Amino acid dipepetide frequency for Xanthomonas virus phiXaf18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.919AlaAla: 20.919 ± 2.502
1.539AlaCys: 1.539 ± 0.365
7.766AlaAsp: 7.766 ± 0.696
5.457AlaGlu: 5.457 ± 0.809
3.498AlaPhe: 3.498 ± 0.549
9.865AlaGly: 9.865 ± 1.033
2.659AlaHis: 2.659 ± 0.319
5.527AlaIle: 5.527 ± 0.658
4.478AlaLys: 4.478 ± 0.626
12.384AlaLeu: 12.384 ± 1.016
3.918AlaMet: 3.918 ± 0.496
4.058AlaAsn: 4.058 ± 0.587
6.507AlaPro: 6.507 ± 0.632
6.437AlaGln: 6.437 ± 0.776
7.696AlaArg: 7.696 ± 0.941
5.947AlaSer: 5.947 ± 0.728
8.676AlaThr: 8.676 ± 0.861
8.676AlaVal: 8.676 ± 0.787
1.959AlaTrp: 1.959 ± 0.405
2.589AlaTyr: 2.589 ± 0.424
0.0AlaXaa: 0.0 ± 0.0
Cys
1.189CysAla: 1.189 ± 0.313
0.07CysCys: 0.07 ± 0.065
0.98CysAsp: 0.98 ± 0.262
0.35CysGlu: 0.35 ± 0.194
0.21CysPhe: 0.21 ± 0.122
1.329CysGly: 1.329 ± 0.426
0.42CysHis: 0.42 ± 0.159
0.56CysIle: 0.56 ± 0.18
0.14CysLys: 0.14 ± 0.102
0.77CysLeu: 0.77 ± 0.227
0.28CysMet: 0.28 ± 0.146
0.21CysAsn: 0.21 ± 0.129
0.56CysPro: 0.56 ± 0.304
0.63CysGln: 0.63 ± 0.242
1.609CysArg: 1.609 ± 0.332
1.259CysSer: 1.259 ± 0.295
0.28CysThr: 0.28 ± 0.139
0.49CysVal: 0.49 ± 0.161
0.21CysTrp: 0.21 ± 0.172
0.14CysTyr: 0.14 ± 0.096
0.0CysXaa: 0.0 ± 0.0
Asp
8.536AspAla: 8.536 ± 0.773
1.049AspCys: 1.049 ± 0.301
2.379AspAsp: 2.379 ± 0.434
3.148AspGlu: 3.148 ± 0.551
2.099AspPhe: 2.099 ± 0.378
3.918AspGly: 3.918 ± 0.42
0.91AspHis: 0.91 ± 0.291
2.729AspIle: 2.729 ± 0.414
2.169AspLys: 2.169 ± 0.444
6.157AspLeu: 6.157 ± 0.774
1.049AspMet: 1.049 ± 0.274
1.539AspAsn: 1.539 ± 0.351
3.988AspPro: 3.988 ± 0.62
2.379AspGln: 2.379 ± 0.481
4.058AspArg: 4.058 ± 0.545
3.008AspSer: 3.008 ± 0.619
3.218AspThr: 3.218 ± 0.635
4.058AspVal: 4.058 ± 0.464
1.399AspTrp: 1.399 ± 0.342
1.749AspTyr: 1.749 ± 0.365
0.0AspXaa: 0.0 ± 0.0
Glu
5.947GluAla: 5.947 ± 0.627
0.28GluCys: 0.28 ± 0.129
2.589GluAsp: 2.589 ± 0.383
1.959GluGlu: 1.959 ± 0.379
1.959GluPhe: 1.959 ± 0.324
3.358GluGly: 3.358 ± 0.459
0.91GluHis: 0.91 ± 0.304
2.449GluIle: 2.449 ± 0.409
1.119GluLys: 1.119 ± 0.262
4.967GluLeu: 4.967 ± 0.803
1.189GluMet: 1.189 ± 0.269
0.77GluAsn: 0.77 ± 0.265
2.379GluPro: 2.379 ± 0.431
2.309GluGln: 2.309 ± 0.481
4.338GluArg: 4.338 ± 0.498
2.729GluSer: 2.729 ± 0.562
2.939GluThr: 2.939 ± 0.429
3.078GluVal: 3.078 ± 0.435
