1.493GluMet: 1.493 ± 0.034	1.828GluAsn: 1.828 ± 0.036	1.968GluPro: 1.968 ± 0.042	2.697GluGln: 2.697 ± 0.055	3.7GluArg: 3.7 ± 0.059	2.779GluSer: 2.779 ± 0.047	2.807GluThr: 2.807 ± 0.052	3.34GluVal: 3.34 ± 0.057	0.709GluTrp: 0.709 ± 0.024	1.226GluTyr: 1.226 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.098PheAla: 4.098 ± 0.059	0.427PheCys: 0.427 ± 0.019	2.514PheAsp: 2.514 ± 0.046	2.042PheGlu: 2.042 ± 0.045	1.524PhePhe: 1.524 ± 0.039	3.401PheGly: 3.401 ± 0.063	0.769PheHis: 0.769 ± 0.025	1.977PheIle: 1.977 ± 0.047	1.362PheLys: 1.362 ± 0.032	3.267PheLeu: 3.267 ± 0.062	0.912PheMet: 0.912 ± 0.027	1.366PheAsn: 1.366 ± 0.035	1.623PhePro: 1.623 ± 0.036	1.089PheGln: 1.089 ± 0.027	1.913PheArg: 1.913 ± 0.038	2.641PheSer: 2.641 ± 0.049	1.919PheThr: 1.919 ± 0.04	2.619PheVal: 2.619 ± 0.055	0.485PheTrp: 0.485 ± 0.022	1.058PheTyr: 1.058 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.131GlyAla: 9.131 ± 0.123	0.752GlyCys: 0.752 ± 0.03	4.176GlyAsp: 4.176 ± 0.079	3.955GlyGlu: 3.955 ± 0.065	3.209GlyPhe: 3.209 ± 0.05	6.721GlyGly: 6.721 ± 0.134	1.743GlyHis: 1.743 ± 0.039	4.815GlyIle: 4.815 ± 0.069	4.014GlyLys: 4.014 ± 0.058	8.048GlyLeu: 8.048 ± 0.091	2.517GlyMet: 2.517 ± 0.046	2.809GlyAsn: 2.809 ± 0.118	2.689GlyPro: 2.689 ± 0.053	2.924GlyGln: 2.924 ± 0.058	4.844GlyArg: 4.844 ± 0.07	4.598GlySer: 4.598 ± 0.081	3.849GlyThr: 3.849 ± 0.1	5.883GlyVal: 5.883 ± 0.087	1.197GlyTrp: 1.197 ± 0.032	2.278GlyTyr: 2.278 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.692HisAla: 2.692 ± 0.054	0.252HisCys: 0.252 ± 0.013	1.239HisAsp: 1.239 ± 0.035	1.053HisGlu: 1.053 ± 0.029	0.934HisPhe: 0.934 ± 0.025	1.967HisGly: 1.967 ± 0.044	0.603HisHis: 0.603 ± 0.023	1.182HisIle: 1.182 ± 0.03	0.629HisLys: 0.629 ± 0.028	2.126HisLeu: 2.126 ± 0.044	0.519HisMet: 0.519 ± 0.022	0.604HisAsn: 0.604 ± 0.024	1.415HisPro: 1.415 ± 0.04	0.743HisGln: 0.743 ± 0.023	1.325HisArg: 1.325 ± 0.037	1.085HisSer: 1.085 ± 0.03	0.974HisThr: 0.974 ± 0.031	1.439HisVal: 1.439 ± 0.034	0.343HisTrp: 0.343 ± 0.017	0.669HisTyr: 0.669 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.754IleAla: 7.754 ± 0.084	0.537IleCys: 0.537 ± 0.024	4.002IleAsp: 4.002 ± 0.054	3.501IleGlu: 3.501 ± 0.063	1.852IlePhe: 1.852 ± 0.045	5.199IleGly: 5.199 ± 0.084	1.019IleHis: 1.019 ± 0.029	2.373IleIle: 2.373 ± 0.05	2.22IleLys: 2.22 ± 0.046	4.673IleLeu: 4.673 ± 0.062	1.119IleMet: 1.119 ± 0.032	1.844IleAsn: 1.844 ± 0.046	2.466IlePro: 2.466 ± 0.043	1.507IleGln: 1.507 ± 0.037	3.014IleArg: 3.014 ± 0.045	3.317IleSer: 3.317 ± 0.054	2.797IleThr: 2.797 ± 0.062	4.32IleVal: 4.32 ± 0.053	0.638IleTrp: 0.638 ± 0.028	1.295IleTyr: 1.295 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.318LysAla: 4.318 ± 0.073	0.21LysCys: 0.21 ± 0.014	1.993LysAsp: 1.993 ± 0.037	1.889LysGlu: 1.889 ± 0.044	1.253LysPhe: 1.253 ± 0.035	2.581LysGly: 2.581 ± 0.052	0.752LysHis: 0.752 ± 0.028	2.47LysIle: 2.47 ± 0.049	2.027LysLys: 2.027 ± 0.053	4.171LysLeu: 4.171 ± 0.063	1.239LysMet: 1.239 ± 0.035	1.54LysAsn: 1.54 ± 0.041	2.252LysPro: 2.252 ± 0.055	1.675LysGln: 1.675 ± 0.037	2.437LysArg: 2.437 ± 0.051	2.264LysSer: 2.264 ± 0.048	2.349LysThr: 2.349 ± 0.048	2.679LysVal: 2.679 ± 0.061	0.478LysTrp: 0.478 ± 0.021	0.901LysTyr: 0.901 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.311LeuAla: 13.311 ± 0.133	1.028LeuCys: 1.028 ± 0.033	5.609LeuAsp: 5.609 ± 0.079	5.09LeuGlu: 5.09 ± 0.075	3.78LeuPhe: 3.78 ± 0.051	7.758LeuGly: 7.758 ± 0.099	2.382LeuHis: 2.382 ± 0.047	5.41LeuIle: 5.41 ± 0.064	4.096LeuLys: 4.096 ± 0.06	11.322LeuLeu: 11.322 ± 0.145	2.621LeuMet: 2.621 ± 0.048	3.347LeuAsn: 3.347 ± 0.063	5.835LeuPro: 5.835 ± 0.085	4.269LeuGln: 4.269 ± 0.072	6.807LeuArg: 6.807 ± 0.092	6.515LeuSer: 6.515 ± 0.088	5.657LeuThr: 5.657 ± 0.072	6.384LeuVal: 6.384 ± 0.081	1.051LeuTrp: 1.051 ± 0.032	2.214LeuTyr: 2.214 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.053MetAla: 3.053 ± 0.053	0.169MetCys: 0.169 ± 0.014	1.23MetAsp: 1.23 ± 0.03	1.217MetGlu: 1.217 ± 0.03	0.841MetPhe: 0.841 ± 0.026	1.722MetGly: 1.722 ± 0.039	0.712MetHis: 0.712 ± 0.024	1.34MetIle: 1.34 ± 0.036	1.181MetLys: 1.181 ± 0.035	3.074MetLeu: 3.074 ± 0.055	0.707MetMet: 0.707 ± 0.026	0.952MetAsn: 0.952 ± 0.029	1.689MetPro: 1.689 ± 0.041	1.353MetGln: 1.353 ± 0.031	1.88MetArg: 1.88 ± 0.042	1.713MetSer: 1.713 ± 0.04	1.634MetThr: 1.634 ± 0.034	1.693MetVal: 1.693 ± 0.037	0.18MetTrp: 0.18 ± 0.012	0.464MetTyr: 0.464 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.082AsnAla: 4.082 ± 0.067	0.296AsnCys: 0.296 ± 0.016	1.774AsnAsp: 1.774 ± 0.067	1.427AsnGlu: 1.427 ± 0.034	1.215AsnPhe: 1.215 ± 0.035	2.913AsnGly: 2.913 ± 0.072	0.588AsnHis: 0.588 ± 0.023	1.908AsnIle: 1.908 ± 0.056	1.159AsnLys: 1.159 ± 0.033	3.149AsnLeu: 3.149 ± 0.06	0.834AsnMet: 0.834 ± 0.027	1.183AsnAsn: 1.183 ± 0.048	2.01AsnPro: 2.01 ± 0.044	1.067AsnGln: 1.067 ± 0.031	1.879AsnArg: 1.879 ± 0.038	1.632AsnSer: 1.632 ± 0.055	1.733AsnThr: 1.733 ± 0.059	2.333AsnVal: 2.333 ± 0.057	0.445AsnTrp: 0.445 ± 0.021	0.838AsnTyr: 0.838 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.936ProAla: 6.936 ± 0.11	0.327ProCys: 0.327 ± 0.016	3.206ProAsp: 3.206 ± 0.057	3.046ProGlu: 3.046 ± 0.055	1.774ProPhe: 1.774 ± 0.043	3.992ProGly: 3.992 ± 0.064	1.141ProHis: 1.141 ± 0.032	2.256ProIle: 2.256 ± 0.043	1.751ProLys: 1.751 ± 0.048	4.969ProLeu: 4.969 ± 0.07	1.19ProMet: 1.19 ± 0.03	1.451ProAsn: 1.451 ± 0.039	2.407ProPro: 2.407 ± 0.056	2.027ProGln: 2.027 ± 0.048	2.465ProArg: 2.465 ± 0.049	2.593ProSer: 2.593 ± 0.045	2.1ProThr: 2.1 ± 0.041	3.76ProVal: 3.76 ± 0.071	0.542ProTrp: 0.542 ± 0.021	1.216ProTyr: 1.216 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.136GlnAla: 5.136 ± 0.089	0.301GlnCys: 0.301 ± 0.017	1.785GlnAsp: 1.785 ± 0.035	1.752GlnGlu: 1.752 ± 0.041	1.368GlnPhe: 1.368 ± 0.035	2.646GlnGly: 2.646 ± 0.054	0.875GlnHis: 0.875 ± 0.028	2.336GlnIle: 2.336 ± 0.046	1.561GlnLys: 1.561 ± 0.038	4.211GlnLeu: 4.211 ± 0.068	1.133GlnMet: 1.133 ± 0.033	1.204GlnAsn: 1.204 ± 0.037	1.939GlnPro: 1.939 ± 0.04	2.047GlnGln: 2.047 ± 0.056	2.906GlnArg: 2.906 ± 0.053	2.245GlnSer: 2.245 ± 0.048	2.039GlnThr: 2.039 ± 0.038	2.501GlnVal: 2.501 ± 0.046	0.52GlnTrp: 0.52 ± 0.023	0.976GlnTyr: 0.976 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.526ArgAla: 6.526 ± 0.089	0.489ArgCys: 0.489 ± 0.02	3.423ArgAsp: 3.423 ± 0.057	3.512ArgGlu: 3.512 ± 0.063	2.551ArgPhe: 2.551 ± 0.05	4.024ArgGly: 4.024 ± 0.058	1.72ArgHis: 1.72 ± 0.04	3.863ArgIle: 3.863 ± 0.067	2.52ArgLys: 2.52 ± 0.047	6.724ArgLeu: 6.724 ± 0.089	1.772ArgMet: 1.772 ± 0.035	2.22ArgAsn: 2.22 ± 0.045	2.746ArgPro: 2.746 ± 0.052	2.839ArgGln: 2.839 ± 0.054	4.29ArgArg: 4.29 ± 0.079	3.108ArgSer: 3.108 ± 0.051	2.83ArgThr: 2.83 ± 0.059	3.866ArgVal: 3.866 ± 0.057	0.881ArgTrp: 0.881 ± 0.028	1.875ArgTyr: 1.875 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.76SerAla: 6.76 ± 0.084	0.482SerCys: 0.482 ± 0.022	3.101SerAsp: 3.101 ± 0.056	2.683SerGlu: 2.683 ± 0.042	2.086SerPhe: 2.086 ± 0.041	5.476SerGly: 5.476 ± 0.077	1.257SerHis: 1.257 ± 0.032	3.163SerIle: 3.163 ± 0.061	2.028SerLys: 2.028 ± 0.045	5.769SerLeu: 5.769 ± 0.067	1.546SerMet: 1.546 ± 0.039	1.845SerAsn: 1.845 ± 0.052	2.691SerPro: 2.691 ± 0.044	1.894SerGln: 1.894 ± 0.039	3.315SerArg: 3.315 ± 0.057	3.287SerSer: 3.287 ± 0.074	2.898SerThr: 2.898 ± 0.06	3.967SerVal: 3.967 ± 0.069	0.663SerTrp: 0.663 ± 0.022	1.468SerTyr: 1.468 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.912ThrAla: 