1.049GluTrp: 1.049 ± 0.216
1.469GluTyr: 1.469 ± 0.291
0.0GluXaa: 0.0 ± 0.0
Phe
3.638PheAla: 3.638 ± 0.395
0.56PheCys: 0.56 ± 0.211
2.239PheAsp: 2.239 ± 0.408
2.099PheGlu: 2.099 ± 0.411
0.77PhePhe: 0.77 ± 0.244
3.148PheGly: 3.148 ± 0.495
0.49PheHis: 0.49 ± 0.277
0.98PheIle: 0.98 ± 0.315
0.63PheLys: 0.63 ± 0.191
2.099PheLeu: 2.099 ± 0.342
0.49PheMet: 0.49 ± 0.184
1.539PheAsn: 1.539 ± 0.342
1.609PhePro: 1.609 ± 0.338
1.049PheGln: 1.049 ± 0.305
1.889PheArg: 1.889 ± 0.413
1.539PheSer: 1.539 ± 0.406
1.889PheThr: 1.889 ± 0.334
2.869PheVal: 2.869 ± 0.49
0.63PheTrp: 0.63 ± 0.214
0.42PheTyr: 0.42 ± 0.175
0.0PheXaa: 0.0 ± 0.0
Gly
8.816GlyAla: 8.816 ± 1.235
1.329GlyCys: 1.329 ± 0.301
3.988GlyAsp: 3.988 ± 0.595
3.498GlyGlu: 3.498 ± 0.456
3.428GlyPhe: 3.428 ± 0.608
9.235GlyGly: 9.235 ± 2.981
1.399GlyHis: 1.399 ± 0.322
3.148GlyIle: 3.148 ± 0.425
2.729GlyLys: 2.729 ± 0.391
6.297GlyLeu: 6.297 ± 0.6
1.539GlyMet: 1.539 ± 0.331
2.379GlyAsn: 2.379 ± 0.456
2.379GlyPro: 2.379 ± 0.391
3.218GlyGln: 3.218 ± 0.552
6.717GlyArg: 6.717 ± 0.826
4.338GlySer: 4.338 ± 0.804
5.457GlyThr: 5.457 ± 0.747
6.647GlyVal: 6.647 ± 0.631
1.119GlyTrp: 1.119 ± 0.307
2.659GlyTyr: 2.659 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
1.609HisAla: 1.609 ± 0.284
0.28HisCys: 0.28 ± 0.224
0.63HisAsp: 0.63 ± 0.164
1.049HisGlu: 1.049 ± 0.272
0.56HisPhe: 0.56 ± 0.188
1.609HisGly: 1.609 ± 0.378
0.35HisHis: 0.35 ± 0.158
0.7HisIle: 0.7 ± 0.227
0.42HisLys: 0.42 ± 0.192
1.189HisLeu: 1.189 ± 0.267
0.49HisMet: 0.49 ± 0.166
0.49HisAsn: 0.49 ± 0.222
1.959HisPro: 1.959 ± 0.407
0.14HisGln: 0.14 ± 0.106
1.679HisArg: 1.679 ± 0.387
1.259HisSer: 1.259 ± 0.292
1.329HisThr: 1.329 ± 0.326
2.099HisVal: 2.099 ± 0.378
0.28HisTrp: 0.28 ± 0.173
0.35HisTyr: 0.35 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
4.967IleAla: 4.967 ± 0.6
0.28IleCys: 0.28 ± 0.174
4.128IleAsp: 4.128 ± 0.483
2.659IleGlu: 2.659 ± 0.336
0.84IlePhe: 0.84 ± 0.27
3.428IleGly: 3.428 ± 0.45
0.7IleHis: 0.7 ± 0.22
1.539IleIle: 1.539 ± 0.319
1.609IleLys: 1.609 ± 0.356
3.008IleLeu: 3.008 ± 0.376
0.63IleMet: 0.63 ± 0.235
1.609IleAsn: 1.609 ± 0.375
2.799IlePro: 2.799 ± 0.482
1.469IleGln: 1.469 ± 0.364
2.939IleArg: 2.939 ± 0.344
2.029IleSer: 2.029 ± 0.328
3.218IleThr: 3.218 ± 0.498
2.729IleVal: 2.729 ± 0.623
0.56IleTrp: 0.56 ± 0.183
1.259IleTyr: 1.259 ± 0.334
0.0IleXaa: 0.0 ± 0.0
Lys
3.918LysAla: 3.918 ± 0.685
0.14LysCys: 0.14 ± 0.097
1.259LysAsp: 1.259 ± 0.316
1.749LysGlu: 1.749 ± 0.405
0.77LysPhe: 0.77 ± 0.183
1.469LysGly: 1.469 ± 0.302
0.56LysHis: 0.56 ± 0.19
1.749LysIle: 1.749 ± 0.326
1.259LysLys: 1.259 ± 0.276
2.729LysLeu: 2.729 ± 0.441
1.119LysMet: 1.119 ± 0.32
0.98LysAsn: 0.98 ± 0.265
2.239LysPro: 2.239 ± 0.41
1.259LysGln: 1.259 ± 0.276
2.099LysArg: 2.099 ± 0.441
1.539LysSer: 1.539 ± 0.366
1.259LysThr: 1.259 ± 0.257
2.589LysVal: 2.589 ± 0.407
0.63LysTrp: 0.63 ± 0.179
0.98LysTyr: 0.98 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
10.075LeuAla: 10.075 ± 0.901
0.63LeuCys: 0.63 ± 0.24
6.157LeuAsp: 6.157 ± 0.805
5.037LeuGlu: 5.037 ± 0.863
2.309LeuPhe: 2.309 ± 0.453
5.667LeuGly: 5.667 ± 0.545
1.329LeuHis: 1.329 ± 0.386
3.428LeuIle: 3.428 ± 0.52
2.029LeuLys: 2.029 ± 0.341
5.317LeuLeu: 5.317 ± 0.712
2.729LeuMet: 2.729 ± 0.429
2.939LeuAsn: 2.939 ± 0.447
5.177LeuPro: 5.177 ± 0.835
4.338LeuGln: 4.338 ± 0.66
5.177LeuArg: 5.177 ± 0.641
6.367LeuSer: 6.367 ± 0.708
6.227LeuThr: 6.227 ± 0.765
6.087LeuVal: 6.087 ± 0.782
1.469LeuTrp: 1.469 ± 0.31
1.749LeuTyr: 1.749 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
3.568MetAla: 3.568 ± 0.507
0.49MetCys: 0.49 ± 0.202
1.399MetAsp: 1.399 ± 0.368
0.63MetGlu: 0.63 ± 0.218
0.49MetPhe: 0.49 ± 0.206
1.189MetGly: 1.189 ± 0.358
0.42MetHis: 0.42 ± 0.146
1.119MetIle: 1.119 ± 0.298
0.91MetLys: 0.91 ± 0.316
1.469MetLeu: 1.469 ± 0.342
0.28MetMet: 0.28 ± 0.137
1.119MetAsn: 1.119 ± 0.419
1.259MetPro: 1.259 ± 0.304
1.329MetGln: 1.329 ± 0.34
1.679MetArg: 1.679 ± 0.337
1.889MetSer: 1.889 ± 0.344
2.169MetThr: 2.169 ± 0.327
0.91MetVal: 0.91 ± 0.232
0.56MetTrp: 0.56 ± 0.154
0.56MetTyr: 0.56 ± 0.165
0.0MetXaa: 0.0 ± 0.0
Asn
4.338AsnAla: 4.338 ± 0.494
0.56AsnCys: 0.56 ± 0.202
1.889AsnAsp: 1.889 ± 0.422
1.119AsnGlu: 1.119 ± 0.265
1.049AsnPhe: 1.049 ± 0.252
3.358AsnGly: 3.358 ± 0.627
0.7AsnHis: 0.7 ± 0.287
0.98AsnIle: 0.98 ± 0.31
1.049AsnLys: 1.049 ± 0.288
2.799AsnLeu: 2.799 ± 0.336
0.7AsnMet: 0.7 ± 0.215
1.119AsnAsn: 1.119 ± 0.267
2.239AsnPro: 2.239 ± 0.378
1.119AsnGln: 1.119 ± 0.268
2.729AsnArg: 2.729 ± 0.477
1.469AsnSer: 1.469 ± 0.345
2.099AsnThr: 2.099 ± 0.349
1.959AsnVal: 1.959 ± 0.419
0.63AsnTrp: 0.63 ± 0.169
1.049AsnTyr: 1.049 ± 0.269