5.912 ± 0.081	0.344ThrCys: 0.344 ± 0.019	2.531ThrAsp: 2.531 ± 0.058	2.406ThrGlu: 2.406 ± 0.053	1.745ThrPhe: 1.745 ± 0.037	4.442ThrGly: 4.442 ± 0.128	1.087ThrHis: 1.087 ± 0.034	2.831ThrIle: 2.831 ± 0.055	1.419ThrLys: 1.419 ± 0.036	6.025ThrLeu: 6.025 ± 0.101	1.179ThrMet: 1.179 ± 0.034	1.405ThrAsn: 1.405 ± 0.041	3.19ThrPro: 3.19 ± 0.053	1.798ThrGln: 1.798 ± 0.04	2.797ThrArg: 2.797 ± 0.05	2.647ThrSer: 2.647 ± 0.061	2.441ThrThr: 2.441 ± 0.048	4.146ThrVal: 4.146 ± 0.078	0.537ThrTrp: 0.537 ± 0.021	1.201ThrTyr: 1.201 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.127ValAla: 8.127 ± 0.089	0.646ValCys: 0.646 ± 0.023	3.927ValAsp: 3.927 ± 0.064	3.743ValGlu: 3.743 ± 0.062	2.667ValPhe: 2.667 ± 0.053	4.941ValGly: 4.941 ± 0.078	1.363ValHis: 1.363 ± 0.035	3.967ValIle: 3.967 ± 0.06	2.906ValLys: 2.906 ± 0.055	7.307ValLeu: 7.307 ± 0.089	1.89ValMet: 1.89 ± 0.039	2.277ValAsn: 2.277 ± 0.048	3.264ValPro: 3.264 ± 0.056	2.524ValGln: 2.524 ± 0.05	4.14ValArg: 4.14 ± 0.06	4.163ValSer: 4.163 ± 0.06	3.848ValThr: 3.848 ± 0.07	5.167ValVal: 5.167 ± 0.081	0.726ValTrp: 0.726 ± 0.023	1.568ValTyr: 1.568 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.945TrpAla: 0.945 ± 0.028	0.132TrpCys: 0.132 ± 0.01	0.544TrpAsp: 0.544 ± 0.019	0.586TrpGlu: 0.586 ± 0.022	0.533TrpPhe: 0.533 ± 0.02	0.696TrpGly: 0.696 ± 0.025	0.323TrpHis: 0.323 ± 0.016	0.728TrpIle: 0.728 ± 0.026	0.487TrpLys: 0.487 ± 0.018	1.676TrpLeu: 1.676 ± 0.043	0.387TrpMet: 0.387 ± 0.019	0.463TrpAsn: 0.463 ± 0.018	0.576TrpPro: 0.576 ± 0.022	0.658TrpGln: 0.658 ± 0.023	1.062TrpArg: 1.062 ± 0.034	0.717TrpSer: 0.717 ± 0.025	0.555TrpThr: 0.555 ± 0.022	0.727TrpVal: 0.727 ± 0.024	0.156TrpTrp: 0.156 ± 0.013	0.332TrpTyr: 0.332 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.049	0.26TyrCys: 0.26 ± 0.015	1.364TyrAsp: 1.364 ± 0.033	1.246TyrGlu: 1.246 ± 0.036	1.14TyrPhe: 1.14 ± 0.031	2.102TyrGly: 2.102 ± 0.042	0.49TyrHis: 0.49 ± 0.02	1.067TyrIle: 1.067 ± 0.026	0.906TyrLys: 0.906 ± 0.031	2.714TyrLeu: 2.714 ± 0.053	0.536TyrMet: 0.536 ± 0.02	0.777TyrAsn: 0.777 ± 0.024	1.275TyrPro: 1.275 ± 0.032	1.034TyrGln: 1.034 ± 0.031	1.881TyrArg: 1.881 ± 0.041	1.423TyrSer: 1.423 ± 0.038	1.248TyrThr: 1.248 ± 0.043	1.663TyrVal: 1.663 ± 0.037	0.369TyrTrp: 0.369 ± 0.018	0.682TyrTyr: 0.682 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3601 proteins (1228013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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