0.0AsnXaa: 0.0 ± 0.0
Pro
7.416ProAla: 7.416 ± 0.814
0.28ProCys: 0.28 ± 0.154
3.988ProAsp: 3.988 ± 0.558
3.638ProGlu: 3.638 ± 0.562
2.099ProPhe: 2.099 ± 0.337
5.107ProGly: 5.107 ± 0.671
0.91ProHis: 0.91 ± 0.301
2.309ProIle: 2.309 ± 0.433
0.84ProLys: 0.84 ± 0.261
4.058ProLeu: 4.058 ± 0.559
1.399ProMet: 1.399 ± 0.289
2.519ProAsn: 2.519 ± 0.444
3.288ProPro: 3.288 ± 0.66
2.869ProGln: 2.869 ± 0.519
2.589ProArg: 2.589 ± 0.367
3.358ProSer: 3.358 ± 0.477
4.618ProThr: 4.618 ± 0.742
3.918ProVal: 3.918 ± 0.483
0.84ProTrp: 0.84 ± 0.244
1.399ProTyr: 1.399 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
6.297GlnAla: 6.297 ± 0.6
0.7GlnCys: 0.7 ± 0.262
2.309GlnAsp: 2.309 ± 0.501
1.609GlnGlu: 1.609 ± 0.377
1.609GlnPhe: 1.609 ± 0.32
2.449GlnGly: 2.449 ± 0.38
0.98GlnHis: 0.98 ± 0.392
2.869GlnIle: 2.869 ± 0.446
0.84GlnLys: 0.84 ± 0.231
4.268GlnLeu: 4.268 ± 0.549
0.49GlnMet: 0.49 ± 0.172
1.189GlnAsn: 1.189 ± 0.267
2.239GlnPro: 2.239 ± 0.392
3.008GlnGln: 3.008 ± 0.627
2.939GlnArg: 2.939 ± 0.481
3.008GlnSer: 3.008 ± 0.459
3.008GlnThr: 3.008 ± 0.472
3.358GlnVal: 3.358 ± 0.501
0.84GlnTrp: 0.84 ± 0.289
1.119GlnTyr: 1.119 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
7.766ArgAla: 7.766 ± 0.904
0.77ArgCys: 0.77 ± 0.212
4.338ArgAsp: 4.338 ± 0.678
3.428ArgGlu: 3.428 ± 0.539
2.169ArgPhe: 2.169 ± 0.542
4.058ArgGly: 4.058 ± 0.517
1.189ArgHis: 1.189 ± 0.228
2.309ArgIle: 2.309 ± 0.386
2.939ArgLys: 2.939 ± 0.581
5.737ArgLeu: 5.737 ± 0.702
1.959ArgMet: 1.959 ± 0.337
2.169ArgAsn: 2.169 ± 0.57
3.778ArgPro: 3.778 ± 0.626
3.498ArgGln: 3.498 ± 0.553
5.247ArgArg: 5.247 ± 0.78
4.898ArgSer: 4.898 ± 0.827
3.358ArgThr: 3.358 ± 0.478
3.568ArgVal: 3.568 ± 0.436
1.539ArgTrp: 1.539 ± 0.346
2.379ArgTyr: 2.379 ± 0.305
0.0ArgXaa: 0.0 ± 0.0
Ser
8.186SerAla: 8.186 ± 1.447
0.49SerCys: 0.49 ± 0.174
3.218SerAsp: 3.218 ± 0.589
2.869SerGlu: 2.869 ± 0.494
1.819SerPhe: 1.819 ± 0.363
6.227SerGly: 6.227 ± 0.822
1.189SerHis: 1.189 ± 0.431
2.939SerIle: 2.939 ± 0.404
2.099SerLys: 2.099 ± 0.343
4.688SerLeu: 4.688 ± 0.596
0.98SerMet: 0.98 ± 0.243
1.749SerAsn: 1.749 ± 0.271
3.708SerPro: 3.708 ± 0.467
2.239SerGln: 2.239 ± 0.377
2.589SerArg: 2.589 ± 0.371
2.869SerSer: 2.869 ± 0.486
3.918SerThr: 3.918 ± 0.652
3.918SerVal: 3.918 ± 0.63
0.98SerTrp: 0.98 ± 0.287
1.189SerTyr: 1.189 ± 0.268
0.0SerXaa: 0.0 ± 0.0
Thr
8.256ThrAla: 8.256 ± 1.17
0.42ThrCys: 0.42 ± 0.17
3.498ThrAsp: 3.498 ± 0.459
2.169ThrGlu: 2.169 ± 0.405
1.539ThrPhe: 1.539 ± 0.319
5.877ThrGly: 5.877 ± 0.731
1.399ThrHis: 1.399 ± 0.244
3.078ThrIle: 3.078 ± 0.511
1.329ThrLys: 1.329 ± 0.342
6.507ThrLeu: 6.507 ± 0.819
1.609ThrMet: 1.609 ± 0.375
2.099ThrAsn: 2.099 ± 0.35
4.618ThrPro: 4.618 ± 0.593
3.008ThrGln: 3.008 ± 0.37
2.939ThrArg: 2.939 ± 0.5
3.148ThrSer: 3.148 ± 0.445
3.778ThrThr: 3.778 ± 0.779
5.667ThrVal: 5.667 ± 0.739
1.469ThrTrp: 1.469 ± 0.292
1.959ThrTyr: 1.959 ± 0.401
0.0ThrXaa: 0.0 ± 0.0
Val
9.935ValAla: 9.935 ± 0.822
0.84ValCys: 0.84 ± 0.239
4.268ValAsp: 4.268 ± 0.484
3.568ValGlu: 3.568 ± 0.382
2.099ValPhe: 2.099 ± 0.485
5.597ValGly: 5.597 ± 0.697
0.98ValHis: 0.98 ± 0.217
2.589ValIle: 2.589 ± 0.401
2.589ValLys: 2.589 ± 0.472
5.667ValLeu: 5.667 ± 0.698
1.959ValMet: 1.959 ± 0.36
2.589ValAsn: 2.589 ± 0.427
4.268ValPro: 4.268 ± 0.643
2.729ValGln: 2.729 ± 0.452
4.828ValArg: 4.828 ± 0.642
4.058ValSer: 4.058 ± 0.481
4.128ValThr: 4.128 ± 0.632
5.177ValVal: 5.177 ± 0.563
1.399ValTrp: 1.399 ± 0.261
1.889ValTyr: 1.889 ± 0.374
0.0ValXaa: 0.0 ± 0.0
Trp
2.309TrpAla: 2.309 ± 0.405
0.49TrpCys: 0.49 ± 0.189
0.91TrpAsp: 0.91 ± 0.228
0.98TrpGlu: 0.98 ± 0.25
0.42TrpPhe: 0.42 ± 0.165
0.91TrpGly: 0.91 ± 0.229
0.35TrpHis: 0.35 ± 0.152
0.63TrpIle: 0.63 ± 0.254
0.49TrpLys: 0.49 ± 0.184
1.889TrpLeu: 1.889 ± 0.334
0.35TrpMet: 0.35 ± 0.15
0.63TrpAsn: 0.63 ± 0.221
1.049TrpPro: 1.049 ± 0.28
0.84TrpGln: 0.84 ± 0.212
1.469TrpArg: 1.469 ± 0.323
1.679TrpSer: 1.679 ± 0.389
1.119TrpThr: 1.119 ± 0.339
0.91TrpVal: 0.91 ± 0.225
0.42TrpTrp: 0.42 ± 0.164
0.7TrpTyr: 0.7 ± 0.211
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.869TyrAla: 2.869 ± 0.438
0.49TyrCys: 0.49 ± 0.186
1.609TyrAsp: 1.609 ± 0.314
0.77TyrGlu: 0.77 ± 0.285
0.84TyrPhe: 0.84 ± 0.214
2.519TyrGly: 2.519 ± 0.34
0.63TyrHis: 0.63 ± 0.195
0.77TyrIle: 0.77 ± 0.198
0.63TyrLys: 0.63 ± 0.206
2.239TyrLeu: 2.239 ± 0.478
0.21TyrMet: 0.21 ± 0.106
1.259TyrAsn: 1.259 ± 0.272
1.399TyrPro: 1.399 ± 0.349
1.259TyrGln: 1.259 ± 0.242
1.889TyrArg: 1.889 ± 0.348
1.469TyrSer: 1.469 ± 0.323
1.749TyrThr: 1.749 ± 0.355
2.449TyrVal: 2.449 ± 0.533
0.56TyrTrp: 0.56 ± 0.216
0.56TyrTyr: 0.56 ± 0.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski